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公开(公告)号：US20120203202A1
公开(公告)日：2012-08-09
申请号：US13446768
申请日：2012-04-13
IPC分类号： A61M5/00
CPC分类号： A61M25/10 , A61F2/013 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/40 , A61L2300/432 , A61L2300/62 , A61L2430/26 , A61M25/04 , A61M2025/0057 , A61M2025/0073 , A61M2025/105
摘要： A method is described including introducing a delivery device to a point within a renal artery or a renal segmental artery and delivering a treatment agent from the delivery device according to conditions that create a turbulent blood flow and wherein the treatment agent is capable of inhibiting a biological process contributing to nephropathy. In other embodiments, an apparatus and kit are described including a delivery device for insertion to a point within a renal artery or renal segmental artery and delivery of a treatment agent capable of inhibiting a biological process contributing to nephropathy.
摘要翻译： 描述了一种方法，包括将递送装置引入肾动脉或肾节段动脉内的点，并根据产生湍流血流的条件从递送装置输送治疗剂，并且其中处理剂能够抑制生物 造成肾病的过程。 在其它实施方案中，描述了一种装置和试剂盒，其包括用于插入肾动脉或肾节段动脉内的点的递送装置和递送能够抑制造成肾病的生物过程的处理剂。
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公开(公告)号：US20110046709A1
公开(公告)日：2011-02-24
申请号：US12543340
申请日：2009-08-18
IPC分类号： A61F2/84
CPC分类号： A61F2/958 , A61F2/966 , A61F2/97 , A61F2002/821 , A61F2002/9583
摘要： Various methods for implanting a stent into an ostium or a proximal portion of a body vessel utilizing a guide catheter, rather than a convention balloon angioplasty balloon catheter, as the primary delivery device are disclosed. The guide catheter can be used as the primary stent delivery catheter for the ostium region of the body vessel and can be anchored to the vessel to allow secondary treatment devices to be advanced to distal locations in the body vessel.
摘要翻译： 公开了使用导向导管而不是常规球囊血管成形术球囊导管将支架植入体腔的口或近端部分的各种方法，作为主要输送装置。 引导导管可以用作体内容器的口腔区域的主支架输送导管，并且可以锚定到容器，以允许二次治疗装置前进到体内血管的远端位置。
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公开(公告)号：US20090118700A1
公开(公告)日：2009-05-07
申请号：US11936668
申请日：2007-11-07
申请人： Peter L. Callas , Eric J. Willis , Fozan O. El-Nounou , Florian N. Ludwig , William E. Webler , Paul M. Consigny
发明人： Peter L. Callas , Eric J. Willis , Fozan O. El-Nounou , Florian N. Ludwig , William E. Webler , Paul M. Consigny
CPC分类号： A61B17/3478 , A61B17/02 , A61B90/37 , A61B2017/00247 , A61B2017/22061 , A61B2017/320044 , A61B2018/00392 , A61M25/0026 , A61M25/0084 , A61M25/10 , A61M2025/0166 , A61M2025/1004
摘要： A method is provided including introducing a delivery device through a vessel wall to a treatment site within one of a peri-adventitial space or a pericardium adjacent a coronary blood vessel and delivering a treatment agent through the delivery device. The treatment agent is delivered through the delivery device according to conditions that hydraulically dissect tissue planes within the peri-adventitial space. A kit is provided including a delivery device having a needle to be advanced through one of an epicardium of a heart and a wall of a coronary blood vessel into a peri-adventitial space and a treatment agent comprising particles having an average diameter on the order of 15 microns or more to be delivered through the delivery device into the peri-adventitial space.
摘要翻译： 提供了一种方法，包括将输送装置通过血管壁引入邻近冠状血管的周围空间或心包膜内的治疗部位，并通过输送装置输送治疗剂。 治疗剂通过输送装置根据液压解剖周围空间内的组织平面的条件递送。 提供了一种试剂盒，其包括具有针头的输送装置，所述针头通过心脏的心外膜和冠状血管的壁之一进入周围空间，以及包含平均直径为 15微米或更多，以通过输送装置输送到周围空间。
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公开(公告)号：US20080287911A1
公开(公告)日：2008-11-20
申请号：US11749665
申请日：2007-05-16
IPC分类号： A61M25/01
CPC分类号： A61M25/0082 , A61M25/01 , A61M2025/0004 , A61M2025/0073 , A61M2206/11
摘要： Catheters with laminar flow bioactive agent delivery properties and methods of using for treating or preventing vascular disease are disclosed.
摘要翻译： 公开了具有层流生物活性剂递送性质的导管和用于治疗或预防血管疾病的方法。
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公开(公告)号：US08496615B2
公开(公告)日：2013-07-30
申请号：US13446761
申请日：2012-04-13
IPC分类号： A61M29/00
CPC分类号： A61M25/10 , A61F2/013 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/40 , A61L2300/432 , A61L2300/62 , A61L2430/26 , A61M25/04 , A61M2025/0057 , A61M2025/0073 , A61M2025/105
摘要： A method is described including introducing a delivery device to a point within a renal artery or a renal segmental artery and delivering a treatment agent from the delivery device according to conditions that create a turbulent blood flow and wherein the treatment agent is capable of inhibiting a biological process contributing to nephropathy. In other embodiments, an apparatus and kit are described including a delivery device for insertion to a point within a renal artery or renal segmental artery and delivery of a treatment agent capable of inhibiting a biological process contributing to nephropathy.
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公开(公告)号：US20080300573A1
公开(公告)日：2008-12-04
申请号：US11756376
申请日：2007-05-31
CPC分类号： A61M25/10 , A61F2/013 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/40 , A61L2300/432 , A61L2300/62 , A61L2430/26 , A61M25/04 , A61M2025/0057 , A61M2025/0073 , A61M2025/105
摘要： A method is described including introducing a delivery device to a point within a renal artery or a renal segmental artery and delivering a treatment agent from the delivery device according to conditions that create a turbulent blood flow and wherein the treatment agent is capable of inhibiting a biological process contributing to nephropathy. In other embodiments, an apparatus and kit are described including a delivery device for insertion to a point within a renal artery or renal segmental artery and delivery of a treatment agent capable of inhibiting a biological process contributing to nephropathy.
摘要翻译： 描述了一种方法，包括将递送装置引入肾动脉或肾节段动脉内的点，并根据产生湍流血流的条件从递送装置输送治疗剂，并且其中处理剂能够抑制生物 造成肾病的过程。 在其它实施方案中，描述了一种装置和试剂盒，其包括用于插入肾动脉或肾节段动脉内的点的递送装置和递送能够抑制造成肾病的生物过程的处理剂。
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公开(公告)号：US09144509B2
公开(公告)日：2015-09-29
申请号：US12902405
申请日：2010-10-12
申请人： Paul M. Consigny , David C. Gale , Florian Ludwig , Randolpf von Oepen , Fozan O. El-Nounou , Pamela A. Kramer-Brown , Travis R. Yribarren , William E. Webler, Jr.
发明人： Paul M. Consigny , David C. Gale , Florian Ludwig , Randolpf von Oepen , Fozan O. El-Nounou , Pamela A. Kramer-Brown , Travis R. Yribarren , William E. Webler, Jr.
摘要： Devices for delivering drugs or other treatment agents locally to the vasculature of a mammal are disclosed. These devices have several related structures and are designed to deliver the drugs to facilitate rapid mixing with the blood flowing past the devices.
摘要翻译： 公开了将药物或其它治疗剂局部递送到哺乳动物脉管系统的装置。 这些装置具有几种相关的结构，并被设计成递送药物以促进与流过装置的血液的快速混合。
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公开(公告)号：US09108028B2
公开(公告)日：2015-08-18
申请号：US13446768
申请日：2012-04-13
CPC分类号： A61M25/10 , A61F2/013 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/40 , A61L2300/432 , A61L2300/62 , A61L2430/26 , A61M25/04 , A61M2025/0057 , A61M2025/0073 , A61M2025/105
摘要： A method is described including introducing a delivery device to a point within a renal artery or a renal segmental artery and delivering a treatment agent from the delivery device according to conditions that create a turbulent blood flow and wherein the treatment agent is capable of inhibiting a biological process contributing to nephropathy. In other embodiments, an apparatus and kit are described including a delivery device for insertion to a point within a renal artery or renal segmental artery and delivery of a treatment agent capable of inhibiting a biological process contributing to nephropathy.
摘要翻译： 描述了一种方法，包括将递送装置引入肾动脉或肾节段动脉内的点，并根据产生湍流血流的条件从递送装置输送治疗剂，并且其中处理剂能够抑制生物 造成肾病的过程。 在其它实施方案中，描述了一种装置和试剂盒，其包括用于插入肾动脉或肾节段动脉内的点的递送装置和递送能够抑制造成肾病的生物过程的处理剂。
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公开(公告)号：US08309023B2
公开(公告)日：2012-11-13
申请号：US12649044
申请日：2009-12-29
CPC分类号： A61L2/20 , A61F2/958 , A61L2/08 , A61L2/087 , A61L2/206 , A61L2/208 , A61L2202/10 , A61L2202/24 , A61M25/0097 , A61M25/10 , A61M2025/0019
摘要： Sterilization methods for implantable prostheses are described where a polymeric stent may be sterilized, e.g., via ETO sterilization, at a temperature below a glass transition temperature of the stent. A separate delivery catheter may be sterilized separately and the stent and delivery catheter may then be combined in an aseptic or semi-aseptic environment and sterilized as an assembled system such that the requirements for sterilizing the system are relatively lower. Additionally and/or alternatively, valve and filter assemblies may be used with an optional mandrel assembly for maintaining sterility of the internal components of a catheter system.
摘要翻译： 描述了可植入假体的灭菌方法，其中可以在低于支架的玻璃化转变温度的温度下，例如经由ETO灭菌将聚合物支架灭菌。 单独的输送导管可以单独灭菌，然后将支架和输送导管组合在无菌或半无菌环境中并作为组装系统消毒，使得对系统消毒的要求相对较低。 另外和/或替代地，阀和过滤器组件可以与可选的心轴组件一起使用，以保持导管系统的内部组件的无菌性。
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公开(公告)号：US20100185270A1
公开(公告)日：2010-07-22
申请号：US12649044
申请日：2009-12-29
CPC分类号： A61L2/20 , A61F2/958 , A61L2/08 , A61L2/087 , A61L2/206 , A61L2/208 , A61L2202/10 , A61L2202/24 , A61M25/0097 , A61M25/10 , A61M2025/0019
摘要： Sterilization methods for implantable prostheses are described where a polymeric stent may be sterilized, e.g., via ETO sterilization, at a temperature below a glass transition temperature of the stent. A separate delivery catheter may be sterilized separately and the stent and delivery catheter may then be combined in an aseptic or semi-aseptic environment and sterilized as an assembled system such that the requirements for sterilizing the system are relatively lower. Additionally and/or alternatively, valve and filter assemblies may be used with an optional mandrel assembly for maintaining sterility of the internal components of a catheter system.
摘要翻译： 描述了可植入假体的灭菌方法，其中可以在低于支架的玻璃化转变温度的温度下，例如经由ETO灭菌将聚合物支架灭菌。 单独的输送导管可以单独灭菌，然后将支架和输送导管组合在无菌或半无菌环境中并作为组装系统消毒，使得对系统消毒的要求相对较低。 另外和/或替代地，阀和过滤器组件可以与可选的心轴组件一起使用，以保持导管系统的内部组件的无菌性。
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