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10 条记录 (耗时 0.026 秒)

    Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists
    8.
    发明申请
    Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists 审中-公开
    氮杂桥连双环氨基酸衍生物作为α4整联蛋白拮抗剂

    公开(公告)号：US20060223846A1

    公开(公告)日：2006-10-05

    申请号：US11370665

    申请日：2006-03-08

    申请人： Alexey Dyatkin ,  Yong Gong ,  Wei He ,  Tamara Miskowski

    发明人： Alexey Dyatkin ,  Yong Gong ,  Wei He ,  Tamara Miskowski

    IPC分类号： C07D453/02 ,  A61K31/46

    CPC分类号： C07D453/02 ,  C07D453/06

    摘要： The invention is directed to aza-bridged-bicyclic compounds having Formula (I): and pharmaceutically acceptable salts thereof. The compounds are useful α4 integrin receptor antagonists and, in particular, α4β1 and α4β7 integrin receptor antagonists. The invention is further directed to methods for use of the instant compounds for treating integrin mediated disorders including, but not limited to, inflammatory disorders, autoimmune disorders and cell-proliferative disorders, methods for preparing the compounds and methods for preparing the intermediates, derivatives and pharmaceutical compositions thereof.

    摘要翻译： 本发明涉及具有式（I）的氮杂桥联双环化合物及其药学上可接受的盐。 该化合物是有用的α4整联蛋白受体拮抗剂，特别是α4β1和α4β7整联蛋白受体拮抗剂。 本发明进一步涉及本发明化合物用于治疗整联蛋白介导的病症的方法，包括但不限于炎症性疾病，自身免疫性疾病和细胞增殖性疾病，制备化合物的方法和制备中间体，衍生物和 其药物组合物。

    Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists
    10.
    发明申请
    Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists 审中-公开
    氮杂桥连双环氨基酸衍生物作为α4整联蛋白拮抗剂

    公开(公告)号：US20050176755A1

    公开(公告)日：2005-08-11

    申请号：US10976091

    申请日：2004-10-27

    申请人： Alexey Dyatkin ,  Yong Gong ,  Tamara Miskowski ,  Wei He

    发明人： Alexey Dyatkin ,  Yong Gong ,  Tamara Miskowski ,  Wei He

    IPC分类号： C07D451/14 ,  C07D453/06 ,  C07D453/04 ,  A61K31/407 ,  A61K31/46

    CPC分类号： C07D453/06

    摘要： The invention is directed to aza-bridged-bicyclic compounds having Formula (I): and pharmaceutically acceptable salts thereof. The compounds are useful α4 integrin receptor antagonists and, in particular, α4β1 and α4β7 integrin receptor antagonists. The invention is further directed to methods for use of the instant compounds for treating integrin mediated disorders including, but not limited to, inflammatory disorders, autoimmune disorders and cell-proliferative disorders, methods for preparing the compounds and methods for preparing the intermediates, derivatives and pharmaceutical compositions thereof.

    摘要翻译： 本发明涉及具有式（I）的氮杂桥联双环化合物及其药学上可接受的盐。 该化合物是有用的α4整联蛋白受体拮抗剂，特别是α4β1和α4β7整联蛋白受体拮抗剂。 本发明进一步涉及本发明化合物用于治疗整联蛋白介导的病症的方法，包括但不限于炎症性疾病，自身免疫性疾病和细胞增殖性疾病，制备化合物的方法和制备中间体，衍生物和 其药物组合物。