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26 条记录 (耗时 0.021 秒)

    Muscle-relaxant 1,3,4-thiadiazin-2-amines
    1.
    发明授权
    Muscle-relaxant 1,3,4-thiadiazin-2-amines 失效
    肌肉松弛剂1,3,4-噻二嗪-2-胺

    公开(公告)号：US4309426A

    公开(公告)日：1982-01-05

    申请号：US208728

    申请日：1980-11-20

    申请人： Winton D. Jones, Jr. ,  Francis P. Miller

    发明人： Winton D. Jones, Jr. ,  Francis P. Miller

    IPC分类号： C07D285/16 ,  A61K31/54

    CPC分类号： C07D285/16 ,  Y10S514/906

    摘要： A method of achieving a muscle-relaxing effect in a patient comprises administering to a patient in which a muscle relaxing effect is desired an amount effective to achieve a muscle-relaxing effect of a compound of the formula ##STR1## wherein R is H, or C.sub.1-7 straight or branched chain alkyl;R.sub.1 is H, C.sub.1-7 straight or branched chain alkyl, allyl or phenyl;R.sub.2 is phenyl, phenyl monosubstituted with F, Cl, C.sub.1-4 straight or branched chain alkyl or phenyl disubstituted in the 2- and 4-positions with Cl or C.sub.1-4 straight or branched chain alkyl; andR.sub.3 is H or C.sub.1-4 straight or branched chain alkyl, with the proviso that when R.sub.3 is straight or branched chain alkyl, R.sub.2 is unsubstituted phenyl;or a pharmaceutically acceptable acid addition salt thereof.

    摘要翻译： 实现患者肌肉放松效果的方法包括向其中需要肌肉松弛效果的患者施用有效实现下式化合物的肌肉松弛作用的量：其中R是H，或 C 1-7直链或支链烷基; R1是H，C1-7直链或支链烷基，烯丙基或苯基; R 2是苯基，被F，Cl，C 1-4直链或支链烷基单取代的苯基或在2-或4-位与C 1-4或C 1-4直链或支链烷基二取代的苯基; 且R 3为H或C 1-4直链或支链烷基，条件是当R 3为直链或支链烷基时，R 2为未取代的苯基; 或其药学上可接受的酸加成盐。

    3-aryl-5-alkylthio-4H-1,2,4-triazoles
    4.
    发明授权
    3-aryl-5-alkylthio-4H-1,2,4-triazoles 失效
    3-芳基-5-烷硫基-4H-1,2,4-三唑

    公开(公告)号：US5143933A

    公开(公告)日：1992-09-01

    申请号：US770837

    申请日：1991-10-04

    申请人： John M. Kane ,  Francis P. Miller

    发明人： John M. Kane ,  Francis P. Miller

    IPC分类号： C07D249/12 ,  C07D401/04 ,  C07D409/04

    CPC分类号： C07D401/04 ,  C07D249/12 ,  C07D409/04

    摘要： This invention relates to novel sulfone and sulfoxide derivatives of 3-aryl-5-alkylthio-4H-1,2,4-triazoles and to the use of 3-aryl-5-alkylthio-, alkylsulfinyl- and alkylsulfonyl-4H-1,2,4-triazoles in the treatment of patients suffering from convulsant seizures.

    摘要翻译： 本发明涉及3-芳基-5-烷硫基-4H-1,2,4-三唑的新型砜和亚砜衍生物以及3-芳基-5-烷硫基 - 烷基亚磺酰基 - 和烷基磺酰基-4H-1的用途， 2,4-三唑治疗患有惊厥发作的患者。

    Tetrahydro-7a-(optionally substituted phenyl)-1H-pyrrolo[1,2-b][1,2,4]-triazole-2(3H)-thiones
    7.
    发明授权
    Tetrahydro-7a-(optionally substituted phenyl)-1H-pyrrolo[1,2-b][1,2,4]-triazole-2(3H)-thiones 失效
    四氢-7a-（任选取代的苯基）-1H-吡咯并[1,2-b] [1,2,4] - 三唑-2（3H） - 硫杂

    公开(公告)号：US4358457A

    公开(公告)日：1982-11-09

    申请号：US286950

    申请日：1981-07-27

    申请人： Winton D. Jones ,  John M. Kane ,  Francis P. Miller

    发明人： Winton D. Jones ,  John M. Kane ,  Francis P. Miller

    IPC分类号： C07D471/04 ,  A61K31/41 ,  C07D487/04

    CPC分类号： C07D471/04

    摘要： Compounds of the formula ##STR1## wherein R is H or C.sub.1-5 straight or branched chain alkyl; R.sub.1 is H, C.sub.1-10 straight or branched chain alkyl, allyl or phenyl; and R.sub.2 is phenyl or phenyl substituted with F, Cl, C.sub.1-5 straight or branched chain alkyl, di-F, di-Cl or di-Br; and the pharmaceutically acceptable acid addition salts thereof; are useful as muscle relaxants, anticonvulsants and analgesics.

    摘要翻译： 其中R为H或C 1-5直链或支链烷基的式IMAMA的化合物; R1是H，C1-10直链或支链烷基，烯丙基或苯基; R 2为苯基或被F，Cl，C 1-5直链或支链烷基取代的苯基，二-F，二-C1或二-Br; 及其药学上可接受的酸加成盐; 可用作肌肉松弛剂，抗惊厥药和镇痛药。