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24 条记录 (耗时 0.016 秒)

    Compositions and methods for diagnosing and treating cancer
    22.
    发明申请
    Compositions and methods for diagnosing and treating cancer 有权
    用于诊断和治疗癌症的组合物和方法

    公开(公告)号：US20070117751A1

    公开(公告)日：2007-05-24

    申请号：US11589931

    申请日：2006-10-31

    申请人： Austin Gurney ,  John Lewicki ,  Sanjeev Satyal ,  Timothy Hoey

    发明人： Austin Gurney ,  John Lewicki ,  Sanjeev Satyal ,  Timothy Hoey

    IPC分类号： A61K38/17 ,  C07K14/705 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/723 ,  C07K16/00 ,  C07K16/18 ,  C07K16/28 ,  C07K2319/30 ,  C07K2319/33 ,  G01N33/57423 ,  G01N33/57492

    摘要： The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides a soluble FZD receptor comprising an extracellular domain of a human FZD receptor that inhibits growth of tumor cells. The present invention still further provides a soluble receptor comprising a Fri domain of a human FZD receptor that binds a ligand of a human FZD receptor and said soluble receptor is capable of inhibiting tumor growth. The present invention still further provides a method of treating cancer comprising administering a soluble FZD receptor comprising for example, either an extracellular domain of a human FZD receptor or a Fri domain of a human FZD receptor, in an amount effective to inhibit tumor growth.

    摘要翻译： 本发明涉及用于表征，诊断和治疗癌症的组合物和方法。 特别地，本发明提供了用于癌症的诊断，表征，预后和治疗以及特异性靶向癌症干细胞的方法和方法。 本发明提供了包含抑制肿瘤细胞生长的人FZD受体的细胞外结构域的可溶性FZD受体。 本发明还提供一种可溶性受体，其包含结合人FZD受体的配体的人FZD受体的Fri结构域，并且所述可溶性受体能够抑制肿瘤生长。 本发明还提供一种治疗癌症的方法，其包括以有效抑制肿瘤生长的量施用包含例如人FZD受体的细胞外结构域或人FZD受体的Fri结构域的可溶性FZD受体。

    Subcutaneous administration of natriuretic peptide
    24.
    发明授权
    Subcutaneous administration of natriuretic peptide 失效
    皮下给药利尿钠肽

    公开(公告)号：US06586396B1

    公开(公告)日：2003-07-01

    申请号：US09287892

    申请日：1999-04-07

    申请人： J. Jeffrey Seilhamer ,  John Lewicki ,  Robert M. Scarborough ,  J. Gordon Porter

    发明人： J. Jeffrey Seilhamer ,  John Lewicki ,  Robert M. Scarborough ,  J. Gordon Porter

    IPC分类号： A61K3822

    CPC分类号： C12P21/02 ,  A61K38/00 ,  C07K14/58 ,  C07K14/582 ,  C07K16/241 ,  C07K16/2803 ,  C07K2317/622 ,  G01N33/74

    摘要： The cDNA sequence encoding porcine brain natriuretic peptide and related genes encoding canine and human peptides with natriuretic activity are disclosed. The gene is shown to make accessible the DNAs encoding analogous natriuretic peptides in other vertebrate species. The genes encoding these NPs can be used to effect modifications of the sequence to produce alternate forms of the NPs and to provide practical amounts of these proteins. The NPs of the invention can also be synthesized chemically. The invention peptides have the formula: R1-Cys-Phe-Gly-Arg-Arg-/-Leu/-Asp-Arg- (1)                    Lys  Met    Ile-Gly/-Ser-Leu/-Ser-Gly-Leu-Gly-Cys-R2        Ser      Ser wherein R1 is selected from the group consisting of:                                             (H);                                            Gly-;                                        Ser-Gly-;                                  Asp/                                  Lys/ -Ser-Gly-;                                  Gly                           Arg/   Asp/                           His/ - Lys/ -Ser-Gly-;                           Gln    Gly                           Arg/   Asp/                    Met/ - His/ - Lys/ -Ser-Gly-;                    Val    Gln    Gly                           Arg/   Asp/              Thr/ -Met/ - His/ - Lys/ -Ser-Gly-;              Met   Val    Gln    Gly                           Arg/   Asp/         Lys- Thr/ -Met/ - His/ - Lys/ -Ser-Gly-;              Met   Val    Gln    Gly                           Arg/   Asp/     Pro-Lys- Thr/ -Met/ - His/ - Lys/ -Ser-Gly-;              Met   Val    Gln    Gly                           Arg/   Asp/ Ser-Pro-Lys- Thr/ -Met/ - His/ - Lys/ -Ser-Gly-;              Met   Val    Gln    Gly or a 10- to 109-amino acid sequence shown as the native upstream sequence for porcine, canine or human BNP in FIG. 8, or a composite thereof; R2 is (OH), NH2, or NR′R″ wherein R′ and R″ are independently lower alkyl (1-4C) or is Asn/ Lys Asn/ -Val Lys Asn/ -Val-Leu Lys Asn/ -Val-Leu-Arg Lys Asn/ -Val-Leu-Arg- Arg/ Lys Lys Asn/ -Val-Leu-Arg- Arg/ - Tyr/ Lys Lys His or the amides (NH2 or NR′R″) thereof, with the proviso that if formula (1) is R1-Cys-Phe-Gly-Arg-Arg-Leu-Asp-Arg- Ile-Gly-Ser-Leu-Ser-Gly-Leu-Gly-Cys-R2 and R1 is Asp-Ser-Gly-, R2 cannot be Asn-Val-Leu-Arg-Arg-Tyr. The peptides of the invention can be formulated into pharmaceutical compositions and used to treat conditions associated with high extracellular fluid levels, especially congestive heart failure.

    摘要翻译： 公开了编码猪脑利钠肽的cDNA序列和编码具有利尿钠活性的犬和人肽的相关基因。 该基因显示可使得其他脊椎动物物种中编码类似利尿钠肽的DNA可见。 编码这些NP的基因可用于影响序列的修饰以产生NP的替代形式并提供实际量的这些蛋白质。 本发明的NP也可以化学合成。 本发明的肽具有下式：其中R 1选自由图中的猪，犬或人BNP的天然上游序列显示的10-或109-氨基酸序列。 8或其复合物; R 2为（OH），NH 2或NR'R“，其中R'和R”独立地为低级烷基（1-4C）或R 1为Asp-Ser-Gly-，R 2不能 是Asn-Val-Leu-Arg-Arg-Tyr。本发明的肽可以配制成药物组合物并用于治疗与高细胞外液体水平，特别是充血性心力衰竭相关的病症。