公开(公告)号：US08088381B2

公开(公告)日：2012-01-03

申请号：US11418624

申请日：2006-05-05

Applicant: Ingrid Langsetmo Parobok ,  Christopher T. Jacob ,  David Y. Liu

Inventor： Ingrid Langsetmo Parobok ,  Christopher T. Jacob ,  David Y. Liu

IPC: A61K39/395 ,  G01N33/49

CPC classification number: C07K16/22 ,  A61K2039/505

Abstract: The present invention relates to methods for treating impaired cardiac function. Methods for treating various physiological and pathological features associated with cardiac dysfunction by administering an agent that inhibits the expression or activity of connective tissue growth factor (CTGF) are provided.

Abstract translation: 本发明涉及治疗心脏功能受损的方法。 提供了通过施用抑制结缔组织生长因子（CTGF）的表达或活性的药物来治疗与心脏功能障碍相关的各种生理和病理特征的方法。

公开(公告)号：US20110039886A1

公开(公告)日：2011-02-17

申请号：US12804066

申请日：2010-07-12

Applicant: Stephen J. Klaus ,  Christopher J. Molineaux ,  Thomas B. Neff ,  Volkmar Guenzler-Pukall ,  Ingrid Langsetmo Parobok ,  Todd W. Seeley ,  Robert C. Stephenson

Inventor： Stephen J. Klaus ,  Christopher J. Molineaux ,  Thomas B. Neff ,  Volkmar Guenzler-Pukall ,  Ingrid Langsetmo Parobok ,  Todd W. Seeley ,  Robert C. Stephenson

IPC: A61K31/472 ,  A61P3/02 ,  A61P7/06

CPC classification number: C07D217/24 ,  A61K31/00 ,  A61K31/165 ,  A61K31/17 ,  A61K31/395 ,  A61K31/472 ,  C07C275/40

Abstract: The present invention relates to methods and compounds for regulating or enhancing erthropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.

Abstract translation: 本发明涉及用于调节或增强红细胞生成和铁代谢以及用于治疗或预防慢性疾病的铁缺乏和贫血的方法和化合物。

公开(公告)号：US20100278941A1

公开(公告)日：2010-11-04

申请号：US12804033

申请日：2010-07-12

Applicant: Stephen J. Klaus ,  Christopher J. Molineaux ,  Thomas B. Neff ,  Volkmar Guenzler-Pukall ,  Ingrid Langsetmo Parobok ,  Todd W. Seeley ,  Robert C. Stephenson

Inventor： Stephen J. Klaus ,  Christopher J. Molineaux ,  Thomas B. Neff ,  Volkmar Guenzler-Pukall ,  Ingrid Langsetmo Parobok ,  Todd W. Seeley ,  Robert C. Stephenson

IPC: A61K33/26 ,  A61K31/472 ,  A61K31/18 ,  A61K31/51 ,  A61K31/525 ,  A61K31/4415 ,  A61K31/714 ,  A61P7/06 ,  A61P29/00 ,  A61P31/00 ,  A61P37/00 ,  A61P35/00 ,  A61P3/02

CPC classification number: C07D217/24 ,  A61K31/00 ,  A61K31/165 ,  A61K31/17 ,  A61K31/395 ,  A61K31/472 ,  C07C275/40

Abstract: The present invention relates to methods and compounds for regulating or enhancing erthropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.

Abstract translation: 本发明涉及用于调节或增强红细胞生成和铁代谢以及用于治疗或预防慢性疾病的铁缺乏和贫血的方法和化合物。