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公开(公告)号：US20130096669A1
公开(公告)日：2013-04-18
申请号：US13271513
申请日：2011-10-12
CPC分类号： C22C27/04 , A61F2/91 , A61F2/915 , A61L31/022 , C22C19/07 , C22C27/02 , C22C38/18 , C22F1/18
摘要： A stent and method for manufacturing a stent that achieves both strength as well as ductility. In the manufacturing process, the material used to form the stent is only partially annealed to lower the grain size across the thickness of the stent. The material is partially annealed either prior to or after the cutting a stent pattern into a tube.
摘要翻译： 用于制造实现强度和延展性的支架的支架和方法。 在制造过程中，用于形成支架的材料仅部分退火，以降低穿过支架厚度的晶粒尺寸。 在将支架图案切割成管之前或之后，该材料部分退火。
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2.发明申请IMPLANTABLE MEDICAL DEVICES INCLUDING A HEAT-TREATED TANTALUM-ALLOY BODY HAVING A DRUG-ELUTING COATING THEREON, AND METHODS OF MAKING AND USING SAME 审中-公开包括具有药物涂覆涂层的热处理的钛合金体的可植入医疗装置及其制造方法和使用方法公开(公告)号：US20130096666A1
公开(公告)日：2013-04-18
申请号：US13271511
申请日：2011-10-12
CPC分类号： A61L31/088 , A61L31/022 , A61L31/146 , A61L31/16 , A61L2300/416
摘要： The present disclosure is directed to a drug-eluting implantable medical devices that includes a tantalum-alloy body having a drug-eluting coating thereon for delivering a drug to treat, for example, restenosis. In an embodiment, an implantable medical device includes a body sized and configured to be implanted in a living subject. At least a portion of the body may comprise a tantalum alloy. The tantalum alloy includes a tantalum content of about 77 weight % (“wt %”) to about 92 wt %, a niobium content of about 7 wt % to about 13 wt %, and a tungsten content of about 1 wt % to about 10 wt %. The tantalum alloy exhibits at least one mechanical property modified by heat treatment thereof. The body has a drug-eluting coating thereon.
摘要翻译： 本公开涉及药物洗脱可植入医疗装置，其包括其上具有药物洗脱涂层的钽合金体，用于递送药物以治疗例如再狭窄。 在一个实施例中，可植入医疗装置包括尺寸和构造成植入生物体内的体。 身体的至少一部分可以包括钽合金。 钽合金包括约77重量％（“重量％”）至约92重量％的钽含量，约7重量％至约13重量％的铌含量和约1重量％至约10重量％的钨含量 重量％。 钽合金具有通过其热处理而改性的至少一种机械性能。 身体上有药物洗脱涂层。
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3.发明申请RADIOPAQUE INTRALUMINAL STENTS COMPRISING COBALT-BASED ALLOYS CONTAINING ONE OR MORE PLATINUM GROUP METALS, REFRACTORY METALS, OR COMBINATIONS THEREOF 审中-公开包含含有一种或多种铂族金属，碱金属或其组合的基于钴的合金的放射性体系公开(公告)号：US20120123525A1
公开(公告)日：2012-05-17
申请号：US13298070
申请日：2011-11-16
IPC分类号： A61F2/82
CPC分类号： A61L31/022 , A61L31/18
摘要： Embodiments are directed to radiopaque implantable structures (e.g., stents) formed of cobalt-based alloys that comprise cobalt, chromium and one or more platinum group metals, refractory metals, or combinations thereof. Platinum group metals include platinum, palladium, ruthenium, rhodium, osmium, and iridium. Here, the term “refractory metals” include zirconium, niobium, rhodium, molybdenum, hafnium, tantalum, tungsten, rhenium, as well as the precious metals silver and gold. In one embodiment, the one or more included platinum group or refractory metals substitute for nickel, such that the alloy is substantially nickel free. The stents exhibit improved radiopacity as compared to similar alloys including greater amounts of nickel.
摘要翻译： 实施例涉及由包含钴，铬和一种或多种铂族金属，难熔金属或其组合的钴基合金形成的不透射线的可植入结构（例如，支架）。 铂族金属包括铂，钯，钌，铑，锇和铱。 这里，术语“难熔金属”包括锆，铌，铑，钼，铪，钽，钨，铼以及贵金属银和金。 在一个实施方案中，一种或多种包括的铂族或难熔金属代替镍，使得该合金基本上不含镍。 与包括更大量的镍的类似合金相比，支架表现出改善的射线不透性。
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4.发明申请METHODS AND SYSTEMS FOR LASER CUTTING AND PROCESSING TUBING TO MAKE MEDICAL DEVICES 有权用于激光切割和加工管道以制造医疗装置的方法和系统公开(公告)号：US20100193485A1
公开(公告)日：2010-08-05
申请号：US12757842
申请日：2010-04-09
申请人： Boris Anukhin , Larry Baughman , Pamela A. Kramer-Brown , Neil Burkhart , Li Chen , Duane M. DeMore , Keif Fitzgerald , Gregory W. Johnson , Z. C. Lin , David Mackiewicz , Karim S. Osman , Randolf Von Oepen , William E. Webler, JR. , Travis R. Yribarren
发明人： Boris Anukhin , Larry Baughman , Pamela A. Kramer-Brown , Neil Burkhart , Li Chen , Duane M. DeMore , Keif Fitzgerald , Gregory W. Johnson , Z. C. Lin , David Mackiewicz , Karim S. Osman , Randolf Von Oepen , William E. Webler, JR. , Travis R. Yribarren
IPC分类号： B23K26/18
CPC分类号： B23K26/4005 , A61F2/07 , A61F2/91 , B23K26/16 , B23K26/38 , B23K26/40 , B23K26/402 , B23K2101/04 , B23K2101/06 , B23K2103/50
摘要： Methods for making devices include providing a tubular member to be formed into a device, placing a removable sacrificial block material in the lumen of the tubular member and laser cutting the tubular member. A doping material can be added to the melted portion of the tubular member to promote the formation of brittle slag. A fixture can be used to hold a cut workpiece in order to ream sacrificial material from the surface of the workpiece. Pressurized gas can be supplied to the inner lumen of the tubular member to cause slag to form on the outside surface, rather than the inner surface, of the tubular member. A tubular member made from nickel-titanium alloy can be tightly adhered to a sacrificial sleeve utilizing the phase changes associated with nickel-titanium. A rotating mandrel can be placed within the lumen of the tubular member during laser cutting. A mandrel which includes an enlarged diameter section causes the workpiece to expand slightly within its elastic deformation range to dislodge islands from the workpiece. Such a mandrel could be formed from a tubular member which has a central lumen that can be used to deliver a pressurized medium to “blast” islands from the workpiece.
摘要翻译： 制造装置的方法包括提供要形成装置的管状构件，将可移除的牺牲块材料放置在管状构件的内腔中并激光切割管状构件。 可以将掺杂材料添加到管状构件的熔融部分中以促进脆性炉渣的形成。 夹具可用于夹持切割的工件，以便从工件的表面获得牺牲材料。 加压气体可以供应到管状构件的内腔，以在管状构件的外表面而不是内表面上形成炉渣。 利用与镍 - 钛相关联的相变，由镍 - 钛合金制成的管状部件可以紧密地粘附到牺牲套管上。 在激光切割期间，旋转心轴可以放置在管状构件的内腔内。 包括扩大直径部分的心轴使得工件在其弹性变形范围内稍微膨胀以从工件移除岛。 这种心轴可以由管状构件形成，该管状构件具有可用于将加压介质输送到工件的“鼓风”岛的中心腔。
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5.发明申请HEAT TREATING APPARATUSES HAVING A MAGNETIC DRIVE SYSTEM AND RELATED METHODS 审中-公开具有磁力驱动系统的热处理装置及相关方法公开(公告)号：US20130092299A1
公开(公告)日：2013-04-18
申请号：US13271917
申请日：2011-10-12
申请人： Rainer Bregulla , Randolf Von Oepen
发明人： Rainer Bregulla , Randolf Von Oepen
摘要： Embodiments of methods for vacuum heat treating refractory metal articles (e.g., implantable medical devices), and heat treating apparatuses for use in such methods are disclosed. Heat treating refractory metal articles under high vacuum (e.g., 10−6 Torr) may improve strength and ductility and remove material contaminants (e.g., oxygen or hydrogen) that may be absorbed during manufacturing processes. Heat treating methods include disposing a refractory metal article in a heat treating apparatus, drawing a vacuum therein, and moving the article to a heated zone in the furnace using a drive system that permits movement of the article while the vacuum is maintained in the apparatus. A heat treating apparatus may include an elongate furnace tube that may be sealed and placed under vacuum, a heating element disposed around at least a portion of the tube, and a drive system configured for moving articles disposed inside the furnace tube while under vacuum.
摘要翻译： 公开了用于真空热处理难熔金属制品（例如，可植入医疗装置）的方法的实施例和用于这种方法的热处理装置。 在高真空（例如，10 -6乇）下热处理难熔金属制品可以提高强度和延展性，并去除可能在制造过程中被吸收的材料污染物（例如氧气或氢气）。 热处理方法包括将难熔金属制品放置在热处理装置中，在其中抽吸真空，并使用驱动系统将制品移动到炉中的加热区域，该驱动系统允许制品在设备内保持真空的同时运动。 热处理装置可以包括可以密封并放置在真空下的细长的炉管，设置在管的至少一部分周围的加热元件，以及构造成用于在真空下移动设置在炉管内部的物品的驱动系统。
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公开(公告)号：US08261420B2
公开(公告)日：2012-09-11
申请号：US12119945
申请日：2008-05-13
CPC分类号： A61F2/91 , A61F2210/0014 , A61F2230/0013 , A61F2230/0054 , A61F2240/001 , Y10T29/49863 , Y10T29/49865 , Y10T29/53657 , Y10T29/53909 , Y10T29/53987 , Y10T29/53996 , Y10T29/54
摘要： The invention relates to a method and apparatus of reducing stress during stent manufacture. Particularly, the invention is directed to a method and apparatus for expanding a stent using primarily radial loads thereby reducing the stresses that are generated due to the axial loads applied during loading of the stent onto a mandrel or other expansion device. The method of the invention provides for the stepwise expansion of shape memory stents, while reducing the overall stresses that the stent encounters, and thereby improving manufacturing yields due to fractured struts during expansion.
摘要翻译： 本发明涉及减少支架制造过程中的压力的方法和装置。 特别地，本发明涉及一种用于使用主要径向载荷来扩张支架的方法和装置，从而减少由于在将支架装载到心轴或其它扩张装置上时施加的轴向载荷而产生的应力。 本发明的方法提供了形状记忆支架的逐步扩张，同时降低了支架遭受的总体应力，从而提高了在扩张期间由于断裂的支柱引起的制造产量。
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7.发明授权Device comprising biodegradable bistable or multistable cells and methods of use 有权包含可生物降解的双稳态或多态细胞的装置和使用方法公开(公告)号：US08663311B2
公开(公告)日：2014-03-04
申请号：US11317495
申请日：2005-12-22
IPC分类号： A61F2/06
CPC分类号： A61B17/11 , A61F2/0009 , A61F2/064 , A61F2/91 , A61F2/915 , A61F2002/30062 , A61F2002/828 , A61F2002/91541 , A61F2002/91558 , A61F2002/91575 , A61F2210/0004 , A61F2230/0013 , B23K2103/42 , B23K2103/50 , B33Y80/00
摘要： Expandable biodegradable devices formed of bistable and multistable unit cells for use in devices, such as stents and graft systems, are provided, in which the device has two or more stable configurations, including a contracted configuration and an expanded configuration, the contracted stable configuration having a smaller diameter than the expanded configuration.
摘要翻译： 提供了用于诸如支架和移植物系统的装置中的双稳态和多单元电池形成的可膨胀的可生物降解的装置，其中装置具有两个或多个稳定的构造，包括收缩构型和扩张构型，收缩的稳定构型具有 直径比扩张结构小。
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公开(公告)号：US08530783B2
公开(公告)日：2013-09-10
申请号：US12699262
申请日：2010-02-03
IPC分类号： B23K26/14
CPC分类号： B23K26/38
摘要： A laser cutting system including a chamber configured to provide a controlled environment while the laser is being used to cut a pattern into a material to reduce or eliminate heat and oxygen related changes to the mechanical characteristics of the material. A system for providing a gas to the controlled environment within the chamber, as well as a means for exhausting gas and cutting debris from the chamber is also described. A cutting mandrel that provides for flow of a shielding gas and also provides a means for dispersing a laser beam before it can produce unwanted damage to a section of tubing is also described.
摘要翻译： 一种激光切割系统，包括被配置为在激光被用于将图案切割成材料以便减少或消除与材料的机械特性相关的热和氧相关变化时提供受控环境的腔室。 还描述了一种用于向室内的受控环境提供气体的系统，以及用于从气室排出气体和切割碎屑的装置。 还描述了提供保护气体流动的切割心轴，并且还提供了用于在激光束可以对管道的一部分产生不希望的损坏之前分散激光束的装置。
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9.发明申请MEDICAL IMPLANTS CONTAINING FK506 (TACROLIMUS) METHODS OF MAKING AND METHODS OF USE THEREOF 审中-公开包含FK506（TACROLIMUS）制造方法的医用植绒及其使用方法公开(公告)号：US20120239139A1
公开(公告)日：2012-09-20
申请号：US13481129
申请日：2012-05-25
申请人： Stephan Wnendt , Randolf Von Oepen , Bernd Kuttler , Gerhard Lang , Guenter Lorenz , Axel Grandt
发明人： Stephan Wnendt , Randolf Von Oepen , Bernd Kuttler , Gerhard Lang , Guenter Lorenz , Axel Grandt
CPC分类号： A61L31/16 , A61L2300/416 , A61L2300/606
摘要： Implants and methods of making same are provided for treatment or prophylaxis of coronary or peripheral vascular constrictions or vascular occlusions, and particularly, stenoses or restenoses, that comprise FK506 in chemically covalently bound, non-covalently bound or physically immobilized form.
摘要翻译： 提供了植入物及其制备方法，用于治疗或预防化学共价结合，非共价结合或物理固定化形式的冠状或外周血管收缩或血管闭塞，特别是狭窄或再狭窄，其包含FK506。
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公开(公告)号：US20120209317A1
公开(公告)日：2012-08-16
申请号：US13028041
申请日：2011-02-15
申请人： Randolf Von Oepen
发明人： Randolf Von Oepen
IPC分类号： A61B17/03
CPC分类号： A61B17/0057 , A61B17/0644 , A61B17/068 , A61B46/10 , A61B2017/00398 , A61B2017/00668
摘要： A power driven vessel closure device is configured for closing a hole in a wall of a body lumen. The vessel closure device can include a power operated drive system and a closure element delivery system. The closure element delivery system can be removably, operably, couplable with the power operated drive system. That is, the closure element system can be directly or indirectly attached to and removed from the power operated drive system, or components thereof. The operation of the power operated drive system can operate the closure element delivery system so as to move the closure element within the vessel closure device and deploy the closure element to close the hole.
摘要翻译： 动力驱动的容器封闭装置构造成用于封闭体腔的壁中的孔。 容器封闭装置可以包括动力驱动的驱动系统和闭合元件输送系统。 闭合元件输送系统可以与动力驱动的驱动系统可拆卸地，可操作地连接。 也就是说，闭合元件系统可以直接或间接附接到动力驱动系统或其部件上并从其移除。 动力驱动驱动系统的操作可以操作闭合元件输送系统，以便将封闭元件移动到容器封闭装置内并展开封闭元件以封闭孔。
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