公开(公告)号：US06615067B2

公开(公告)日：2003-09-02

申请号：US09811778

申请日：2001-03-20

Applicant: Bertil Hoek ,  Lars Tenerz ,  Leif Smith

Inventor： Bertil Hoek ,  Lars Tenerz ,  Leif Smith

IPC: A61B504

CPC classification number: A61B5/6851 ,  A61B5/0008 ,  A61B5/0215 ,  A61M25/09 ,  A61M2025/0002 ,  A61M2230/30 ,  A61M2230/50

Abstract: A guide wire for measuring physiological characteristics inside a body includes a sensor (14) for monitoring the physical variable and for forming an output signal characteristic for the value of the physical variable. The sensor is connected to a first electrical potential of an electronic unit (22) via an electrical wire (11) extending along the guide wire. An internal body electrode (17) is connected to the sensor (14) and is in contact with body fluids surrounding the sensor circuit. The guide wire (10) is inserted into a vessel of the body (25), and a second electrode (21) is applied near the internal body electrode, and the sensor circuit is powered by a second potential of the electronic unit (22) via a part of the body.

Abstract translation: 用于测量身体内的生理特性的引导线包括用于监测物理变量并形成用于物理变量的值的特征的输出信号的传感器（14）。 传感器通过沿导丝延伸的电线（11）连接到电子单元（22）的第一电位。 内部体电极（17）连接到传感器（14）并且与围绕传感器电路的体液接触。 引导线（10）被插入到主体（25）的容器中，并且第二电极（21）被施加在内部主体电极附近，传感器电路由电子单元（22）的第二电位供电， 通过身体的一部分。

公开(公告)号：US06343514B1

公开(公告)日：2002-02-05

申请号：US09117416

申请日：1999-04-06

Applicant: Leif Smith

Inventor： Leif Smith

IPC: G01L902

CPC classification number: G01L19/0092 ,  A61B5/0215 ,  A61B5/028 ,  A61M2025/0002 ,  G01F1/6845 ,  G01K1/045 ,  G01L19/148

Abstract: The invention relates to a device for measuring pressure, temperature and/or flow velocity. It includes a sensor (6) with a sensor support body (13) provided with a diaphragm (15) covering a cavity (14) formed in the support body (13). A pressure sensitive element (41) is mounted on the diaphragm, for recording pressure. Furthermore, a temperature sensitive resistor (42) is mounted in the vicinity of the pressure sensitive resistor and has a known temperature dependence, for recording temperature. It also includes an electrical circuit (43, 44, 45, 46) selectively outputting signals from either of the pressure sensitive element and the temperature sensitive resistor.

Abstract translation: 本发明涉及一种用于测量压力，温度和/或流速的装置。 它包括具有传感器支撑体（13）的传感器（6），传感器支撑体（13）设置有覆盖形成在支撑体（13）中的空腔（14）的隔膜（15）。 压力敏感元件（41）安装在隔膜上，用于记录压力。 此外，温度敏感电阻器（42）安装在压敏电阻附近，并具有已知的温度依赖性，用于记录温度。 它还包括选择性地输出来自压敏元件和温度敏感电阻器中的任一个的信号的电路（43,44,45,46）。

公开(公告)号：US5984853A

公开(公告)日：1999-11-16

申请号：US805296

申请日：1997-02-25

Applicant: Leif Smith

Inventor： Leif Smith

IPC: A61N5/10 ,  H01J35/32 ,  G21K5/00 ,  A61B6/12

CPC classification number: A61N5/1001 ,  H01J35/32

Abstract: A method and apparatus of creating a miniaturized source of radiation and delivering radiation to a location such as therapy location. The radiation source comprises a member made of a material emitting electrons when energy is supplied to the member. There is an electron retarding member disposed opposite the electron emitting member, and the electron retarding member is made of a material emitting ionizing radiation when electrons are retarded therein. The radiation source is further provided on an elongated member in the distal region thereof, and the elongated member is insertable into the body.

Abstract translation: 一种创建微型辐射源并将辐射传送到诸如治疗位置的位置的方法和装置。 辐射源包括当能量被供应到构件时由发射电子的材料制成的构件。 存在与电子发射部件相对设置的电子延迟部件，并且当电子被延迟时，电子阻挡部件由发射电离辐射的材料制成。 辐射源还设置在其远侧区域中的细长构件上，并且细长构件可插入身体。

公开(公告)号：US09949647B2

公开(公告)日：2018-04-24

申请号：US11628251

申请日：2005-06-01

Applicant: Leif Smith ,  Ola Hammarström ,  Per Egnelöv ,  Dan Åkerfeldt

Inventor： Leif Smith ,  Ola Hammarström ,  Per Egnelöv ,  Dan Åkerfeldt

IPC: A61B5/0215 ,  A61B5/00 ,  A61M25/09 ,  A61M25/00

CPC classification number: A61B5/0215 ,  A61B5/6851 ,  A61M25/09 ,  A61M2025/0002 ,  A61M2025/09083 ,  A61M2025/09175

Abstract: The invention relates to a sensor and guide wire assembly (21) for intravascular measurements of physiological variables in a living body, comprising a core wire (22), a first coil (23), a jacket (24), and a second coil (25). The jacket (24) comprises a first end portion (24a), which is crimped onto the core wire (22) and over which a portion of the first coil (23) is threaded, and a second end portion (24b), which is crimped onto the core wire (22) and over which a portion of the second coil (25) is threaded.

公开(公告)号：US09120861B2

公开(公告)日：2015-09-01

申请号：US12589115

申请日：2009-10-16

Applicant: James Leif Smith

Inventor： James Leif Smith

IPC: C07K14/00 ,  C07K14/315

CPC classification number: C07K14/315 ,  C07K14/00

Abstract: The present invention provides methods for adding functional hydrophobic, charge, polar, and other structural groups on antimicrobial compounds for enhancing the physicochemical properties of the antimicrobial compounds, thereby creating novel antimicrobial analogs with enhanced functions.

Abstract translation: 本发明提供了在抗微生物化合物上添加功能性疏水，电荷，极性和其它结构基团以增强抗微生物化合物的物理化学性质，从而产生具有增强功能的新型抗微生物类似物的方法。

公开(公告)号：US08974398B2

公开(公告)日：2015-03-10

申请号：US12742025

申请日：2008-08-22

Applicant: Leif Smith

Inventor： Leif Smith

IPC: A61B5/00 ,  A61B5/02 ,  A61M25/00 ,  A61B5/0215 ,  H01R24/66 ,  H01R24/76 ,  A61M25/09 ,  H01R13/622 ,  H01R13/66 ,  H01R103/00

CPC classification number: A61B5/0215 ,  A61B5/0002 ,  A61B5/6851 ,  A61B2560/0214 ,  A61B2560/0443 ,  A61B2562/225 ,  A61M25/09 ,  H01R13/622 ,  H01R13/6683 ,  H01R13/6691 ,  H01R24/66 ,  H01R24/76 ,  H01R2103/00

Abstract: A transmitter unit with an attachable energy source is provided for a sensor guidewire. The transmitter unit is adapted to be connected to a proximal end of a sensor guidewire provided, at its distal end, with a sensor to measure a physiological parameter inside a patient. In some embodiments, the transmitter unit is adapted to wirelessly communicate by a communication signal with a communication unit, arranged in connection with an external device, in order to transfer measured physiological data to the external device. The attachable energy source can be a battery pack or battery holder provided with connecting electrical connecting surfaces. Preferably, the connection is protected from penetrating fluids by a protective seal.

Abstract translation: 为传感器导丝提供具有可附接能量的发射器单元。 发射器单元适于连接到传感器导丝的近端，传感器导丝在其远端处设置有用于测量患者体内生理参数的传感器。 在一些实施例中，发射机单元适于通过通信信号与通信单元进行无线通信，该通信单元与外部设备结合地布置，以将测量的生理数据传送到外部设备。 可附接能源可以是具有连接电连接表面的电池组或电池座。 优选地，通过保护性密封来保护连接不渗透流体。

公开(公告)号：US08579832B2

公开(公告)日：2013-11-12

申请号：US12739326

申请日：2008-10-24

Applicant: Pär Von Malmborg ,  Leif Smith

Inventor： Pär Von Malmborg ,  Leif Smith

IPC: A61B5/00 ,  A61B6/00 ,  A61M25/00

CPC classification number: A61B5/0215 ,  A61M25/09 ,  A61M2025/09108 ,  A61M2025/09133

Abstract: There is a sensor guide wire (1) for intravascular measurements of physiological variables in a living body. The sensor guide wire (1) comprises at least two elongate sections, a first tubular elongate section (2) being tubular in the longitudinal direction of the sensor guide wire (1), and a second elongate section (3) that is adapted to be inserted a predetermined distance (5) into said first tubular section (2), a sensor element (10) provided in the distal part of said sensor guide wire (1), for measuring the physiological variable and to generate a sensor signal in response to said variable, at least one signal transmitting cable connected to the sensor element (10) to transmit sensor signals to a male connector provided in the proximal part of said sensor guide wire (1). The tubular section (2) is provided with at least one through-going opening (4) in a direction perpendicular to the longitudinal direction of the guide wire (1) and positioned a second predetermined distance (6) from one end of the tubular section (2), wherein the guide wire (1) comprises a locking member (7) to be fitted into the opening (4) in order to join the sections (2, 3) together when the second elongate section (3) is inserted into the tubular section (2).

Abstract translation: 传感器导丝（1）用于生物体内生理变量的血管内测量。 传感器导丝（1）包括至少两个细长部分，沿着传感器导丝（1）的纵向方向管状的第一管状细长部分（2）和适于成为 将预定距离（5）插入所述第一管状部分（2）中，设置在所述传感器导丝（1）的远端部分中的传感器元件（10），用于测量生理变量并响应于 所述变量，连接到所述传感器元件（10）的至少一个信号传输电缆将传感器信号发送到设置在所述传感器导丝（1）的近端部分中的公连接器。 管状部分（2）在垂直于导丝（1）的纵向方向的方向上设置有至少一个贯穿开口（4），并且从管状部分的一端定位第二预定距离（6） （2），其中所述导丝（1）包括锁定构件（7），以在所述第二细长部分（3）插入时将所述锁定构件（7）装配到所述开口（4）中，以便将所述部分（2,3） 管状部分（2）。

公开(公告)号：US20120172731A1

公开(公告)日：2012-07-05

申请号：US13395769

申请日：2010-09-14

Applicant: Leif Smith

Inventor： Leif Smith

IPC: A61B5/0215 ,  A61B5/01 ,  A61M25/09

CPC classification number: A61B5/0215 ,  A61B5/02158 ,  A61B5/6852 ,  A61M2025/0002 ,  A61M2025/0183

Abstract: Rapid exchange guide unit comprising an elongated support member 3, and a guide wire member (11) provided with a guide wire lumen (13) having a distal guide wire opening (15) and a proximal guide wire opening (17), the guide wire lumen is arranged close to the distal end of said elongated support member, and is adapted to receive a guide wire. The rapid exchange guide unit further comprises at least one sensor (19) arranged close to the distal end of the elongated support member, and being adapted to measure a parameter in a living body, and to generate a sensor signal in dependence of the measured parameter. The sensor signal is applied to a signal processing unit adapted to process the sensor signal and to generate a processed sensor signal.

Abstract translation: 包括细长支撑构件3的快速交换引导单元和设置有具有远侧导丝开口（15）和近端导丝开口（17）的导丝管腔（13）的导丝构件（11），该导丝 管腔布置成靠近所述细长支撑构件的远端，并且适于接收导丝。 快速交换引导单元还包括至少一个布置在细长支撑构件的远端附近的传感器（19），并且适于测量活体中的参数，并且根据所测量的参数产生传感器信号 。 传感器信号被施加到适于处理传感器信号并产生经处理的传感器信号的信号处理单元。

公开(公告)号：US07967761B2

公开(公告)日：2011-06-28

申请号：US11607120

申请日：2006-12-01

Applicant: Leif Smith

Inventor： Leif Smith

IPC: A61B5/00

CPC classification number: A61B5/036 ,  A61B5/6851 ,  A61M25/09033 ,  A61M2025/0002

Abstract: A sensor and guide wire assembly (21; 41; 61; 81) for intravascular measurements of a physiological variable in a living body includes a sensor element (22; 42; 62; 82) mounted at a distal sensor portion (23; 43; 63; 83) of a guide wire (24; 44; 64; 84), wherein the sensor portion exhibits a maximal cross-sectional dimension which is larger than a maximal cross-sectional dimension of guide wire portions (28, 30; 48, 50; 68, 70) located proximally of the sensor portion.

Abstract translation: 用于生物体内生理变量的血管内测量的传感器和导丝线组件（21; 41; 61; 81）包括安装在远端传感器部分（23; 43; 43）处的传感器元件（22; 42; 62; 导线（24; 44; 64; 84）的最大横截面尺寸大于导丝部分（28,30; 48; 84）的最大截面尺寸， 50; 68,70）位于传感器部分的近侧。

公开(公告)号：US07343811B2

公开(公告)日：2008-03-18

申请号：US11359761

申请日：2006-02-23

Applicant: Lars Tenerz ,  Leif Smith

Inventor： Lars Tenerz ,  Leif Smith

IPC: A61B5/00 ,  G01L7/00

CPC classification number: A61M25/09 ,  A61B5/0215 ,  A61B5/6851 ,  A61M2025/0166 ,  A61M2025/09083 ,  G01L9/0022 ,  G01L9/06 ,  G01L19/142 ,  G01L19/147 ,  H01L2224/48091 ,  H01L2224/48137 ,  H01L2924/00014

Abstract: The invention relates to a sensor (23) adapted for a sensor and guide wire assembly for intravascular measurements in a living body, wherein the sensor (23) comprises a pressure sensitive part (24) and an electronic part (25), said pressure sensitive part (24) comprising a first chip (26) provided with at least one pressure sensitive device (27) and at least one piezoelectric element (35), and said electronic part (25) comprising a second chip (28) provided with at least one electric circuit, and wherein said pressure sensitive part (24) and electronic part (25) are spatially separated from each other and are electrically connected with at least one electrical lead (29).

Abstract translation: 本发明涉及一种适用于生物体内用于血管内测量的传感器和导丝组件的传感器（23），其中传感器（23）包括压敏部件（24）和电子部件（25），所述压敏 包括设置有至少一个压敏装置（27）和至少一个压电元件（35）的第一芯片（26）的部分（24），并且所述电子部件（25）包括至少设置有第二芯片 一个电路，并且其中所述压敏部件（24）和电子部件（25）在空间上彼此分离并且与至少一个电引线（29）电连接。