Abstract:
The present invention refers to the use of the Mst protein or a nucleotide sequence coding for the Mst protein for the treatment of a thromboembolic disorder and to a method of screening a modulator of the Mst protein or the nucleotide sequence coding for the Mst protein.
Abstract:
The present invention refers to a method of diagnosis of a predisposition to develop thrombotic disease, to test systems and their use for the diagnosis of a predisposition to develop thrombotic disease, to a P2X1 promoter variant and its use for screening for an anti-thrombotic agent, and to methods for identifying an individual that can be prophylactically or therapeutically treated with an anti-thrombotic agent, or for adapting a therapeutic or prophylactic dose of an anti-thrombotic agent.
Abstract:
The present invention refers to a method for the in vitro or in vivo diagnosis of cardiovascular diseases, in particular high blood pressure, stenosis, vessel occlusion and/or other thrombotic events, wherein the nucleotide at position 950 of a nucleic acid coding for the human ARK2 protein or the amino acid at position 298 of the human ARK2 protein of a sample of a person is determined as well as to the use of ARK2 for the development and/or production of a medicament for treating a cardiovascular disease.
Abstract:
The present invention refers to a method for the in vitro diagnosis of thromboembolic and/or coronary heart diseases, wherein the nucleotide at position 470 of a nucleic acid coding for the human EGLN2 protein or the amino acid at position 58 of the human EGLN2 protein of a sample of a person is determined.
Abstract:
The use of the single nucleotide polymorphism (SNP) at position −(97) of the GIP gene for the identification of a cardiovascular disease or of an increased risk for developing a cardiovascular disease in a biological sample taken from an individual to be examined.
Abstract:
A receiver for a radio broadcast signal, in particular a car radio, and a method for receiving a radio broadcast signal, including a signal decoder for decoding an audio signal contained in the radio broadcast signal in encoded form, and/or for decoding a data signal contained in the radio broadcast signal in encoded form, the signal decoder being operable so that the encoded signal is only decoded, when the signal decoder obtains an external authentication signal, which is received via an external transmission path that is different from the transmission path of the radio broadcast signal.
Abstract:
The digital filter includes a first multiplier (2) receiving an input signal, an adder (3) connected to the first multiplier (2) to receive its output signal, a delay element (6) connected to the adder (3) to receive its output signal, a second multiplier (7) connected between the delay element (6) and a second input of the adder (3) in a feedback branch, a device (16) for supplying either of two values (K1.1, K1.2) of a first multiplier coefficient to the first multiplier (2) and a device (17) for supplying either of two values (K2.1, K2.2) of a second multiplier coefficient to the second multiplier (7). The second one (K2.2) of the two values of the second multiplier coefficient is advantageously 0, while the second one (K1.2) of the first multiplier coefficient values is equal to a quotient of a predetermined first one of the first multiplier coefficient values and a difference between one and a predetermined first one of the second multiplier coefficient values.
Abstract:
In a circuit for deriving at least one quality signal that is dependent on the quality of a received signal, where the received signal is demodulated, a first auxiliary signal which is dependent on the field strength, and a second or further auxiliary signal, are derived from the demodulated signal. The auxiliary signal and the second or further auxiliary signal are combined to derive the quality signal.
Abstract:
In a circuit for suppressing short-lived noise phenomena in a digital audio signal, in particular during a temporary test reception of another transmitter, the audio signal is multiplied by a factor which, prior to the appearance of the noise phenomenon, is brought from a maximum value to a minimum value in accordance with a predetermined time function, and at the end of the noise phenomenon, is returned to a maximum value. The invention has special application to the Radio Data System defined by the European Broadcasting Union, and the testing of "Alternative Frequencies" in that system.
Abstract:
The invention relates to novel compounds of formula I where R1, R2, R3, R4, R5, R6, R7, R8, Q1, Q2 and Q3 are each as defined below. The compounds of formula I have antithrombotic activity and inhibit especially protease-activated receptor 1 (PAR1). The invention further relates to a process for preparing the compound of formula I and to the use thereof as a medicament.