公开(公告)号：US07589180B2

公开(公告)日：2009-09-15

申请号：US10145598

申请日：2002-05-13

申请人： Lloyd J. Old ,  Terrance Grant Johns ,  Con Panousis ,  Andrew Mark Scott ,  Christoph Renner ,  Gerd Ritter ,  Achim Jungbluth ,  Elisabeth Stockert ,  Peter Collins ,  Webster K. Cavenee ,  Huei-Jen Su Huang ,  Antony Wilks Burgess ,  Edouard Collins Nice

发明人： Lloyd J. Old ,  Terrance Grant Johns ,  Con Panousis ,  Andrew Mark Scott ,  Christoph Renner ,  Gerd Ritter ,  Achim Jungbluth ,  Elisabeth Stockert ,  Peter Collins ,  Webster K. Cavenee ,  Huei-Jen Su Huang ,  Antony Wilks Burgess ,  Edouard Collins Nice

IPC分类号： C07K16/28

CPC分类号： C07K16/2863 ,  A61K39/395 ,  A61K39/39541 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/77 ,  A61K2300/00

摘要： The invention relates to specific binding members, particularly antibodies and active fragments thereof, which recognize an aberrant post-translationally modified, particularly an aberrant glycosylated form of the EGFR. The binding members, particularly antibodies and fragments thereof, of the invention do not bind to EGFR on normal cells in the absence of amplification of the wild-type gene and are capable of binding the de2-7 EGFR at an epitope which is distinct from the junctional peptide. Antibodies of this type are exemplified by the novel antibody 806 whose VH and VL sequences are illustrated as SEQ ID NOs: 2 and 4 and chimeric antibodies thereof as exemplified by ch806.

公开(公告)号：US20090220510A1

公开(公告)日：2009-09-03

申请号：US12317683

申请日：2008-12-23

申请人： Lloyd J. Old ,  Terrance Grant Johns ,  Con Panousis ,  Andrew Mark Scott ,  Christoph Renner ,  Gred Ritter ,  Achim Jungbluth ,  Elisabeth Stockert ,  V. Peter Collins ,  Webster K. Cavenee ,  Huei-Jen Su Huang ,  Antony Wilks Burgess ,  Edouard Collins Nice

发明人： Lloyd J. Old ,  Terrance Grant Johns ,  Con Panousis ,  Andrew Mark Scott ,  Christoph Renner ,  Gred Ritter ,  Achim Jungbluth ,  Elisabeth Stockert ,  V. Peter Collins ,  Webster K. Cavenee ,  Huei-Jen Su Huang ,  Antony Wilks Burgess ,  Edouard Collins Nice

IPC分类号： A61K39/395 ,  C07K16/18 ,  C12N15/11 ,  C12P21/00 ,  G01N33/574 ,  C12N1/21 ,  C12N1/19 ,  C12N5/06 ,  C12N5/04

CPC分类号： C07K16/2863 ,  A61K39/395 ,  A61K39/39541 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/77 ,  A61K2300/00

摘要： The invention relates to specific binding members, particularly antibodies and active fragments thereof, which recognize an aberrant post-translationally modified, particularly an aberrant glycosylated form of the EGFR. The binding members, particularly antibodies and fragments thereof, of the invention do not bind to EGFR on normal cells in the absence of amplification of the wild-type gene and are capable of binding the de2-7 EGFR at an epitope which is distinct from the junctional peptide. Antibodies of this type are exemplified by the novel antibody 806 whose VH and VL sequences are illustrated as SEQ ID NOs: 2 and 4 and chimeric antibodies thereof as exemplified by ch806.

摘要翻译： 本发明涉及特异性结合成员，特别是抗体及其活性片段，其识别异常翻译后修饰，特别是EGFR的异常糖基化形式。 本发明的结合成员，特别是抗体及其片段在正常细胞上不与野生型基因扩增结合，并且能够以不同于 连接肽。 这种抗体的例子是其VH和VL序列如SEQ ID NO：2和4以及其嵌合抗体如ch806所示的新抗体806。

公开(公告)号：US20090137782A1

公开(公告)日：2009-05-28

申请号：US10145598

申请日：2002-05-13

申请人： Lloyd J. Old ,  Terrance Grant Johns ,  Con Panousis ,  Andrew Mark Scott ,  Christoph Renner ,  Gerd Ritter ,  Achim Jungbluth ,  Elisabeth Stockert ,  V. Peter Collins ,  Webster K. Cavenee ,  Huei-Jen Su Huang ,  Antony Wilks Burgess ,  Edouard Collins Nice

发明人： Lloyd J. Old ,  Terrance Grant Johns ,  Con Panousis ,  Andrew Mark Scott ,  Christoph Renner ,  Gerd Ritter ,  Achim Jungbluth ,  Elisabeth Stockert ,  V. Peter Collins ,  Webster K. Cavenee ,  Huei-Jen Su Huang ,  Antony Wilks Burgess ,  Edouard Collins Nice

IPC分类号： C07K16/30

CPC分类号： C07K16/2863 ,  A61K39/395 ,  A61K39/39541 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/77 ,  A61K2300/00

摘要： The invention relates to specific binding members, particularly antibodies and active fragments thereof, which recognize an aberrant post-translationally modified, particularly an aberrant glycosylated form of the EGFR. The binding members, particularly antibodies and fragments thereof, of the invention do not bind to EGFR on normal cells in the absence of amplification of the wild-type gene and are capable of binding the de2-7 EGFR at an epitope which is distinct from the junctional peptide. Antibodies of this type are exemplified by the novel antibody 806 whose VH and VL sequences are illustrated as SEQ ID NOs: 2 and 4 and chimeric antibodies thereof as exemplified by ch806.

摘要翻译： 本发明涉及特异性结合成员，特别是抗体及其活性片段，其识别异常翻译后修饰，特别是EGFR的异常糖基化形式。 本发明的结合成员，特别是抗体及其片段在正常细胞上不与野生型基因扩增结合，并且能够以不同于 连接肽。 这种抗体的例子是其VH和VL序列如SEQ ID NO：2和4以及其嵌合抗体如ch806所示的新抗体806。

公开(公告)号：US20080314699A1

公开(公告)日：2008-12-25

申请号：US12090544

申请日：2006-10-06

申请人： Mark Scott

发明人： Mark Scott

IPC分类号： F16D65/04

CPC分类号： F16D65/0977 ,  F16D65/0006 ,  F16D65/095 ,  F16D65/0978 ,  F16D2055/007

摘要： A pad retention device for a brake calliper for a disc brake for a vehicle comprises four spaced elongate cylindrical abutment pins (11) to (14) dispersed at spaced intervals around the periphery of the pad (10). The pins comprise two leading edge pins (11) and (12) and two trailing edge pins (13) and (14). Pin (13) is disposed adjacent the upper leading edge and a further pin (15) provides a centre locating and retaining pin which extends through an aperture (16) in the back plate of the pad. A cantilever spring (17) is mounted on pin (15) and pin (13). In use the spring (17) bears down on the pad (10), using pin (13) as a reaction point and centre locating and retaining pin (15) as a pivot, on the trailing edge side of the pin (15). This in turn tends to rotate the pad in an anticlockwise direction reducing or eliminating pad to abutment pin air gaps and therefore pad rattle and pad knock. This arrangement also provides improved squeal noise resistance.

摘要翻译： 用于车辆的盘式制动器的制动钳的衬垫保持装置包括围绕衬垫（10）的周边以间隔开的间隔分散的四个间隔开的细长圆柱形邻接销（11）至（14）。 销包括两个前缘销（11）和（12）以及两个后缘销钉（13）和（14）。 销（13）邻近上引导边缘设置，另外的引脚（15）提供延伸穿过焊盘后板中的孔（16）的中心定位和固定销。 悬臂弹簧（17）安装在销（15）和销（13）上。 在使用中，弹簧（17）在销（15）的后缘侧上使用销（13）作为反作用点和中心定位和固定销（15）作为枢轴，在衬垫（10）上承载。 这反过来倾向于在逆时针方向上旋转焊盘，从而减少或消除焊盘到邻接销的气隙，并因此缓冲拨浪鼓和垫敲击。 这种布置还提供了改善的尖叫噪音。

公开(公告)号：US20080286272A1

公开(公告)日：2008-11-20

申请号：US12045589

申请日：2008-03-10

申请人： Martin Lackmann ,  Andrew Mark Scott ,  Christopher R. Bebbington ,  Geoffrey T. Yarranton ,  Carmelina Murone ,  Catherine To

发明人： Martin Lackmann ,  Andrew Mark Scott ,  Christopher R. Bebbington ,  Geoffrey T. Yarranton ,  Carmelina Murone ,  Catherine To

IPC分类号： A61K39/395 ,  A61P35/00

CPC分类号： C07K16/2866 ,  A61K47/6803 ,  A61K47/6849 ,  A61K51/1033 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/73

摘要： The invention provides methods and compositions comprising anti-EphA3 antibodies for the treatment of solid tumors.

摘要翻译： 本发明提供包含用于治疗实体瘤的抗EphA3抗体的方法和组合物。

公开(公告)号：US20080171024A1

公开(公告)日：2008-07-17

申请号：US12004841

申请日：2007-12-21

申请人： Sandra M. Ramirez-Arcos ,  Elisabeth Maurer ,  Mark Scott

发明人： Sandra M. Ramirez-Arcos ,  Elisabeth Maurer ,  Mark Scott

IPC分类号： A01N63/00 ,  A01N1/02

CPC分类号： A61K35/14 ,  A61K47/60

摘要： A method for preventing bacterial biofilm formation in a blood product, the method comprising modifying a blood product with a polymer selected from the group consisting of polyethylene glycol (PEG), PEG derivatives and mixtures thereof. Preventing bacterial biofilm formation in this way increases the planktonic to adherent ratio of any contaminating bacteria, and thereby facilitates detection of bacterial contamination.

摘要翻译： 一种用于预防血液制品中细菌生物膜形成的方法，所述方法包括用选自聚乙二醇（PEG），PEG衍生物及其混合物的聚合物改性血液制品。 以这种方式防止细菌生物膜形成增加了任何污染细菌的浮游与粘附比，从而有助于细菌污染的检测。

公开(公告)号：US20070093882A1

公开(公告)日：2007-04-26

申请号：US11583432

申请日：2006-10-19

申请人： Thomas Anderson ,  Shad Lindrud ,  Gary Maharaj ,  Carol Panser ,  Mark Scott ,  Teryl Woodwick Sides

发明人： Thomas Anderson ,  Shad Lindrud ,  Gary Maharaj ,  Carol Panser ,  Mark Scott ,  Teryl Woodwick Sides

IPC分类号： A61F7/00

CPC分类号： A61F7/00 ,  A61F7/0097 ,  A61F2007/0001 ,  A61F2007/006 ,  A61F2007/0091 ,  A61F2007/0233 ,  A61F2007/0288

摘要： A multifunction warming device for perioperative use includes a clinical garment and two convective warming apparatuses supported on an inside surface of the clinical garment. A first convective apparatus is disposed transversely in an upper portion of the clinical garment, running between sleeves of the clinical garment. The second convective apparatus is disposed longitudinally in a lower portion of the clinical garment and has separately inflatable sections, each for enabling a particular mode of warming.

摘要翻译： 用于围手术期使用的多功能加温装置包括临床服装和支撑在临床服装的内表面上的两个对流加温装置。 第一对流装置横向设置在临时服装的上部，在临时服装的袖子之间延伸。 第二对流装置纵向设置在临床服装的下部，并且具有单独的可膨胀部分，每个部分用于实现特定的加温模式。

公开(公告)号：US20060269411A1

公开(公告)日：2006-11-30

申请号：US11141246

申请日：2005-05-31

申请人： Fabio Bertolotti ,  Mark Scott ,  Brian Wake ,  T. Egolf ,  Duane McCormick

发明人： Fabio Bertolotti ,  Mark Scott ,  Brian Wake ,  T. Egolf ,  Duane McCormick

IPC分类号： B64C27/50

CPC分类号： B64C27/12 ,  B64C1/00 ,  B64C7/00 ,  B64C27/04 ,  B64C27/10 ,  B64C27/14 ,  B64C27/20

摘要： A rotor hub fairing system includes an upper hub fairing, a lower hub fairing and a shaft fairing therebetween. The rotor hub fairing system is sized and configured to reduce the overall drag on a dual, counter-rotating, coaxial rotor system. Preferably, the rotor hub fairing is fully integrated. The shaft fairing preferably includes a minimal thickness at the midsection to reduce drag with an increasing thickness adjacent the upper and lower hub fairings to reduce the flow separation on the hub fairing surfaces without overly excessive drag. Other aerodynamic structures, such as a horizontal splitter and/or a plurality of turning vanes may be mounted to the shaft fairing to facilitate flow around the upper and lower hub fairings to reduce flow separation and drag.

摘要翻译： 转子轮毂整流罩系统包括上部轮毂整流罩，下部轮毂整流罩和在其间的整流装置。 转子轮毂整流罩系统的尺寸和构造可以减少双重反向旋转同轴转子系统的整体阻力。 优选地，转子毂整流罩完全集成。 轴整流罩优选地包括在中部的最小厚度，以减小邻近上部和下部轮毂整流罩的增加的厚度的阻力，以减少轮毂整流面上的流动分离，而不会过度的过大阻力。 其他空气动力学结构，例如水平分流器和/或多个转向叶片可以安装到轴整流罩上，以便于围绕上部和下部轮毂整流罩流动以减少流动分离和阻力。

公开(公告)号：US07010979B2

公开(公告)日：2006-03-14

申请号：US10433868

申请日：2001-12-18

申请人： David Mark Scott

发明人： David Mark Scott

IPC分类号： G01N9/04

CPC分类号： G01N15/0255 ,  G01N15/02 ,  G01N29/036 ,  G01N29/11 ,  G01N29/348 ,  G01N29/46 ,  G01N2291/02416 ,  G01N2291/0422 ,  G01N2291/0428 ,  G01N2291/045 ,  G01N2291/048 ,  G01N2291/102

摘要： A particle size distribution monitor, comprising: a transducer adapted to be a source of ultrasonic energy and positioned in contact with a suspension containing a percent by volume of particles in a liquid, the transducer transmitting ultrasonic energy through the suspension wherein the energy comprises a wideband pulse containing a range of frequency components; a transducer adapted to be a receiver of ultrasonic energy and positioned in contact with said suspension to receive said wideband range of ultrasonic energy which has passed through the suspension; a first means adapted to accept a signal from said receiver and make an instantaneous determination of the attenuation of the wideband ultrasonic energy in passing through the suspension. A method of monitoring the particle size distribution of particles in a suspension under dynamic conditions, comprising the steps of: transmitting a first pulse of ultrasonic energy containing a wideband range of frequency components through the suspension which attenuates the pulse; receiving the attenuated pulse after it has passed through the suspension; developing a first signal representative of the attenuated first pulse; digitizing the first signal with a high speed analog-to-digital converter to form a time domain signal; applying a Fourier transform to convert the time domain signal to an equivalent frequency domain signal, or spectrum, for each signal; converting the spectrum into dB to express the attenuation as a function of frequency.

摘要翻译： 一种粒度分布监测器，包括：换能器，其适于作为超声波能量源并且定位成与液体中含有一定体积比例的颗粒的悬浮液接触，所述换能器通过所述悬浮液传递超声能量，其中所述能量包括宽带 包含频率分量范围的脉冲; 换能器，其适于作为超声能量的接收器并且定位成与所述悬架接触以接收已经通过所述悬架的所述宽带范围的超声波能量; 第一装置，适于接收来自所述接收机的信号，并且对穿过悬架的宽带超声波能量的衰减进行瞬时确定。 一种在动态条件下监测悬浮液中颗粒的粒度分布的方法，包括以下步骤：通过使脉冲衰减的悬浮液传输包含宽带范围的频率分量的超声波能量的第一脉冲; 在衰减脉冲通过悬架后接收衰减脉冲; 开发代表衰减的第一脉冲的第一信号; 用高速模数转换器数字化第一信号以形成时域信号; 对每个信号应用傅里叶变换将时域信号转换成等效的频域信号或频谱; 将频谱转换成dB，以表示作为频率的函数的衰减。

公开(公告)号：US20050072814A1

公开(公告)日：2005-04-07

申请号：US10449231

申请日：2003-05-30

申请人： Michael Bravo ,  Craig Rowles ,  John Sullivan ,  David Markham ,  Mark Scott ,  Chris Buiten ,  Gregory Mascoli ,  Robert Slack ,  Corinna Lee

发明人： Michael Bravo ,  Craig Rowles ,  John Sullivan ,  David Markham ,  Mark Scott ,  Chris Buiten ,  Gregory Mascoli ,  Robert Slack ,  Corinna Lee

IPC分类号： B44D3/12 ,  B65D25/28 ,  B65D25/32 ,  B65D25/42 ,  B65D43/02 ,  B67D5/60

CPC分类号： B65D23/104 ,  B44D3/127 ,  B44D3/128 ,  B65D23/108 ,  B65D25/2876 ,  B65D25/32 ,  B65D25/42 ,  B65D43/0231 ,  B65D2543/00092 ,  B65D2543/00296 ,  B65D2543/005 ,  B65D2543/00537 ,  B65D2543/00555 ,  B65D2543/0087 ,  B65D2543/00972 ,  B65D2543/0099

摘要： An improved container for storing, dispensing and handling viscous and semi-viscous fluids such as paint and the like, having novel spout and other design features that enable substantially dripless dispensing and improved handling and storage.

摘要翻译： 一种用于储存，分配和处理粘性和半粘性流体（如油漆等）的改进容器，具有新颖的喷口和其它设计特征，可实现基本上无滴漏的分配和改进的处理和储存。