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公开(公告)号：US20140142088A1
公开(公告)日：2014-05-22
申请号：US14083013
申请日：2013-11-18
申请人： Edward R. Bacon , Thomas R. Bailey , Nadine C. Becknell , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Kurt A. Josef , Lars J.S. Knutsen , Ming Tao , Alison L. Zulli
发明人： Edward R. Bacon , Thomas R. Bailey , Nadine C. Becknell , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Kurt A. Josef , Lars J.S. Knutsen , Ming Tao , Alison L. Zulli
IPC分类号： C07D498/04 , C07D237/14 , C07D409/04 , C07D237/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D495/04
CPC分类号： C07D498/04 , C07D237/14 , C07D237/26 , C07D237/32 , C07D237/36 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/04 , C07D495/04
摘要： The present invention is directed to novel pyridazinone derivatives that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of the histamine H3 receptor, including, for example, neurodegenerative disorders, sleep/wake disorders, attention deficit hyperactivity disorder and cognition.
摘要翻译： 本发明涉及介导酶活性的新的哒嗪酮衍生物。 特别地，这些化合物可有效治疗与组胺H3受体活性相关的疾病或疾病状态，包括例如神经变性疾病，睡眠/觉醒障碍，注意力缺陷多动障碍和认知。
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22.发明授权Methods of treating disorders mediated by histamine H3 receptors using pyridazinone derivatives 有权使用哒嗪酮衍生物治疗由组胺H3受体介导的病症的方法公开(公告)号：US08673916B2
公开(公告)日：2014-03-18
申请号：US13197243
申请日：2011-08-03
申请人： Edward R. Bacon , Thomas R. Bailey , Nadine C. Becknell , Sankar Chatterjee , Derek D. Dunn , Greg A. Hostetler , Robert L. Hudkins , Kurt A. Josef , Lars J. S. Knutsen , Ming Tao , Allison L. Zulli
发明人： Edward R. Bacon , Thomas R. Bailey , Nadine C. Becknell , Sankar Chatterjee , Derek D. Dunn , Greg A. Hostetler , Robert L. Hudkins , Kurt A. Josef , Lars J. S. Knutsen , Ming Tao , Allison L. Zulli
CPC分类号： C07D498/04 , C07D237/14 , C07D237/26 , C07D237/32 , C07D237/36 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/04 , C07D495/04
摘要： The present invention is directed to methods of treating disorders mediated by Histamine H3 receptors by administering novel pyridazinone derivatives. In particular, the pyridazinone compounds may be effective in the treatment of diseases or disease states related to the activity of the histamine H3 receptor, including, for example, neurodegenerative disorders, sleep/wake disorders, attention deficit hyperactivity disorder and cognition/cognitive disorders.
摘要翻译： 本发明涉及通过施用新的哒嗪酮衍生物治疗由组胺H3受体介导的病症的方法。 特别地，哒嗪酮化合物可有效治疗与组胺H3受体活性相关的疾病或疾病状态，包括例如神经退行性疾病，睡眠/觉醒障碍，注意缺陷多动障碍和认知/认知障碍。
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23.发明授权Substituted phenoxypropylcycloamine derivatives as histamine-3 (H3) receptor ligands 失效取代的苯氧基丙胺环胺衍生物作为组胺-3（H3）受体配体公开(公告)号：US08648067B2
公开(公告)日：2014-02-11
申请号：US13334311
申请日：2011-12-22
申请人： Edward R. Bacon , Thomas R. Bailey , Sankar Chatterjee , Derek D. Dunn , Greg A. Hostetler , Robert L. Hudkins , Brigitte Lesur , Babu G. Sundar , Allison L. Zulli , Christophe Yue
发明人： Edward R. Bacon , Thomas R. Bailey , Sankar Chatterjee , Derek D. Dunn , Greg A. Hostetler , Robert L. Hudkins , Brigitte Lesur , Babu G. Sundar , Allison L. Zulli , Christophe Yue
IPC分类号： A61K31/55 , A61K31/54 , A61K31/45 , A61K31/535 , A61K31/497 , A61K31/545 , A61K31/445 , A01N43/40 , C07D223/18 , C07D279/10 , C07D413/00 , C07D403/00 , C07D401/00 , C07D217/00 , C07D211/00 , C07D405/00 , C07D295/00
CPC分类号： C07D403/12 , C07C217/54 , C07D207/06 , C07D207/08 , C07D207/10 , C07D207/27 , C07D209/44 , C07D211/14 , C07D211/22 , C07D211/38 , C07D211/46 , C07D215/02 , C07D215/06 , C07D217/04 , C07D241/08 , C07D295/108 , C07D295/185 , C07D401/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07D487/04
摘要： The present invention provides compounds of formula I: their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceutical compositions thereof.
摘要翻译： 本发明提供式I化合物：它们用作H3拮抗剂/反向激动剂，其制备方法及其药物组合物。
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公开(公告)号：US08586588B2
公开(公告)日：2013-11-19
申请号：US12815813
申请日：2010-06-15
申请人： Edward R. Bacon , Thomas R. Bailey , Nadine C. Becknell , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Kurt A. Josef , Lars J. S. Knutsen , Ming Tao , Allison L. Zulli
发明人： Edward R. Bacon , Thomas R. Bailey , Nadine C. Becknell , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Kurt A. Josef , Lars J. S. Knutsen , Ming Tao , Allison L. Zulli
IPC分类号： C07D403/12 , C07D401/14 , A61K31/501 , A61P25/20 , A61P3/04 , A61P25/18 , A61P29/00 , A61P25/06 , A61P25/24 , A61P25/08
CPC分类号： C07D498/04 , C07D237/14 , C07D237/26 , C07D237/32 , C07D237/36 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/04 , C07D495/04
摘要： The present invention is directed to novel pyridazinone derivatives that mediate enzymatic activity. In particular, the compounds and/or their pharmaceutically acceptable salts may be effective in the treatment of diseases or disease states related to the activity of the histamine H3 receptor, including, for example, neurodegenerative disorders, sleep/wake disorders, attention deficit hyperactivity disorder and cognition/cognitive disorders.
摘要翻译： 本发明涉及介导酶活性的新的哒嗪酮衍生物。 特别地，化合物和/或其药学上可接受的盐可有效治疗与组胺H3受体活性相关的疾病或疾病状态，包括例如神经变性障碍，睡眠/觉醒障碍，注意缺陷多动障碍 和认知/认知障碍。
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公开(公告)号：US20120004231A1
公开(公告)日：2012-01-05
申请号：US13231293
申请日：2011-09-13
申请人： Robert L. Hudkins , Lars J.S. Knutsen , Catherine P. Prouty , Babu G. Sundar , Kevin J. Wells-Knecht
发明人： Robert L. Hudkins , Lars J.S. Knutsen , Catherine P. Prouty , Babu G. Sundar , Kevin J. Wells-Knecht
IPC分类号： A61K31/501 , A61P25/28 , A61P25/00 , A61P3/00 , A61K31/5377 , A61K31/502
CPC分类号： C07D237/12 , C07D237/08 , C07D237/14 , C07D237/18 , C07D237/20 , C07D401/12 , C07D403/04 , C07D405/04 , C07D409/04
摘要： The present invention is directed to compounds having histamine H3 antagonist activity, as well as methods of their use and preparation.
摘要翻译： 本发明涉及具有组胺H3拮抗剂活性的化合物及其使用和制备方法。
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公开(公告)号：US20110059959A1
公开(公告)日：2011-03-10
申请号：US12949254
申请日：2010-11-18
申请人： Sankar Chatterjee , James L. Diebold , Derek Dunn , Robert L. Hudkins , Reddeppareddy Dandu , Gregory J. Wells , Allison L. Zulli
发明人： Sankar Chatterjee , James L. Diebold , Derek Dunn , Robert L. Hudkins , Reddeppareddy Dandu , Gregory J. Wells , Allison L. Zulli
IPC分类号： A61K31/5377 , C07D471/14 , A61K31/437 , C07D487/04 , A61K31/407 , C07D413/14 , C07D249/08 , A61K31/4196 , C07D401/12 , A61K31/454 , C07D403/14 , A61K31/496 , A61P25/00 , A61P25/16 , A61P25/28 , A61P9/10 , A61P3/00 , A61P19/02 , A61P17/06 , A61P35/00 , C12N5/02
CPC分类号： C07D491/14 , C07D471/14 , C07D487/04 , C07D491/04 , C07D495/04 , C07D519/00
摘要： The present invention is directed to novel multicyclic molecules that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of PARP, VEGFR2, and MLK3 enzymes, including, for example, neurodegenerative diseases, inflammation, ischemia, and cancer.
摘要翻译： 本发明涉及介导酶活性的新型多环分子。 特别地，所述化合物可有效治疗与PARP，VEGFR2和MLK3酶的活性相关的疾病或疾病状态，包括例如神经变性疾病，炎症，局部缺血和癌症。
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公开(公告)号：US20100280007A1
公开(公告)日：2010-11-04
申请号：US12815800
申请日：2010-06-15
申请人： Edward R. Bacon , Thomas R. Bailey , Nadine C. Becknell , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Kurt A. Josef , Lars J.S. Knutsen , Ming Tao , Allison L. Zulli
发明人： Edward R. Bacon , Thomas R. Bailey , Nadine C. Becknell , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Kurt A. Josef , Lars J.S. Knutsen , Ming Tao , Allison L. Zulli
IPC分类号： A61K31/55 , A61K31/5377 , A61K31/502 , A61K31/501 , C07D413/12 , C07D498/04 , C07D403/12 , A61P25/00 , A61P3/04 , A61P25/28 , A61P25/18 , A61P25/08 , A61P11/00 , A61P25/24 , A61P29/00 , A61P9/10 , A61P1/00 , A61P25/06 , A61P43/00 , C07D495/04 , C07D401/14 , C07D409/14 , A61K31/5025
CPC分类号： C07D498/04 , C07D237/14 , C07D237/26 , C07D237/32 , C07D237/36 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/04 , C07D495/04
摘要： The present invention is directed to novel pyridizinone derivatives that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of the histamine H3 receptor, including, for example, neurodegenerative disorders, sleep/wake disorders, attention deficit hyperactivity disorder and cognition.
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28.发明授权Methods for preventing/treating damage to sensory hair cells and cochlear neurons 有权用于预防/治疗感觉毛细胞和耳蜗神经元的损伤的方法公开(公告)号：US07789610B2
公开(公告)日：2010-09-07
申请号：US10041224
申请日：2002-01-08
IPC分类号： A61K31/40
CPC分类号： A61K31/403 , A61K31/407 , A61K31/4439 , A61K31/553
摘要： Methods for preventing or treating damage to sensory hair cells and cochlear neurons are disclosed. The methods comprise the administration of an effective amount of a compound of Formula I or Formula II. The method provides for the prevention/treatment of both hearing loss and loss of the sense of balance.
摘要翻译： 公开了用于预防或治疗感觉毛细胞和耳蜗神经元损伤的方法。 所述方法包括施用有效量的式I或式II化合物。 该方法用于预防/治疗听力损失和失去平衡感。
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公开(公告)号：US07241779B2
公开(公告)日：2007-07-10
申请号：US11017915
申请日：2004-12-22
IPC分类号： A61K31/403 , A61K31/4427 , A61K31/497 , A61K31/5355 , A61K31/416 , A61K31/4162 , C07D487/22
CPC分类号： C07D487/14 , C07D487/04 , C07D513/14 , C09B57/00 , C09B57/08
摘要： The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
摘要翻译： 本发明一般涉及选择的稠合吡咯并唑，包括其药物组合物和用其治疗疾病的方法。 本发明还涉及制备这些稠合的吡咯并咔唑的中间体和方法。
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公开(公告)号：US06872746B2
公开(公告)日：2005-03-29
申请号：US10422164
申请日：2003-04-24
申请人： Robert L. Hudkins
发明人： Robert L. Hudkins
IPC分类号： A61K20060101 , A61K31/4015 , A61K31/403 , A61K31/407 , A61K31/437 , A61K31/4439 , A61P20060101 , A61P9/10 , A61P9/14 , A61P11/00 , A61P13/08 , A61P15/00 , A61P17/02 , A61P17/06 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D20060101 , C07D209/00 , C07D209/04 , C07D209/56 , C07D221/00 , C07D311/00 , C07D333/00 , C07D401/02 , C07D471/14 , C07D487/02 , C07D487/04 , C07D491/14 , C07D491/147 , C07D495/14 , C07D498/14 , A61K31/385 , A61K31/44 , C07D515/16
CPC分类号： C07D471/14 , C07D487/04 , C07D491/14 , C07D495/14
摘要： The present invention is directed to novel fused pyrrolocarbazoles and isoindolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods of using the same as therapeutics. The invention is also directed to intermediates and processes for making these novel compounds.
摘要翻译： 本发明涉及新的稠合吡咯并咔唑和异吲哚酮，包括药物组合物，诊断试剂盒，测定标准品或含有它们的试剂，以及将其用作治疗剂的方法。 本发明还涉及制备这些新化合物的中间体和方法。
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