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    Pharmaceutical compositions and methods using natriuretic peptides
    3.
    发明授权
    Pharmaceutical compositions and methods using natriuretic peptides 失效

    公开(公告)号：US06974861B2

    公开(公告)日：2005-12-13

    申请号：US10402021

    申请日：2003-03-27

    申请人： J. Jeffrey Seilhamer ,  John Lewicki ,  Robert M. Scarborough ,  J. Gordon Porter

    发明人： J. Jeffrey Seilhamer ,  John Lewicki ,  Robert M. Scarborough ,  J. Gordon Porter

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/22 ,  A61P9/08 ,  A61P9/12 ,  C07K7/08 ,  C07K14/00 ,  C07K14/575 ,  C07K14/58 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/12 ,  C12N15/16 ,  C12P21/02 ,  C12R1/19 ,  C07K17/00

    CPC分类号： C12P21/02 ,  A61K38/00 ,  C07K14/58 ,  C07K14/582 ,  C07K16/241 ,  C07K16/2803 ,  C07K2317/622 ,  G01N33/74

    摘要： The cDNA sequence encoding porcine brain natriuretic peptide and related genes encoding canine and human peptides with natriuretic activity are disclosed. The gene is shown to make accessible the DNAs encoding analogous natriuretic peptides in other vertebrate species. The genes encoding these NPs can be used to effect modifications of the sequence to produce alternate forms of the NPs and to provide practical amounts of these proteins. The NPs of the invention can also be synthesized chemically. The invention peptides have the formula: R1-Cys-Phe-Gly-Arg- Arg/ - Leu/ -Asp-Arg-                     Lys    Met                                                (1)    Ile- Gly/ -Ser- Leu/ -Ser-Gly-Leu-Gly-Cys-R-2         Ser        Ser wherein R1 is selected from the group consisting of:                                              (H);                                             Gly-;                                         Ser-Gly-;                                   Asp/                                   Lys/ -Ser-Gly-;                                   Gly                            Arg/   Asp/                            His/ - Lys/ -Ser-Gly-;                            Gln    Gly                            Arg/   Asp/                     Met/ - His/ - Lys/ -Ser-Gly-;                     Val    Gln    Gly                            Arg/   Asp/              Thr/ - Met/ - His/ - Lys/ -Ser-Gly-;              Met    Val    Gln    Gly                            Arg/   Asp/         Lys- Thr/ - Met/ - His/ - Lys/ -Ser-Gly-;              Met    Val    Gln    Gly                            Arg/   Asp/     Pro-Lys- Thr/ - Met/ - His/ - Lys/ -Ser-Gly-;              Met    Val    Gln    Gly                            Arg/   Asp/ Ser-Pro-Lys- Thr/ - Met/ - His/ - Lys/ -Ser-Gly-;              Met    Val    Gln    Gly or a 10- to 109-amino acid sequence shown as the native upstream sequence for porcine, canine or human BNP in FIG. 8, or a composite thereof; R2 is (OH), NH2, or NR′R″ wherein R′ and R″ are independently lower alkyl (1-4C) or is Asn/ Lys Asn/ -Val Lys Asn/ -Val-Leu Lys Asn/ -Val-Leu-Arg Lys Asn/ -Val-Leu-Arg- Arg/ Lys                Lys Asn/ -Val-Leu-Arg- Arg/ - Tyr/ Lys                Lys    His or the amides (NH2 or NR′R″) thereof, with the proviso that if formula (1) is R1-Cys-Phe-Gly-Arg-Arg-Leu-Asp-Arg-    Ile-Gly-Ser-Leu-Ser-Gly-Leu-Gly-Cys-R2 and R1 is Asp-Ser-Gly-, R2 cannot be Asn-Val-Leu-Arg-Arg-Tyr. The peptides of the invention can be formulated into pharmaceutical compositions and used to treat conditions associated with high extracellular fluid levels, especially congestive heart failure.

    Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
    5.
    发明授权
    Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth 有权
    用于抑制Wnt依赖性实体瘤细胞生长的组合物和方法

    公开(公告)号：US07723477B2

    公开(公告)日：2010-05-25

    申请号：US11589931

    申请日：2006-10-31

    申请人： Austin Gurney ,  John Lewicki ,  Sanjeev Satyal ,  Timothy Hoey

    发明人： Austin Gurney ,  John Lewicki ,  Sanjeev Satyal ,  Timothy Hoey

    IPC分类号： A61K38/00 ,  C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/723 ,  C07K16/00 ,  C07K16/18 ,  C07K16/28 ,  C07K2319/30 ,  C07K2319/33 ,  G01N33/57423 ,  G01N33/57492

    摘要： The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides a soluble FZD receptor comprising an extracellular domain of a human FZD receptor that inhibits growth of tumor cells. The present invention still further provides a soluble receptor comprising a Fri domain of a human FZD receptor that binds a ligand of a human FZD receptor and said soluble receptor is capable of inhibiting tumor growth. The present invention still further provides a method of treating cancer comprising administering a soluble FZD receptor comprising for example, either an extracellular domain of a human FZD receptor or a Fri domain of a human FZD receptor, in an amount effective to inhibit tumor growth.

    摘要翻译： 本发明涉及用于表征，诊断和治疗癌症的组合物和方法。 特别地，本发明提供了用于癌症的诊断，表征，预后和治疗以及特异性靶向癌症干细胞的方法和方法。 本发明提供了包含抑制肿瘤细胞生长的人FZD受体的细胞外结构域的可溶性FZD受体。 本发明还提供一种可溶性受体，其包含结合人FZD受体的配体的人FZD受体的Fri结构域，并且所述可溶性受体能够抑制肿瘤生长。 本发明还提供一种治疗癌症的方法，其包括以有效抑制肿瘤生长的量给予包含例如人FZD受体的细胞外结构域或人FZD受体的Fri结构域的可溶性FZD受体。

    Compositions and methods for treating and diagnosing cancer
    6.
    发明申请
    Compositions and methods for treating and diagnosing cancer 审中-公开
    用于治疗和诊断癌症的组合物和方法

    公开(公告)号：US20070105133A1

    公开(公告)日：2007-05-10

    申请号：US11451774

    申请日：2006-06-13

    申请人： Michael Clarke ,  Xinhao Wang ,  John Lewicki ,  Austin Gurney

    发明人： Michael Clarke ,  Xinhao Wang ,  John Lewicki ,  Austin Gurney

    IPC分类号： C12Q1/68 ,  G01N33/574 ,  C12N5/08

    CPC分类号： G01N33/6887 ,  C12N5/0693 ,  C12N5/0695 ,  C12N2501/58 ,  C12Q1/6886 ,  G01N33/57484 ,  G01N2333/705

    摘要： The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides gene expression profiles and signatures associated with solid tumor stem cells, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of solid tumor stem cells. More particularly, the present invention identifies two profiles of cancer stem cells useful for the diagnosis, characterization, and treatment of cancer and cancer metastases. The invention also provides a variety of reagents such as stem cell gene signatures for use in the diagnosis and management of cancer.

    摘要翻译： 本发明涉及用于治疗，表征和诊断癌症的组合物和方法。 特别地，本发明提供了与实体肿瘤干细胞相关的基因表达谱和特征，以及用于实体瘤干细胞的诊断，表征，预后和治疗的新型干细胞癌标记。 更具体地，本发明鉴定了可用于癌症和癌症转移的诊断，表征和治疗的癌症干细胞的两个概况。 本发明还提供用于诊断和治疗癌症的多种试剂如干细胞基因特征。