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    Substitued [1,2,4]triazolo[1,5-a]pyrazines as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
    23.
    发明授权
    Substitued [1,2,4]triazolo[1,5-a]pyrazines as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes 有权
    取代的[1,2,4]三唑并[1,5-a]吡嗪作为二肽基肽酶-IV抑制剂用于治疗或预防糖尿病

    公开(公告)号：US07812027B2

    公开(公告)日：2010-10-12

    申请号：US12226584

    申请日：2007-05-11

    申请人： Tesfaye Biftu ,  Ping Chen ,  Danqing Feng ,  Ann E. Weber

    发明人： Tesfaye Biftu ,  Ping Chen ,  Danqing Feng ,  Ann E. Weber

    IPC分类号： A61K31/50

    CPC分类号： C07D487/04 ,  C07D471/04

    摘要： The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

    摘要翻译： 本发明涉及结构式I的新型取代的氨基四氢吡喃，其是二肽基肽酶-IV酶的抑制剂，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如糖尿病，特别是 2型糖尿病 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

    Aminotetrahydropyrans as Dipeptidyl Peptidase-IV Inhibitors for the Treatment or Prevention of Diabetes
    24.
    发明申请
    Aminotetrahydropyrans as Dipeptidyl Peptidase-IV Inhibitors for the Treatment or Prevention of Diabetes 有权
    氨基四氢吡喃作为二肽基肽酶-IV抑制剂用于治疗或预防糖尿病

    公开(公告)号：US20090209544A1

    公开(公告)日：2009-08-20

    申请号：US12226584

    申请日：2007-05-11

    申请人： Tesfaye Biftu ,  Ping Chen ,  Danqing Feng ,  Ann E. Weber

    发明人： Tesfaye Biftu ,  Ping Chen ,  Danqing Feng ,  Ann E. Weber

    IPC分类号： A61K31/4985 ,  A61K31/519 ,  A61K31/437 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  A61P3/10

    CPC分类号： C07D487/04 ,  C07D471/04

    摘要： The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

    摘要翻译： 本发明涉及结构式I的新型取代的氨基四氢吡喃，其是二肽基肽酶-IV酶的抑制剂，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如糖尿病，特别是 2型糖尿病 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

    Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
    25.
    发明申请
    Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes 有权
    氨基四氢吡喃作为二肽基肽酶-IV抑制剂用于治疗或预防糖尿病

    公开(公告)号：US20070232676A1

    公开(公告)日：2007-10-04

    申请号：US11728673

    申请日：2007-03-27

    申请人： Tesfaye Biftu ,  Ann E. Weber

    发明人： Tesfaye Biftu ,  Ann E. Weber

    IPC分类号： A01N43/56

    CPC分类号： C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04

    摘要： The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

    摘要翻译： 本发明涉及结构式I的新型取代的氨基四氢吡喃，其是二肽基肽酶-IV酶的抑制剂，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如糖尿病，特别是 2型糖尿病 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

    Antiprotozoal imidazopyridine compounds
    29.
    发明申请
    Antiprotozoal imidazopyridine compounds 有权
    抗原虫咪唑并吡啶化合物

    公开(公告)号：US20060293303A1

    公开(公告)日：2006-12-28

    申请号：US10573363

    申请日：2004-12-06

    申请人： Tesfaye Biftu ,  Matthew Wyvratt ,  Michael Fisher

    发明人： Tesfaye Biftu ,  Matthew Wyvratt ,  Michael Fisher

    IPC分类号： A61K31/506 ,  C07D471/04

    CPC分类号： C07D471/04

    摘要： Compounds described by the Formula (I) or (II): or pharmaceutically acceptable salts, or N-oxides thereof. The compounds are useful for the treatment and prevention of protozoal diseases in mammals and birds. A method for controlling coccidiosis in poultry comprises administering an effective amount of the compound alone, or in combination with one or more anticoccidieal agent(s). A composition for controlling coccidiosis in poultry comprises the compound alone, or in combination with one or more anticoccidial agent(s). Methods for the treatment and prevention of mammalian protozoal diseases, such as, for example, toxoplasmosis, malaria. African typanosomiasis, Chagas disease, and opportunistic infections comprise administering the compound alone, or in combination with one or more antiprotozoal agent(s).

    摘要翻译： 由式（I）或（II）表示的化合物：或其药学上可接受的盐或N-氧化物。 该化合物可用于治疗和预防哺乳动物和鸟类中的原生动物疾病。 用于控制家禽中球虫病的方法包括单独施用有效量的化合物，或与一种或多种抗球虫剂组合施用。 用于控制家禽中球虫病的组合物包含单独的化合物，或与一种或多种抗球虫剂组合。 用于治疗和预防哺乳动物原生动物疾病的方法，例如弓形体病，疟疾。 非洲typanosomias，恰加斯病和机会性感染包括单独施用化合物，或与一种或多种抗原虫剂组合施用。

    Antiprotozoal imidazopyridine compounds
    30.
    发明申请
    Antiprotozoal imidazopyridine compounds 有权

    公开(公告)号：US20060178358A1

    公开(公告)日：2006-08-10

    申请号：US10548154

    申请日：2004-03-02

    申请人： Matthew Wyvratt ,  Tesfaye Biftu ,  Michael Fisher ,  Dennis Schmatz

    发明人： Matthew Wyvratt ,  Tesfaye Biftu ,  Michael Fisher ,  Dennis Schmatz

    IPC分类号： A61K31/506 ,  C07D471/04

    CPC分类号： C07D471/04 ,  C07D519/00

    摘要： Compounds described by the Formula (I): (I) or pharmaceutically acceptable salts, or N-oxides thereof. The compounds are useful for the treatment and prevention of protozoal diseases in mammals and birds. A method for controlling coccidiosis in poultry comprises administering an effective amount of the compound alone, or in combination with one or more anticoccidial agent(s). A composition for controlling coccidiosis in poultry comprises the compound alone, or in combination with one or more anticoccidial agent(s). Methods for the treatment and prevention of mammalian protozoal diseases, such as, for example, toxoplasmosis, malaria, African trypanosomiasis, Chagas disease, and opportunistic infections comprise administering the compound alone, or in combination with one or more antiprotozoal agent(s).