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    Methods of synthesis and/or purification of diaminophenothiazinium compounds
    21.
    发明授权
    Methods of synthesis and/or purification of diaminophenothiazinium compounds 有权
    二氨基吩噻嗪鎓化合物的合成和/或纯化方法

    公开(公告)号：US07956183B2

    公开(公告)日：2011-06-07

    申请号：US12373216

    申请日：2007-07-10

    Applicant: Claude Michel Wischik ,  John Mervyn David Storey ,  Colin Marshall ,  James Peter Sinclair ,  Thomas Craven Baddeley

    Inventor： Claude Michel Wischik ,  John Mervyn David Storey ,  Colin Marshall ,  James Peter Sinclair ,  Thomas Craven Baddeley

    IPC: C07D279/28

    CPC classification number: A61K31/5415 ,  C07D279/18 ,  C07D279/20

    Abstract: A method for the synthesis of a diaminophenothiazinium compound of the following formula: comprising (a) purifying a corresponding reduced compound which is N-acylated at the heterocyclic nitrogen; (b) deacylating the purified compound to provide the corresponding reduced compound; and (c) oxidizing the reduced compound to provide the diaminophenothiazinium compound. Optional purification may performed, for example, after deacylating and after oxidizing. The method provides high purity diaminophenothiazinium compounds which are suitable for pharmaceutical and related therapeutic uses. Such uses include inactivating pathogens, the treatment of the infectious diseases, and for the treatment of diseases of protein aggregation, such as tauopathies, including Alzheimer's disease.

    Abstract translation: 一种用于合成下式的二氨基吩噻嗪鎓化合物的方法：包括（a）在杂环氮中纯化相应的N-酰化的还原化合物; （b）将纯化的化合物去酰化以提供相应的还原化合物; 和（c）氧化还原的化合物以提供二氨基吩噻嗪鎓化合物。 任选的纯化可以例如在脱酰基后和氧化后进行。 该方法提供了适用于药物和相关治疗用途的高纯度二氨基吩噻嗪鎓化合物。 这样的用途包括灭活病原体，感染性疾病的治疗以及治疗蛋白质聚集的疾病，诸如包括阿尔茨海默病在内的tau蛋白病。

    METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS
    22.
    发明申请
    METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS 有权
    二氨基苯甲酸酯化合物的合成和/或纯化方法

    公开(公告)号：US20090259040A1

    公开(公告)日：2009-10-15

    申请号：US12373216

    申请日：2007-07-10

    Applicant: Claude Michel Wischik ,  John Mervyn David Storey ,  Colin Marshall ,  James Peter Sinclair ,  Thomas Craven Baddeley

    Inventor： Claude Michel Wischik ,  John Mervyn David Storey ,  Colin Marshall ,  James Peter Sinclair ,  Thomas Craven Baddeley

    IPC: C07D279/18

    CPC classification number: A61K31/5415 ,  C07D279/18 ,  C07D279/20

    Abstract: This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesis and/or purification of certain 3,7 diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (also known as Methylene Blue). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g., tablets, capsules), and their use in methods of inactivating pathogens, and methods of medical treatment, prophylaxis, and diagnosis, etc., for example, a tauopathy; a disease of tau protein aggregation; Alzheimer's disease (AD); Pick's disease; Progressive Supranuclear Palsy (PSP); fronto temporal dementia (FTD); parkinsonism linked to chromosome 17 (FTDP-17); disinhibition-dementia-parkinsonism-amyotrophy complex (DDPAC); pallido-ponto-nigral degeneration (PPND); Guam-ALS syndrome; pallido-nigro-luysian degeneration (PNLD); cortico-basal degeneration (CBD); mild cognitive impairment (MCI); skin cancer; melanoma; methemoglobinemia; a viral infection; a bacterial infection; a protozoal infection; a parasitic infection; malaria; visceral leishmaniasis; African sleeping sickness; toxoplasmosis; giardiasis; Chagas' disease; Hepatitis C virus (HCV) infection; human immunodeficiency virus (HIV) infection; West Nile virus (WNV) infection; a synucleinopathy; Parkinson's disease (PD); dementia with Lewy bodies (DLB); multiple system atrophy (MSA); drug-induced parkinsonism; and pure autonomic failure (PAF).

    Abstract translation: 本发明一般涉及化学合成和纯化领域，更具体地涉及合成和/或纯化某些3,7-二氨基吩噻嗪-5-肟化合物（本文称为“二氨基吩噻嗪鎓化合物”）的方法，包括甲基硫堇 （MTC）（也称为亚甲蓝）。 本发明还涉及所得的（高纯度）化合物，包含它们的组合物（例如片剂，胶囊）及其在灭活病原体的方法中的用途，以及医学治疗，预防和诊断等方法 ，tau病 tau蛋白聚集的疾病; 阿尔茨海默病（AD）; 皮克病 进行性核核麻痹（PSP） 颞痴呆（FTD）; 与17号染色​​体相关的帕金森综合征（FTDP-17）; 去抑痴呆 - 帕金森综合征 - 肌萎缩综合征（DDPAC）; 苍白球 - 黑质变性（PPND）; 关岛ALS综合征 苍白球黑素瘤变性（PNLD）; 皮质基底变性（CBD）; 轻度认知障碍（MCI）; 皮肤癌; 黑色素瘤 高铁血红蛋白血症; 病毒感染; 细菌感染; 原生动物感染; 寄生虫感染; 疟疾; 内脏利什曼病 非洲昏睡病 弓形体病 贾第虫病 恰加斯病 丙型肝炎病毒（HCV）感染; 人类免疫缺陷病毒（HIV）感染; 西尼罗病毒（WNV）感染; 突触核蛋白病 帕金森病（PD）; 路易体痴呆（DLB）; 多系统萎缩（MSA）; 药物引起的帕金森综合征 和纯自主神经衰竭（PAF）。

    Secure communication methods
    24.
    发明授权
    Secure communication methods 有权
    安全沟通方式

    公开(公告)号：US09235732B2

    公开(公告)日：2016-01-12

    申请号：US14055868

    申请日：2013-10-16

    Applicant: Michael Eynon ,  Peter Sinclair ,  James Lloyd

    Inventor： Michael Eynon ,  Peter Sinclair ,  James Lloyd

    IPC: G06F21/00 ,  G06F21/83 ,  G06F21/60 ,  H04L9/32 ,  H04L29/06

    CPC classification number: G06F21/83 ,  G06F21/554 ,  G06F21/602 ,  G06F21/84 ,  H04L9/3247 ,  H04L63/0823 ,  H04L63/10 ,  H04L63/105

    Abstract: Secure communication of user inputs is achieved by isolating part of an endpoint device such that certificates and encryption keys are protected from corruption by malware. Further, the communication is passed through a trusted data relay that is configured to decrypt and/or certify the user inputs encrypted by the isolated part of the endpoint device. The trusted data relay can determine that the user inputs were encrypted or certified by the protected certificates and encryption keys, thus authenticating their origin within the endpoint device. The trusted data relay then forwards the inputs to an intended destination. In some embodiments, the isolated part of the endpoint device is configured to detect input created by auto-completion logic and/or spell checking logic.

    Abstract translation: 通过隔离端点设备的一部分来实现用户输入的安全通信，从而保护证书和加密密钥免受恶意软件的破坏。 此外，通信被传递通过被配置为解密和/或认证由端点设备的隔离部分加密的用户输入的可信数据中继。 可信数据中继器可以确定用户输入被受保护的证书和加密密钥加密或认证，从而在端点设备内对其来源进行认证。 然后，可信数据中继器将输入转发到预定的目的地。 在一些实施例中，端点设备的隔离部分被配置为检测由自动完成逻辑和/或拼写检查逻辑创建的输入。

    Trusted data relay
    25.
    发明授权
    Trusted data relay 有权
    可信数据中继

    公开(公告)号：US09235731B2

    公开(公告)日：2016-01-12

    申请号：US14055861

    申请日：2013-10-16

    Applicant: James Lloyd ,  Michael Eynon ,  Peter Sinclair

    Inventor： James Lloyd ,  Michael Eynon ,  Peter Sinclair

    IPC: G06F21/00 ,  G06F21/83 ,  G06F21/60 ,  H04L9/32 ,  H04L29/06

    CPC classification number: G06F21/83 ,  G06F21/554 ,  G06F21/602 ,  G06F21/84 ,  H04L9/3247 ,  H04L63/0823 ,  H04L63/10 ,  H04L63/105

    Abstract: Secure communication of user inputs is achieved by isolating part of an endpoint device such that certificates and encryption keys are protected from corruption by malware. Further, the communication is passed through a trusted data relay that is configured to decrypt and/or certify the user inputs encrypted by the isolated part of the endpoint device. The trusted data relay can determine that the user inputs were encrypted or certified by the protected certificates and encryption keys, thus authenticating their origin within the endpoint device. The trusted data relay then forwards the inputs to an intended destination. In some embodiments, the isolated part of the endpoint device is configured to detect input created by auto-completion logic and/or spell checking logic.

    Abstract translation: 通过隔离端点设备的一部分来实现用户输入的安全通信，从而保护证书和加密密钥免受恶意软件的破坏。 此外，通信被传递通过被配置为解密和/或认证由端点设备的隔离部分加密的用户输入的可信数据中继。 可信数据中继器可以确定用户输入被受保护的证书和加密密钥加密或认证，从而在端点设备内对其来源进行认证。 然后，可信数据中继器将输入转发到预定的目的地。 在一些实施例中，端点设备的隔离部分被配置为检测由自动完成逻辑和/或拼写检查逻辑创建的输入。

    Secure Communication Architecture
    27.
    发明申请
    Secure Communication Architecture 有权
    安全通信架构

    公开(公告)号：US20140108820A1

    公开(公告)日：2014-04-17

    申请号：US14055706

    申请日：2013-10-16

    Applicant: Michael Eynon ,  Peter Sinclair ,  James Lloyd

    Inventor： Michael Eynon ,  Peter Sinclair ,  James Lloyd

    IPC: G06F21/83

    CPC classification number: G06F21/83 ,  G06F21/554 ,  G06F21/602 ,  G06F21/84 ,  H04L9/3247 ,  H04L63/0823 ,  H04L63/10 ,  H04L63/105

    Abstract: Secure communication of user inputs is achieved by isolating part of an endpoint device such that certificates and encryption keys are protected from corruption by malware. Further, the communication is passed through a trusted data relay that is configured to decrypt and/or certify the user inputs encrypted by the isolated part of the endpoint device. The trusted data relay can determine that the user inputs were encrypted or certified by the protected certificates and encryption keys, thus authenticating their origin within the endpoint device. The trusted data relay then forwards the inputs to an intended destination. In some embodiments, the isolated part of the endpoint device is configured to detect input created by auto-completion logic and/or spell checking logic.

    Abstract translation: 通过隔离端点设备的一部分来实现用户输入的安全通信，从而保护证书和加密密钥免受恶意软件的破坏。 此外，通信被传递通过被配置为解密和/或认证由端点设备的隔离部分加密的用户输入的可信数据中继。 可信数据中继器可以确定用户输入被受保护的证书和加密密钥加密或认证，从而在端点设备内对其来源进行认证。 然后，可信数据中继器将输入转发到预定的目的地。 在一些实施例中，端点设备的隔离部分被配置为检测由自动完成逻辑和/或拼写检查逻辑创建的输入。

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