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    System for neural control of respiration
    22.
    发明授权
    System for neural control of respiration 有权
    呼吸神经控制系统

    公开(公告)号：US08036750B2

    公开(公告)日：2011-10-11

    申请号：US11151122

    申请日：2005-06-13

    申请人： Anthony Caparso ,  Imad Libbus ,  M. Jason Brooke ,  Kent Lee ,  Jonathan Kwok ,  Yachuan Pu

    发明人： Anthony Caparso ,  Imad Libbus ,  M. Jason Brooke ,  Kent Lee ,  Jonathan Kwok ,  Yachuan Pu

    IPC分类号： A61N1/18

    CPC分类号： A61N1/3601 ,  A61N1/36114

    摘要： A system, device and method for neural control of respiration are provided. One aspect of this disclosure relates to an implantable medical device for sensing and controlling respiration during incidence of central respiratory diseases. According to various embodiments, the device includes a sensing circuit to receive sensed signals representative of an incidence of a central respiratory disease. The device also includes a neural stimulator adapted to generate neural stimulation signals, and a controller to communicate with the sensing circuit and to control the neural stimulator to stimulate a desired neural target in response to the detection of the incidence of a central respiratory disease. In an embodiment, the device includes a plurality of sensors which are adapted to monitor physiological parameters to detect the incidence of a central respiratory disease and to send signals to the sensing circuit. Other aspects and embodiments are provided herein.

    摘要翻译： 提供了一种用于呼吸神经控制的系统，装置和方法。 本公开的一个方面涉及用于在中枢呼吸系统疾病发作期间感测和控制呼吸的可植入医疗装置。 根据各种实施例，该装置包括感测电路，用于接收代表中枢呼吸系统疾病发生率的感测信号。 该装置还包括适于产生神经刺激信号的神经刺激器，以及响应于检测到中枢性呼吸系统疾病发生率而控制器与感测电路通信并控制神经刺激器以刺激所需神经靶标。 在一个实施例中，该装置包括多个传感器，其适于监测生理参数以检测中枢性呼吸系统疾病的发生并向感测电路发送信号。 本文提供了其它方面和实施例。

    CAPTURE DETECTION BASED ON PROPAGATED DEPOLARIZATION FROM A PACING SITE
    23.
    发明申请
    CAPTURE DETECTION BASED ON PROPAGATED DEPOLARIZATION FROM A PACING SITE 审中-公开
    基于从PACING站点传播分解的捕获检测

    公开(公告)号：US20110224751A1

    公开(公告)日：2011-09-15

    申请号：US13104437

    申请日：2011-05-10

    申请人： Alok S. Sathaye ,  M. Jason Brooke ,  Scott A. Meyer

    发明人： Alok S. Sathaye ,  M. Jason Brooke ,  Scott A. Meyer

    IPC分类号： A61N1/362

    CPC分类号： A61N1/371

    摘要： A methods and devices for capture detection are based on sensing a propagated depolarization from a contralateral cardiac chamber. An intersite sensing interval is determined based on an intersite pacing delay and an intersite conduction delay associated with first and second pacing sites. Pacing pulses are delivered to the first pacing site and the second pacing site, the pacing pulses separated in time by the intersite pacing delay. An intersite sensing interval is timed. The process includes sensing, during the intersite sensing interval, at the first pacing site for a depolarization propagated to the first pacing site from the second pacing site. It a depolarization propagated from the second pacing site is not sensed, then capture of the first and second pacing sites is detected.

    摘要翻译： 用于捕获检测的方法和装置基于感测来自对侧心室的传播的去极化。 基于场间起搏延迟和与第一和第二起搏部位相关联的间歇间传导延迟确定位置间感测间隔。 起搏脉冲被传送到第一起搏部位和第二起搏部位，起搏脉冲及时地通过位置间起搏延迟分开。 站间感知间隔是定时的。 该过程包括在第一起搏部位期间在站间感测间隔期间感测到从第二起搏部位传播到第一起搏部位的去极化。 从第二起搏部位传播的去极化不被感测，然后检测到第一和第二起搏部位的捕获。

    AUTOMATIC ELECTRODE INTEGRITY MANAGEMENT SYSTEMS AND METHODS
    24.
    发明申请
    AUTOMATIC ELECTRODE INTEGRITY MANAGEMENT SYSTEMS AND METHODS 有权
    自动电极整体管理系统与方法

    公开(公告)号：US20110144713A1

    公开(公告)日：2011-06-16

    申请号：US13031762

    申请日：2011-02-22

    申请人： Derek D. Bohn ,  M. Jason Brooke ,  Rajesh Krishan Gandhi ,  Alok S. Sathaye ,  Aaron McCabe

    发明人： Derek D. Bohn ,  M. Jason Brooke ,  Rajesh Krishan Gandhi ,  Alok S. Sathaye ,  Aaron McCabe

    IPC分类号： A61N1/37

    CPC分类号： A61N1/37282 ,  A61N1/368 ,  A61N1/3684 ,  A61N1/3706 ,  A61N2001/083

    摘要： This document discusses, among other things, systems and methods for automatic electrode integrity management. Interelectrode impedance is measured for various electrode combinations of an implantable cardiac function management device. The impedance data is processed, such as at an external remote server, to determine whether an electrode is failing or has failed, to select an alternate electrode configuration, to alert a physician or patient, to predict a time-to-failure such as by using population data, or to reprogram electrode configuration or other device parameters of the implantable cardiac function management device.

    摘要翻译： 本文件还讨论了自动电极完整性管理的系统和方法。 测量可植入心脏功能管理装置的各种电极组合的电极内阻抗。 处理阻抗数据，例如在外部远程服务器处，以确定电极是否发生故障或失败，选择备用电极配置，以警告医师或患者预测失效时间，例如通过 使用种群数据，或重新编程可植入心脏功能管理装置的电极配置或其他装置参数。

    Method and Apparatus to Ensure Consistent Left Ventricular Pacing
    26.
    发明申请
    Method and Apparatus to Ensure Consistent Left Ventricular Pacing 有权
    确定左心室起搏一致的方法和装置

    公开(公告)号：US20090281590A1

    公开(公告)日：2009-11-12

    申请号：US12435915

    申请日：2009-05-05

    申请人： Barun Maskara ,  Jiang Ding ,  M. Jason Brooke

    发明人： Barun Maskara ,  Jiang Ding ,  M. Jason Brooke

    IPC分类号： A61N1/365 ,  A61N1/37

    CPC分类号： A61N1/371 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

    摘要： A method of operating a cardiac therapy system to deliver cardiac resynchronization therapy (CRT) pacing that includes pacing both ventricles or pacing only the left ventricle is described. Delivery of the CRT pacing to one or both ventricles is scheduled for a cardiac cycle. If an intrinsic depolarization of a ventricle is detected during a pacing delay of the ventricle, then the scheduled CRT pacing to the ventricle is inhibited for the cycle. The intrinsic interval of the ventricle, such as the intrinsic atrioventricular interval concluded by the intrinsic depolarization, is measured. During a subsequent cardiac cycle, the pacing delay of the ventricle is decreased to be less than or equal to the measured intrinsic interval. Capture of the ventricle is verified after pacing is delivered during the subsequent cardiac cycle.

    摘要翻译： 描述了一种操作心脏治疗系统以递送心脏再同步治疗（CRT）起搏的方法，其包括仅对左心室起搏两个心室或起搏。 将CRT起搏送至一个或两个心室，安排进行心动周期。 如果在心室的起搏延迟期间检测到心室的内在去极化，则对该周期抑制预定的对心室的CRT起搏。 测量心室的固有间隔，例如内在去极化结束的内在房室间隔。 在随后的心动周期中，心室的起搏延迟降低到小于或等于测量的固有间期。 在随后的心动周期内进行起搏后验证心室的获取。

    AUTOMATIC ELECTRODE INTEGRITY MANAGEMENT SYSTEMS AND METHODS
    28.
    发明申请
    AUTOMATIC ELECTRODE INTEGRITY MANAGEMENT SYSTEMS AND METHODS 有权
    自动电极整体管理系统与方法

    公开(公告)号：US20070293903A1

    公开(公告)日：2007-12-20

    申请号：US11424579

    申请日：2006-06-16

    申请人： Derek D. Bohn ,  M. Jason Brooke ,  Rajesh Krishan Gandhi ,  Alok S. Sathaye ,  Aaron McCabe

    发明人： Derek D. Bohn ,  M. Jason Brooke ,  Rajesh Krishan Gandhi ,  Alok S. Sathaye ,  Aaron McCabe

    IPC分类号： A61N1/00

    CPC分类号： A61N1/37282 ,  A61N1/368 ,  A61N1/3684 ,  A61N1/3706 ,  A61N2001/083

    摘要： This document discusses, among other things, systems and methods for automatic electrode integrity management. Interelectrode impedance is measured for various electrode combinations of an implantable cardiac function management device. The impedance data is processed, such as at an external remote server, to determine whether an electrode is failing or has failed, to select an alternate electrode configuration, to alert a physician or patient, to predict a time-to-failure such as by using population data, or to reprogram electrode configuration or other device parameters of the implantable cardiac function management device.

    摘要翻译： 本文件还讨论了自动电极完整性管理的系统和方法。 测量可植入心脏功能管理装置的各种电极组合的电极内阻抗。 处理阻抗数据，例如在外部远程服务器处，以确定电极是否发生故障或失败，选择备用电极配置，以警告医师或患者预测失效时间，例如通过 使用种群数据，或重新编程可植入心脏功能管理装置的电极配置或其他装置参数。

    Method and apparatus to ensure consistent left ventricular pacing
    29.
    发明授权
    Method and apparatus to ensure consistent left ventricular pacing 有权
    确保左心室起搏一致的方法和装置

    公开(公告)号：US08676314B2

    公开(公告)日：2014-03-18

    申请号：US12435915

    申请日：2009-05-05

    申请人： Barun Maskara ,  Jiang Ding ,  M. Jason Brooke

    发明人： Barun Maskara ,  Jiang Ding ,  M. Jason Brooke

    IPC分类号： A61N1/00

    CPC分类号： A61N1/371 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

    摘要： A method of operating a cardiac therapy system to deliver cardiac resynchronization therapy (CRT) pacing that includes pacing both ventricles or pacing only the left ventricle is described. Delivery of the CRT pacing to one or both ventricles is scheduled for a cardiac cycle. If an intrinsic depolarization of a ventricle is detected during a pacing delay of the ventricle, then the scheduled CRT pacing to the ventricle is inhibited for the cycle. The intrinsic interval of the ventricle, such as the intrinsic atrioventricular interval concluded by the intrinsic depolarization, is measured. During a subsequent cardiac cycle, the pacing delay of the ventricle is decreased to be less than or equal to the measured intrinsic interval. Capture of the ventricle is verified after pacing is delivered during the subsequent cardiac cycle.

    摘要翻译： 描述了一种操作心脏治疗系统以递送心脏再同步治疗（CRT）起搏的方法，其包括仅对左心室起搏两个心室或起搏。 将CRT起搏送至一个或两个心室，安排进行心动周期。 如果在心室的起搏延迟期间检测到心室的内在去极化，则对该周期抑制预定的对心室的CRT起搏。 测量心室的固有间隔，例如内在去极化结束的内在房室间隔。 在随后的心动周期中，心室的起搏延迟降低到小于或等于测量的固有间期。 在随后的心动周期内进行起搏后验证心室的获取。

    Automatic electrode integrity management systems and methods
    30.
    发明授权
    Automatic electrode integrity management systems and methods 有权
    自动电极完整性管理系统和方法

    公开(公告)号：US08442635B2

    公开(公告)日：2013-05-14

    申请号：US13031762

    申请日：2011-02-22

    申请人： Derek D. Bohn ,  M. Jason Brooke ,  Rajesh K. Gandhi ,  Alok S. Sathaye ,  Aaron R. McCabe

    发明人： Derek D. Bohn ,  M. Jason Brooke ,  Rajesh K. Gandhi ,  Alok S. Sathaye ,  Aaron R. McCabe

    IPC分类号： A61N1/08

    CPC分类号： A61N1/37282 ,  A61N1/368 ,  A61N1/3684 ,  A61N1/3706 ,  A61N2001/083

    摘要： This document discusses, among other things, systems and methods for automatic electrode integrity management. Interelectrode impedance is measured for various electrode combinations of an implantable cardiac function management device. The impedance data is processed, such as at an external remote server, to determine whether an electrode is failing or has failed, to select an alternate electrode configuration, to alert a physician or patient, to predict a time-to-failure such as by using population data, or to reprogram electrode configuration or other device parameters of the implantable cardiac function management device.

    摘要翻译： 本文件还讨论了自动电极完整性管理的系统和方法。 测量可植入心脏功能管理装置的各种电极组合的电极内阻抗。 处理阻抗数据，例如在外部远程服务器处，以确定电极是否发生故障或失败，选择备用电极配置，以警告医师或患者预测失效时间，例如通过 使用种群数据，或重新编程可植入心脏功能管理装置的电极配置或其他装置参数。