公开(公告)号：US20060293303A1

公开(公告)日：2006-12-28

申请号：US10573363

申请日：2004-12-06

申请人： Tesfaye Biftu ,  Matthew Wyvratt ,  Michael Fisher

发明人： Tesfaye Biftu ,  Matthew Wyvratt ,  Michael Fisher

IPC分类号： A61K31/506 ,  C07D471/04

CPC分类号： C07D471/04

摘要： Compounds described by the Formula (I) or (II): or pharmaceutically acceptable salts, or N-oxides thereof. The compounds are useful for the treatment and prevention of protozoal diseases in mammals and birds. A method for controlling coccidiosis in poultry comprises administering an effective amount of the compound alone, or in combination with one or more anticoccidieal agent(s). A composition for controlling coccidiosis in poultry comprises the compound alone, or in combination with one or more anticoccidial agent(s). Methods for the treatment and prevention of mammalian protozoal diseases, such as, for example, toxoplasmosis, malaria. African typanosomiasis, Chagas disease, and opportunistic infections comprise administering the compound alone, or in combination with one or more antiprotozoal agent(s).

摘要翻译： 由式（I）或（II）表示的化合物：或其药学上可接受的盐或N-氧化物。 该化合物可用于治疗和预防哺乳动物和鸟类中的原生动物疾病。 用于控制家禽中球虫病的方法包括单独施用有效量的化合物，或与一种或多种抗球虫剂组合施用。 用于控制家禽中球虫病的组合物包含单独的化合物，或与一种或多种抗球虫剂组合。 用于治疗和预防哺乳动物原生动物疾病的方法，例如弓形体病，疟疾。 非洲typanosomias，恰加斯病和机会性感染包括单独施用化合物，或与一种或多种抗原虫剂组合施用。

公开(公告)号：US20060178358A1

公开(公告)日：2006-08-10

申请号：US10548154

申请日：2004-03-02

申请人： Matthew Wyvratt ,  Tesfaye Biftu ,  Michael Fisher ,  Dennis Schmatz

发明人： Matthew Wyvratt ,  Tesfaye Biftu ,  Michael Fisher ,  Dennis Schmatz

IPC分类号： A61K31/506 ,  C07D471/04

CPC分类号： C07D471/04 ,  C07D519/00

摘要： Compounds described by the Formula (I): (I) or pharmaceutically acceptable salts, or N-oxides thereof. The compounds are useful for the treatment and prevention of protozoal diseases in mammals and birds. A method for controlling coccidiosis in poultry comprises administering an effective amount of the compound alone, or in combination with one or more anticoccidial agent(s). A composition for controlling coccidiosis in poultry comprises the compound alone, or in combination with one or more anticoccidial agent(s). Methods for the treatment and prevention of mammalian protozoal diseases, such as, for example, toxoplasmosis, malaria, African trypanosomiasis, Chagas disease, and opportunistic infections comprise administering the compound alone, or in combination with one or more antiprotozoal agent(s).

公开(公告)号：US11142737B2

公开(公告)日：2021-10-12

申请号：US13402074

申请日：2012-02-22

申请人： Colin Tuohey ,  Thomas Erdenberger ,  Richard Damren ,  Michael Fisher ,  John Swibes

发明人： Colin Tuohey ,  Thomas Erdenberger ,  Richard Damren ,  Michael Fisher ,  John Swibes

IPC分类号： C12M1/12 ,  C12M1/00

摘要： Disclosed herein is a single use continuous recovery, flow-through harvest vessel and corresponding method for harvesting culture medium and simultaneously either leaving the microcarrier beads behind in the vessel or flowing microcarrier beads and medium back into a bioreactor.

公开(公告)号：US09127242B2

公开(公告)日：2015-09-08

申请号：US13262155

申请日：2010-04-05

申请人： Patrick M. Guertin ,  Parrish M. Galliher ,  Michael Fisher ,  Joseph D. Crowell ,  Colin R. Tuohey ,  Laura A. Niklason ,  William E. Tente ,  Shannon M. Dahl ,  Juliana Blum ,  Justin Strader

发明人： Patrick M. Guertin ,  Parrish M. Galliher ,  Michael Fisher ,  Joseph D. Crowell ,  Colin R. Tuohey ,  Laura A. Niklason ,  William E. Tente ,  Shannon M. Dahl ,  Juliana Blum ,  Justin Strader

IPC分类号： C12M1/00 ,  C12M3/00 ,  A01N1/00 ,  C12M1/02 ,  C12M1/12

CPC分类号： C12M27/00 ,  C12M21/08 ,  C12M23/14 ,  C12M23/28 ,  C12M25/14 ,  C12M29/06

摘要： A single-use, single or multiple tissue, organ, and graft bioreactor and environmental control system is designed to replicate the necessary conditions for growth of tissues, organs, or grafts, while addressing problems in scaling up the tissue growth; adaptation to a single-use or disposable format; and operation as a stand-alone unit that provides full environmental control of cell culture conditions.

摘要翻译： 单次使用，单次或多次组织，器官和移植物生物反应器和环境控制系统被设计为复制组织，器官或移植物生长所必需的条件，同时解决扩大组织生长的问题; 适应一次性或一次性格式; 作为提供细胞培养条件的全面环境控制的独立单元的操作。

公开(公告)号：US08900307B2

公开(公告)日：2014-12-02

申请号：US11768636

申请日：2007-06-26

申请人： John Riley Hawkins ,  Anwar Upal ,  Michael J. O'Neil ,  Michael Andrew Slivka ,  Michael Fisher

发明人： John Riley Hawkins ,  Anwar Upal ,  Michael J. O'Neil ,  Michael Andrew Slivka ,  Michael Fisher

IPC分类号： A61F2/44 ,  A61F2/30 ,  A61F2/46

CPC分类号： A61F2/447 ,  A61F2/30744 ,  A61F2/30771 ,  A61F2/30965 ,  A61F2/442 ,  A61F2/4455 ,  A61F2/4611 ,  A61F2002/30062 ,  A61F2002/3008 ,  A61F2002/30331 ,  A61F2002/3038 ,  A61F2002/30387 ,  A61F2002/30403 ,  A61F2002/30438 ,  A61F2002/30448 ,  A61F2002/30457 ,  A61F2002/30481 ,  A61F2002/30579 ,  A61F2002/30604 ,  A61F2002/30685 ,  A61F2002/30841 ,  A61F2002/30904 ,  A61F2002/3093 ,  A61F2002/30975 ,  A61F2002/4475 ,  A61F2002/448 ,  A61F2002/4627 ,  A61F2002/4629 ,  A61F2210/0004 ,  A61F2220/0016 ,  A61F2220/0025 ,  A61F2220/0033 ,  A61F2250/0098 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00059 ,  A61F2310/00161 ,  A61F2310/00203 ,  A61F2310/00239

摘要： A two-piece fusion cage having ramped interior surfaces. One advantage of such a cage is its easy insertion. In a first step, the lower component is inserted into the disc space and is held in place. The first step confirms placement of the implant and its footprint. In a second step, the upper component is inserted into the disc space by sliding its interior surface along the opposed interior surface of the lower component. This two-step method of insertion eliminates the need to provide an independent distraction means.

摘要翻译： 具有斜面内表面的两片式融合笼。 这种笼子的一个优点是易于插入。 在第一步骤中，将下部部件插入盘片空间并保持就位。 第一步确认植入物的位置及其占地面积。 在第二步骤中，通过沿着下部部件的相对的内表面滑动其内表面，将上部部件插入到盘形空间中。 这种两步插入方法消除了提供独立牵引方式的需要。

公开(公告)号：USD716944S1

公开(公告)日：2014-11-04

申请号：US29398735

申请日：2011-08-03

申请人： Michael Fisher ,  Barjinder Chana

设计人： Michael Fisher ,  Barjinder Chana

公开(公告)号：US08758355B2

公开(公告)日：2014-06-24

申请号：US13619227

申请日：2012-09-14

申请人： Michael Fisher ,  Anthony K. Hedley ,  Michael Howard ,  Kevin M. Cordes ,  Toshinobu Katsuya

发明人： Michael Fisher ,  Anthony K. Hedley ,  Michael Howard ,  Kevin M. Cordes ,  Toshinobu Katsuya

IPC分类号： A61B17/17 ,  A61B17/56 ,  A61B17/90

CPC分类号： A61F2/4657 ,  A61B17/1626 ,  A61B17/1675 ,  A61B34/30 ,  A61F2/38 ,  A61F2/3859 ,  A61F2/4684 ,  A61F2002/4666

摘要： A device for performing a surgical procedure on a knee includes an adjustable femoral portion, a tibial portion and at least one sensor coupled with the femoral and/or tibial portions to sense pressure exerted by the a moral and tibial portions against one another. The femoral portion is adapted for removably coupling with a distal end of a femur to adjust tension in soft tissue adjacent the knee and has at least one positioning feature adapted to move relative to the distal end of the femur as the femoral portion is adjusted, thus helping position a femoral prosthetic on the distal end of the femur. The sensor(s) may be adapted to sense pressure at medial and lateral sides of the knee, and relative pressures may be displayed as data on a visual display. Adjustments to the femoral member may be made to balance pressure at flexion and extension of the knee.

公开(公告)号：US08726146B2

公开(公告)日：2014-05-13

申请号：US12101650

申请日：2008-04-11

申请人： Michael Fisher

发明人： Michael Fisher

IPC分类号： G06F17/00

CPC分类号： G06F17/2235 ,  G06F17/30864 ,  G06Q30/0277

摘要： Methods and apparatus are disclosed to identify and associate video content. In one implementation, a method is provided that includes requesting a webpage by a user computer and determining whether a keyword is present on the webpage requested by the user computer. Furthermore, the method includes creating a link on the webpage from the keyword to the video file and displaying the video file when the link is activated.

摘要翻译： 公开了识别和关联视频内容的方法和装置。 在一个实现中，提供了一种方法，其包括由用户计算机请求网页并确定关键字是否存在于用户计算机请求的网页上。 此外，该方法包括在关键字到视频文件的网页上创建链接，并且在链接被激活时显示视频文件。

公开(公告)号：US20130008554A1

公开(公告)日：2013-01-10

申请号：US13635755

申请日：2011-03-17

申请人： Michael Fisher ,  Alan Brown

发明人： Michael Fisher ,  Alan Brown

IPC分类号： D03D23/00 ,  B32B5/16 ,  D03D49/50 ,  D03D25/00

CPC分类号： D03D15/12 ,  A41D31/08 ,  D10B2403/0114 ,  Y10T428/249921

摘要： A fabric may be used in high visibility personal protection clothing. The yarn is capable of being dyed to a high visibility color and a non-fusible yarn are combined in a single fabric so as to provide a fabric which not only has heat and flame resistance but can also be dyed to high visibility colors. In particular, the fabric includes a flame retardant dyeable yarn and a non-fusible fibre yarn, wherein the yarns form a double faced fabric. The fabric may be a double faced weave wherein the flame retardant yarn is a flame retardant polyester and the non-fusible yarn is an aramid yarn.

摘要翻译： 织物可用于高能见度的个人防护服。 该纱线能够被染色成高可见度的颜色，并且将不可熔纱线组合在单个织物中，以便提供不仅具有耐热性和阻燃性，而且可以染色成高可见度颜色的织物。 特别地，织物包括阻燃染色纱线和不可熔纤维纱线，其中纱线形成双面织物。 织物可以是双面织物，其中阻燃纱线是阻燃聚酯，不可熔纱线是芳族聚酰胺纱线。

公开(公告)号：US08298054B2

公开(公告)日：2012-10-30

申请号：US11050133

申请日：2005-02-03

申请人： Geoffrey Hodge ,  Parrish Galliher ,  Michael Fisher

发明人： Geoffrey Hodge ,  Parrish Galliher ,  Michael Fisher

IPC分类号： F24F7/00 ,  B01L1/04

CPC分类号： G05D27/02 ,  G05B15/02 ,  G05B19/41865 ,  G05B2219/31075 ,  G05B2219/32287 ,  Y02P90/04 ,  Y02P90/14 ,  Y02P90/16 ,  Y02P90/185 ,  Y02P90/20

摘要： Embodiments of the present invention are directed to a customizable bio-manufacturing system which includes a manufacturing space having a first air handling system for providing supply air and a second air handling system for handling exhaust air, the supply air system being optionally provided with at least one of filtration, heating, cooling and or humidity control and a plurality of portable modules provided within the manufacturing space. At least one module having an interior capable of being interconnected with another module interior and each module's interior includes one or more components to perform at least one specific task of a biological, chemical, and/or pharmaceutical manufacturing process. At least one module includes an on-board environmental control system for controlling an environment within the module and a connection means for interconnecting the module interior with another module interior. The system also includes a central controller operating to at least perform one or more of operation and information collection for the operation of at least one of the system and one or more modules.

摘要翻译： 本发明的实施例涉及一种可定制的生物制造系统，其包括具有用于提供供应空气的第一空气处理系统和用于处理排气的第二空气处理系统的制造空间，供应空气系统可选地至少设置 过滤，加热，冷却和/或湿度控制之一以及设置在制造空间内的多个便携式模块。 至少一个模块具有能够与另一个模块内部互连的内部，并且每个模块的内部包括执行生物，化学和/或药物制造过程的至少一个特定任务的一个或多个组件。 至少一个模块包括用于控制模块内的环境的车载环境控制系统和用于将模块内部与另一个模块内部互连的连接装置。 该系统还包括中央控制器，其操作以至少执行用于系统和一个或多个模块中的至少一个的操作的操作和信息收集中的一个或多个。