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公开(公告)号：US08084198B2
公开(公告)日：2011-12-27
申请号：US11913873
申请日：2006-05-03
申请人： Detlef Kozian , Matthias Herrmann , Karl-Ernst Siegler , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
发明人： Detlef Kozian , Matthias Herrmann , Karl-Ernst Siegler , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
CPC分类号： C12Q1/6883 , C12Q1/6897 , C12Q2600/156 , C12Q2600/158
摘要： The use of the single nucleotide polymorphism (SNP) at position −(97) of the GIP gene for the identification of a cardiovascular disease or of an increased risk for developing a cardiovascular disease in a biological sample taken from an individual to be examined.
摘要翻译： 在GIP基因的位置（97）处使用单核苷酸多态性（SNP）来鉴定从被检查个体获取的生物样品中的心血管疾病或发展心血管疾病的风险增加。
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公开(公告)号：US20100062431A1
公开(公告)日：2010-03-11
申请号：US12300200
申请日：2007-05-09
申请人： Detlef Kozian , Matthias Herrmann , Karl-Ernst Siegler , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
发明人： Detlef Kozian , Matthias Herrmann , Karl-Ernst Siegler , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G01N2800/32
摘要： The use of the single nucleotide polymorphism (SNP) of the ADAMTS4 gene for the identification of cardiovascular and peripheral vascular disorders or of an increased risk for developing cardiovascular and peripheral vascular disorders in a biological sample taken from an individual to be examined; the use of ADAMTS4 for identifying substances active in preventing and/or treating cardiovascular and peripheral vascular disorders and methods for doing so.
摘要翻译： 使用ADAMTS4基因的单核苷酸多态性（SNP）来鉴定从被检查个体获取的生物样品中的心血管和外周血管疾病或发展为心血管和外周血管疾病的风险增加的单核苷酸多态性（SNP） 使用ADAMTS4鉴别预防和/或治疗心血管和外周血管疾病的物质及其方法。
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公开(公告)号：US20080312098A1
公开(公告)日：2008-12-18
申请号：US11913873
申请日：2006-05-03
申请人： Detlef Kozian , Matthias Herrmann , Karl-Ernst Siegler , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
发明人： Detlef Kozian , Matthias Herrmann , Karl-Ernst Siegler , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
IPC分类号： C40B30/04 , C12Q1/68 , C12Q1/02 , G01N33/566 , A61K31/15 , A61P9/00 , C07H21/04 , G01N33/567 , G01N33/53
CPC分类号： C12Q1/6883 , C12Q1/6897 , C12Q2600/156 , C12Q2600/158
摘要： The use of the single nucleotide polymorphism (SNP) at position −(97) of the GIP gene for the identification of a cardiovascular disease or of an increased risk for developing a cardiovascular disease in a biological sample taken from an individual to be examined.
摘要翻译： 在GIP基因的位置（97）处使用单核苷酸多态性（SNP）来鉴定从被检查个体获取的生物样品中的心血管疾病或发展心血管疾病的风险增加。
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4.发明授权Association of EDG5 polymorphism V286A with type II diabetes mellitus and venous thrombosis/pulmonary embolism and the use thereof 失效EDG5多态性V286A与II型糖尿病和静脉血栓形成/肺栓塞的关系及其用途公开(公告)号：US07888020B2
公开(公告)日：2011-02-15
申请号：US11834998
申请日：2007-08-07
申请人： Detlef Kozian , Evi Kostenis , Karl-Ernst Siegler , Martina Jacobs , Sylvain Ricard , Sandrine Mace , Jean-Francois Deleuze
发明人： Detlef Kozian , Evi Kostenis , Karl-Ernst Siegler , Martina Jacobs , Sylvain Ricard , Sandrine Mace , Jean-Francois Deleuze
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention relates to a method of identifying an increase in risk for type II Diabetes mellitus, venous thrombosis, or pulmonary embolism in a subject, wherein the presence of an amino acid exchange at position 286 from valine (Val) to alanine (Ala) in the EDG5 protein in a biological sample taken from the subject.
摘要翻译： 本发明涉及鉴定受试者中II型糖尿病，静脉血栓形成或肺栓塞风险增加的方法，其中286位从缬氨酸（Val）到丙氨酸（Ala）的氨基酸交换的存在 在取自受试者的生物样品中的EDG5蛋白中。
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5.发明申请Analysis and use of PAR1 polymorphisms for evaluating the risk of cardiovascular disorders 审中-公开分析和使用PAR1多态性评估心血管疾病风险公开(公告)号：US20050019795A1
公开(公告)日：2005-01-27
申请号：US10831552
申请日：2004-04-23
申请人： Detlef Kozian , Joerg Czech , Karl-Ernst Siegler , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
发明人： Detlef Kozian , Joerg Czech , Karl-Ernst Siegler , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
CPC分类号： C12Q1/6883 , C07H17/08 , C07K14/723 , C12Q2600/156
摘要： The invention relates to polynucleotide sequences comprising genetic variations of the PAR1 gene at positions 3090 and/or 3329. The occurrence of these variants in humans correlates with increased occurrence of particular cardiovascular disorders. The invention furthermore relates to methods for detecting said genetic variations for the purpose of patient diagnosis.
摘要翻译： 本发明涉及包含位点3090和/或3329上的PAR1基因的遗传变异的多核苷酸序列。人类中这些变体的发生与特定心血管疾病的增加的发生相关。 本发明还涉及用于检测用于患者诊断目的的所述遗传变异的方法。
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6.发明授权Method for the identification of a risk for a thrombogenic disorder by determining the TAFI-Ile347 polymorphism 失效通过确定TAFI-Ile347多态性来鉴定血栓形成障碍风险的方法公开(公告)号：US07560290B2
公开(公告)日：2009-07-14
申请号：US11184010
申请日：2004-04-01
申请人： Detlef Kozian , Stefan Schaefer , Bernward Schoelkens , Karl-Ernst Siegler , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
发明人： Detlef Kozian , Stefan Schaefer , Bernward Schoelkens , Karl-Ernst Siegler , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , Y10S436/811
摘要： The present invention is directed to a method identifying a risk for a thrombogenic disorder, to a method for selecting patients with a risk for a thrombogenic disorder, to a method for identifying a pharmaceutical for the therapy or prophylaxis of a thrombogenic disorder as well as to a method for producing a medicament and a diagnostic by employing the TAFI-Ile347 polymorphism.
摘要翻译： 本发明涉及一种鉴定血栓形成疾病风险的方法，选择患有血栓形成疾病风险的患者的方法，用于鉴定用于治疗或预防血栓形成疾病的药物的方法，以及 通过采用TAFI-Ile347多态性制备药物和诊断方法。
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公开(公告)号：US20070292859A1
公开(公告)日：2007-12-20
申请号：US11574839
申请日：2005-08-27
申请人： Detlef Kozian , Heinz Goegelein , Karl-Ernst Siegler , Martina Jacobs , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
发明人： Detlef Kozian , Heinz Goegelein , Karl-Ernst Siegler , Martina Jacobs , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The invention concerns methods of identifying an increase in risk for coronary heart disease in an individual, wherein the presence of another amino acid than Glutaminic Acid at position 23 and/or the presence of another amino acid than Valine at position 337 in the Kir6.2 protein is determined in a sample. Moreover, probes, primers, polypeptides or polynucleotides suitable for said methods are claimed.
摘要翻译： 本发明涉及鉴定个体中冠状动脉心脏病风险增加的方法，其中在Kir6.2中存在另一个氨基酸比谷氨酸在第23位和/或存在另外一个氨基酸比缬氨酸337位置存在 在样品中测定蛋白质。 此外，要求适用于所述方法的探针，引物，多肽或多核苷酸。
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8.发明申请Method for the identification of a risk for a thrombogenic disorder by determining the TAFI-IIe347 polymorphism 失效通过确定TAFI-IIe347多态性来鉴定血栓形成障碍风险的方法公开(公告)号：US20060040296A1
公开(公告)日：2006-02-23
申请号：US11184010
申请日：2004-04-01
申请人： Detlef Kozian , Stefan Schaefer , Bernward Schoelkens , Karl-Ernst Siegler , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
发明人： Detlef Kozian , Stefan Schaefer , Bernward Schoelkens , Karl-Ernst Siegler , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
CPC分类号： G01N33/6893 , Y10S436/811
摘要： The present invention is directed to a method identifying a risk for a thrombogenic disorder including, without limitation, atrial fibrillation, stroke, prolonged intermitted neurological deficit (PRIND), transitory ischemic attack (TIA), atherosclerotic cerebrovascular disease (CVD) and/or coronary heart disease, as well as to a method for selecting patients with a risk for a thrombogenic disorder, to a method for identifying a pharmaceutical for the therapy or prophylaxis of a thrombogenic disorder as well as to a method for producing a medicament and a diagnostic by employing the TAFI-Ile347 polymorphism.
摘要翻译： 本发明涉及一种鉴定血栓形成疾病风险的方法，包括但不限于心房颤动，中风，延迟性间歇性神经功能缺损（PRIND），短暂性缺血发作（TIA），动脉粥样硬化性脑血管病（CVD）和/或冠状动脉疾病 心脏病以及用于选择具有血栓形成障碍风险的患者的方法，用于鉴定用于治疗或预防血栓形成疾病的药物的方法以及用于制备药物的方法和诊断方法 采用TAFI-Ile347多态性。
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9.发明授权Method for the identification of a risk for a thrombogenic disorder by determining the TAFI-lle347 polymorphism 失效通过确定TAFI-ILE347多态性来鉴定血栓形成障碍风险的方法公开(公告)号：US07985562B2
公开(公告)日：2011-07-26
申请号：US12474794
申请日：2009-05-29
申请人： Detlef Kozian , Stefan Schaefer , Bernward Schoelkens , Karl-Ernst Siegler , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
发明人： Detlef Kozian , Stefan Schaefer , Bernward Schoelkens , Karl-Ernst Siegler , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
IPC分类号： G01N33/00
CPC分类号： G01N33/6893 , Y10S436/811
摘要： The present invention is directed to a method identifying a risk for a thrombogenic disorder, to a method for selecting patients with a risk for a thrombogenic disorder, to a method for identifying a pharmaceutical for the therapy or prophylaxis of a thrombogenic disorder as well as to a method for producing a medicament and a diagnostic by employing the TAFI-Ile347 polymorphism.
摘要翻译： 本发明涉及一种鉴定血栓形成疾病风险的方法，选择患有血栓形成疾病风险的患者的方法，用于鉴定用于治疗或预防血栓形成疾病的药物的方法，以及 通过采用TAFI-Ile347多态性制备药物和诊断方法。
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10.发明授权Analysis and use of PAR1 polymorphisms for evaluating the risk of cardiovascular disorders 失效分析和使用PAR1多态性评估心血管疾病风险公开(公告)号：US07892744B2
公开(公告)日：2011-02-22
申请号：US12567942
申请日：2009-09-28
申请人： Detlef Kozian , Joerg Czech , Karl-Ernst Siegler , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
发明人： Detlef Kozian , Joerg Czech , Karl-Ernst Siegler , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
CPC分类号： C12Q1/6883 , C07H17/08 , C07K14/723 , C12Q2600/156
摘要： The invention relates to polynucleotide sequences comprising genetic variations of the PAR1 gene at positions 3090 and/or 3329. The occurrence of these variants in humans correlates with increased occurrence of particular cardiovascular disorders. The invention furthermore relates to methods for detecting said genetic variations for the purpose of patient diagnosis.
摘要翻译： 本发明涉及包含位点3090和/或3329上的PAR1基因的遗传变异的多核苷酸序列。人类中这些变体的发生与特定心血管疾病的增加的发生相关。 本发明还涉及用于检测用于患者诊断目的的所述遗传变异的方法。
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