公开(公告)号：US20210378975A1

公开(公告)日：2021-12-09

申请号：US16764551

申请日：2019-04-03

Applicant: NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY, CHINA

Inventor： Lele LI ,  Congli WANG ,  Zhenghan DI

IPC: A61K9/51

Abstract: The present application relates to a metal-nucleic acid nanoparticle which is a nanoparticle having a spherical structure formed by assembly of metal ions with nucleic acids via coordination. The preparation thereof is mixing a metal ion solution with a nucleic acid solution to obtain a mixture followed by vortex, heating, centrifugation, washing with water and resuspension to obtain the metal-nucleic acid nanoparticles.

公开(公告)号：US20210033504A1

公开(公告)日：2021-02-04

申请号：US17043038

申请日：2018-08-03

Applicant: NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY

Inventor： Jiashu Sun

IPC: G01N1/40 ,  G01N1/44 ,  G01N21/64 ,  G01N15/06

Abstract: The invention relates to a micro-nano particles detection system and a method thereof. The system comprises a heating unit (1), a sample chamber unit (2), and a signal acquisition unit (4), wherein the heating unit (1) is arranged outside the sample chamber unit (2) for heating a sample in the sample chamber unit (2). Micro-nano particle fluid is loaded in the sample chamber unit (2). After the heating unit (1) heats the sample chamber unit (2), the sample chamber unit (2) generates a thermophoresis effect, so that the micro-nano particles are gathered at one side with temperature lower than the micro-nano particle fluid in the sample chamber unit (2). The signal acquisition unit (4) is used for collecting relevant information of the gathered micro-nano particles, and carrying out corresponding analysis.

公开(公告)号：US10823758B2

公开(公告)日：2020-11-03

申请号：US16086821

申请日：2016-03-29

Applicant: National Center for Nanoscience and Technology

Inventor： Jianxun Xu ,  Yuliang Zhao

IPC: G01R1/067 ,  B81C1/00 ,  B81B1/00 ,  G01Q70/10 ,  G01Q70/18 ,  B82Y30/00 ,  G01Q30/02 ,  G01Q70/12 ,  G01R3/00

Abstract: Provided is a conical nano-carbon material functionalized needle tip, formed by assembling a nano-carbon material with a material of a needle tip by means of a covalent bond; and the material of the needle tip is a metal selected from one or more of tungsten, iron, cobalt, nickel and titanium. Further provided is a method for preparing the conical nano-carbon material functionalized needle tip. The conical nano-material functionalized needle tip has an outstanding interface formed by metal-carbide covalent bonds, and the orientation of the conical nano-material is matched with the axial direction of the metal needle tip (illustrated in FIG. 6). The proposed preparation method affords a robust interface and avoids the potential pollution to the nano-material caused during the deposition of fixing materials, such as carbon or platinum or the like, in other preparation methods.

公开(公告)号：US09526771B2

公开(公告)日：2016-12-27

申请号：US14394986

申请日：2013-02-04

Applicant: National Center for Nanoscience and Technology

Inventor： Guangjun Nie ,  Xin Tian ,  Motao Zhu

IPC: A61K39/00 ,  C12N5/0784

CPC classification number: A61K39/0011 ,  A61K2039/5154 ,  A61K2039/5158 ,  C12N5/0639 ,  C12N2501/052 ,  C12N2501/22 ,  C12N2501/2304

Abstract: The present invention provides a preparation method of an antigen composition. The preparation method comprises the following steps: (1) obtaining a tumor antigen protein; (2) making the tumor antigen protein into contact with an immature dendritic cell; (3) inducing the immature dendritic cell in contact with the tumor antigen into a mature dendritic cell; and (4) separating a cell vesicle of the mature dendritic cell. The present invention further provides an antigen composition obtained through the preparation method and the application thereof in preparing a tumor vaccine.

Abstract translation: 本发明提供抗原组合物的制备方法。 制备方法包括以下步骤：（1）获得肿瘤抗原蛋白; （2）使肿瘤抗原蛋白与未成熟树突状细胞接触; （3）将与肿瘤抗原接触的未成熟树突状细胞诱导成成熟树突状细胞; 和（4）分离成熟树突状细胞的细胞囊泡。 本发明还提供通过制备方法获得的抗原组合物及其在制备肿瘤疫苗中的应用。

公开(公告)号：US20150291429A1

公开(公告)日：2015-10-15

申请号：US14417637

申请日：2012-07-27

Applicant: Guanglu GE ,  Lirong WANG ,  Xue XUE ,  Xingjie LIANG ,  National Center for Nanoscience and Technology

Inventor： Guanglu Ge ,  Lirong Wang ,  Xue Xue ,  Xingjie Liang

IPC: C01B31/02 ,  B01D21/26

CPC classification number: C01B32/172 ,  B03D3/00 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/174 ,  Y10S977/845

Abstract: Provided is a method for treating single-walled carbon nanotube, comprising: (1) allowing single-walled carbon nanotubes to contact with a surfactant and a dispersant sequentially in the present of a solvent, to obtain highly dispersed single-walled carbon nanotubes in which the content of single dispersed single-walled carbon nanotubes is not lower than 50 wt %, wherein, the single-walled carbon nanotubes can be dispersed in the solvent, and the surfactant and dispersant can be dissolved in the solvent; (2) employing density gradient centrifugation to sort the highly dispersed single-walled carbon nanotubes obtained in step (1). This method can effectively separate single-walled carbon nanotubes with different structural properties.

Abstract translation: 本发明提供一种处理单壁碳纳米管的方法，包括：（1）使单壁碳纳米管与溶剂中的表面活性剂和分散剂顺序接触，得到高度分散的单壁碳纳米管，其中 单分散单壁碳纳米管的含量不低于50重量％，其中单壁碳纳米管可以分散在溶剂中，表面活性剂和分散剂可以溶解在溶剂中; （2）使用密度梯度离心分离步骤（1）中获得的高度分散的单壁碳纳米管。 该方法可以有效地分离具有不同结构特性的单壁碳纳米管。