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公开(公告)号：US20080269234A1
公开(公告)日：2008-10-30
申请号：US12138168
申请日：2008-06-12
IPC分类号： A61K31/501 , A61P35/00 , A61K31/4188 , A61K31/415 , A61K31/675 , A61K31/175 , A61K31/195 , A61K31/282 , A61K33/24 , A61K31/505 , A61K31/519 , A61K31/506 , A61K31/4375 , A61K38/00 , A61K31/439
CPC分类号： A61K31/502 , A61K31/551 , A61K45/06 , A61N5/10 , C07D237/32 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14
摘要： Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods of treating patients using them are disclosed.
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公开(公告)号：US08450320B2
公开(公告)日：2013-05-28
申请号：US13086556
申请日：2011-04-14
申请人： Gui-Dong Zhu , Virajkumar B. Gandhi , Alexander R. Shoemaker , Thomas D. Penning , Jianchun Gong
发明人： Gui-Dong Zhu , Virajkumar B. Gandhi , Alexander R. Shoemaker , Thomas D. Penning , Jianchun Gong
IPC分类号： A61K31/4985
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, R1c, X, Y, Z, n, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中R1a，R1b，R1c，X，Y，Z，n和m在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如Cdc7的激酶和治疗诸如癌症的疾病的方法。
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23.发明授权公开(公告)号：US08217070B2
公开(公告)日：2012-07-10
申请号：US12765293
申请日：2010-04-22
申请人： Gui-Dong Zhu , Virajkumar B. Gandhi , Jianchun Gong , Thomas D. Penning , Vincent L. Giranda , Sheela Thomas
发明人： Gui-Dong Zhu , Virajkumar B. Gandhi , Jianchun Gong , Thomas D. Penning , Vincent L. Giranda , Sheela Thomas
IPC分类号： A61K31/4184 , C07D235/04
CPC分类号： C07D235/14 , C07D401/04 , C07D401/12 , C07D403/06
摘要： Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
摘要翻译： 式（I）的化合物抑制PARP酶，并且可用于治疗与PARP相关的疾病或病症。 还公开了包含式（I）化合物，包含式（I）化合物的治疗方法的药物组合物，以及抑制包含式（I）化合物的PARP酶的方法。
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公开(公告)号：US20120046303A1
公开(公告)日：2012-02-23
申请号：US13282826
申请日：2011-10-27
IPC分类号： A61K31/4439 , A61K31/497 , A61K31/427 , A61K31/454 , C07D409/14 , A61K31/4184 , C07D413/14 , A61K31/422 , A61K31/4245 , A61P37/08 , A61P19/02 , A61P9/00 , A61P35/00 , A61P29/00 , A61P3/10 , A61P19/06 , A61P7/04 , A61P3/08 , A61P1/00 , A61P9/10 , A61P13/12 , A61P35/02 , A61P1/16 , A61P25/00 , A61P37/06 , A61P25/16 , A61P27/02 , A61P31/14 , A61P17/00 , C07D417/14
CPC分类号： C07D417/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： Compounds which inhibit the activity of poly(ADP-ribose)polymerase (PARP), compositions containing the compounds and methods of treating diseases using them are disclosed.
摘要翻译： 公开了抑制聚（ADP-核糖）聚合酶（PARP）活性的化合物，含有该化合物的组合物和使用它们治疗疾病的方法。
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25.发明授权1H-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent PARP inhibitors 有权在2-位被季碳取代的1H-苯并咪唑-4-甲酰胺是有效的PARP抑制剂公开(公告)号：US07550603B2
公开(公告)日：2009-06-23
申请号：US11401638
申请日：2006-04-11
IPC分类号： A61K31/4184 , C07D403/04
CPC分类号： C07D403/04 , C07D207/16 , C07D401/04 , C07D401/14 , C07D405/14
摘要： Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
摘要翻译： 式（I）的化合物抑制PARP酶，并且可用于治疗与PARP相关的疾病或病症。 还公开了包含式（I）化合物，包含式（I）化合物的治疗方法的药物组合物，以及抑制包含式（I）化合物的PARP酶的方法。
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公开(公告)号：US20080161280A1
公开(公告)日：2008-07-03
申请号：US11964822
申请日：2007-12-27
IPC分类号： A61K31/501 , C07D403/10 , C07D401/10 , A61K31/506 , C07D413/10 , A61K31/5377 , C07D471/04 , A61P35/00
CPC分类号： C07D403/10 , C07D237/32 , C07D403/12 , C07D403/14 , Y02P20/582
摘要： Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods of treating patients using them are disclosed.
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27.发明申请SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS 审中-公开取代的1H-苯并咪唑-4-羧酰胺是残留的PARP抑制剂公开(公告)号：US20070259937A1
公开(公告)日：2007-11-08
申请号：US11743200
申请日：2007-05-02
申请人： Vincent L. Giranda , Thomas D. Penning , Virajkamar B. Gandhi , Sheela A. Thomas , Gui-Dong Zhu , Jianchun Gong
发明人： Vincent L. Giranda , Thomas D. Penning , Virajkamar B. Gandhi , Sheela A. Thomas , Gui-Dong Zhu , Jianchun Gong
IPC分类号： A61K31/4184 , C07D403/02
CPC分类号： C07D403/10 , C07D235/18 , C07D409/04
摘要： The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.
摘要翻译： 本发明涉及式（I）的1H-苯并咪唑-4-甲酰胺，其制备及其作为制备药物的聚（ADP-核糖）聚合酶的抑制剂的用途。
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公开(公告)号：US20110257187A1
公开(公告)日：2011-10-20
申请号：US13086580
申请日：2011-04-14
申请人： Gui-Dong Zhu , Virajkumar B. Gandhi , Alexander R. Shoemaker , Thomas D. Penning , Jianchun Gong
发明人： Gui-Dong Zhu , Virajkumar B. Gandhi , Alexander R. Shoemaker , Thomas D. Penning , Jianchun Gong
IPC分类号： A61K31/502 , C07D401/02 , A61P35/00 , C07D401/14
CPC分类号： C07D471/04 , C07D401/04
摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, R1c, X, Y, Z, n, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中R1a，R1b，R1c，X，Y，Z，n和m在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如Cdc7的激酶和治疗诸如癌症的疾病的方法。
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29.发明申请公开(公告)号：US20100234425A1
公开(公告)日：2010-09-16
申请号：US12765293
申请日：2010-04-22
申请人： Gui-Dong Zhu , Virajkumar B. Gandhi , Jianchun Gong , Thomas D. Penning , Vincent L. Giranda , Sheela Thomas
发明人： Gui-Dong Zhu , Virajkumar B. Gandhi , Jianchun Gong , Thomas D. Penning , Vincent L. Giranda , Sheela Thomas
IPC分类号： A61K31/4184 , C07D235/04 , C07D235/14 , C07D403/02 , C07D401/00 , A61K31/4439 , A61K31/4545 , A61P29/00
CPC分类号： C07D235/14 , C07D401/04 , C07D401/12 , C07D403/06
摘要： Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
摘要翻译： 式（I）的化合物抑制PARP酶，并且可用于治疗与PARP相关的疾病或病症。 还公开了包含式（I）化合物，包含式（I）化合物的治疗方法的药物组合物，以及抑制包含式（I）化合物的PARP酶的方法。
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30.发明授权Substituted 1H-benzimidazole-4-carboxamides are potent PARP inhibitors 有权取代的1H-苯并咪唑-4-甲酰胺是有效的PARP抑制剂公开(公告)号：US07595406B2
公开(公告)日：2009-09-29
申请号：US11830318
申请日：2007-07-30
申请人： Thomas D. Penning , Sheela A. Thomas , Gui-Dong Zhu , Jianchun Gong , Vincent L. Giranda , Viraj B. Gandhi
发明人： Thomas D. Penning , Sheela A. Thomas , Gui-Dong Zhu , Jianchun Gong , Vincent L. Giranda , Viraj B. Gandhi
IPC分类号： A61K31/4184 , C07D235/18
CPC分类号： C07D235/18 , C07D409/04 , C07D413/04 , C07D417/04
摘要： Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
摘要翻译： 式（I）的化合物抑制PARP酶，并且可用于治疗与PARP相关的疾病或病症。 还公开了包含式（I）化合物，包含式（I）化合物的治疗方法的药物组合物，以及抑制包含式（I）化合物的PARP酶的方法。
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