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35 条记录 (耗时 0.017 秒)

    Antisecretory 1,2,4-triazole-3-thiols
    21.
    发明授权
    Antisecretory 1,2,4-triazole-3-thiols 失效
    苯基-1,2,4-三唑-3-硫醇

    公开(公告)号：US4411905A

    公开(公告)日：1983-10-25

    申请号：US273531

    申请日：1981-06-15

    申请人： William L. Albrecht ,  Winton D. Jones

    发明人： William L. Albrecht ,  Winton D. Jones

    IPC分类号： C07D209/48 ,  C07D249/12 ,  A61K31/41

    CPC分类号： C07D209/48 ,  C07D249/12 ,  Y10S514/926 ,  Y10S514/927

    摘要： Compounds of the formula ##STR1## wherein R.sub.1 is H or NH.sub.2 ; R.sub.2 is C.sub.1-6 straight or branched chain alkyl; --CH.sub.2 OH; --(CH.sub.2).sub.n --O--(CH.sub.2).sub.m --CH.sub.3 ; phenyl; or --(CH.sub.2).sub.p NH.sub.2 ;n is 1-3;m is 0-3; andp is 1-5;and the pharmaceutically acceptable acid addition salts of those compounds of basic character,have antisecretory activity.

    摘要翻译： 其中R1是H或NH2的式“IMAGE”的化合物; R2是C1-6直链或支链烷基; -CH 2 OH; - （CH 2）n -O-（CH 2）m -CH 3; 苯基; 或 - （CH 2）p NH 2; n为1-3; m为0-3; p为1-5; 和具有基本特征的化合物的药学上可接受的酸加成盐具有抗分泌活性。

    Muscle-relaxant 1,3,4-thiadiazin-2-amines
    22.
    发明授权
    Muscle-relaxant 1,3,4-thiadiazin-2-amines 失效
    肌肉松弛剂1,3,4-噻二嗪-2-胺

    公开(公告)号：US4309426A

    公开(公告)日：1982-01-05

    申请号：US208728

    申请日：1980-11-20

    申请人： Winton D. Jones, Jr. ,  Francis P. Miller

    发明人： Winton D. Jones, Jr. ,  Francis P. Miller

    IPC分类号： C07D285/16 ,  A61K31/54

    CPC分类号： C07D285/16 ,  Y10S514/906

    摘要： A method of achieving a muscle-relaxing effect in a patient comprises administering to a patient in which a muscle relaxing effect is desired an amount effective to achieve a muscle-relaxing effect of a compound of the formula ##STR1## wherein R is H, or C.sub.1-7 straight or branched chain alkyl;R.sub.1 is H, C.sub.1-7 straight or branched chain alkyl, allyl or phenyl;R.sub.2 is phenyl, phenyl monosubstituted with F, Cl, C.sub.1-4 straight or branched chain alkyl or phenyl disubstituted in the 2- and 4-positions with Cl or C.sub.1-4 straight or branched chain alkyl; andR.sub.3 is H or C.sub.1-4 straight or branched chain alkyl, with the proviso that when R.sub.3 is straight or branched chain alkyl, R.sub.2 is unsubstituted phenyl;or a pharmaceutically acceptable acid addition salt thereof.

    摘要翻译： 实现患者肌肉放松效果的方法包括向其中需要肌肉松弛效果的患者施用有效实现下式化合物的肌肉松弛作用的量：其中R是H，或 C 1-7直链或支链烷基; R1是H，C1-7直链或支链烷基，烯丙基或苯基; R 2是苯基，被F，Cl，C 1-4直链或支链烷基单取代的苯基或在2-或4-位与C 1-4或C 1-4直链或支链烷基二取代的苯基; 且R 3为H或C 1-4直链或支链烷基，条件是当R 3为直链或支链烷基时，R 2为未取代的苯基; 或其药学上可接受的酸加成盐。

    5-(Optionally substituted phenyl)-6H-1,3,4-thiadiazine-2-amines
    23.
    发明授权
    5-(Optionally substituted phenyl)-6H-1,3,4-thiadiazine-2-amines 失效
    5-（任选取代的苯基）-6H-1,3,4-噻二嗪-2-胺

    公开(公告)号：US4272532A

    公开(公告)日：1981-06-09

    申请号：US71954

    申请日：1979-09-04

    申请人： Winton D. Jones ,  Francis P. Miller

    发明人： Winton D. Jones ,  Francis P. Miller

    IPC分类号： C07D285/16 ,  A61K31/54

    CPC分类号： C07D285/16

    摘要： A method of inducing sedation in a patient comprises administering to a patient in which sedation is desired an amount effective for inducing sedation of a compound of the formula ##STR1## wherein R is H, or C.sub.1-5 or 7 -straight or branched chain alkyl:R.sub.1 is H, C.sub.1-5 or 7 -straight or branched chain alkyl or allyl;R.sub.2 is phenyl or phenyl substituted with F, Cl, Br, NO.sub.2, C.sub.1-5 straight or branched chain alkyl, C.sub.1-5 straight or branched chain alkoxy, 2,4-di-Cl, 2,4-di-F or 2,4-di-Br, with the proviso that when the phenyl group is monosubstituted with F, the F atom is not in the o-position; andR.sub.3 is H or C-1-5 straight or branched chain alkyl, with the proviso that when R.sub.3 is straight or branched chain alkyl, R.sub.2 is unsubstituted phenyl; ora pharmaceutically acceptable acid addition salt thereof.

    摘要翻译： 诱导患者镇静的方法包括向需要镇静的患者施用有效诱导下式化合物镇静的量，其中R为H，或C 1-5或7-直链或支链烷基 R1为H，C1-5或7-直链或支链烷基或烯丙基; R2是苯基或被F，Cl，Br，NO2，C1-5直链或支链烷基，C1-5直链或支链烷氧基，2,4-二Cl，2,4-di-F或2 ，4-二-Br，条件是当苯基被F单取代时，F原子不在o位; 且R 3为H或C 1-5直链或支链烷基，条件是当R 3为直链或支链烷基时，R 2为未取代的苯基; 或其药学上可接受的酸加成盐。

    Prevention of glycoprotein enveloped virus infectivity by quinolyl- and isoquinolyloxazole-2-zones
    26.
    发明授权
    Prevention of glycoprotein enveloped virus infectivity by quinolyl- and isoquinolyloxazole-2-zones 失效
    通过喹啉基和异喹唑啉-2-区预防糖蛋白包膜病毒感染

    公开(公告)号：US5061715A

    公开(公告)日：1991-10-29

    申请号：US590523

    申请日：1990-10-03

    申请人： Sai P. Sunkara ,  Winton D. Jones

    发明人： Sai P. Sunkara ,  Winton D. Jones

    IPC分类号： A61K31/47

    CPC分类号： A61K31/47

    摘要： This invention relates to quinolyloxazole-2-ones which are useful anti-enveloped virus agents by virtue of their ability to act as protein kinase C inhibitors. These derivatives are disclosed to be effective in treating enveloped virus infections including HIV infections and are thus useful in the treatment of AIDS and ARC.

    摘要翻译： 本发明涉及由于其作为蛋白激酶C抑制剂的能力而是有用的抗包膜病毒剂的喹喔啉-2-酮。 这些衍生物被公开以有效地治疗包括HIV感染的包膜病毒感染，因此可用于治疗AIDS和ARC。

    Certain 5-acyl-2-(1H)-pyridinones useful in treating cardiac failure
    28.
    发明授权
    Certain 5-acyl-2-(1H)-pyridinones useful in treating cardiac failure 失效
    某些5-酰基-2-（1H） - 吡啶酮可用于治疗心力衰竭

    公开(公告)号：US4992452A

    公开(公告)日：1991-02-12

    申请号：US345751

    申请日：1989-05-01

    申请人： Winton D. Jones ,  Richard C. Dage ,  Richard A. Schnettler

    发明人： Winton D. Jones ,  Richard C. Dage ,  Richard A. Schnettler

    IPC分类号： C07D213/85

    CPC分类号： C07D213/85

    摘要： Novel 5-acyl-2-(1H)-pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic solvent.

    摘要翻译： 新型5-酰基-2-（1H） - 吡啶酮及其作为强心剂的用途。 典型的化合物是通过将阴离子氰基乙酰胺与3 - [（二甲基氨基）亚甲基] -2,4-戊二酮缩合而制备的5-乙酰基-1,2-二氢-6-甲基-2-氧代-3-吡啶腈 惰性有机溶剂。