公开(公告)号：US20090281590A1

公开(公告)日：2009-11-12

申请号：US12435915

申请日：2009-05-05

申请人： Barun Maskara ,  Jiang Ding ,  M. Jason Brooke

发明人： Barun Maskara ,  Jiang Ding ,  M. Jason Brooke

IPC分类号： A61N1/365 ,  A61N1/37

CPC分类号： A61N1/371 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

摘要： A method of operating a cardiac therapy system to deliver cardiac resynchronization therapy (CRT) pacing that includes pacing both ventricles or pacing only the left ventricle is described. Delivery of the CRT pacing to one or both ventricles is scheduled for a cardiac cycle. If an intrinsic depolarization of a ventricle is detected during a pacing delay of the ventricle, then the scheduled CRT pacing to the ventricle is inhibited for the cycle. The intrinsic interval of the ventricle, such as the intrinsic atrioventricular interval concluded by the intrinsic depolarization, is measured. During a subsequent cardiac cycle, the pacing delay of the ventricle is decreased to be less than or equal to the measured intrinsic interval. Capture of the ventricle is verified after pacing is delivered during the subsequent cardiac cycle.

摘要翻译： 描述了一种操作心脏治疗系统以递送心脏再同步治疗（CRT）起搏的方法，其包括仅对左心室起搏两个心室或起搏。 将CRT起搏送至一个或两个心室，安排进行心动周期。 如果在心室的起搏延迟期间检测到心室的内在去极化，则对该周期抑制预定的对心室的CRT起搏。 测量心室的固有间隔，例如内在去极化结束的内在房室间隔。 在随后的心动周期中，心室的起搏延迟降低到小于或等于测量的固有间期。 在随后的心动周期内进行起搏后验证心室的获取。

公开(公告)号：US08676314B2

公开(公告)日：2014-03-18

申请号：US12435915

申请日：2009-05-05

申请人： Barun Maskara ,  Jiang Ding ,  M. Jason Brooke

发明人： Barun Maskara ,  Jiang Ding ,  M. Jason Brooke

IPC分类号： A61N1/00

CPC分类号： A61N1/371 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

摘要： A method of operating a cardiac therapy system to deliver cardiac resynchronization therapy (CRT) pacing that includes pacing both ventricles or pacing only the left ventricle is described. Delivery of the CRT pacing to one or both ventricles is scheduled for a cardiac cycle. If an intrinsic depolarization of a ventricle is detected during a pacing delay of the ventricle, then the scheduled CRT pacing to the ventricle is inhibited for the cycle. The intrinsic interval of the ventricle, such as the intrinsic atrioventricular interval concluded by the intrinsic depolarization, is measured. During a subsequent cardiac cycle, the pacing delay of the ventricle is decreased to be less than or equal to the measured intrinsic interval. Capture of the ventricle is verified after pacing is delivered during the subsequent cardiac cycle.

摘要翻译： 描述了一种操作心脏治疗系统以递送心脏再同步治疗（CRT）起搏的方法，其包括仅对左心室起搏两个心室或起搏。 将CRT起搏送至一个或两个心室，安排进行心动周期。 如果在心室的起搏延迟期间检测到心室的内在去极化，则对该周期抑制预定的对心室的CRT起搏。 测量心室的固有间隔，例如内在去极化结束的内在房室间隔。 在随后的心动周期中，心室的起搏延迟降低到小于或等于测量的固有间期。 在随后的心动周期内进行起搏后验证心室的获取。

公开(公告)号：US08560072B2

公开(公告)日：2013-10-15

申请号：US13596595

申请日：2012-08-28

申请人： Anthony V. Caparso ,  Imad Libbus ,  M. Jason Brooke ,  Kent Lee ,  Jonathan Kwok ,  Yachuan Pu

发明人： Anthony V. Caparso ,  Imad Libbus ,  M. Jason Brooke ,  Kent Lee ,  Jonathan Kwok ,  Yachuan Pu

IPC分类号： A61N1/18

CPC分类号： A61N1/3601 ,  A61N1/36114

摘要： A system, device and method for neural control of respiration are provided. One aspect of this disclosure relates to an implantable medical device for sensing and controlling respiration during incidence of central respiratory diseases. According to various embodiments, the device includes a sensing circuit to receive sensed signals representative of an incidence of a central respiratory disease. The device also includes a neural stimulator adapted to generate neural stimulation signals, and a controller to communicate with the sensing circuit and to control the neural stimulator to stimulate a desired neural target in response to the detection of the incidence of a central respiratory disease. In an embodiment, the device includes a plurality of sensors which are adapted to monitor physiological parameters to detect the incidence of a central respiratory disease and to send signals to the sensing circuit. Other aspects and embodiments are provided herein.

摘要翻译： 提供了一种用于呼吸神经控制的系统，装置和方法。 本公开的一个方面涉及用于在中枢呼吸系统疾病发作期间感测和控制呼吸的可植入医疗装置。 根据各种实施例，该装置包括感测电路，用于接收代表中枢呼吸系统疾病发生率的感测信号。 该装置还包括适于产生神经刺激信号的神经刺激器，以及响应于检测到中枢性呼吸系统疾病发生率而控制器与感测电路通信并控制神经刺激器以刺激所需神经靶标。 在一个实施例中，该装置包括多个传感器，其适于监测生理参数以检测中枢性呼吸系统疾病的发生并向感测电路发送信号。 本文提供了其它方面和实施例。

公开(公告)号：US20120323292A1

公开(公告)日：2012-12-20

申请号：US13596595

申请日：2012-08-28

申请人： Anthony Caparso ,  Imad Libbus ,  M. Jason Brooke ,  Kent Lee ,  Jonathan Kwok ,  Yachuan Pu

发明人： Anthony Caparso ,  Imad Libbus ,  M. Jason Brooke ,  Kent Lee ,  Jonathan Kwok ,  Yachuan Pu

IPC分类号： A61N1/36

CPC分类号： A61N1/3601 ,  A61N1/36114

摘要： A system, device and method for neural control of respiration are provided. One aspect of this disclosure relates to an implantable medical device for sensing and controlling respiration during incidence of central respiratory diseases. According to various embodiments, the device includes a sensing circuit to receive sensed signals representative of an incidence of a central respiratory disease. The device also includes a neural stimulator adapted to generate neural stimulation signals, and a controller to communicate with the sensing circuit and to control the neural stimulator to stimulate a desired neural target in response to the detection of the incidence of a central respiratory disease. In an embodiment, the device includes a plurality of sensors which are adapted to monitor physiological parameters to detect the incidence of a central respiratory disease and to send signals to the sensing circuit. Other aspects and embodiments are provided herein.

摘要翻译： 提供了一种用于呼吸神经控制的系统，装置和方法。 本公开的一个方面涉及用于在中枢呼吸系统疾病发作期间感测和控制呼吸的可植入医疗装置。 根据各种实施例，该装置包括感测电路，用于接收代表中枢呼吸系统疾病发生率的感测信号。 该装置还包括适于产生神经刺激信号的神经刺激器，以及响应于检测到中枢性呼吸系统疾病发生率而控制器与感测电路通信并控制神经刺激器以刺激所需神经靶标。 在一个实施例中，该装置包括多个传感器，其适于监测生理参数以检测中枢性呼吸系统疾病的发生并向感测电路发送信号。 本文提供了其它方面和实施例。

公开(公告)号：US08209013B2

公开(公告)日：2012-06-26

申请号：US11520879

申请日：2006-09-14

申请人： M. Jason Brooke ,  Alok S. Sathaye ,  Yanting Dong ,  Scott Walczak

发明人： M. Jason Brooke ,  Alok S. Sathaye ,  Yanting Dong ,  Scott Walczak

IPC分类号： A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/3712

摘要： Energy parameters for electrical stimulation pulses that produce a desired activation, and avoid an undesirable activation, are determined. A strength-duration relationship for at least one desired activation produced by therapeutic electrical stimulation is measured. A strength-duration relationship for at least one undesirable activation produced by the therapeutic electrical stimulation is provided. A medical device selects, based on the desired and undesirable strength-duration relationships, one or more energy parameters for the therapeutic electrical stimulation that produce the desired activation and avoid the undesirable activation.

摘要翻译： 确定产生所需激活的电刺激脉冲的能量参数，并避免不期望的激活。 测量通过治疗性电刺激产生的至少一种所需活化的强度 - 持续时间关系。 提供了由治疗性电刺激产生的至少一种不期望的激活的强度 - 持续时间关系。 医疗设备基于期望的和不期望的强度 - 持续时间关系选择产生所需激活的治疗性电刺激的一个或多个能量参数，并避免不期望的激活。

公开(公告)号：US20100268194A1

公开(公告)日：2010-10-21

申请号：US12825174

申请日：2010-06-28

申请人： Allan C. Shuros ,  M. Jason Brooke ,  Tasneem Poonawala

发明人： Allan C. Shuros ,  M. Jason Brooke ,  Tasneem Poonawala

IPC分类号： A61B17/122 ,  A61N1/36 ,  A61M25/00

CPC分类号： A61N1/3606 ,  A61M25/00 ,  A61N1/05 ,  A61N1/36007 ,  A61N1/36135

摘要： Renal function may be modulated by an implantable device having one or more leads or catheters disposed near the kidney via the lymphatic system. In one embodiment, lymphatic drainage from the kidney is modulated to increase or decrease tubular reabsorption of salt and water. The renal function modulation therapy may be delivered in an open-loop or closed-loop fashion, with the latter dependent upon a physiological variable such as blood pressure or cardiac output.

摘要翻译： 肾功能可以由具有通过淋巴系统设置在肾附近的一个或多个引线或导管的可植入装置调节。 在一个实施方案中，来自肾脏的淋巴引​​流被调节以增加或减少盐和水的管状再吸收。 肾功能调节治疗可以以开环或闭环方式递送，后者取决于诸如血压或心输出量的生理变量。

公开(公告)号：US20100121406A1

公开(公告)日：2010-05-13

申请号：US12691392

申请日：2010-01-21

申请人： Imad Libbus ,  Anthony Caparso ,  M. Jason Brooke ,  Jonathan Kwok ,  Kent Lee ,  Yachuan Pu

发明人： Imad Libbus ,  Anthony Caparso ,  M. Jason Brooke ,  Jonathan Kwok ,  Kent Lee ,  Yachuan Pu

IPC分类号： A61N1/36

CPC分类号： A61N1/36185 ,  A61N1/3611

摘要： Various aspects relate to an implantable device. Various device embodiments include at least one sensor for use in detecting sleep disordered breathing, a pulse generator adapted to deliver a first electrical signal through at least one electrode to stimulate a neural target, and a controller adapted to communicate with the at least one sensor and with the pulse generator. The controller is adapted to detect sleep disordered breathing using the at least one sensor and provide a therapy for sleep disordered breathing in response to a detected apneic event. The therapy for sleep disordered breathing is adapted to deliver the first electrical signal through the at least one electrode to induce a cough reflex to terminate the apneic event. Various embodiments stimulate a superior laryngeal nerve, various embodiments stimulate a recurrent laryngeal nerve, and various embodiments stimulate a vagus nerve. Other aspects and embodiments are provided herein.

摘要翻译： 各种方面涉及可植入装置。 各种装置实施例包括用于检测睡眠无序呼吸的至少一个传感器，适于通过至少一个电极传递第一电信号以刺激神经靶的脉冲发生器，以及适于与至少一个传感器和 与脉冲发生器。 所述控制器适于使用所述至少一个传感器检测睡眠呼吸障碍，并响应于检测到的呼吸暂停事件提供针对睡眠呼吸障碍的治疗。 用于睡眠呼吸紊乱的治疗适于通过至少一个电极传递第一电信号以引起咳嗽反射以终止呼吸暂停事件。 各种实施方案刺激上喉神经，各种实施方案刺激复发性喉神经，并且各种实施方案刺激迷走神经。 本文提供了其它方面和实施例。

公开(公告)号：US20100023082A1

公开(公告)日：2010-01-28

申请号：US12507436

申请日：2009-07-22

申请人： Yanting Dong ,  M. Jason Brooke ,  Dan Li ,  Kevin J. Stalsberg

发明人： Yanting Dong ,  M. Jason Brooke ,  Dan Li ,  Kevin J. Stalsberg

IPC分类号： A61N1/365 ,  A61B5/00

CPC分类号： A61B5/0452 ,  A61B5/0002 ,  A61B5/04525 ,  A61N1/365 ,  A61N1/3702

摘要： An apparatus comprises an implantable sensor, which provides a plurality of physiologic sensor signals of a subject, and a processor. The processor includes a feature module and a detection module. The feature module is configured to identify a feature in the sensor signals and to determine a measure of quality of the feature in the sensor signals. The detection module is configured to perform a morphology analysis of a subsequent portion of at least one of the sensor signals using the feature when the measure of quality of the feature satisfies a quality measure threshold.

摘要翻译： 一种装置包括可植入传感器，其提供对象的多个生理传感器信号和处理器。 处理器包括特征模块和检测模块。 特征模块被配置为识别传感器信号中的特征并且确定传感器信号中的特征的质量的度量。 所述检测模块被配置为当所述特征的质量度量满足质量测量阈值时，使用所述特征来对所述传感器信号中的至少一个的后续部分进行形态分析。

公开(公告)号：US20090043352A1

公开(公告)日：2009-02-12

申请号：US12220496

申请日：2008-07-24

申请人： M. Jason Brooke ,  Andrea E. Acuna

发明人： M. Jason Brooke ,  Andrea E. Acuna

IPC分类号： A61N1/37

CPC分类号： A61N1/3708 ,  A61N1/36185 ,  A61N1/3627 ,  A61N1/3684 ,  A61N1/3686 ,  A61N1/37 ,  A61N1/3706 ,  A61N1/371 ,  A61N1/37211 ,  A61N1/37241 ,  A61N1/3962

摘要： The present invention involves approaches for selecting one or more electrode combinations. Various method embodiments can include implanting a plurality of cardiac electrodes supported by one or more leads in a patient, attaching the one or more leads to a patient external analyzer circuit, delivering electrical stimulation to the patient's heart using the plurality of cardiac electrodes and the analyzer circuit, evaluating, for each electrode combination of a plurality of electrode combinations of the plurality of cardiac electrodes, one or more first parameters and one or more second parameters produced by the electrical stimulation delivered using the electrode combination, the first parameters supportive of cardiac function consistent with a prescribed therapy and the second parameters not supportive of cardiac function consistent with the prescribed therapy, selecting one or more electrode combinations of the plurality of cardiac electrodes based on the evaluation, the one or more electrode combinations selected as being associated with the one or more first parameters and less associated with the one or more second parameters relative to other electrode combinations of the plurality of cardiac electrodes, programming an implantable pacing circuit to deliver a cardiac pacing therapy that preferentially uses the selected one or more electrode combinations relative to other electrode combinations of the plurality of cardiac electrodes, detaching the one or more leads from the analyzer circuit, attaching the one or more leads to the implantable pacing circuit, and implanting the implantable pacing circuit.

摘要翻译： 本发明涉及用于选择一种或多种电极组合的方法。 各种方法实施例可以包括将患者中的一个或多个引线支撑的多个心脏电极植入患者体内，将一个或多个引线附接到患者外部分析器电路，使用多个心脏电极和分析器向患者的心脏输送电刺激 电路，评估多个心电极的多个电极组合的每个电极组合，一个或多个第一参数和通过使用电极组合递送的电刺激产生的一个或多个第二参数，第一参数支持心脏功能 与规定的治疗一致，并且第二参数不支持符合规定治疗的心脏功能，基于评估选择多个心电极的一个或多个电极组合，所选择的一个或多个电极组合与一个 或更多的第一参数 并且与所述多个心电极的其它电极组合相关联的所述一个或多个第二参数较少地相关联，编程可植入起搏电路以递送心脏起搏治疗，所述心脏起搏疗法相对于所述心脏起搏电极的其它电极组合优先使用所选择的一个或多个电极组合 多个心脏电极，从分析器电路分离一个或多个引线，将一个或多个引线附接到可植入起搏电路，以及植入可植入起搏电路。

公开(公告)号：US09031650B2

公开(公告)日：2015-05-12

申请号：US12986762

申请日：2011-01-07

申请人： Aaron R. McCabe ,  Imad Libbus ,  Yi Zhang ,  Paul A. Haefner ,  Alok S. Sathaye ,  Anthony V. Caparso ,  M. Jason Brooke

发明人： Aaron R. McCabe ,  Imad Libbus ,  Yi Zhang ,  Paul A. Haefner ,  Alok S. Sathaye ,  Anthony V. Caparso ,  M. Jason Brooke

IPC分类号： A61N1/365 ,  A61N1/36

CPC分类号： A61N1/36139 ,  A61N1/36114 ,  A61N1/36135 ,  A61N1/365 ,  A61N1/36592 ,  A61N1/3962 ,  A61N1/3987

摘要： Various aspects of the present subject matter relate to a method. According to various method embodiments, cardiac activity is detected, and neural stimulation is synchronized with a reference event in the detected cardiac activity. Neural stimulation is titrated based on a detected response to the neural stimulation. Other aspects and embodiments are provided herein.

摘要翻译： 本主题的各个方面涉及一种方法。 根据各种方法实施例，检测心脏活动，并且神经刺激与检测到的心脏活动中的参考事件同步。 基于对神经刺激的检测反应来滴定神经刺激。 本文提供了其它方面和实施例。