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21.发明授权公开(公告)号：US08716448B2
公开(公告)日：2014-05-06
申请号：US12806005
申请日：2010-08-02
申请人： Volker Schellenberger , Joshua Silverman , Willem Stemmer , Chia-wei Wang , Benjamin Spink , Nathan Geething , Wayne To
发明人： Volker Schellenberger , Joshua Silverman , Willem Stemmer , Chia-wei Wang , Benjamin Spink , Nathan Geething , Wayne To
IPC分类号： A61K38/36 , C07K14/745
CPC分类号： C12N9/644 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N9/6437 , C12N15/70 , C12Y304/21022
摘要： The present invention relates to compositions comprising factor VII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子VII凝血因子的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及制备和使用这些组合物治疗凝血因子相关的方法 疾病，病症和状况。
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公开(公告)号：US20130039884A1
公开(公告)日：2013-02-14
申请号：US13469902
申请日：2012-05-11
申请人： Oren Bogin , Willem P. Stemmer , Volker Schellenberger , Yong Yin , Chia-wei Wang , Nathan C. Geething
发明人： Oren Bogin , Willem P. Stemmer , Volker Schellenberger , Yong Yin , Chia-wei Wang , Nathan C. Geething
IPC分类号： A61K39/395
CPC分类号： C07K16/30 , A61K38/00 , C07K14/00 , C07K14/535 , C07K14/56 , C07K14/61 , C07K16/2863 , C07K16/32 , C07K16/40 , C07K2317/22 , C07K2317/55 , C07K2317/569 , C07K2317/622 , C07K2317/626 , C07K2319/00 , C07K2319/33
摘要： The present invention relates to biologically active polypeptides linked to one or more accessory polypeptides. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
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公开(公告)号：US20120107314A1
公开(公告)日：2012-05-03
申请号：US13287642
申请日：2011-11-02
IPC分类号： A61K39/395 , C07H21/04
CPC分类号： C07K16/3007 , A61K2039/505 , C07K2317/622 , C07K2319/00
摘要： The present invention relates to CAB molecules, ADEPT constructs directed against CEA, and their use in therapy.
摘要翻译： 本发明涉及CAB分子，针对CEA的ADEPT构建体及其在治疗中的用途。
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24.发明申请BIFUNCTIONAL POLYPEPTIDE COMPOSITIONS AND METHODS FOR TREATMENT OF METABOLIC AND CARDIOVASCULAR DISEASES 审中-公开双功能多肽组合物和治疗代谢性和心脏血管疾病的方法公开(公告)号：US20110312881A1
公开(公告)日：2011-12-22
申请号：US12975054
申请日：2010-12-21
IPC分类号： A61K38/16 , C12N1/19 , C12N1/21 , C12N1/15 , C12N15/63 , C07H21/04 , A61P5/50 , A61P3/10 , A61P9/00 , A61P25/28 , C07K14/00 , C12N5/10 , A61P3/04
CPC分类号： C07K19/00 , C07K2319/00
摘要： The present invention relates to compositions comprising combinations of biologically active proteins linked to extended recombinant polymer, methods of production of the compositions and their use in treatment of metabolic and cardiovascular diseases, disorders and conditions.
摘要翻译： 本发明涉及包含与延伸的重组聚合物连接的生物活性蛋白质的组合的组合物，组合物的生产方法及其在治疗代谢和心血管疾病，病症和病症中的用途。
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25.发明授权公开(公告)号：US07846445B2
公开(公告)日：2010-12-07
申请号：US11715296
申请日：2007-03-06
申请人： Volker Schellenberger , Willem P. Stemmer , Chia-wei Wang , Michael D. Scholle , Mikhail Popkov , Nathaniel C. Gordon , Andreas Crameri
发明人： Volker Schellenberger , Willem P. Stemmer , Chia-wei Wang , Michael D. Scholle , Mikhail Popkov , Nathaniel C. Gordon , Andreas Crameri
CPC分类号： C07K14/415 , A61K38/00 , C07K14/001 , C07K14/475 , C07K2319/21 , C07K2319/43 , C12N15/1044 , C12N2795/14011 , G01N33/68 , G01N33/6845
摘要： The present invention provides methods of using unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities, and the uses thereof. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
摘要翻译： 本发明提供了使用非结构化重组聚合物（URP）和含有一种或多种URP的蛋白质的方法。 本发明还提供微蛋白，毒素和其它相关的蛋白质实体，以及显示这些实体的遗传包装及其用途。 本发明还提供重组多肽，包括编码受试蛋白质实体的载体，以及包含载体的宿主细胞。 主题组合物具有各种实用性，包括一系列药物应用。
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公开(公告)号：US20060199222A1
公开(公告)日：2006-09-07
申请号：US11215675
申请日：2005-08-30
CPC分类号： C12N15/902 , C12N15/102 , C12N15/90
摘要： The present invention provides methods for building DNA constructs in vitro, transforming such constructs into competent Bacillus strains with good efficiency, and generating populations of mutants. Also provided is a method to assemble DNA constructs in situ.
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公开(公告)号：US20050244395A1
公开(公告)日：2005-11-03
申请号：US11008049
申请日：2004-12-09
CPC分类号： B82Y5/00 , A61K38/00 , A61K47/67 , A61K47/6891 , A61K48/00 , C07K2319/00 , C12N9/00 , C12N9/50 , C12N9/86
摘要： The present invention provides targeted enzymes that bind to targets better than the corresponding pre-targeted enzymes bind the target under like conditions, methods of making targeted enzymes, methods of using targeted enzymes to treat diseases, and pharmaceutical compositions comprising targeted enzymes.
摘要翻译： 本发明提供了靶向酶，其比相同的预靶向酶更好地结合靶，在相似条件下与目标酶结合，制备靶向酶的方法，使用靶向酶治疗疾病的方法，以及包含靶向酶的药物组合物。
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公开(公告)号：US06436632B1
公开(公告)日：2002-08-20
申请号：US09970578
申请日：2001-10-04
IPC分类号： C12Q100
摘要： A method for holding samples for analysis and an apparatus thereof includes a testing plate with a pair of opposing surfaces and a plurality of holes. Each of the holes extends from one of the opposing surfaces to the other one of the opposing surfaces. The holes are arranged in groups, where each group has at least two rows and two columns of holes. The groups are arranged in sets, where each set has at least two rows and two columns of groups. To analyze samples, at least one of the opposing surfaces of the testing plate is immersed in a solution to be analyzed. A portion of the solution enters openings for each of the holes in the immersed opposing surface. Once the holes are filled with solution, the testing plate is removed and is held above a supporting surface. Surface tension holds the solution in each of the holes. The solution in one or more of the holes is then analyzed and the solution in one of these holes is identified for further study. The location of the identified solution is marked based upon its location within a particular set and group of holes.
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公开(公告)号：US08933197B2
公开(公告)日：2015-01-13
申请号：US12228859
申请日：2008-08-15
CPC分类号： C07K16/30 , A61K38/00 , C07K14/00 , C07K14/535 , C07K14/56 , C07K14/61 , C07K16/2863 , C07K16/32 , C07K16/40 , C07K2317/22 , C07K2317/55 , C07K2317/569 , C07K2317/622 , C07K2317/626 , C07K2319/00 , C07K2319/33
摘要： The present invention relates to biologically active polypeptides linked to one or more accessory polypeptides. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
摘要翻译： 本发明涉及与一种或多种辅助多肽连接的生物活性多肽。 本发明还提供重组多肽，包括编码受试蛋白质实体的载体，以及包含载体的宿主细胞。 主题组合物具有各种实用性，包括一系列药物应用。
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公开(公告)号：US08673860B2
公开(公告)日：2014-03-18
申请号：US12699761
申请日：2010-02-03
申请人： Volker Schellenberger , Joshua Silverman , Chia-wel Wang , Benjamin Spink , Willem P. Stemmer , Nathan C. Geething , Wayne To , Jeffrey L. Cleland
发明人： Volker Schellenberger , Joshua Silverman , Chia-wel Wang , Benjamin Spink , Willem P. Stemmer , Nathan C. Geething , Wayne To , Jeffrey L. Cleland
IPC分类号： A61K38/16
CPC分类号： C07K14/47 , C07K14/001 , C07K14/545 , C07K14/605 , C07K14/61 , C07K14/745 , C07K2319/31 , C07K2319/35 , C12N9/6437 , C12N9/644
摘要： The present invention relates to compositions comprising biologically active proteins linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of glucose-related diseases, metabolic diseases, coagulation disorders, and growth hormone-related disorders and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的生物活性蛋白质的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及使用这些组合物治疗葡萄糖相关疾病，代谢疾病 ，凝血障碍和生长激素相关的疾病和病症。
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