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公开(公告)号：US12048548B2
公开(公告)日：2024-07-30
申请号：US17691385
申请日：2022-03-10
Applicant: NIHON KOHDEN CORPORATION , NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY , NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE
Inventor： Kunihiko Kiuchi , Takashi Ashihara , Kaori Uchiyama , Akio Ota , Naoki Koura , Koji Takizawa
IPC: A61B5/347 , A61B5/0245 , A61B5/308 , A61B5/339
CPC classification number: A61B5/339 , A61B5/0245 , A61B5/308 , A61B5/347
Abstract: A display control device includes processing circuitry configured to: obtain an intracardiac electrocardiogram of a subject; generate visualization data representing an excitation state of a myocardium based on the intracardiac electrocardiogram; determine a type of excitation dynamics of the myocardium based on the visualization data; and display, on a stereoscopic image of a heart of the subject, a site from which the intracardiac electrocardiogram is obtained with a color in accordance with a ratio of the determined type of the excitation dynamics.
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公开(公告)号：US11911004B2
公开(公告)日：2024-02-27
申请号：US16343990
申请日：2017-10-24
Inventor： Atsushi Yamada , Tohru Tani , Shigeyuki Naka , Shigehiro Morikawa
CPC classification number: A61B1/008 , A61B34/70 , A61M25/0133 , A61B2034/301 , A61M2025/0915 , B25J19/00
Abstract: A bending and extending device 1 comprises an elastic hollow guide unit 2 and a movable part 3 to be movably inserted into the guide unit 2. The movable part 3 is constituted, either partially or entirely, of a plurality of belt-like flexible parts 30a and 30b, which extend in the axial direction of the guide unit 2 and the flexible parts 30a and 30b are connected at distal ends. The bending and extending device 1 is characterized in that, when, by the sliding operation of the flexible parts 30a and 30b, a cross-section in which a contact point T of the flexible part 30a and the inner surface of the guide unit 2 is present on an extending line Y extending from a line segment connecting the centroid P of the flexible part 30b and the axial center G of the guide unit 2 and in which the flexible part 30a and the second flexible part 30b are in contact with each other is generated, and when the cross-section is divided into two ranges by a predetermined straight line X, the centroid P of the flexible part 30b is not positioned in a range in which the contact point T is present; and the predetermined straight line X is a line that passes through the axial center G of the guide unit 2, and that orthogonally crosses the extending line Y.
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公开(公告)号：US20230357715A1
公开(公告)日：2023-11-09
申请号：US18027306
申请日：2021-09-24
Inventor： Hiroshi KAWAMOTO , Yasutoshi AGATA , Seiji NAGANO , Koji TERADA , Kyoko MASUDA , Kenta KONDO
IPC: C12N5/078 , C07K14/725
CPC classification number: C12N5/0634 , C07K14/7051 , C12N2510/00 , C12N2506/02 , C12N2506/45
Abstract: Provided is a method for producing effector cells expressing a desired specificity determining region. In this method, material cells that have a cassette deck structure with a cassette tape gene comprising a gene encoding a marker protein in their genome, wherein the material cells can be differentiated into the effector cells, and wherein the marker protein can be expressed in the effector cells or progenitor cells thereof when the material cells are differentiated into the effector cells or progenitor cells thereof are provided first. The material cells are proliferated, the proliferated cells are differentiated into the effector cells, and then, the gene encoding the marker protein in the effector cells is exchanged with a gene encoding a protein that contribute the desired specificity.
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公开(公告)号：US20230279361A1
公开(公告)日：2023-09-07
申请号：US18006920
申请日：2021-07-27
Inventor： Yasushi ITOH , Hirohito ISHIGAKI , Misako NAKAYAMA , Yoshinori KITAGAWA
CPC classification number: C12N7/00 , C12N5/0686 , C07K16/10 , C12N2501/734 , C12N2770/20032 , C12N2770/20051
Abstract: The present invention addresses the problem of providing a more convenient method for in vitro proliferating a virus belonging to the family Coronaviridae at high proliferation accuracy. This problem is solved by an in vitro virus proliferation method, said method comprising a step for culturing kidney-derived cells, which have been contacted with the virus belonging to the family Coronaviridae, with a use of a cell culture medium to which a protease having an optimum pH of from 7 to 9 is added.
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公开(公告)号：US20230162351A1
公开(公告)日：2023-05-25
申请号：US17920396
申请日：2021-04-22
Inventor： Akihiko SHIINO
CPC classification number: G06T7/0012 , G06T7/11 , G06T7/62 , G16H50/20 , G06T2207/10088 , G06T2207/30016 , G06T2207/20081
Abstract: The possibility that an ADNC patient will develop Alzheimer's disease is predicted with high accuracy. A diagnosis assistance device 2 predicts a possibility that a subject who has ADNC will develop Alzheimer's disease within a prescribed period, the diagnosis assistance device 2 comprising a prediction unit 23 that predicts the possibility that the subject will develop Alzheimer's disease within a prescribed period, according to a machine-learned prediction algorithm D4.
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Patent Agency Ranking
公开(公告)号：US20220378504A1
公开(公告)日：2022-12-01
申请号：US17775831
申请日：2020-11-09
Inventor： Tohru TANI
IPC: A61B18/18
Abstract: A power supply device in which a device shaft provided with a power receiver is inserted in a through-hole of a port site, which is capable of supplying electric power to the power receiver at a low cost and enabling fine operation of the device shaft. The power supply includes a port site; first terminals provided on an inner surface of the through-hole; wires that connect the first terminals and a power source; a device shaft that is insertable into the through-hole; a power receiver provided on the device shaft; second terminals provided on an outer surface of the device shaft; and wires that connect the power receiver and the second terminals. Electric power from the power supply can be supplied to the power receiver by inserting the device shaft into the through-hole to thereby bring the first terminals and the second terminals into contact with each other.
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公开(公告)号：US20220296153A1
公开(公告)日：2022-09-22
申请号：US17691385
申请日：2022-03-10
Applicant: NIHON KOHDEN CORPORATION , NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY , NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE
Inventor： Kunihiko KIUCHI , Takashi ASHIHARA , Kaori UCHIYAMA , Akio OTA , Naoki KOURA , Koji TAKIZAWA
IPC: A61B5/339 , A61B5/0245 , A61B5/308 , A61B5/347
Abstract: A display control device includes processing circuitry configured to: obtain an intracardiac electrocardiogram of a subject; generate visualization data representing an excitation state of a myocardium based on the intracardiac electrocardiogram; determine a type of excitation dynamics of the myocardium based on the visualization data; and display, on a stereoscopic image of a heart of the subject, a site from which the intracardiac electrocardiogram is obtained with a color in accordance with a ratio of the determined type of the excitation dynamics.
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公开(公告)号：US20210024621A1
公开(公告)日：2021-01-28
申请号：US16980667
申请日：2019-03-15
Inventor： Makoto URUSHITANI , Yoshitaka TAMAKI
Abstract: Disclosed is a modified antibody fragment comprising an antibody fragment capable of binding to misfolded TDP-43, and a chaperone-mediated autophagy localizing signal peptide; the antibody fragment comprising a heavy-chain variable region comprising a heavy-chain CDR 1 consisting of an amino acid sequence GFNIKDYY (SEQ ID NO: 1), a heavy-chain CDR 2 consisting of an amino acid sequence IDPEDGET (SEQ ID NO: 2), and a heavy-chain CDR 3 consisting of an amino acid sequence TIIYYYGSRYVDY (SEQ ID NO: 3), the heavy-chain variable region optionally having 3 or fewer amino acid substitutions, and/or a light-chain variable region comprising a light-chain CDR 1 consisting of an amino acid sequence SSISSSY (SEQ ID NO: 4), a light-chain CDR 2 consisting of an amino acid sequence RTS, and a light-chain CDR 3 consisting of an amino acid sequence QQGSSIPLT (SEQ ID NO: 5), the light-chain variable region optionally having 3 or fewer amino acid substitutions; and the antibody fragment being scFv, VH, or VL.
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公开(公告)号：US20200215253A1
公开(公告)日：2020-07-09
申请号：US16638570
申请日：2018-09-07
Applicant: TORAY INDUSTRIES, INC. , NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE
Inventor： Yoshiyuki UENO , Junichi KASUYA , Toru ARAKANE , Ryo MATSUNAGA , Yumiko SEKIYA , Yuji UEDA , Kazuo TERAMOTO , Kazumasa OGASAWARA
Abstract: An objective of the present disclosure is to provide an adsorption material that can selectively adsorb immunosuppressive leukocyte. The present disclosure provides an adsorption material for immunosuppressive leukocyte. The adsorption material includes a water-insoluble carrier to which at least one nitrogen-containing compound selected from a polyamine represented by a predetermined formula and aliphatic amines represented by predetermined formulae are bound. A form of the water-insoluble carrier is a fiber or a particle, a diameter of the fiber or the particle is 15 to 50 μm, and an arithmetic mean roughness of a surface of the water-insoluble carrier is 0.1 to 3.0 μm.
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公开(公告)号：US11633716B2
公开(公告)日：2023-04-25
申请号：US16638586
申请日：2018-09-07
Applicant: TORAY INDUSTRIES, INC. , NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE
Inventor： Junichi Kasuya , Ryo Matsunaga , Yoshiyuki Ueno , Yuji Ueda , Kazuo Teramoto , Kazumasa Ogasawara
IPC: B01J20/26 , A61M1/36 , B01J20/28 , B01J20/32 , C07K14/495
Abstract: An objective of the present disclosure is to provide an adsorption material that has a carrier material with retained physical strength, and efficiently adsorbs an immunosuppressive protein. The present disclosure provides an adsorption material for immunosuppressive protein. The adsorption material includes a water-insoluble carrier to which at least one nitrogen-containing compound selected from a polyamine represented by a predetermined formula and aliphatic amines represented by predetermined formulae is bound. A total content of amino groups on the water-insoluble carrier is more than 0 μmol and 2500 μmol or less per 1 g, and a content of primary amino groups on the water-insoluble carrier is 450 μmol or less per 1 g.
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