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公开(公告)号：US08579960B2
公开(公告)日：2013-11-12
申请号：US13523718
申请日：2012-06-14
Applicant: Pamela A. Kramer-Brown , John William Morris, Jr.
Inventor： Pamela A. Kramer-Brown , John William Morris, Jr.
IPC: A61F2/06
CPC classification number: A61L29/02 , A61F2/01 , A61F2/91 , A61F2/915 , A61F2002/075 , A61F2002/91533 , A61F2002/91575 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61L31/022 , A61L31/14
Abstract: Medical devices are manufactured from fine grained materials, processed from of a variety of metals and alloys, such as stainless steel, cobalt-chromium and nickel-titanium alloys. A fine grained metal or alloy is formed from a specimen rapidly heated to its recrystallization temperature, and then subjected to high temperature, multi-axial deformation, for example, by heavy cross-forging or swaging. The deformed specimen may be cooled and reheated to a second recrystallization temperature. The metal or alloy in the specimen is then allowed to recrystallize, such that the grain size is controlled by quenching the specimen to room temperature. A desired medical device is then configured from the fine grained material. Decreasing the average grain size of a substrate material and increasing the number of grains across a thickness of a strut or similar component of the medical device increases the strength of the device and imparts other beneficial properties into the device.
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公开(公告)号：US20130096669A1
公开(公告)日：2013-04-18
申请号：US13271513
申请日：2011-10-12
Applicant: Rainer Bregulla , Randolf Von Oepen , Pamela A. Kramer-Brown , Carl P. Frick , Austin M. Leach
Inventor： Rainer Bregulla , Randolf Von Oepen , Pamela A. Kramer-Brown , Carl P. Frick , Austin M. Leach
CPC classification number: C22C27/04 , A61F2/91 , A61F2/915 , A61L31/022 , C22C19/07 , C22C27/02 , C22C38/18 , C22F1/18
Abstract: A stent and method for manufacturing a stent that achieves both strength as well as ductility. In the manufacturing process, the material used to form the stent is only partially annealed to lower the grain size across the thickness of the stent. The material is partially annealed either prior to or after the cutting a stent pattern into a tube.
Abstract translation: 用于制造实现强度和延展性的支架的支架和方法。 在制造过程中，用于形成支架的材料仅部分退火，以降低穿过支架厚度的晶粒尺寸。 在将支架图案切割成管之前或之后，该材料部分退火。
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23.发明申请HEAT-TREATED TANTALUM-ALLOY PRODUCTS, IMPLANTABLE MEDICAL DEVICES INCORPORATING SAME, AND METHODS OF PROCESSING TANTALUM-ALLOY PRODUCTS 有权热处理的钛合金产品，含有其的可植入医疗装置以及处理钛合金产品的方法公开(公告)号：US20130096667A1
公开(公告)日：2013-04-18
申请号：US13271869
申请日：2011-10-12
Applicant: Rainer Bregulla , Randolf von Oepen , Pamela A. Kramer-Brown , Austin M. Leach
Inventor： Rainer Bregulla , Randolf von Oepen , Pamela A. Kramer-Brown , Austin M. Leach
CPC classification number: A61L31/022 , A61L31/14
Abstract: The present disclosure is directed to tantalum-alloy products, implantable medical devices that incorporate tantalum-alloy products such as stents or other implantable medical devices, methods of making and/or processing the tantalum-alloy products and implantable medical devices, and methods of using the implantable medical devices. In an embodiment, a stent includes a stent body having a plurality of struts. At least a portion of the stent body is made from a tantalum alloy. The tantalum alloy includes a tantalum content of about 77 weight % (“wt %”) to about 92 wt %, a niobium content of about 7 wt % to about 13 wt %, and a tungsten content of about 1 wt % to about 10 wt %. The tantalum alloy exhibits at least one mechanical property modified by heat treatment thereof, such as yield strength, ultimate tensile strength, or ductility.
Abstract translation: 本公开涉及钽合金产品，结合钽合金产品例如支架或其他可植入医疗装置的可植入医疗装置，制造和/或加工钽合金产品和可植入医疗装置的方法以及使用方法 可植入医疗器械。 在一个实施例中，支架包括具有多个支柱的支架主体。 支架主体的至少一部分由钽合金制成。 钽合金包括约77重量％（“重量％”）至约92重量％的钽含量，约7重量％至约13重量％的铌含量和约1重量％至约10重量％的钨含量 重量％。 钽合金表现出至少一种通过其热处理改性的机械性能，例如屈服强度，极限拉伸强度或延展性。
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Patent Agency Ranking
公开(公告)号：US20120203174A1
公开(公告)日：2012-08-09
申请号：US13446761
申请日：2012-04-13
Applicant: Paul M. Consigny , Fozan O. El-Nounou , David C. Gale , Pamela A. Kramer-Brown
Inventor： Paul M. Consigny , Fozan O. El-Nounou , David C. Gale , Pamela A. Kramer-Brown
CPC classification number: A61M25/10 , A61F2/013 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/40 , A61L2300/432 , A61L2300/62 , A61L2430/26 , A61M25/04 , A61M2025/0057 , A61M2025/0073 , A61M2025/105
Abstract: A method is described including introducing a delivery device to a point within a renal artery or a renal segmental artery and delivering a treatment agent from the delivery device according to conditions that create a turbulent blood flow and wherein the treatment agent is capable of inhibiting a biological process contributing to nephropathy. In other embodiments, an apparatus and kit are described including a delivery device for insertion to a point within a renal artery or renal segmental artery and delivery of a treatment agent capable of inhibiting a biological process contributing to nephropathy.
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公开(公告)号：US08216209B2
公开(公告)日：2012-07-10
申请号：US11756376
申请日：2007-05-31
Applicant: Paul M. Consigny , Fozan O. El-Nounou , David C. Gale , Pamela A. Kramer-Brown
Inventor： Paul M. Consigny , Fozan O. El-Nounou , David C. Gale , Pamela A. Kramer-Brown
IPC: A61M31/00
CPC classification number: A61M25/10 , A61F2/013 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/40 , A61L2300/432 , A61L2300/62 , A61L2430/26 , A61M25/04 , A61M2025/0057 , A61M2025/0073 , A61M2025/105
Abstract: A method is described including introducing a delivery device to a point within a renal artery or a renal segmental artery and delivering a treatment agent from the delivery device according to conditions that create a turbulent blood flow and wherein the treatment agent is capable of inhibiting a biological process contributing to nephropathy. In other embodiments, an apparatus and kit are described including a delivery device for insertion to a point within a renal artery or renal segmental artery and delivery of a treatment agent capable of inhibiting a biological process contributing to nephropathy.
Abstract translation: 描述了一种方法，包括将递送装置引入肾动脉或肾节段动脉内的点，并根据产生湍流血流的条件从递送装置输送治疗剂，并且其中处理剂能够抑制生物 造成肾病的过程。 在其它实施方案中，描述了一种装置和试剂盒，其包括用于插入肾动脉或肾节段动脉内的点的递送装置和递送能够抑制造成肾病的生物过程的处理剂。
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公开(公告)号：US08211164B2
公开(公告)日：2012-07-03
申请号：US11771819
申请日：2007-06-29
Applicant: Pamela A. Kramer-Brown , John William Morris, Jr.
Inventor： Pamela A. Kramer-Brown , John William Morris, Jr.
IPC: A61F2/06
CPC classification number: A61L29/02 , A61F2/01 , A61F2/91 , A61F2/915 , A61F2002/075 , A61F2002/91533 , A61F2002/91575 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61L31/022 , A61L31/14
Abstract: Medical devices are manufactured from fine grained materials, processed from of a variety of metals and alloys, such as stainless steel, cobalt-chromium and nickel-titanium alloys. A fine grained metal or alloy is formed from a specimen rapidly heated to its recrystallization temperature, and then subjected to high temperature, multi-axial deformation, for example, by heavy cross-forging or swaging. The deformed specimen may be cooled and reheated to a second recrystallization temperature. The metal or alloy in the specimen is then allowed to recrystallize, such that the grain size is controlled by quenching the specimen to room temperature. A desired medical device is then configured from the fine grained material. Decreasing the average grain size of a substrate material and increasing the number of grains across a thickness of a strut or similar component of the medical device increases the strength of the device and imparts other beneficial properties into the device.
Abstract translation: 医疗器械由细粒材料制成，由各种金属和合金（如不锈钢，钴铬和镍钛合金）加工而成。 由快速加热到其再结晶温度的试样形成细粒状金属或合金，然后例如通过重交叉锻造或模锻进行高温多轴变形。 变形的试样可以冷却并再次加热至第二再结晶温度。 然后将样品中的金属或合金重结晶，使得通过将样品淬火至室温来控制晶粒尺寸。 然后从细粒材料配置期望的医疗装置。 降低衬底材料的平均晶粒尺寸并增加穿过医疗装置的支柱或类似部件的厚度的晶粒数增加了装置的强度并赋予装置其它有益特性。
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公开(公告)号：US20110190698A1
公开(公告)日：2011-08-04
申请号：US12902405
申请日：2010-10-12
Applicant: Paul M. Consigny , David C. Gale , Florian Ludwig , Randolph von Oepen , Fozan O. El-Nounou , Pamela A. Kramer-Brown , Travis R. Yribarren, JR. , William E. Webler, JR.
Inventor： Paul M. Consigny , David C. Gale , Florian Ludwig , Randolph von Oepen , Fozan O. El-Nounou , Pamela A. Kramer-Brown , Travis R. Yribarren, JR. , William E. Webler, JR.
IPC: A61M25/10
Abstract: Devices for delivering drugs or other treatment agents locally to the vasculature of a mammal are disclosed. These devices have several related structures and are designed to deliver the drugs to facilitate rapid mixing with the blood flowing past the devices.
Abstract translation: 公开了将药物或其它治疗剂局部递送到哺乳动物脉管系统的装置。 这些装置具有几种相关的结构，并被设计成递送药物以促进与流过装置的血液的快速混合。
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公开(公告)号：US20100312327A1
公开(公告)日：2010-12-09
申请号：US12479440
申请日：2009-06-05
Applicant: Pamela A. KRAMER-BROWN , John F. BOYLAN , Randolf VON OEPEN
Inventor： Pamela A. KRAMER-BROWN , John F. BOYLAN , Randolf VON OEPEN
CPC classification number: A61L31/022 , C22C27/00
Abstract: A medical device such as, for example, an implantable expandable stent is constructed of a ternary alloy of molybdenum, rhenium, and a third metal. In a preferred embodiment, the third metal is a refractory metal selected to improve the ductility of the alloy. The alloy may further be advantageously constructed to have a crystal structure selected from HCP, BCC, FCC, and tetragonal to further optimize the physical characteristics of the medical device.
Abstract translation: 诸如例如可植入式可扩张支架的医疗装置由钼，铼和第三金属的三元合金构成。 在优选实施例中，第三金属是选择用于改善合金的延展性的难熔金属。 该合金还可有利地构造成具有选自HCP，BCC，FCC和四方晶的晶体结构，以进一步优化医疗器件的物理特性。
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