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公开(公告)号:US12215142B2
公开(公告)日:2025-02-04
申请号:US16980667
申请日:2019-03-15
Inventor: Makoto Urushitani , Yoshitaka Tamaki
Abstract: A modified antibody fragment comprising an antibody fragment capable of binding to misfolded TDP-43, and a chaperone-mediated autophagy localizing signal peptide.
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公开(公告)号:US20220087590A1
公开(公告)日:2022-03-24
申请号:US17425459
申请日:2020-01-14
Applicant: Takeshi TSUCHIYA , NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE , NIHON KOHDEN CORPORATION
Inventor: Takashi ASHIHARA , Koji TAKIZAWA , Takeshi TSUCHIYA
Abstract: A recording device includes: an acquisition unit (102) configured to acquire vital signs through a multi-electrode catheter (X) having a plurality of electrodes; a recording unit (104) configured to record a bipolar potential of a main channel which is defined by combining the plurality of electrodes, using the vital signs; an addition unit (32) configured to add a mark to each waveform plotted based on a potential of the bipolar potential, at a predetermined position on a time axis; and an adjusting unit (33) configured to adjust a position of the mark added to each waveform. The adjusting unit (33) is configured to adjust the position of the mark added to the bipolar potential of the main channel, based on bipolar potentials of reference channels including electrodes included in the main channel.
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公开(公告)号:US20200181676A1
公开(公告)日:2020-06-11
申请号:US16615705
申请日:2018-05-24
Inventor: Shin-ya MORITA
Abstract: Disclosed is a method for quantifying phosphatidylinositol in a sample, comprising the following step: (1) treating the sample with phospholipase D and inositol dehydrogenase; and a kit for quantifying phosphatidylinositol, containing phospholipase D and inositol dehydrogenase.
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公开(公告)号:US20150141977A1
公开(公告)日:2015-05-21
申请号:US14400857
申请日:2013-05-14
Inventor: Tohru Tani , Shigeyuki Naka , Hiroya Akabori
CPC classification number: A61B17/320068 , A61B17/32 , A61B18/1815 , A61B2017/320012 , A61B2017/320072 , A61B2018/0019 , A61B2018/00267 , A61B2018/00529 , A61B2018/00589 , A61B2018/00601 , A61B2018/1861 , A61B2018/1892 , A61B2218/002 , A61B2218/007
Abstract: It is an object to provide a surgical tool for excising a hard solid organ such as cirrhotic liver or cutting the organ into a groove without causing bleeding. The inventors of the present invention have found that an organ resection tool including a brush-like structure capable of performing microwave irradiation and/or a brush-like structure capable of receiving a microwave can achieve the above-mentioned object, to thereby arrive at the present invention (organ resection tool including a brush structure capable of performing microwave irradiation). For example, an organ can be crushed or scraped away by manually abrading the organ with a brush of a solid organ resection tool including a brush structure capable of performing microwave irradiation according to the present invention. Further, the organ can be concurrently coagulated through the microwave irradiation to stop bleeding.
Abstract translation: 本发明的目的是提供一种用于切除硬固体器官如肝硬化肝脏或将器官切割成凹槽而不引起出血的外科手术工具。 本发明的发明人已经发现,包括能够进行微波照射的刷状结构和/或能够接收微波的刷状结构的器官切除工具可以实现上述目的,从而达到 本发明(包括能够进行微波照射的刷结构的器官切除工具)。 例如,可以用包括能够进行根据本发明的微波照射的刷结构的实体器官切除工具的刷子手动研磨器官来将器官压碎或刮掉。 此外,器官可以通过微波照射同时凝结以止血。
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公开(公告)号:US12186088B2
公开(公告)日:2025-01-07
申请号:US17425459
申请日:2020-01-14
Applicant: NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE , NIHON KOHDEN CORPORATION , Takeshi TSUCHIYA
Inventor: Takashi Ashihara , Koji Takizawa , Takeshi Tsuchiya
Abstract: A recording device includes an acquisition unit configured to acquire vital signs through a sensor device having a plurality of electrodes, a recording unit configured to record a bipolar potential of a main channel which is defined by combining the plurality of electrodes, using the vital signs, an addition unit configured to add a mark to each waveform plotted based on variation of the bipolar potential over time, at a predetermined position on a time axis, and an adjusting unit configured to adjust a position of the mark added to each waveform. The adjusting unit is configured to adjust the position of the mark added to the bipolar potential of the main channel, based on bipolar potentials of reference channels including electrodes included in the main channel.
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公开(公告)号:US20240408129A1
公开(公告)日:2024-12-12
申请号:US18576858
申请日:2022-07-05
Inventor: Akeo HAGIWARA , Hiroyuki TSUJIMOTO , Tsunehito HORII , Noritaka ISOGAI , Kohei HAGIWARA , Yosaku HAGIWARA
IPC: A61K31/734 , A61L27/20 , A61L27/50 , A61P17/02
Abstract: An object of the present invention is to provide a tissue-forming agent. Provided is a tissue-forming agent comprising alginic acid or a salt thereof.
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公开(公告)号:US20240350668A1
公开(公告)日:2024-10-24
申请号:US18688563
申请日:2022-08-31
Inventor: Keizo TOMONAGA , Akiko MAKINO , Madoka SAKAI , Ryo KOMORIZONO , Makoto URUSHITANI , Toshifumi MORIMURA , Sumio MINAMIYAMA
CPC classification number: A61K48/005 , A61P25/28 , C07K16/40 , C12N15/86 , C07K2317/24 , C07K2317/565 , C07K2317/622 , C12N2760/00043
Abstract: Disclosed are a bornavirus vector comprising a nucleic acid encoding an antibody or antibody fragment capable of binding to a mutant SOD1 protein, the antibody or antibody fragment comprising a heavy-chain variable region comprising a heavy-chain CDR1 consisting of an amino acid sequence GFSLNTSGMG (SEQ ID NO: 1), a heavy-chain CDR2 consisting of an amino acid sequence IWWDDDK (SEQ ID NO: 2), and a heavy-chain CDR3 consisting of an amino acid sequence ARLGYAMDY (SEQ ID NO: 3), the heavy-chain variable region optionally having 3 or fewer amino acid substitutions, and/or a light-chain variable region comprising a light-chain CDR1 consisting of an amino acid sequence ONVGTN (SEQ ID NO: 4), a light-chain CDR2 consisting of an amino acid sequence SAS, and a light-chain CDR3 consisting of an amino acid sequence QQYYIYPYT (SEQ ID NO: 5), the light-chain variable region optionally having 3 or fewer amino acid substitutions; a recombinant virus comprising RNA encoded by the bornavirus vector; a cell infected with the recombinant virus; and a pharmaceutical composition comprising the cell.
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公开(公告)号:US20230301697A1
公开(公告)日:2023-09-28
申请号:US18014889
申请日:2021-07-06
Inventor: Shinji IMAI
IPC: A61B17/88
CPC classification number: A61B17/88
Abstract: Provided is a surgical instrument that can easily bring the coracoid process into proximity with the scapular neck. A surgical instrument 1 of the present invention includes a shaft 2 extending in the first direction, and an inclined part 3 extending from the tip of the shaft 2 in the second direction. The second direction, in which the inclined part 3 extends, is inclined at an angle of α in a range of 95° or more and 115° or less to the first direction, in which the shaft 2 extends, and the inclined part 3 includes on the outer edge thereof a notch 10 through which a screw is passed.
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公开(公告)号:US20220152357A1
公开(公告)日:2022-05-19
申请号:US17593619
申请日:2020-03-02
Inventor: Tohru TANI , Atsushi YAMADA , Tatsuya SHIMA , Wataru YONEMICHI
Abstract: A steerable catheter includes a flexible tube having a distal end and a proximal end. The tube includes a first tube section (sheath body section) the flexibility of which does not substantially change even upon receiving compression force in the axial direction; and a second tube section (deflection section) joined so as to be continuous with the distal end of the first tube section and constituted by a porous tube becoming hard upon being compressed according to the degree of the compression force acting in the axial direction and returning to being soft when the compression force is released. The tube includes operation means (wires) for releasably exerting a compression force compressing the second tube section in the axial direction and a deflection force deflecting the second tube section. According to some embodiments, both operability and insertability of the steerable catheter can be improved.
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公开(公告)号:US20210146096A1
公开(公告)日:2021-05-20
申请号:US17048061
申请日:2019-04-09
Inventor: Atsushi YAMADA , Tohru TANI , Wataru YONEMICHI
Abstract: A movable catheter is provided with a tube having a main lumen. The tube has a plurality of wire lumens and is provided with a wire. A substantial half on one end portion side thereof is inserted through the wire lumen, an intermediate part thereof is folded back in the distal end portion of the tube, and a substantial half on the other end portion side thereof is inserted through the wire lumen. The one end portion and the other end portion thereof are disposed on the proximal end side of the tube. Various embodiments enable the number of components to be reduced, and to reduce the number of manufacturing steps.
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