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    Method for enhancing chemical sensitivity or radiosensitivity of cancer cells by inhibiting expression of TSPYL5
    22.
    发明授权
    Method for enhancing chemical sensitivity or radiosensitivity of cancer cells by inhibiting expression of TSPYL5 有权
    通过抑制TSPYL5的表达来提高癌细胞的化学敏感性或放射敏感性的方法

    公开(公告)号：US08343940B2

    公开(公告)日：2013-01-01

    申请号：US12823035

    申请日：2010-06-24

    Applicant: In Gyu Kim ,  Tae Lim Kim ,  Kug Chan Kim ,  Eun Jin Kim ,  So Yong Lee ,  Il Lae Jung

    Inventor： In Gyu Kim ,  Tae Lim Kim ,  Kug Chan Kim ,  Eun Jin Kim ,  So Yong Lee ,  Il Lae Jung

    IPC: C12N15/11 ,  C07H21/02 ,  C07H21/04

    CPC classification number: G01N33/5011 ,  G01N33/574

    Abstract: Disclosed herein is a method for enhancing sensitivity of cancer cells to compounds or radiation by inhibiting the expression of testis-specific protein, Y-encoded like 5 (TSPYL5). More specifically, because methylation of TSPYL5 protein expressed in lung cancer cell line was inhibited to increase the expression level of the gene, resistance to stress such as radiation or anticancer agents was increased. Because the sensitivity of cancer cells to stress such as radiation or anticancer agents was increased by inhibiting the expression of the TSPYL5 gene to promote the apoptosis of the cells, an anticancer supplement agent containing an inhibitor of the expression or activity of the TSPYL5 gene of the present invention inhibits the growth of cancer cells and enhances the sensitivity to various stresses to maximize the apoptosis. Thus, when used in combination with radiotherapy or chemotherapy, the anticancer supplement agent may be used very usefully for anticancer treatment.

    Abstract translation: 本文公开了通过抑制Y编码的5（TSPYL5）的睾丸特异性蛋白质的表达来增强癌细胞对化合物或辐射的敏感性的方法。 更具体地说，由于在肺癌细胞系中表达的TSPYL5蛋白的甲基化被抑制以增加基因的表达水平，所以对抗应激性（如放射线或抗癌剂）的抗性增加。 因为通过抑制TSPYL5基因的表达以促进细胞凋亡来增加癌细胞对诸如放射线或抗癌剂之类的应激的敏感性，所以可以使用含有TSPYL5基因的表达或活性抑制剂的抗癌补充剂 本发明抑制癌细胞的生长并且增强对各种应激的敏感性以使细胞凋亡最大化。 因此，当与放射治疗或化疗组合使用时，抗癌补充剂可以非常有用地用于抗癌治疗。

    Tray apparatus
    24.
    发明授权
    Tray apparatus 有权
    托盘设备

    公开(公告)号：US08109424B2

    公开(公告)日：2012-02-07

    申请号：US12325130

    申请日：2008-11-28

    Applicant: Jong Sun Lee ,  Yang Gi Lee ,  Tae Hoon Song ,  In Gyu Kim ,  Jin Wan Park ,  Yong Gu Kang

    Inventor： Jong Sun Lee ,  Yang Gi Lee ,  Tae Hoon Song ,  In Gyu Kim ,  Jin Wan Park ,  Yong Gu Kang

    IPC: B60R7/06

    CPC classification number: B60R7/06 ,  B60R7/04

    Abstract: A tray apparatus may include a housing, a tray slidably accommodated in the housing to be opened or closed, a rotary lock pivotally coupled to the housing at a hinge portion of the rotary lock and locking the tray to the housing when external shock is applied to the tray beyond a predetermined value, wherein a center of gravity of the rotary lock is positioned above the hinge portion, and a holding unit for holding the rotary lock in a normal state so that the rotary lock maintains an original position thereof.

    Abstract translation: 托盘装置可以包括壳体，可滑动地容纳在壳体中以被打开或关闭的托盘，在旋转锁的铰链部分处枢转地联接到壳体的旋转锁，并且当外部冲击施加到托架装置时将托盘锁定到壳体 所述托盘超过预定值，其中所述旋转锁的重心位于所述铰链部分的上方，以及保持单元，用于将所述旋转锁保持在正常状态，使得所述旋转锁保持其初始位置。

    Method of overproduction of polyhydroxybutyrate
    25.
    发明授权
    Method of overproduction of polyhydroxybutyrate 有权
    聚羟基丁酸酯过量生产的方法

    公开(公告)号：US07771964B2

    公开(公告)日：2010-08-10

    申请号：US10998473

    申请日：2004-11-29

    Applicant: In Gyu Kim ,  Il Lae Jung ,  Hyo Kook Park ,  Kug Chan Kim ,  Byung Ho Choi

    Inventor： In Gyu Kim ,  Il Lae Jung ,  Hyo Kook Park ,  Kug Chan Kim ,  Byung Ho Choi

    IPC: C12P1/00 ,  C12P7/00 ,  C12P7/02 ,  C12P7/18

    CPC classification number: C12P7/62

    Abstract: The present invention relates to a recombinant Escherichia coli having phbCAB originated from Alcaligenes eutrophus and an overproduction method of polyhydroxyalkanoate using the same, more precisely, a recombinant Escherichia coli ‘MG1655/pTZ18U-PHB’ or ‘JIL938/pTZ18U-PHB’ having phbCAB originated from Alcaligenes eutrophus and an overproduction method of polyhydroxyalkanoate comprising the steps of preparing transformed Escherichia coli having phbCAB originated from Alcaligenes eutrophus, inoculating and culturing the cells (growth phase), inducing the production of polyhydroxyalkanoate in the recomibnant Escherichia coli (stationary phase and producing phase), and inducing the extracellular secretion of the polyhydroxyalkanoate from the recombinant Escherichia coli. The method of the present invention facilitates not only overproduction of polyhydroxyalkanoate such as polyhydroxybutyrate by a simple batch culture but also industrial use of biodegradable polyhydroxyalkanoate replacing conventional non-biodegradable plastics by its simple and easy fermentation, separation and purification process.

    Abstract translation: 本发明涉及具有源自嗜碱性杆菌的phbCAB的重组大肠杆菌，以及使用该重组大肠杆菌的具有phbCAB的重组大肠杆菌MG1655 / pTZ18U-PHB'或'JIL938 / pTZ18U-PHB'的多羟基链烷酸酯的过量产生方法 来自产碱杆菌属的富含嗜碱性细菌的产生方法和多羟基链烷酸酯的过量产生方法，包括以下步骤：制备具有源自产碱杆菌属细菌的phbCAB的转化大肠杆菌，接种和培养细胞（生长期），诱导在大肠杆菌（稳定期和生产阶段）中产生聚羟基链烷酸酯 ），并诱导来自重组大肠杆菌的聚羟基链烷酸酯的细胞外分泌。 本发明的方法不仅通过简单的分批培养而不仅过度生产聚羟基链烷酸酯如聚羟基丁酸酯，而且还通过其简单且容易的发酵，分离和纯化方法替代常规的不可生物降解的塑料来生产可降解的聚羟基链烷酸酯的工业应用。

    Gas radiation oven range
    26.
    发明授权
    Gas radiation oven range 有权
    燃气辐射炉范围

    公开(公告)号：US07690374B2

    公开(公告)日：2010-04-06

    申请号：US10536395

    申请日：2002-11-29

    Applicant: Dae-Rae Lee ,  In-Gyu Kim ,  Dae-Hee Jung ,  Sug-Moon Choung ,  Yang Ho Kim

    Inventor： Dae-Rae Lee ,  In-Gyu Kim ,  Dae-Hee Jung ,  Sug-Moon Choung ,  Yang Ho Kim

    IPC: F24C3/00

    CPC classification number: F24C15/101 ,  F24C3/067

    Abstract: A gas radiation oven range including an outer case (10) which is formed with an upper side opened, having an internal space, a ceramic glass (20) which is covered and combined with an upper end of the outer case (10), a plurality of burner housings (300) which are combined to be contacted with a lower surface of the ceramic glass (20), forms an exhaust passage (F) with the lower surface of the ceramic glass (20), and is integrally combined with a plurality of ports with different sizes, a radiant burner (40) which is combined with a side surface of the respective burner housings (300), for generating a radiant wave, combusting mixed gas and a shared discharge unit which is positioned among the burner housings (300) and combined to be connected to respective exhaust passages (F) which are formed at a side portion of the burner housings (300).

    Abstract translation: 一种气体放射线烘炉范围，包括外壳（10），其形成有具有内部空间的上侧开口的陶瓷玻璃（20），所述陶瓷玻璃（20）与所述外壳（10）的上端被覆盖并组合， 多个与陶瓷玻璃（20）的下表面接触的燃烧器壳体（300）与陶瓷玻璃（20）的下表面形成排气通道（F），并与 多个具有不同尺寸的端口，辐射燃烧器（40），其与各个燃烧器壳体（300）的侧表面组合，用于产生辐射波，燃烧混合气体和共享排放单元，其位于燃烧器壳体 （300）并且组合以连接到形成在燃烧器壳体（300）的侧部处的各个排气通道（F）。

    Combustion fan installation structure of gas radiation oven range
    30.
    发明申请
    Combustion fan installation structure of gas radiation oven range 有权
    燃气灶安装结构燃气灶的范围

    公开(公告)号：US20060070616A1

    公开(公告)日：2006-04-06

    申请号：US10536394

    申请日：2002-11-29

    Applicant: Dae-Rae Lee ,  In-Gyu Kim ,  Dae-Hee Jung ,  Sug-Moon Choung ,  Yang-Ho Kim

    Inventor： Dae-Rae Lee ,  In-Gyu Kim ,  Dae-Hee Jung ,  Sug-Moon Choung ,  Yang-Ho Kim

    IPC: F24C15/20

    CPC classification number: F24C15/101 ,  F24C3/067

    Abstract: A combustion fan installation structure of a gas radiation oven range is disclosed in which a combustion fan (200) is coupled at a space outside a space where a radiant burner (40) is positioned. Since the temperature of the sucked air for combustion is constantly maintained, an air with a sufficient air density can be supplied. Thus, it can have a stable combustion performance. In addition, an influence of the temperature change generated when the oven or the grill is operated can be excluded. Accordingly, a reliability of a combustion performance of the gas radiation oven range to be mainly used in kitchens or in hotels can be improved.

    Abstract translation: 公开了一种燃气灶具范围的燃烧风扇安装结构，其中燃烧风扇（200）在位于辐射燃烧器（40）的空间外部的空间处连接。 由于用于燃烧的吸入空气的温度恒定地保持，所以能够供给足够的空气密度的空气。 因此，它可以具有稳定的燃烧性能。 此外，可以排除在烤箱或格栅操作时产生的温度变化的影响。 因此，可以提高主要在厨房或酒店中使用的气体放射线炉范围的燃烧性能的可靠性。

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