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    Caspase inhibitors and uses thereof
    21.
    发明授权
    Caspase inhibitors and uses thereof 失效
    胱天蛋白酶抑制剂及其用途

    公开(公告)号：US07442790B2

    公开(公告)日：2008-10-28

    申请号：US11770093

    申请日：2007-06-28

    Applicant: Michael Mortimore ,  Andrew Miller ,  John Studley ,  Jean-Damien Charrier

    Inventor： Michael Mortimore ,  Andrew Miller ,  John Studley ,  Jean-Damien Charrier

    IPC: C07J43/00

    CPC classification number: A61K31/55 ,  A61K31/4015 ,  A61K31/403 ,  A61K31/407 ,  A61K31/435 ,  A61K31/45 ,  A61K31/498 ,  A61K31/5025 ,  A61K31/538 ,  A61K31/54 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/389

    Abstract: This invention provides caspase inhibitors of formula I: wherein Z is oxygen or sulfur; R1 is hydrogen, —CHN2, R, CH2OR, CH2SR, or —CH2Y; between R3 and R4 represents a single or double bond; Y is an electronegative leaving group; R2 is CO2H, CH2CO2H, or esters, amides or isosteres thereof; R3is a group capable of fitting into the S2 subsite of a caspase enzyme; R4 is a hydrogen or C1-6 alkyl or R3 and R4 taken together form a ring; Ring A and Ring B are each heterocyclic rings, and R and R5 are as described in the specification. The compounds are effective inhibitors of apoptosis and IL-1β secretion.

    Abstract translation: 本发明提供了式I的半胱天冬酶抑制剂：其中Z是氧或硫; R 1是氢，-CHN 2，R 2，CH 2 OR，CH 2 SR或-CH 2 Y; “img id =”CUSTOM-CHARACTER-00001“he =”2.79mm“wi =”6.35mm“file =”US07442790-20081028-P00001.TIF“alt =”custom character“img-content =”character“img-format R 3和R 4之间的=“tif”/>表示单键或双键; Y是电负离子团; R 2是CO 2 H，CH 2 CO 2 H，或它们的酯，酰胺或等体醇; R 3是能够适应半胱天冬酶的S2亚位点的基团; R 4是氢或C 1-6烷基或R 3和R 4合在一起形成环 ; 环A和环B各自是杂环，R和R 5如说明书中所述。 这些化合物是凋亡和IL-1β分泌的有效抑制剂。

    Hybrid arm index
    23.
    发明申请
    Hybrid arm index 有权
    混合臂指数

    公开(公告)号：US20070078743A1

    公开(公告)日：2007-04-05

    申请号：US11541130

    申请日：2006-09-28

    Applicant: Vikas Shilpiekandula ,  Andrew Miller

    Inventor： Vikas Shilpiekandula ,  Andrew Miller

    IPC: G06Q40/00

    CPC classification number: G06Q40/02 ,  G06Q40/025 ,  G06Q40/06

    Abstract: In at least one aspect, the invention comprises constructing one or more hybrid adjustable rate mortgage aggregates based on one or more of: agency, program, coupon, and origination year; for each of one or more of the aggregates, constructing one or more sub-aggregates based on one or more of: rate-index, capitalization structure, and existence of interest-only feature; mapping pools of adjustable rate mortgages to the aggregates and sub-aggregates; constructing an index based on the mapping; and pricing the index.

    Abstract translation: 在至少一个方面，本发明包括基于以下一个或多个构建一个或多个混合可调整利率抵押汇总：代理，计划，优惠券和发起年份; 对于一个或多个聚合中的每一个，基于以下一个或多个构建一个或多个子聚合：速率指数，大小写结构和仅存在兴趣特征的存在; 将可调利率抵押贷款的汇总图与汇总和子汇总; 基于映射构建索引; 并对该指数进行定价。

    Method and apparatus for isolating cell nuclei from biopsy obtained tissue
    27.
    发明申请
    Method and apparatus for isolating cell nuclei from biopsy obtained tissue 审中-公开
    用于从活组织检查获得的组织中分离细胞核的方法和装置

    公开(公告)号：US20050070944A1

    公开(公告)日：2005-03-31

    申请号：US10847950

    申请日：2004-05-14

    Applicant: Mark Holl ,  Andrew Miller ,  Matthew Stanton ,  Carissa Sanchez ,  Thomas Paulson ,  Brian Reid ,  Deirdre Meldrum

    Inventor： Mark Holl ,  Andrew Miller ,  Matthew Stanton ,  Carissa Sanchez ,  Thomas Paulson ,  Brian Reid ,  Deirdre Meldrum

    IPC: A61B17/14 ,  C12M3/08

    CPC classification number: C12M47/06

    Abstract: A rotor (14) is located within a rotor chamber (12) formed in a housing (24). A drive shaft (16) extends from a motor and couples to the drive shaft interconnect (46) at the center of the rotor (14). One side of the rotor (14) is provided with circumferentially spaced apart radial rows of mincing edges (20). These edges (20) are situated on concentric circles or on a spiral. They are elongated circumferentially and may be situated substantially on an arc and substantially on an arc or on a chord. During use, the rotor (14) is rotated after biopsy obtained tissue (10) has been placed in the rotor chamber (12) on the side of the rotor (14) that includes the mincing edges (20). A fluid is delivered into and out from the rotor chamber (12) as the rotor (14) is being rotated to mince the biopsy, lyse the cells, and release the cell nuclei from the obtained tissue. Cell nuclei are expelled from the chamber (12) and are moved through a filter (58). The cell nuclei are collected and then delivered to a flow cytometry apparatus to be analyzed.

    Abstract translation: 转子（14）位于形成在壳体（24）内的转子室（12）内。 驱动轴（16）从马达延伸并在转子（14）的中心处联接到驱动轴互连（46）。 转子（14）的一侧设置有周向间隔开的排列的切割边缘（20）。 这些边缘（20）位于同心圆或螺旋上。 它们沿周向延伸并且可以基本上位于弧形上并且基本上位于弧形或弦上。 在使用过程中，在活组织检查后，转子（14）在组装（10）被放置在转子室（12）的转子（14）的包括切碎边缘（20）的侧面上后旋转。 当转子（14）旋转时，将流体输送到转子室（12）中并使其流出，从而破坏活组织检查，裂解细胞，并从获得的组织释放细胞核。 细胞核从腔室（12）排出并移动通过过滤器（58）。 收集细胞核，然后送至流式细胞术仪器进行分析。

    Genotyping the human UDP-glucuronosyltransferase 2B7 (UGT2B7) gene
    29.
    发明授权
    Genotyping the human UDP-glucuronosyltransferase 2B7 (UGT2B7) gene 失效
    对人类UDP-葡糖醛酸基转移酶2B7（UGT2B7）基因进行基因分型

    公开(公告)号：US06586175B1

    公开(公告)日：2003-07-01

    申请号：US09356806

    申请日：1999-07-20

    Applicant: Margaret Galvin ,  Andrew Miller ,  Laura Penny ,  Michael Riedy

    Inventor： Margaret Galvin ,  Andrew Miller ,  Laura Penny ,  Michael Riedy

    IPC: C07H2104

    CPC classification number: C12Q1/6883 ,  C12Q2600/156

    Abstract: Genetic polymorphisms are identified in the human UGT2B4, UGT2B7 and UGT2B15 genes that alter UGT2B activity. Nucleic acids comprising the polymorphic sequences are used to screen patients for altered metabolism for UGT2B substrates, potential drug-drug interactions, and adverse/side effects, as well as diseases that result from environmental or occupational exposure to toxins. The nucleic acids are used to establish animal, cell and in vitro models for drug metabolism.

    Abstract translation: 在改变UGT2B活性的人UGT2B4，UGT2B7和UGT2B15基因中鉴定遗传多态性。 包含多态性序列的核酸用于筛选患者UGT2B底物改变的代谢，潜在的药物 - 药物相互作用以及不良/副作用，以及由环境或职业暴露于毒素引起的疾病。 核酸用于建立用于药物代谢的动物，细胞和体外模型。

    Plastic card transport apparatus and inspection system
    30.
    发明授权
    Plastic card transport apparatus and inspection system 失效
    塑胶卡运输仪器和检验系统

    公开(公告)号：US6131817A

    公开(公告)日：2000-10-17

    申请号：US168856

    申请日：1998-10-09

    Applicant: Andrew Miller

    Inventor： Andrew Miller

    IPC: G06K13/07 ,  G06K13/00

    CPC classification number: G06K13/07

    Abstract: A plastic card transport apparatus and a plastic card inspection system. A group of lower support wheels is positioned with their circumferential surfaces aligned to define a card transport path having a plurality of card operation locations therealong. The wheels support a plastic card by its lower edge as the plastic card is transported along the card transport path from a first one of the card operation locations to a second one of the card operation locations. A drive source continuously drives selected ones of the lower support wheels to move the plastic card along the card transport path between card operation locations. A controller is responsive to a control signal to drive a selected one of the lower support wheel members, adjacent a first one of the card operation locations, to move the plastic card along the card transport path from that first one of the card operation locations to an adjacent one of the continuously driven lower support wheels, to transport the plastic card to a second one of the card operation locations. The plastic card inspection system includes such a plastic card transport apparatus to transport the plastic cards from a plastic card input location to a plastic card inspection location for inspection, and then to a plastic card output location selected on the basis of the inspection results. The cards are discharged to a tray having a fiber material on its side surfaces to align the cards as they are discharged.

    Abstract translation: 塑料卡运输设备和塑料卡检查系统。 一组下支撑轮定位成其周向表面对齐以限定其上具有多个卡操作位置的卡传送路径。 当塑料卡沿着卡传送路径从卡操作位置中的第一个传送到卡操作位置的第二个时，轮由其下边缘支撑塑料卡。 驱动源连续地驱动下支撑轮中的选定的一个以沿着卡操作位置之间的卡传送路径移动塑料卡。 控制器响应于控制信号来驱动与所述卡操作位置中的第一个相邻的所述下支撑轮构件中的所选择的一个，以将所述塑料卡沿着所述卡传送路径从所述卡操作位置中的所述一个操作位置移动到 连续驱动的下支撑轮中的相邻一个，以将塑料卡传送到卡操作位置中的第二个。 塑料卡检查系统包括这样的塑料卡运输装置，用于将塑料卡从塑料卡输入位置运输到塑料卡检查位置进行检查，然后根据检查结果选择塑料卡输出位置。 卡在其侧表面上被排出到具有纤维材料的托盘，以便在排出卡时对准卡。

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