公开(公告)号：US20020120096A1

公开(公告)日：2002-08-29

申请号：US10083555

申请日：2002-02-27

Applicant: Japan Science and Technology Corporation

Inventor： Eishun Tsuchida ,  Shinji Takeoka ,  Keitaro Sou ,  Haruki Ohkawa

IPC: C08G069/26 ,  C08G065/34

CPC classification number: C07C237/22 ,  C07C229/26 ,  C07C233/47 ,  C07C271/22 ,  C07K5/02 ,  C07K5/0215 ,  C07K7/02 ,  C07K14/001

Abstract: An amphiphilic compound having a dendritic branch structure represented by general formula (I): 1 In the formula (I), R0 is a hydrophilic group; R1 and R2 are independently a hydrophobic group; and n is an integer of 1 to 4. This amphiphilic compound is capable of stably fixing a water-soluble polymer onto a surface structure by taking advantage of intermolecular interaction, thereby enabling the water-soluble polymer to be carried thereon without giving any damage to the function thereof.

Abstract translation: 具有由通式（I）表示的树枝状结构的两亲化合物：在式（I）中，R 0为亲水基团; R1和R2独立地是疏水基团; n是1〜4的整数。该两亲性化合物能够通过利用分子间相互作用而将水溶性聚合物稳定地固定在表面结构上，从而使水溶性聚合物能够在其上承载而不会对 其功能。

公开(公告)号：US20020095108A1

公开(公告)日：2002-07-18

申请号：US10073084

申请日：2002-02-12

Applicant: Japan Science and Technology Corporation

Inventor： Eishun Tsuchida ,  Hiromi Sakai ,  Hiroto Onuma ,  Shinji Takeoka

IPC: A61M037/00 ,  C02F001/48

CPC classification number: A61K31/525 ,  A61K31/045 ,  A61K31/198 ,  A61K31/7004 ,  A61K31/7016 ,  A61K38/42 ,  A61K47/6445

Abstract: Disclosed is a method and apparatus for regenerating an oxygen-binding ability by reducing the methemoglobin contained in hemoglobin-vesicle by light irradiation. This method comprises adding electron donors such as amino acids, saccharides, alcohols, and/or flavin derivatives in appropriate amounts to the inner aqueous phase of the hemoglobin-vesicle, applying light to the vesicle when the content of methemoglobin increases as a result of oxidation of hemoglobin, thereby reducing the metohemoglobin. In this manner, the oxygen-binding ability is recovered, thereby maintaining the function of the hemoglobin-vesicle.

Abstract translation: 公开了通过光照射还原血红蛋白囊泡中所含的高铁血红蛋白来再生氧结合能力的方法和装置。 该方法包括将适当量的电子给体如氨基酸，糖类和/或黄素衍生物加入到血红蛋白 - 囊泡的内部水相中，当由于氧化而使高铁血红蛋白的含量增加时，向小泡施加光 的血红蛋白，从而减少血红蛋白。 以这种方式，回收氧结合能力，从而保持血红蛋白 - 囊泡的功能。

公开(公告)号：US20040268432A1

公开(公告)日：2004-12-30

申请号：US10625821

申请日：2003-07-22

Applicant: Japan Science and Technology Corporation

Inventor： Satoshi Mori ,  Hiromi Nakanishi ,  Hiroyuki Oki ,  Hirotaka Yamaguchi

IPC: C07H021/04 ,  C12N015/82 ,  C12N015/87

CPC classification number: C12N9/0036 ,  C12N15/8216 ,  C12N15/8243 ,  C12N15/8261 ,  Y02A40/146

Abstract: A method for achieving the sufficient expression of a gene in a useful higher plant which has been transformed by transferring the above gene encoding a protein having a function carried by another organism so as to impart the function to the plant. Namely, a method for transforming a useful plant by transferring a gene of another species into the plant characterized in that the region of a factor relating to the poly(A) addition of the mRNA of the useful plant to be transformed contained in the base sequence of the gene of the other species is denatured into another base sequence not relating to the poly(A) addition of the mRNA without substantially altering the function of the protein encoded by the gene to be transferred; and a gene usable in the gene transfer.

Abstract translation: 通过转移上述编码具有由另一种生物体携带的功能的蛋白质的基因转化的有用的较高植物中的基因的充分表达以赋予植物功能的方法。 即，通过将其他物种的基因转移到植物中来转化有用植物的方法，其特征在于与碱基序列中包含的待转化有用植物的mRNA的poly（A）加成相关的因子的区域 的其他物种的基因被变性成不与mRNA的poly（A）添加无关的另一个碱基序列，而基本上不改变由待转移的基因编码的蛋白质的功能; 和可用于基因转移的基因。

公开(公告)号：US20040202604A1

公开(公告)日：2004-10-14

申请号：US10837686

申请日：2004-05-04

Applicant: Morikawa Industries Corporation ,  Japan Science and Technology Corporation

Inventor： Yahata Taneaki ,  Tsuchiya Yuji ,  Toba Masahiko

IPC: C01F011/20

CPC classification number: A62D3/30 ,  A62D3/40 ,  A62D2101/22 ,  A62D2203/10 ,  B01D53/70 ,  B01J8/003 ,  B01J8/0045 ,  B01J8/087 ,  B01J8/10 ,  B01J8/12 ,  B01J2208/00407 ,  B01J2208/00415 ,  B01J2208/0061 ,  B01J2219/185 ,  B01J2219/1943

Abstract: A bed of calcium oxide and/or barium oxide in particulate form is continuously moved through a contact reaction zone such that it enters into countercurrent reaction with the feedstock and the reaction is performed in a reaction column equipped with an agitating/moving device by which the halide which is the product of reaction between the organic halide and the oxide is continuously discharged to the outside of the reaction zone.

Abstract translation: 颗粒形式的氧化钙和/或氧化钡床被连续移动通过接触反应区，使得其与原料进行逆流反应，反应在装备有搅拌/移动装置的反应塔中进行， 作为有机卤化物和氧化物之间的反应产物的卤化物被连续地排放到反应区的外部。

公开(公告)号：US20040072346A1

公开(公告)日：2004-04-15

申请号：US10602234

申请日：2003-06-23

Applicant: Japan Science and Technology Corporation

Inventor： Makoto Sawada

IPC: C12N005/08 ,  A61K038/19 ,  A61K038/20 ,  A61K045/00

CPC classification number: A61K48/00 ,  A61K38/00 ,  C12N5/0622 ,  C12N2501/22 ,  C12N2510/00

Abstract: A subcultivatable, established microglia having the following properties. (a) Form: Both or either of a macrophage-like or spherical form in the presence of a granulocyte-macrophage colony stimulation factor and a branched form similar to branched microglia present in the brain in the absence of the factor. (b) Functional characteristics: specific affinity for the brain highly poor phagocytic action. (c) Cell proliferation: proliferative depending upon a granulocyte-macrophage colony stimulation factor. Preparation, separation, and screening methods of the microglia, a pharmaceutical composition using the microglia, and a method for treatment of cerebral diseases using the composition.

Abstract translation: 具有以下性质的可转移性良好的小胶质细胞。 （a）形式：存在粒细胞 - 巨噬细胞集落刺激因子时存在巨噬细胞样或球形形式的两种或任何一种，并且在不存在该因子的情况下，存在于脑中存在的支链小胶质细胞的分支形式。 （b）功能特征：对脑的特异性亲和力差的吞噬作用。 （c）细胞增殖：取决于粒细胞 - 巨噬细胞集落刺激因子的增殖。 小胶质细胞的制备，分离和筛选方法，使用小胶质细胞的药物组合物，以及使用该组合物治疗脑疾病的方法。

公开(公告)号：US20030137084A1

公开(公告)日：2003-07-24

申请号：US10283035

申请日：2002-10-25

Applicant: Japan Science and Technology Corporation

Inventor： Akira Kohyama ,  Masaki Kotani ,  Yutai Katoh

IPC: C04B035/565

CPC classification number: C04B35/571 ,  C04B35/575 ,  C04B35/806 ,  C04B2235/3834 ,  C04B2235/3873 ,  C04B2235/483 ,  C04B2235/5244 ,  C04B2235/80

Abstract: SiC fiber-reinforced SiC-matrix composite has the structure that SiC filaments are inserted into SiC matrix formed as a pyrolysis product of polyvinyl-silane (PVS) infiltrated into openings of said SiC filaments. PVS as a polymeric SiC precursor has structural units (a) and (b) at an a/b ratio of 1. A SiC fiber preform is impregnated with PVS slurry in an open or vacuum atmosphere, preheated at 300-400null C. in an inert gas atmosphere to moderate PVS to a viscous or semi-cured state, and then pyrolyzed in an argon atmosphere under application of a unidirectional pressure. A product is SiC fiber-reinforced SiC-matrix composite excellent in mechanical strength and high-temperature property with high density. The SiC composite is further densified by infiltration of PVS slurry suspending fine SiC particles therein or by repetition of impregnation with sole PVS and pressure-less pyrolysis after the pressurized pyrolysis. (a) nullSiH2nullCH2nullCH2null 1

Abstract translation: SiC纤维增强SiC基复合材料具有将SiC长丝插入SiC基体中形成的结构，其形成为聚硅氧烷（PVS）的热解产物渗透到所述SiC丝的开口中。 作为聚合物SiC前体的PVS具有a / b比为1的结构单元（a）和（b）。在开放或真空气氛中，将SiC纤维预制体浸渍在PVS浆料中，在300-400℃预热 惰性气体气氛，将PVS调节至粘性或半固化状态，然后在氩气氛下在施加单向压力下热解。 一种产品是SiC纤维增强SiC基复合材料，机械强度和高温性能优良，密度高。 通过在其中悬浮细小的SiC颗粒的PVS浆料的浸渗或通过在加压热解后重复用唯一PVS浸渍和无压力热解来进一步致密化SiC复合材料。 （a）-SiH 2 -CH 2 -CH 2 -

公开(公告)号：US20020137221A1

公开(公告)日：2002-09-26

申请号：US10091440

申请日：2002-03-07

Applicant: Japan Science and Technology Corporation

Inventor： Eishun Tsuchida ,  Hiromi Sakai ,  Kenichi Tomiyama ,  Shinji Takeoka ,  Keitaro Sou

IPC: G01N033/72

CPC classification number: A61K9/0026 ,  A61K31/555 ,  A61K47/54 ,  A61K47/543 ,  A61K47/544 ,  A61K47/60 ,  A61K47/643 ,  A61K47/6445 ,  Y10T436/100833 ,  Y10T436/20 ,  Y10T436/207497 ,  Y10T436/25 ,  Y10T436/2525

Abstract: There is provided a method for preserving an oxygen infusion comprising a suspension containing hemoglobin or a heme derivative contained in molecular assemblies suspended in a aqueous medium, comprising modifying the molecular assemblies with polyoxyethylene, and making the hemoglobin or the heme derivative to a deoxy-type by removing oxygen from the suspension.

Abstract translation: 提供了一种保存氧气输注的方法，其包括含有悬浮在水性介质中的分子组装体中所含的血红蛋白或血红素衍生物的悬浮液，包括用聚氧乙烯改性分子组装体，并使血红蛋白或血红素衍生物变为脱氧型 通过从悬浮液中除去氧气。