公开(公告)号：US20220304573A1

公开(公告)日：2022-09-29

申请号：US17647585

申请日：2022-01-10

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Philip M. BUSCEMI ,  Matthias PFISTER ,  Stephan WYDER ,  Amitava GUPTA

IPC: A61B3/10 ,  G01B9/02091

Abstract: An OCT axial length measurement device is configured to measure an area of the retina within a range from about 0.05 mm to about 2.0 mm. The area can be measured with a scanned measurement beam or plurality of substantially fixed measurement beams. The OCT measurement device may comprise a plurality of reference optical path lengths, in which a first optical path length corresponds to a first position of a cornea, and a second optical path length corresponds to a second position of the retina, in which the axial length is determined based on a difference between the first position and the second position. An axial length map can be generated to determine alignment of the eye with the measurement device and improve accuracy and repeatability of the measurements. In some embodiments, the OCT measurement device comprises a swept source vertical cavity surface emitting laser (“VCSEL”).

公开(公告)号：US20220214564A1

公开(公告)日：2022-07-07

申请号：US17655496

申请日：2022-03-18

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Philip M. BUSCEMI ,  Amitava GUPTA ,  Stefan BAUER ,  Benjamin CROOK ,  Julien SAUVET

IPC: G02C7/08 ,  G02C7/06 ,  G02C7/14 ,  G02C7/10 ,  G02C7/02

Abstract: An apparatus to treat refractive error of an eye comprises an optic comprising an optical zone and a peripheral defocus optical structure to form images of a plurality of stimuli anterior or posterior to a peripheral portion of a retina of the eye. In some embodiments, the peripheral defocus optical structure located outside the optical zone. In some embodiments, the peripheral defocus optical structure comprises optical power to focus light to a different depth of the eye than the optical zone. In some embodiments, the optic comprises one or more of a lens, an optically transparent substrate, a beam splitter, a prism, or an optically transmissive support.

公开(公告)号：US20210311326A1

公开(公告)日：2021-10-07

申请号：US17250507

申请日：2019-07-26

Applicant: ACUCELA INC.

Inventor： Beat WYSS ,  Jean-Noël FEHR ,  Glenn NORONHA ,  Karim HAROUD ,  Julien SAUVET ,  Hans BERNHARD ,  Christian OGGENFUSS ,  Amitava GUPTA ,  Ryo KUBOTA

IPC: G02C7/04 ,  G02C11/04 ,  G02C7/14

Abstract: A soft contact lens comprises a plurality of light sources coupled to a plurality of optical elements. The plurality of light sources and the plurality of optical elements are embedded in a soft contact lens material. Each of said plurality of optical elements generates an image focused in front of a peripheral retina of a wearer. In some embodiments, each of the images is focused at a distance in front of the peripheral retina at a location, and each of the images comprises a depth of focus and a spatial resolution. The depth of focus can be less than the distance, and the spatial resolution greater than a spatial resolution of the peripheral retina at the location.

公开(公告)号：US20250076682A1

公开(公告)日：2025-03-06

申请号：US18952067

申请日：2024-11-19

Applicant: ACUCELA INC.

Inventor： Beat WYSS ,  Jean-Noel FEHR ,  Glenn NORONHA ,  Karim HAROUD ,  Julien SAUVET ,  Hans BERNHARD ,  Christian OGGENFUSS ,  Amitava GUPTA ,  Ryo KUBOTA

IPC: G02C7/04 ,  G02C7/14 ,  G02C11/04

Abstract: A soft contact lens comprises a plurality of light sources coupled to a plurality of optical elements. The plurality of light sources and the plurality of optical elements are embedded in a soft contact lens material. Each of said plurality of optical elements generates an image focused in front of a peripheral retina of a wearer. In some embodiments, each of the images is focused at a distance in front of the peripheral retina at a location, and each of the images comprises a depth of focus and a spatial resolution. The depth of focus can be less than the distance, and the spatial resolution greater than a spatial resolution of the peripheral retina at the location.

公开(公告)号：US20240252835A1

公开(公告)日：2024-08-01

申请号：US18632487

申请日：2024-04-11

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Karim HAROUD ,  Beat WYSS ,  Hans BERNHARD ,  Jean-Noel FEHR ,  Patrizia WEBER ,  Moritz HAEBERLI ,  Amitava GUPTA

IPC: A61N5/06 ,  G02B27/01 ,  G02B27/30

CPC classification number: A61N5/0622 ,  G02B27/0172 ,  G02B27/30 ,  A61N2005/063 ,  A61N2005/0648 ,  A61N2005/0652 ,  A61N2005/0663 ,  G02B2027/0178

Abstract: A device to stimulate the retina comprises one or more light sources coupled to one or more optical elements. The one or more optical elements is configured to illuminate the retina with one or more images at a location away from a fovea of a wearer. In some embodiments, each of the one or more images comprises a depth of focus and a spatial resolution. The one or more images can be formed at a distance anterior to the retina, at a distance posterior to the retina or on the retina. In some embodiments, the depth of focus is less than the distance, and the spatial resolution greater than a spatial resolution of the retina at the location.

公开(公告)号：US20230168521A1

公开(公告)日：2023-06-01

申请号：US18160200

申请日：2023-01-26

Applicant: ACUCELA INC.

Inventor： Beat WYSS ,  Jean-Noel FEHR ,  Glenn NORONHA ,  Karim HAROUD ,  Julien SAUVET ,  Hans BERNHARD ,  Christian OGGENFUSS ,  Amitava GUPTA ,  Ryo KUBOTA

IPC: G02C7/04 ,  G02C7/14 ,  G02C11/04

CPC classification number: G02C7/04 ,  G02C7/14 ,  G02C11/04 ,  G02C2202/24

Abstract: A soft contact lens comprises a plurality of light sources coupled to a plurality of optical elements. The plurality of light sources and the plurality of optical elements are embedded in a soft contact lens material. Each of said plurality of optical elements generates an image focused in front of a peripheral retina of a wearer. In some embodiments, each of the images is focused at a distance in front of the peripheral retina at a location, and each of the images comprises a depth of focus and a spatial resolution. The depth of focus can be less than the distance, and the spatial resolution greater than a spatial resolution of the peripheral retina at the location.

公开(公告)号：US20230118068A1

公开(公告)日：2023-04-20

申请号：US18067552

申请日：2022-12-16

Applicant: ACUCELA INC.

Inventor： Amitava GUPTA ,  Ryo KUBOTA

IPC: G02C7/02 ,  G02C7/04 ,  G02C11/04 ,  G02C11/00

Abstract: A contact lens configured to decrease dark adaptation comprises one or more LEDs and directs light from the LED away from the fovea and toward the parafovea or perifoveal regions of the retina. In some embodiments, soft contact lens embedded with one or more arrays of microLEDs and electronics operating the LEDs is configured to be worn at night in order to inhibit dark adaptation and reduce oxygen consumption by the rods. The contact lens may be made of a single layer of a contact lens material or multiple layers sandwiching a flexible transparent plastic layer comprising the electronics and the LED arrays. The contact lens may be made of a hydrophilic hydrogel material that is biocompatible to the human cornea, or a silicone hydrogel material. The contact lens may be spherical and may provide refractive correction to the eye of the wearer.

公开(公告)号：US20220413318A1

公开(公告)日：2022-12-29

申请号：US17929852

申请日：2022-09-06

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Nabin JOSHI ,  Arkady SELENOW ,  Steven ALI ,  Stefan BAUER ,  Jean-Noel FEHR ,  Moritz HAEBERLI ,  Patrizia WEBER ,  Julien SAUVET ,  Amitava GUPTA

IPC: G02C7/02 ,  A61F9/00 ,  G02C11/04 ,  A61B3/00 ,  G02C7/04 ,  G02C7/06

Abstract: An apparatus to treat refractive error of the eye comprises one or more optics configured to project stimuli comprising out of focus images onto the peripheral retina outside the macula. While the stimuli can be configured in many ways, in some embodiments the stimuli are arranged to decrease interference with central vison such as macular vision. The stimuli can be out of focus images may comprise an amount of defocus within a range from about 3 Diopters (“D”) to about 6 D. In some embodiments, the brightness of the stimuli is greater than a brightness of background illumination by an appropriate amount such as at least 3 times the background brightness. In some embodiments, each of a plurality of stimuli comprises a spatial frequency distribution with an amplitude profile having spatial frequencies within a range from about range of 1×10−1 to 2.5×101 cycles per degree.

公开(公告)号：US20220221738A1

公开(公告)日：2022-07-14

申请号：US17657036

申请日：2022-03-29

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Amitava GUPTA

IPC: G02C7/08 ,  G02F1/29

Abstract: An apparatus to treat refractive error of an eye comprises an electroactive component configured to switch between a light scattering or optical power providing configuration to treat refractive error of the eye and a substantially transparent configuration to allow normal viewing. The electroactive component can be located on the lens away from a central axis of the lens to provide light to a peripheral region of the retina to decrease the progression of myopia. The electroactive component can be located on the lens away from the central axis of the lens in order for the wearer to view objects through an optical zone while the electroactive component scatters light. The electroactive component can be configured to switch to the substantially transparent configuration to allow light to pass through the electroactive component and to allow the lens to refract light to correct vision and allow normal viewing through the lens.

公开(公告)号：US20210356767A1

公开(公告)日：2021-11-18

申请号：US17302827

申请日：2021-05-13

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Amitava GUPTA

IPC: G02C7/08 ,  G02F1/29

Abstract: An apparatus to treat refractive error of an eye comprises an electroactive component configured to switch between a light scattering or optical power providing configuration to treat refractive error of the eye and a substantially transparent configuration to allow normal viewing. The electroactive component can be located on the lens away from a central axis of the lens to provide light to a peripheral region of the retina to decrease the progression of myopia. The electroactive component can be located on the lens away from the central axis of the lens in order for the wearer to view objects through an optical zone while the electroactive component scatters light. The electroactive component can be configured to switch to the substantially transparent configuration to allow light to pass through the electroactive component and to allow the lens to refract light to correct vision and allow normal viewing through the lens.