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1.发明授权公开(公告)号：US08716448B2
公开(公告)日：2014-05-06
申请号：US12806005
申请日：2010-08-02
申请人： Volker Schellenberger , Joshua Silverman , Willem Stemmer , Chia-wei Wang , Benjamin Spink , Nathan Geething , Wayne To
发明人： Volker Schellenberger , Joshua Silverman , Willem Stemmer , Chia-wei Wang , Benjamin Spink , Nathan Geething , Wayne To
IPC分类号： A61K38/36 , C07K14/745
CPC分类号： C12N9/644 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N9/6437 , C12N15/70 , C12Y304/21022
摘要： The present invention relates to compositions comprising factor VII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子VII凝血因子的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及制备和使用这些组合物治疗凝血因子相关的方法 疾病，病症和状况。
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2.发明申请公开(公告)号：US20110046060A1
公开(公告)日：2011-02-24
申请号：US12806004
申请日：2010-08-02
申请人： Volker Schellenberger , Joshua Silverman , Willem Stemmer , Chia-wei Wang , Benjamin Spink , Nathan Geething , Wayne To
发明人： Volker Schellenberger , Joshua Silverman , Willem Stemmer , Chia-wei Wang , Benjamin Spink , Nathan Geething , Wayne To
IPC分类号： A61K38/36 , C07K14/745 , A61P7/04
CPC分类号： C12N9/644 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N9/6437 , C12N15/70 , C12Y304/21022
摘要： The present invention relates to compositions comprising factor IX coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子IX凝血因子的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及制备和使用这些组合物治疗凝血因子相关的方法 疾病，病症和状况。
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3.发明申请公开(公告)号：US20110046061A1
公开(公告)日：2011-02-24
申请号：US12806005
申请日：2010-08-02
申请人： Volker Schellenberger , Joshua Silverman , Willem Stemmer , Chia-wei Wang , Benjamin Spink , Nathan Geething , Wayne To
发明人： Volker Schellenberger , Joshua Silverman , Willem Stemmer , Chia-wei Wang , Benjamin Spink , Nathan Geething , Wayne To
CPC分类号： C12N9/644 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N9/6437 , C12N15/70 , C12Y304/21022
摘要： The present invention relates to compositions comprising factor VII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子VII凝血因子的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及制备和使用这些组合物治疗凝血因子相关的方法 疾病，病症和状况。
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公开(公告)号：US20080039341A1
公开(公告)日：2008-02-14
申请号：US11715276
申请日：2007-03-06
申请人： Volker Schellenberger , Willem Stemmer , Chia-wei Wang , Michael Scholle , Mikhail Popkov , Nathaniel Gordon , Andreas Crameri
发明人： Volker Schellenberger , Willem Stemmer , Chia-wei Wang , Michael Scholle , Mikhail Popkov , Nathaniel Gordon , Andreas Crameri
CPC分类号： C07K14/56 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/001 , C07K14/415 , C07K14/47 , C07K14/53 , C07K14/535 , C07K14/61 , C07K2319/31 , C07K2319/35 , C12N15/1044 , G01N33/6845
摘要： The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
摘要翻译： 本发明提供非结构化重组聚合物（URP）和含有一种或多种URP的蛋白质。 本发明还提供微蛋白，毒素和其它相关的蛋白质实体，以及显示这些实体的遗传包。 本发明还提供重组多肽，包括编码受试蛋白质实体的载体，以及包含载体的宿主细胞。 主题组合物具有各种实用性，包括一系列药物应用。
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公开(公告)号：US20070212703A1
公开(公告)日：2007-09-13
申请号：US11528950
申请日：2006-09-27
CPC分类号： G01N33/6845 , C07K14/001 , C07K14/415 , C12N15/1044
摘要： The present invention provides cysteine-containing scaffolds and/or proteins, expression vectors, host cell and display systems harboring and/or expressing such cysteine-containing products. The present invention also provides methods of designing libraries of such products, methods of screening such libraries to yield entities exhibiting binding specificities towards a taraget molecule. Further provided by the invention are pharmaceutical compositions comprising the cysteine-containing products of the present invention.
摘要翻译： 本发明提供含半胱氨酸的支架和/或蛋白质，表达载体，宿主细胞和含有和/或表达这种含半胱氨酸的产品的显示系统。 本发明还提供了设计此类产品的文库的方法，筛选此类文库以产生显示针对taraget分子的结合特异性的实体的方法。 本发明进一步提供的是包含本发明的含半胱氨酸的产品的药物组合物。
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公开(公告)号：US20070191272A1
公开(公告)日：2007-08-16
申请号：US11528927
申请日：2006-09-27
CPC分类号： G01N33/6845 , C07K14/001 , C07K14/415 , C12N15/1044
摘要： The present invention provides cysteine-containing scaffolds and/or proteins, expression vectors, host cell and display systems harboring and/or expressing such cysteine-containing products. The present invention also provides methods of designing libraries of such products, methods of screening such libraries to yield entities exhibiting binding specificities towards a target molecule. Further provided by the invention are pharmaceutical compositions comprising the cysteine-containing products of the present invention.
摘要翻译： 本发明提供含半胱氨酸的支架和/或蛋白质，表达载体，宿主细胞和含有和/或表达这种含半胱氨酸的产品的显示系统。 本发明还提供了设计这样的产物的文库的方法，筛选这些文库以产生显示针对目标分子的结合特异性的实体的方法。 本发明进一步提供的是包含本发明的含半胱氨酸的产品的药物组合物。
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公开(公告)号：US20060177831A1
公开(公告)日：2006-08-10
申请号：US11155989
申请日：2005-06-17
申请人： Willem Stemmer , D. Perlroth , Sanjeev Satyal , Benjamin Alba , Alice Bakker , Amy Duguay , Qiang Liu , Joshua Silverman , Richard Smith , Candace Swimmer
发明人： Willem Stemmer , D. Perlroth , Sanjeev Satyal , Benjamin Alba , Alice Bakker , Amy Duguay , Qiang Liu , Joshua Silverman , Richard Smith , Candace Swimmer
IPC分类号： C12P21/02 , C12Q1/68 , C07K14/705 , C07K16/28
CPC分类号： C07K14/47 , A61K38/00 , C07K14/705 , G01N33/566 , G01N33/574 , G01N2333/4753 , G01N2333/82 , G01N2500/00
摘要： Polypeptides comprising monomer domains that bind to c-MET, or portions thereof, are provided.
摘要翻译： 提供了包含与c-MET结合的单体结构域的多肽或其部分。
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公开(公告)号：US20080019988A1
公开(公告)日：2008-01-24
申请号：US11713514
申请日：2007-03-01
申请人： Juha Punnonen , Willem Stemmer , Russell Howard , Phillip Patten
发明人： Juha Punnonen , Willem Stemmer , Russell Howard , Phillip Patten
CPC分类号： A61K39/385 , A61K39/00 , A61K2039/53 , A61K2039/6037 , A61K2039/605 , C12N15/1037 , C12N15/85 , C12N2810/50 , C12N2810/85 , C12N2810/859
摘要： This invention provides methods of obtaining reagents for increasing the specificity of genetic vaccines for a desired target cell or tissue type. The invention also provides delivery vehicles for use to improve genetic vaccine specificity for a target cell or tissue type.
摘要翻译： 本发明提供获得用于增加所需靶细胞或组织类型的遗传疫苗的特异性的试剂的方法。 本发明还提供用于改善靶细胞或组织类型的遗传疫苗特异性的递送载体。
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公开(公告)号：US20060286603A1
公开(公告)日：2006-12-21
申请号：US11392108
申请日：2006-03-28
申请人： Joost Kolkman , Willem Stemmer , Per-Ola Freskgard
发明人： Joost Kolkman , Willem Stemmer , Per-Ola Freskgard
CPC分类号： C40B30/04 , A61K47/62 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , C07K1/047 , C40B40/10 , G01N33/6845
摘要： Methods for identifying discrete monomer domains and immuno-domains with a desired property are provided. Methods for generating multimers from two or more selected discrete monomer domains are also provided, along with methods for identifying multimers possessing a desired property. Presentation systems are also provided which present the discrete monomer and/or immuno-domains, selected monomer and/or immuno-domains, multimers and/or selected multimers to allow their selection. Compositions, libraries and cells that express one or more library member, along with kits and integrated systems, are also included in the present invention.
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公开(公告)号：US20050059109A1
公开(公告)日：2005-03-17
申请号：US10667868
申请日：2003-09-22
申请人： Phillip Patten , Willem Stemmer
发明人： Phillip Patten , Willem Stemmer
IPC分类号： C12N15/09 , A61K38/45 , A61K48/00 , C07K14/435 , C07K14/47 , C07K14/545 , C07K14/56 , C07K16/00 , C12N7/00 , C12N9/02 , C12N9/10 , C12N9/12 , C12N9/38 , C12N9/86 , C12N15/10 , C12N15/52 , C12N15/64 , C12P21/02 , C12Q1/68 , C40B40/02 , G01N33/68 , C12N15/85 , C12P19/34
CPC分类号： C12N15/1031 , A61K38/45 , A61K48/00 , C07K14/43595 , C07K14/545 , C07K14/56 , C07K16/00 , C07K2317/565 , C07K2317/622 , C12N7/00 , C12N9/0069 , C12N9/1007 , C12N9/16 , C12N9/86 , C12N15/10 , C12N15/1027 , C12N15/1034 , C12N15/1037 , C12N15/1058 , C12N15/52 , C12N15/64 , C12N15/67 , C12N2795/14043 , C12N2795/14143 , C12Q1/6811 , C12Q1/6853 , C12Q1/686 , C40B40/02 , C40B40/08 , C40B50/06 , G01N33/68 , G01N33/6845
摘要： Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are also disclosed.
摘要翻译： 提供了用于工业和医药兴趣蛋白质进化的方法，包括进行重组和选择的方法。 还公开了通过这些方法制备的组合物。
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