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1.发明申请Method of Diagnosis of a Predisposition to Develop Thrombotic Disease and Its Uses 失效诊断血栓形成疾病倾向的方法及其应用公开(公告)号：US20080038722A1
公开(公告)日：2008-02-14
申请号：US10592692
申请日：2005-03-16
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention refers to a method of diagnosis of a predisposition to develop thrombotic disease, to test systems and their use for the diagnosis of a predisposition to develop thrombotic disease, to a P2X1 promoter variant and its use for screening for an anti-thrombotic agent, and to methods for identifying an individual that can be prophylactically or therapeutically treated with an anti-thrombotic agent, or for adapting a therapeutic or prophylactic dose of an anti-thrombotic agent.
摘要翻译： 本发明涉及诊断发生血栓形成疾病的倾向，测试系统及其用于诊断倾向于发展血栓形成性疾病的用途的方法，以诊断P 启动子变体及其用于筛选抗血栓形成剂的用途，以及用于鉴定可以用抗血栓形成剂预防性或治疗性治疗的个体的方法，或用于调整治疗或预防剂量的抗血栓形成剂 血栓形成剂。
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公开(公告)号：US08084198B2
公开(公告)日：2011-12-27
申请号：US11913873
申请日：2006-05-03
申请人： Detlef Kozian , Matthias Herrmann , Karl-Ernst Siegler , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
发明人： Detlef Kozian , Matthias Herrmann , Karl-Ernst Siegler , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
CPC分类号： C12Q1/6883 , C12Q1/6897 , C12Q2600/156 , C12Q2600/158
摘要： The use of the single nucleotide polymorphism (SNP) at position −(97) of the GIP gene for the identification of a cardiovascular disease or of an increased risk for developing a cardiovascular disease in a biological sample taken from an individual to be examined.
摘要翻译： 在GIP基因的位置（97）处使用单核苷酸多态性（SNP）来鉴定从被检查个体获取的生物样品中的心血管疾病或发展心血管疾病的风险增加。
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公开(公告)号：US20100062431A1
公开(公告)日：2010-03-11
申请号：US12300200
申请日：2007-05-09
申请人： Detlef Kozian , Matthias Herrmann , Karl-Ernst Siegler , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
发明人： Detlef Kozian , Matthias Herrmann , Karl-Ernst Siegler , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G01N2800/32
摘要： The use of the single nucleotide polymorphism (SNP) of the ADAMTS4 gene for the identification of cardiovascular and peripheral vascular disorders or of an increased risk for developing cardiovascular and peripheral vascular disorders in a biological sample taken from an individual to be examined; the use of ADAMTS4 for identifying substances active in preventing and/or treating cardiovascular and peripheral vascular disorders and methods for doing so.
摘要翻译： 使用ADAMTS4基因的单核苷酸多态性（SNP）来鉴定从被检查个体获取的生物样品中的心血管和外周血管疾病或发展为心血管和外周血管疾病的风险增加的单核苷酸多态性（SNP） 使用ADAMTS4鉴别预防和/或治疗心血管和外周血管疾病的物质及其方法。
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4.发明授权Method of diagnosis of a predisposition to develop thrombotic disease and its uses 失效诊断倾向性发展为血栓性疾病及其用途的方法公开(公告)号：US07785781B2
公开(公告)日：2010-08-31
申请号：US10592692
申请日：2005-03-16
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention refers to a method of diagnosis of a predisposition to develop thrombotic disease, to test systems and their use for the diagnosis of a predisposition to develop thrombotic disease, to a P2X1 promoter variant and its use for screening for an anti-thrombotic agent, and to methods for identifying an individual that can be prophylactically or therapeutically treated with an anti-thrombotic agent, or for adapting a therapeutic or prophylactic dose of an anti-thrombotic agent.
摘要翻译： 本发明涉及诊断P2V1启动子变体及其用于筛选抗血栓形成剂的用于发展血栓形成疾病，测试系统及其用于诊断倾向于发展血栓形成疾病的用途的倾向性的方法 以及用于鉴定可以用抗血栓形成剂预防性或治疗性治疗的个体的方法，或用于调整治疗或预防剂量的抗血栓形成剂。
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公开(公告)号：US20080312098A1
公开(公告)日：2008-12-18
申请号：US11913873
申请日：2006-05-03
申请人： Detlef Kozian , Matthias Herrmann , Karl-Ernst Siegler , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
发明人： Detlef Kozian , Matthias Herrmann , Karl-Ernst Siegler , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
IPC分类号： C40B30/04 , C12Q1/68 , C12Q1/02 , G01N33/566 , A61K31/15 , A61P9/00 , C07H21/04 , G01N33/567 , G01N33/53
CPC分类号： C12Q1/6883 , C12Q1/6897 , C12Q2600/156 , C12Q2600/158
摘要： The use of the single nucleotide polymorphism (SNP) at position −(97) of the GIP gene for the identification of a cardiovascular disease or of an increased risk for developing a cardiovascular disease in a biological sample taken from an individual to be examined.
摘要翻译： 在GIP基因的位置（97）处使用单核苷酸多态性（SNP）来鉴定从被检查个体获取的生物样品中的心血管疾病或发展心血管疾病的风险增加。
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6.发明授权EGLN2 variants and use thereof in preventing or treating thromboembolic disorders and coronary heart diseases 失效EGLN2变体及其在预防或治疗血栓栓塞性疾病和冠心病中的用途公开(公告)号：US08211427B2
公开(公告)日：2012-07-03
申请号：US13015994
申请日：2011-01-28
申请人： Detlef Kozian , Matthias Herrmann
发明人： Detlef Kozian , Matthias Herrmann
CPC分类号： C12N9/0071
摘要： The present invention refers to human EGLN2 variants having at position 58 of the amino acid sequence a serine or a leucine and their use in the prevention or treatment of thromboembolic or coronary heart diseases, in particular stroke, prolonged reversible ischemic neurological deficit (PRIND), transitoric ischemic attack (TIA), myocardial infarction and/or early myocardial infarction.
摘要翻译： 本发明涉及具有丝氨酸或亮氨酸的氨基酸序列58位的人EGLN2变异体及其在预防或治疗血栓栓塞或冠心病，特别是中风，长期可逆性缺血性神经功能缺损（PRIND）， 经皮缺血发作（TIA），心肌梗死和/或早期心肌梗死。
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7.发明申请EGLN2 VARIANTS AND USE THEREOF IN PREVENTING OR TREATING THROMBOEMBOLIC DISORDERS AND CORONARY HEART DISEASE 失效EGLN2变异体及其在预防或治疗血栓性疾病和冠状动脉疾病中的应用公开(公告)号：US20090220479A1
公开(公告)日：2009-09-03
申请号：US12089627
申请日：2006-09-30
申请人： Detlef Kozian , Matthias Herrmann
发明人： Detlef Kozian , Matthias Herrmann
IPC分类号： A61K38/46 , C12N9/14 , C12N15/11 , C12N15/00 , C12N5/06 , A01K67/027 , C07K16/18 , C12P21/02 , C12Q1/68 , C12Q1/34 , C40B30/00
CPC分类号： C12N9/0071
摘要： The present invention refers to human EGLN2 variants having at position 58 of the amino acid sequence a serine or a leucine and their use in the prevention or treatment of thromboembolic or coronary heart diseases, in particular stroke, prolonged reversible ischemic neurological deficit (PRIND), transitoric ischemic attack (TIA), myocardial infarction and/or early myocardial infarction.
摘要翻译： 本发明涉及具有丝氨酸或亮氨酸的氨基酸序列58位的人EGLN2变异体及其在预防或治疗血栓栓塞或冠心病，特别是中风，长期可逆性缺血性神经功能缺损（PRIND）， 经皮缺血发作（TIA），心肌梗死和/或早期心肌梗死。
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8.发明授权EGLN2 variants and use thereof in preventing or treating thromboembolic disorders and coronary heart disease 失效EGLN2变体及其在预防或治疗血栓栓塞性疾病和冠心病中的用途公开(公告)号：US08114398B2
公开(公告)日：2012-02-14
申请号：US12089627
申请日：2006-09-30
申请人： Detlef Kozian , Matthias Herrmann
发明人： Detlef Kozian , Matthias Herrmann
CPC分类号： C12N9/0071
摘要： The present invention refers to human EGLN2 variants having at position 58 of the amino acid sequence a serine or a leucine and their use in the prevention or treatment of thromboembolic or coronary heart diseases, in particular stroke, prolonged reversible ischemic neurological deficit (PRIND), transitoric ischemic attack (TIA), myocardial infarction and/or early myocardial infarction.
摘要翻译： 本发明涉及具有丝氨酸或亮氨酸的氨基酸序列58位的人EGLN2变异体及其在预防或治疗血栓栓塞或冠心病，特别是中风，长期可逆性缺血性神经功能缺损（PRIND）， 经皮缺血发作（TIA），心肌梗死和/或早期心肌梗死。
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9.发明申请USE OF CLEC1B FOR THE DETERMINATION OF CARDIOVASCULAR AND THROMBOTIC RISK 审中-公开CLEC1B用于确定心血管和血栓风险的应用公开(公告)号：US20100311053A1
公开(公告)日：2010-12-09
申请号：US12679547
申请日：2008-09-13
申请人： Detlef Kozian , Peter Wonerow , Matthias Herrmann
发明人： Detlef Kozian , Peter Wonerow , Matthias Herrmann
CPC分类号： G01N33/566 , C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , G01N2333/7056 , G01N2500/04 , G01N2800/32 , G01N2800/50 , G01N2800/52
摘要： The use of the single nucleotide polymorphism (SNP) of the CLEC1B gene for the identification of cardiovascular and/or thrombotic disorders or of an increased risk for developing cardiovascular and/or thrombotic disorders in a biological sample taken from an individual to be examined; the use of CLEC1B for identifying substances active in preventing and/or treating cardiovascular and/or thrombotic disorders and methods for doing so.
摘要翻译： 使用CLEC1B基因的单核苷酸多态性（SNP）来鉴定从被检查个体获取的生物样品中的心血管和/或血栓形成障碍或发生心血管和/或血栓形成障碍的风险增加; 使用CLEC1B来鉴别预防和/或治疗心血管和/或血栓形成障碍的物质及其方法。
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公开(公告)号：US08329167B2
公开(公告)日：2012-12-11
申请号：US13331581
申请日：2011-12-20
申请人： Detlef Kozian , Matthias Herrmann
发明人： Detlef Kozian , Matthias Herrmann
CPC分类号： C12N9/0071
摘要： The present invention refers to human EGLN2 variants having at position 58 of the amino acid sequence a serine or a leucine and their use in the prevention or treatment of thromboembolic or coronary heart diseases, in particular stroke, prolonged reversible ischemic neurological deficit (PRIND), transitoric ischemic attack (TIA), myocardial infarction and/or early myocardial infarction.
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