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    6-deoxy erythromycin derivatives, method for preparing same and use as medicines
    22.
    发明授权
    6-deoxy erythromycin derivatives, method for preparing same and use as medicines 有权
    6-脱氧红霉素衍生物，其制备方法，用作药物

    公开(公告)号：US06706692B1

    公开(公告)日：2004-03-16

    申请号：US09744320

    申请日：2001-04-10

    申请人： Jean-Michel Auger ,  Alexis Denis

    发明人： Jean-Michel Auger ,  Alexis Denis

    IPC分类号： A61K3170

    CPC分类号： C07H17/08

    摘要： The invention concerns compounds of formula (I) wherein: X represents a (NH)a, CH2 or SO2 radical or an oxygen atom; a represents 0 or 1; Y represents a (CH2)m-(CH═CH)n-(CH2)o radical with m+n+o≦8, n=0 or 1; Ar represents an aryl or heteroaryl radical, optionally substituted; W represents a hydrogen atom or a halogen atom; Z represents a hydrogen atom or an acid residue, and their addition salts with acids. The compounds of formula (I) have antibiotic properties

    摘要翻译： 本发明涉及式（I）的化合物，其中：X表示（NH）a，CH 2或SO 2基团或氧原子; a表示0或1; Y表示具有m + n + o = 8，n = 0或1的（CH = CH）n - （CH 2） Ar表示任选取代的芳基或杂芳基; W表示氢原子或卤素原子; Z表示氢原子或酸残基，它们与酸的加成盐。 式（I）化合物具有抗生素特性

    Propanal derivatives
    24.
    发明授权
    Propanal derivatives 失效
    丙醛衍生物

    公开(公告)号：US5760233A

    公开(公告)日：1998-06-02

    申请号：US805439

    申请日：1997-02-25

    申请人： Constantin Agouridas ,  Yannick Benedetti ,  Jean-Francois Chantot ,  Alexis Denis ,  Odile Le Martret

    发明人： Constantin Agouridas ,  Yannick Benedetti ,  Jean-Francois Chantot ,  Alexis Denis ,  Odile Le Martret

    IPC分类号： C07H17/08 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/00 ,  A61P31/04 ,  C07H17/00 ,  C07D215/00 ,  C07C13/00 ,  C07D271/00 ,  C07D277/04

    CPC分类号： C07H17/08 ,  C07H17/00

    摘要： A compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and an optionally unsaturated hydrocarbon of up to 24 carbon atoms optionally interrupted by at least one heteroatom selected from the group consisting of oxygen, sulfur and nitrogen and optionally having at least one functional group or taken together form ##STR2## and R'.sub.1 and R'.sub.2 are individually selected from the group consisting of hydrogen and an optionally unsaturated hydrocarbon of up to 23 carbon atoms optionally interrupted by at least one heteroatom selected from the group consisting of nitrogen, oxygen and sulfur and optionally having at least one functional group, Z is hydrogen or acyl of an organic carboxylic acid of 1 to 18 carbon atoms and the wavy line indicates the 10-methyl may have R or S configuration or a mixture of R+S and their non-toxic, pharmaceutically acceptable acid addition salts having antibiotic properties.

    摘要翻译： 选自下式的化合物的化合物其中R 1和R 2分别选自氢和至多24个碳原子的任选不饱和烃，任选地被至少一个选自以下的杂原子间隔的杂原子 由氧，硫和氮组成并且任选地具有至少一个官能团或一起形成的基团组成，并且R'1和R'2分别选自氢和任选不饱和的烃，最多达23个 碳原子任选地被至少一个选自氮，氧和硫并且任选具有至少一个官能团的杂原子中断，Z是氢或具有1至18个碳原子的有机羧酸的酰基，波浪线表示 该10-甲基可具有R或S构型或R + S与其无毒的药学上可接受的具有抗生素的酸加成盐的混合物 tic属性。

    Derivatives . . . use as medicaments
    27.
    发明授权
    Derivatives . . . use as medicaments 有权
    衍生品。 。 。 用作药物

    公开(公告)号：US06455505B2

    公开(公告)日：2002-09-24

    申请号：US09433146

    申请日：1999-11-03

    申请人： Constantin Agouridas ,  Alexis Denis ,  Claude Fromentin

    发明人： Constantin Agouridas ,  Alexis Denis ,  Claude Fromentin

    IPC分类号： A61K3170

    CPC分类号： C07D233/64 ,  C07H17/08

    摘要： A subject of the invention is, as new chemical products, the compounds of formula (I) in which X represents a hydrogen atom or a halogen atom and Z represents a hydrogen atom or the remainder of an acid as well as their addition salts with acids. The compounds of formula (I) have antibiotic properties.

    摘要翻译： 本发明的主题是作为新的化学产品，其中X表示氢原子或卤素原子，Z表示氢原子或酸的其余部分的式（I）化合物及其与酸的加成盐 。 式（I）化合物具有抗生素特性。

    Derivatives of erythromycin, their preparation process and their use as medicaments
    28.
    发明授权
    Derivatives of erythromycin, their preparation process and their use as medicaments 有权
    红霉素的衍生物，其制备方法及其作为药物的用途

    公开(公告)号：US06440941B1

    公开(公告)日：2002-08-27

    申请号：US09442681

    申请日：1999-11-18

    申请人： Alexis Denis

    发明人： Alexis Denis

    IPC分类号： A61K3170

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/04 ,  C07H17/08

    摘要： A subject of the invention is the compounds of formula (I) in which Y represents a hydrogen atom or a fluorine atom, n represents an integer comprised between 1 and 8, Z represents a hydrogen atom or the remainder of a carboxylic acid, optionally substituted on the heterocycle by one or more alkyl, alkenyl, alkynyl, O-alkyl, O-alkenyl, O-alkynyl, S-alkyl, S-alkenyl, S-alkynyl radicals containing up to 8 carbon atoms, one or more OH, NH2, C═N, NO2, CF3 radicals or one or more aryl radicals containing up to 14 carbon atoms or heteroaryl radicals containing one or more nitrogen oxygen or sulphur atoms, the aryl or heteroaryl radicals themselves being able to be substituted as well as their addition salts with acids, The products of formula (I) have antibiotic properties.

    摘要翻译： 本发明的主题是式（I）的化合物，其中Y代表氢原子或氟原子，n表示1至8之间的整数，Z表示氢原子或羧酸的其余部分，任选在 通过一个或多个烷基，烯基，炔基，O-烷基，O-链烯基，O-炔基，S-烷基，S-烯基，含有至多8个碳原子的S-炔基，一个或多个OH，NH 2， C = N，NO 2，CF 3基团或含有至多14个碳原子的一个或多个芳基或含有一个或多个氮氧原子或硫原子的杂芳基，芳基或杂芳基自身能够被取代，以及它们的加成盐 与酸，式（I）的产物具有抗生素特性。

    Erythromycin derivatives, a process for their preparation and their use as medicaments
    29.
    发明授权
    Erythromycin derivatives, a process for their preparation and their use as medicaments 有权
    红霉素衍生物，其制备方法及其用作药物

    公开(公告)号：US06433151B1

    公开(公告)日：2002-08-13

    申请号：US09350224

    申请日：1999-07-08

    申请人： Alexis Denis ,  Giuseppe Gigliotti

    发明人： Alexis Denis ,  Giuseppe Gigliotti

    IPC分类号： C07H1708

    CPC分类号： C07H17/08

    摘要： The invention relates to compounds of the formula (I) in which R represents a radical (CH2)mOn(X)YAr  in which m represents the number 0 or 1, n represents the number 0 or 1, X represents a radical (NH)a, CH2 or SO2, where a represents the number 0 or 1, Y represents a radical (CH2)b—(CH═CH)c—(CH2)d, where c=0 or 1 and b+c+d ≦8, Z represents a hydrogen or halogen atom, Ar represents an optionally substituted aryl or heteroaryl radical and W represents a hydrogen atom or an acyl radical, and their acid addition salts. The compounds of the formula (1) have antibiotic properties.

    摘要翻译： 本发明涉及式（I）化合物，其中R表示基团，其中m表示数字0或1，n表示数字0或1，X表示基团（NH）a，CH 2或SO 2，其中a表示 数字0或1，Y表示基团（CH 2）b - （CH = CH）c - （CH 2）d，其中c = 0或1，b + c + d <= 8，Z表示氢或卤素原子 ，Ar表示任选取代的芳基或杂芳基，W表示氢原子或酰基，以及它们的酸加成盐。式（1）化合物具有抗生素特性。