公开(公告)号：US07388012B2

公开(公告)日：2008-06-17

申请号：US11227698

申请日：2005-09-15

申请人： Andrew Crew ,  An-Hu Li ,  Hanqing Dong ,  Tao Zhang

发明人： Andrew Crew ,  An-Hu Li ,  Hanqing Dong ,  Tao Zhang

IPC分类号： A61K31/4709 ,  A61K31/381 ,  A61K31/497 ,  C07D215/14 ,  C07D409/12 ,  C07D333/36 ,  C07D333/38

CPC分类号： C07D409/12 ,  C07D409/14

摘要： Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein A and J are defined herein, are useful in the treatment of tumors and cancers such as mastocytosis/mast cell leukemia, gastrointestinal stromal tumors (GIST), germ cell tumors, small cell lung carcinoma (SCLC), sinonasal natural killer/T-cell lymphoma, testicular cancer (seminoma), thyroid carcinoma, malignant melanoma, ovarian carcinoma, adenoid cystic carcinoma, acute myelogenous leukemia (AML), breast carcinoma, pediatric T-cell acute lymphoblastic leukemia, neuroblastoma, mast cell leukemia, angiosarcoma, anaplastic large cell lymphoma, endometrial carcinoma, and prostate carcinoma.

摘要翻译： 式（I）表示的化合物或其药学上可接受的盐或N-氧化物，其中A和J在本文中定义，可用于治疗肿瘤和癌症如肥大细胞增多症/肥大细胞白血病，胃肠道间质瘤（GIST） ，生殖细胞肿瘤，小细胞肺癌（SCLC），鼻窦自然杀伤/ T细胞淋巴瘤，睾丸癌（精原细胞瘤），甲状腺癌，恶性黑素瘤，卵巢癌，腺样囊性癌，急性骨髓性白血病（AML），乳腺癌 ，儿科T细胞急性淋巴细胞白血病，神经母细胞瘤，肥大细胞白血病，血管肉瘤，间变性大细胞淋巴瘤，子宫内膜癌和前列腺癌。

公开(公告)号：US20060069121A1

公开(公告)日：2006-03-30

申请号：US11227697

申请日：2005-09-15

申请人： Andrew Crew ,  An-Hu Li ,  Bijoy Panicker

发明人： Andrew Crew ,  An-Hu Li ,  Bijoy Panicker

IPC分类号： A61K31/4709 ,  C07D409/14

CPC分类号： C07D409/12 ,  C07D409/14

摘要： Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein A, Q, Y, R1, R2, and R5 are defined herein, are useful in the treatment of tumors and cancers such as mastocytosis/mast cell leukemia, gastrointestinal stromal tumors (GIST), germ cell tumors, small cell lung carcinoma (SCLC), sinonasal natural killer/T-cell lymphoma, testicular cancer (seminoma), thyroid carcinoma, malignant melanoma, ovarian carcinoma, adenoid cystic carcinoma, acute myelogenous leukemia (AML), breast carcinoma, pediatric T-cell acute lymphoblastic leukemia, neuroblastoma, mast cell leukemia, angiosarcoma, anaplastic large cell lymphoma, endometrial carcinoma, and prostate carcinoma.

摘要翻译： 由式（I）表示的化合物：

公开(公告)号：US20060063773A1

公开(公告)日：2006-03-23

申请号：US11227698

申请日：2005-09-15

申请人： Andrew Crew ,  An-Hu Li ,  Hanqing Dong ,  Tao Zhang

发明人： Andrew Crew ,  An-Hu Li ,  Hanqing Dong ,  Tao Zhang

IPC分类号： A61K31/496 ,  A61K31/4709 ,  C07D409/02

CPC分类号： C07D409/12 ,  C07D409/14

摘要： Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein A and J are defined herein, are useful in the treatment of tumors and cancers such as mastocytosis/mast cell leukemia, gastrointestinal stromal tumors (GIST), germ cell tumors, small cell lung carcinoma (SCLC), sinonasal natural killer/T-cell lymphoma, testicular cancer (seminoma), thyroid carcinoma, malignant melanoma, ovarian carcinoma, adenoid cystic carcinoma, acute myelogenous leukemia (AML), breast carcinoma, pediatric T-cell acute lymphoblastic leukemia, neuroblastoma, mast cell leukemia, angiosarcoma, anaplastic large cell lymphoma, endometrial carcinoma, and prostate carcinoma.

摘要翻译： 由式（I）表示的化合物：

公开(公告)号：US20050154014A1

公开(公告)日：2005-07-14

申请号：US10973870

申请日：2004-10-26

申请人： Jason Bloxham ,  Andrew Crew ,  Ayako Honda ,  An-Hu Li ,  Bijoy Panicker ,  Lawrence Tardibono ,  Graham Wynne

发明人： Jason Bloxham ,  Andrew Crew ,  Ayako Honda ,  An-Hu Li ,  Bijoy Panicker ,  Lawrence Tardibono ,  Graham Wynne

IPC分类号： A61K31/381 ,  A61K31/437 ,  A61K31/4436 ,  A61K31/4709 ,  A61K31/4745 ,  A61K45/06 ,  C07D409/12 ,  C07D409/14 ,  C07D471/04 ,  C07D49/02

CPC分类号： A61K31/381 ,  A61K31/437 ,  A61K31/4436 ,  A61K31/4709 ,  A61K31/4745 ,  A61K45/06 ,  C07D409/12 ,  C07D409/14 ,  C07D471/04 ,  A61K2300/00

摘要： Amidoaryl/amidoheteroaryl substituted thiophenes, further substituted with a heteroarylmethylamino group, are useful in the treatment of cancer.

摘要翻译： 进一步被杂芳基甲基氨基取代的酰胺芳基/酰胺基芳基取代的噻吩可用于治疗癌症。