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    Human antigen binding proteins that bind β-Klotho, FGF receptors and complexes thereof
    25.
    发明授权
    Human antigen binding proteins that bind β-Klotho, FGF receptors and complexes thereof 有权

    公开(公告)号：US10570205B2

    公开(公告)日：2020-02-25

    申请号：US15280662

    申请日：2016-09-29

    Applicant: AMGEN INC.

    Inventor： Shaw-Fen Sylvia Hu ,  Ian Nevin Foltz ,  Chadwick Terence King ,  Yang Li ,  Taruna Arora

    IPC: A61K39/00 ,  C07K16/28 ,  C07K16/40 ,  C07K14/71 ,  C07K16/18

    Abstract: The present invention provides compositions and methods relating to or derived from antigen binding proteins activate FGF21-mediated signaling. In embodiments, the antigen binding proteins specifically bind to (i) β-Klotho; (ii) FGFR1c, FGFR2c, FGFR3c or FGFR4; or (iii) a complex comprising β-Klotho and one of FGFR1c, FGFR2c, FGFR3c, and FGFR4. In some embodiments the antigen binding proteins induce FGF21-like signaling. In some embodiments, an antigen binding protein is a fully human, humanized, or chimeric antibodies, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind to (i) β-Klotho; (ii) FGFR1c, FGFR2c, FGFR3c or FGFR4; or (iii) a complex comprising β-Klotho and one of FGFR1c, FGFR2c, FGFR3c, and FGFR4. Other embodiments provide nucleic acids encoding such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, and methods of using such antigen binding proteins, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from type 2 diabetes, obesity, NASH, metabolic syndrome and related disorders or conditions.

    HUMAN ANTIGEN BINDING PROTEINS THAT BIND TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9
    28.
    发明申请
    HUMAN ANTIGEN BINDING PROTEINS THAT BIND TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 审中-公开
    人体抗原结合蛋白质，其结合了转化子分泌素KEXIN 9型

    公开(公告)号：US20160039945A1

    公开(公告)日：2016-02-11

    申请号：US14777371

    申请日：2014-03-12

    Applicant: AMGEN INC.

    Inventor： Chadwick Terence King ,  Simon Mark Jackson

    IPC: C07K16/40 ,  A61K45/06 ,  G01N33/573 ,  A61K39/395

    CPC classification number: C07K16/40 ,  A61K39/3955 ,  A61K45/06 ,  C07K2317/21 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/573 ,  G01N2333/96433

    Abstract: The present invention provides compositions and methods relating to or derived from antigen binding proteins capable of inhibiting PCSK9 binding to LDLR. In embodiments, the antigen binding proteins specifically bind PCSK9. In some embodiments, an antigen binding protein is a fully human, humanized, or chimeric antibodies, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind PCSK9 Other embodiments provide nucleic acids encoding such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, and methods of using such antigen binding proteins, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from hypercholesterolemia and related disorders or conditions.

    Abstract translation: 本发明提供与能够抑制PCSK9与LDLR结合的抗原结合蛋白有关或衍生的组合物和方法。 在实施方案中，抗原结合蛋白特异性结合PCSK9。 在一些实施方案中，抗原结合蛋白是完全人，人源化或嵌合抗体，此类抗体的结合片段和衍生物，以及特异性结合PCSK9的多肽其他实施方案提供编码此类抗原结合蛋白的核酸及其片段和衍生物， 和多肽，包含此类多核苷酸的细胞，制备此类抗原结合蛋白的方法及其片段和衍生物，以及多肽，以及使用此类抗原结合蛋白，其片段及其衍生物和多肽的方法，包括治疗或诊断受试者的方法 来自高胆固醇血症和相关疾病或病症。

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