公开(公告)号：US20240327390A1

公开(公告)日：2024-10-03

申请号：US18659052

申请日：2024-05-09

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Navnath Dnyanoba Yadav ,  Rajeev S. Bhide ,  Rajesh Onkardas Bora ,  Prashantha Gunaga ,  Manoranjan Panda ,  Eldon Scott Priestley ,  Jeremy Richter

IPC: C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04

CPC classification number: C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04

Abstract: Disclosed are compounds of Formula (I)




or a salt thereof,

wherein R1 is:





each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3a, R3b, L1, B, V, Y, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.

公开(公告)号：US10676460B2

公开(公告)日：2020-06-09

申请号：US16243400

申请日：2019-01-09

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： James A. Johnson ,  John Lloyd ,  Heather Finlay ,  James Neels ,  Naveen Kumar Dhondi ,  Prashantha Gunaga ,  Abhisek Banerjee ,  Ashokkumar Adisechan

IPC: C07D401/14 ,  C07D239/95 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D407/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/549 ,  A61K45/06 ,  C07D239/94 ,  C07D405/12 ,  C07D471/04 ,  C07D513/04

Abstract: A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.

公开(公告)号：US20190248769A1

公开(公告)日：2019-08-15

申请号：US16344823

申请日：2017-11-02

Applicant: Bristol-Myers Squibb Company

Inventor： Prashantha Gunaga ,  Rajeev S. Bhide ,  Rajesh Onkardas Bora ,  Manoranjan Panda ,  Navnath Dnyanoba Yadav ,  Eldon Scott Priestley ,  Jeremy Richter

IPC: C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  A61P9/12 ,  A61P9/04 ,  A61P13/02 ,  C07D471/04

Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein R1 is (II) or (III); each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3, L1, L2, R1a, R1b, R1c, and n are define herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.

公开(公告)号：US20180346453A1

公开(公告)日：2018-12-06

申请号：US15993683

申请日：2018-05-31

Applicant: Bristol-Myers Squibb Company

Inventor： Navnath Dnyanoba Yadav ,  Rajeev S. Bhide ,  Rajesh Onkardas Bora ,  Prashantha Gunaga ,  Manoranjan Panda ,  Eldon Scott Priestley ,  Jeremy Richter

IPC: C07D405/14 ,  C07D417/14 ,  C07D413/14

CPC classification number: C07D413/14 ,  C07D405/14 ,  C07D417/14 ,  C07D487/04

Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein R1 is: each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3a, R3b, L1, B, V, Y, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.

公开(公告)号：US20180030034A1

公开(公告)日：2018-02-01

申请号：US15724566

申请日：2017-10-04

Applicant: Bristol-Myers Squibb Company

Inventor： John Lloyd ,  Heather Finlay ,  Prashantha Gunaga ,  Abhisek Banerjee ,  Ashokkumar Adisechan

IPC: C07D401/14 ,  A61K31/549 ,  C07D513/04 ,  A61K45/06 ,  C07D239/94 ,  C07D405/12 ,  C07D471/04 ,  A61K31/517 ,  C07D417/14 ,  C07D417/12 ,  C07D413/14 ,  C07D407/12 ,  C07D403/12 ,  C07D403/04 ,  C07D401/12 ,  A61K31/5377 ,  C07D239/95

CPC classification number: C07D401/14 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/549 ,  A61K45/06 ,  C07D239/94 ,  C07D239/95 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D407/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D513/04

Abstract: A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.

公开(公告)号：US09458133B2

公开(公告)日：2016-10-04

申请号：US14771902

申请日：2014-03-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Heather Finlay ,  Ashok Kumar Adisechan ,  Naveen Kumar Dhondi ,  Prashantha Gunaga ,  John Lloyd ,  Srinivasu Pothukanuri

IPC: C07D217/12 ,  C07D401/04 ,  C07D405/04 ,  A61K31/4709 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D405/12 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/5377 ,  C07D417/14

CPC classification number: C07D401/12 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/5377 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D417/14

Abstract: A compound of formula (I) (I) wherein A, R1, R1a, R3 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.

公开(公告)号：US09458114B2

公开(公告)日：2016-10-04

申请号：US14038814

申请日：2013-09-27

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： James A. Johnson ,  John Lloyd ,  Heather Finlay ,  Ji Jiang ,  James Neels ,  Naveen Kumar Dhondi ,  Prashantha Gunaga ,  Abhisek Banerjee ,  Ashokkumar Adisechan

IPC: C07D239/94 ,  C07D239/95 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D407/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/549 ,  A61K45/06 ,  C07D405/12 ,  C07D471/04 ,  C07D513/04

CPC classification number: C07D401/14 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/549 ,  A61K45/06 ,  C07D239/94 ,  C07D239/95 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D407/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D513/04

Abstract: A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.

公开(公告)号：US20160016933A1

公开(公告)日：2016-01-21

申请号：US14771902

申请日：2014-03-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Heather Finlay ,  Ashok Kumar Adisechan ,  Naveen Kumar Dhondi ,  Prashantha Gunaga ,  John Lloyd ,  Srinivasu Pothukanuri

IPC: C07D401/12 ,  A61K31/4725 ,  A61K31/5377 ,  A61K31/497 ,  C07D405/04 ,  C07D405/14 ,  C07D417/14 ,  C07D401/14 ,  C07D401/04

CPC classification number: C07D401/12 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/5377 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D417/14

Abstract: A compound of formula (I) (I) wherein A, R1, R1a, R3 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.

Abstract translation: 本文描述其中A，R 1，R 1a，R 3和R 24的式（I）（I）化合物。 这些化合物可用作钾通道功能的抑制剂和治疗和预防心律失常，IKur相关疾病以及由离子通道功能介导的其它病症。

公开(公告)号：US20140031345A1

公开(公告)日：2014-01-30

申请号：US14038814

申请日：2013-09-27

Applicant: Bristol-Myers Squibb Company

Inventor： James A. Johnson ,  John Lloyd ,  Heather Finlay ,  Ji Jiang ,  James Neels ,  Naveen Kumar Dhondi ,  Prashantha Gunaga ,  Abhisek Banerjee

IPC: C07D239/94 ,  A61K31/517 ,  C07D401/12 ,  C07D413/14 ,  C07D403/04 ,  A61K45/06 ,  C07D405/12 ,  A61K31/5377 ,  C07D471/04 ,  C07D513/04 ,  A61K31/549 ,  C07D401/14 ,  C07D417/14

CPC classification number: C07D401/14 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/549 ,  A61K45/06 ,  C07D239/94 ,  C07D239/95 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D407/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D513/04

Abstract: A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.

Abstract translation: 其中A，X，Y，Z，R 1和R 24在本文中描述的式I化合物。 这些化合物可用作钾通道功能的抑制剂和治疗和预防心律失常，IKur相关疾病以及由离子通道功能介导的其它病症。