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公开(公告)号：US08729014B2
公开(公告)日：2014-05-20
申请号：US13284641
申请日：2011-10-28
Applicant: Jerome Courcambeck , Philippe Halfon , Mourad Bouzidi , Steven J. Coats , Richard Anthony Whitaker
Inventor： Jerome Courcambeck , Philippe Halfon , Mourad Bouzidi , Steven J. Coats , Richard Anthony Whitaker
CPC classification number: C07D403/12 , A61K31/4035 , A61K45/06 , A61K2300/00
Abstract: The present invention is directed to compounds, compositions and methods for treating or preventing viral infections, in particular, HCV in human patients or other animal hosts.
Abstract translation: 本发明涉及用于治疗或预防病毒感染的化合物，组合物和方法，特别是人类患者或其他动物宿主中的HCV。
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公开(公告)号：US08372973B2
公开(公告)日：2013-02-12
申请号：US12970461
申请日：2010-12-16
Applicant: Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara Miskowski , Janet L. Ralbovsky , Mark Schulz
Inventor： Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara Miskowski , Janet L. Ralbovsky , Mark Schulz
IPC: C07D403/06 , C07D403/12 , C07D403/14 , C07D401/06 , C07D401/12 , C07D401/14 , A61K31/506 , A61P1/00 , A61P1/06 , A61P1/12
CPC classification number: C07D251/26 , C07D251/46 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/14 , C07D417/14 , C07D487/04
Abstract: The present invention relates to certain novel compounds of Formula (I): and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of prokineticin 1 or prokinetin 1 receptor mediated disorders.
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公开(公告)号：US08324380B2
公开(公告)日：2012-12-04
申请号：US12256891
申请日：2008-10-23
Applicant: Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara A. Miskowski , Janet L. Ralbovsky , Mark J. Schulz
Inventor： Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara A. Miskowski , Janet L. Ralbovsky , Mark J. Schulz
IPC: C07D251/30 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D401/12 , C07D403/12 , A61K31/53 , A61P1/12 , A61P1/06 , A61P1/00
CPC classification number: C07D251/38 , C07D401/12 , C07D403/12 , C07D405/14
Abstract: The present invention relates to certain novel compounds of Formula (I): and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of prokineticin 1 or prokinetin 1 receptor mediated disorders.
Abstract translation: 本发明涉及某些新的式（I）化合物：以及制备这些化合物，组合物，中间体及其衍生物以及用于治疗促动蛋白原1或原激素1受体介导的病症的方法。
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24.发明申请公开(公告)号：US20120302541A1
公开(公告)日：2012-11-29
申请号：US13503433
申请日：2010-10-28
Applicant: Steven J. Coats , Haiyan Bian , Chaozhong Cai , Bart L. DeCorte , Li Liu , Mark J. Macielag , Scott L. Dax , Philip M. Pitis , Peter J. Connolly , Wei He
Inventor： Steven J. Coats , Haiyan Bian , Chaozhong Cai , Bart L. DeCorte , Li Liu , Mark J. Macielag , Scott L. Dax , Philip M. Pitis , Peter J. Connolly , Wei He
IPC: A61K31/40 , C07D211/26 , A61K31/445 , C07D401/12 , A61K31/4439 , C07D405/12 , A61K31/4025 , C07D409/12 , C07D403/12 , A61K31/506 , C07D295/096 , A61K31/495 , C07D413/12 , A61K31/4245 , C07D451/02 , A61K31/46 , C07C217/84 , A61K31/136 , C07D205/04 , A61K31/397 , C07D453/02 , A61K31/439 , A61P29/00 , A61P19/02 , A61P25/06 , A61P11/02 , A61P13/10 , A61P17/00 , A61P11/12 , A61P25/00 , A61P25/02 , A61P1/00 , A61P35/00 , A61P25/24 , A61P25/16 , A61P25/30 , A61P25/32 , A61P13/00 , A61P15/00 , A61P1/12 , A61P9/00 , A61P11/00 , C07D207/14
CPC classification number: C07D401/12 , C07C211/48 , C07C211/50 , C07C233/08 , C07C233/11 , C07C233/65 , C07C255/50 , C07D205/04 , C07D207/09 , C07D211/56 , C07D405/12 , C07D409/12 , C07D413/12 , C07D451/04 , C07D453/02
Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, Ra, and Y are defined herein.
Abstract translation: 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中R1，R2，R3，Ra和Y如本文所定义。
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公开(公告)号：US20120129765A1
公开(公告)日：2012-05-24
申请号：US13284641
申请日：2011-10-28
Applicant: Jerome Courcambeck , Philippe Halfon , Mourad Bouzidi , Steven J. Coats , Richard Anthony Whitaker
Inventor： Jerome Courcambeck , Philippe Halfon , Mourad Bouzidi , Steven J. Coats , Richard Anthony Whitaker
CPC classification number: C07D403/12 , A61K31/4035 , A61K45/06 , A61K2300/00
Abstract: The present invention is directed to compounds, compositions and methods for treating or preventing viral infections, in particular, HCV in human patients or other animal hosts.
Abstract translation: 本发明涉及用于治疗或预防病毒感染的化合物，组合物和方法，特别是人类患者或其他动物宿主中的HCV。
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Patent Agency Ranking
公开(公告)号：US20100279969A1
公开(公告)日：2010-11-04
申请号：US12599951
申请日：2008-05-14
Applicant: Raymond F. Schinazi , John W. Mellors , Nicolas Paul Sluis-Cremer , Frank Amblard , Steven J. Coats , Junxing Shi , Richard Anthony Whitaker
Inventor： Raymond F. Schinazi , John W. Mellors , Nicolas Paul Sluis-Cremer , Frank Amblard , Steven J. Coats , Junxing Shi , Richard Anthony Whitaker
IPC: A61K31/70 , C07H19/16 , C07D473/00 , A61K31/522 , A61P31/18
CPC classification number: C07H19/173 , C07D473/16 , C07D473/18 , C07D473/34
Abstract: The present invention is directed to compounds, compositions and methods for treating or preventing viral infections, in particular, HIV, HBV, and HCV, in human patients or other animal hosts. The compounds are 3′-azido-2′,3′-dideoxy purine nucleosides or phosphonates, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof. In particular, the compounds show potent antiviral activity against HIV-1 resistance mutants including HIV-1K65R, HTV-1K70E, HIV-1L74V, HIV-1M184V, HIV-1Q151M and inhibitory activity against HIV-1 RT harboring TAMS or insertion mutations including HIV-1AZT3, HIV-1AZT7, HIV-1AZT9, HIV-1Q151M, or HIV-169insertion. In one embodiment, the compounds are 3′-azido-ddA, 3′-azido-ddG, or combinations thereof, administered with one or more additional antiviral agents that select for TAM mutations and/or the M 184V mutation, along with a pharmaceutically acceptable carrier.
Abstract translation: 本发明涉及在人类患者或其他动物宿主中用于治疗或预防病毒感染，特别是HIV，HBV和HCV的化合物，组合物和方法。 化合物是3'-叠氮基-2'，3'-二脱氧嘌呤核苷或膦酸酯，及其药学上可接受的盐，前药和其它衍生物。 特别地，这些化合物显示针对HIV-1抗性突变体（包括HIV-1K65R，HTV-1K70E，HIV-1L74V，HIV-1M184V，HIV-1Q151M）的有效的抗病毒活性，以及对携带TAMS或包括HIV的插入突变的HIV-1RT的抑制活性 -1AZT3，HIV-1AZT7，HIV-1AZT9，HIV-1Q151M或HIV-169插入。 在一个实施方案中，化合物是3位 - 叠氮基-ddA，3'-叠氮基-ddG或其组合，与选择TAM突变和/或M 184V突变的一种或多种另外的抗病毒剂一起，连同药物 可接受的载体
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27.发明申请NUCLEOSIDE DERIVATIVES FOR TREATMENT OF CALICIVIRIDAE INFECTIONS, INCLUDING NOROVIRUS INFECTIONS 有权用于治疗卡介菌感染的核苷衍生物，包括非肠道感染公开(公告)号：US20090280084A1
公开(公告)日：2009-11-12
申请号：US12421362
申请日：2009-04-09
Applicant: Raymond F. Schinazi , Richard Anthony Whitaker , Tamara Rosario McBrayer , Steven J. Coats
Inventor： Raymond F. Schinazi , Richard Anthony Whitaker , Tamara Rosario McBrayer , Steven J. Coats
IPC: A61K38/21 , A61K31/7064 , A61K31/7076 , A61K31/706 , A61P31/12
CPC classification number: A61K31/7076 , A61K38/21 , A61K2300/00
Abstract: A method and composition for treating a host infected with a Caliciviridae virus, such as a Norovirus, comprising administering an effective treatment amount of a described modified nucleoside or a pharmaceutically acceptable salt thereof, is provided.
Abstract translation: 提供了用于治疗感染了杯状病毒科（例如诺如病毒）的宿主的方法和组合物，其包括施用有效治疗量的所述修饰的核苷或其药学上可接受的盐。
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公开(公告)号：US07563781B2
公开(公告)日：2009-07-21
申请号：US11329642
申请日：2006-01-11
Applicant: Donald W. Ludovici , Richard W. Connors , Steven J. Coats , Li Liu , Bart L. De Corte , Dana L. Johnson , Mark J. Schulz
Inventor： Donald W. Ludovici , Richard W. Connors , Steven J. Coats , Li Liu , Bart L. De Corte , Dana L. Johnson , Mark J. Schulz
IPC: C07D487/04 , C07F9/40 , A61K31/5355 , A61K31/519 , C07D239/30 , A61P35/00 , G01N33/53 , C07H21/04 , C12P21/06 , C12N5/06 , C07K16/40 , C12N9/12
CPC classification number: C07K14/4738 , C07D487/04 , C12N9/1205 , C12Q1/485 , G01N2500/02
Abstract: The invention relates to the discovery of triazolopyrimidine derivatives of formula (I), which have been found to exhibit inhibitory activity against the serine-tyrosine and tyrosine kinases.
Abstract translation: 本发明涉及已发现对丝氨酸 - 酪氨酸和酪氨酸激酶具有抑制活性的式（I）三唑并嘧啶衍生物的发现。
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29.发明授权公开(公告)号：US08846655B2
公开(公告)日：2014-09-30
申请号：US13503433
申请日：2010-10-28
Applicant: Steven J. Coats , Haiyan Bian , Chaozhong Cai , Bart L. DeCorte , Li Liu , Mark J. Macielag , Scott L. Dax , Philip M. Pitis , Peter J. Connolly , Wei He
Inventor： Steven J. Coats , Haiyan Bian , Chaozhong Cai , Bart L. DeCorte , Li Liu , Mark J. Macielag , Scott L. Dax , Philip M. Pitis , Peter J. Connolly , Wei He
IPC: A61K31/40 , A61K31/445 , A61K31/4439 , A61K31/4025 , A61K31/506 , A61K31/495 , C07D211/56 , C07D405/12 , C07D207/09 , C07C255/50 , C07C211/48 , C07D413/12 , C07D401/12 , C07C211/50 , C07D205/04 , C07C233/08 , C07C233/11 , C07C233/65 , C07D451/04 , C07D453/02 , C07D409/12
CPC classification number: C07D401/12 , C07C211/48 , C07C211/50 , C07C233/08 , C07C233/11 , C07C233/65 , C07C255/50 , C07D205/04 , C07D207/09 , C07D211/56 , C07D405/12 , C07D409/12 , C07D413/12 , C07D451/04 , C07D453/02
Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, Ra, and Y are defined herein.
Abstract translation: 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中R1，R2，R3，Ra和Y如本文所定义。
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公开(公告)号：US08513271B2
公开(公告)日：2013-08-20
申请号：US12913966
申请日：2010-10-28
Applicant: Steven J. Coats , Haiyan Bian , Peter J. Connolly , Gilles Bignan , Chaozhong Cai , Scott L. Dax , Bart L. DeCorte , Shu-Chen Lin , Li Liu , Mark J. Macielag , Philip M. Pitis , Yue-Mei Zhang , Bin Zhu , Wei He
Inventor： Steven J. Coats , Haiyan Bian , Peter J. Connolly , Gilles Bignan , Chaozhong Cai , Scott L. Dax , Bart L. DeCorte , Shu-Chen Lin , Li Liu , Mark J. Macielag , Philip M. Pitis , Yue-Mei Zhang , Bin Zhu , Wei He
IPC: A01N43/54
CPC classification number: C07D239/47 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, and L, A, and Ra are defined herein.
Abstract translation: 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中R1，R2，R3和L，A和Ra在本文中定义。
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