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公开(公告)号：US20220324836A1
公开(公告)日：2022-10-13
申请号：US17231088
申请日：2021-04-15
发明人： James A. Johnson , John Lloyd , Heather Finlay , James Neels , Naveen Kumar Dhondi , Prashantha Gunaga , Abhisek Banerjee , Ashokkumar Adisechan
IPC分类号： C07D401/14 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D407/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/517 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D239/94 , C07D405/12 , C07D471/04 , C07D513/04
摘要： A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
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公开(公告)号：US11008306B2
公开(公告)日：2021-05-18
申请号：US16864825
申请日：2020-05-01
发明人： James A. Johnson , John Lloyd , Heather Finlay , James Neels , Naveen Kumar Dhondi , Prashantha Gunaga , Abhisek Banerjee , Ashokkumar Adisechan
IPC分类号： C07D401/14 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D407/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/517 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D239/94 , C07D405/12 , C07D471/04 , C07D513/04
摘要： A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
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公开(公告)号：US10676460B2
公开(公告)日：2020-06-09
申请号：US16243400
申请日：2019-01-09
发明人： James A. Johnson , John Lloyd , Heather Finlay , James Neels , Naveen Kumar Dhondi , Prashantha Gunaga , Abhisek Banerjee , Ashokkumar Adisechan
IPC分类号： C07D401/14 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D407/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/517 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D239/94 , C07D405/12 , C07D471/04 , C07D513/04
摘要： A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
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公开(公告)号：US20180030034A1
公开(公告)日：2018-02-01
申请号：US15724566
申请日：2017-10-04
IPC分类号： C07D401/14 , A61K31/549 , C07D513/04 , A61K45/06 , C07D239/94 , C07D405/12 , C07D471/04 , A61K31/517 , C07D417/14 , C07D417/12 , C07D413/14 , C07D407/12 , C07D403/12 , C07D403/04 , C07D401/12 , A61K31/5377 , C07D239/95
CPC分类号： C07D401/14 , A61K31/517 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D239/94 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04
摘要： A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
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公开(公告)号：US09458114B2
公开(公告)日：2016-10-04
申请号：US14038814
申请日：2013-09-27
发明人： James A. Johnson , John Lloyd , Heather Finlay , Ji Jiang , James Neels , Naveen Kumar Dhondi , Prashantha Gunaga , Abhisek Banerjee , Ashokkumar Adisechan
IPC分类号： C07D239/94 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D407/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/517 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D405/12 , C07D471/04 , C07D513/04
CPC分类号： C07D401/14 , A61K31/517 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D239/94 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04
摘要： A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
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公开(公告)号：US20200255407A1
公开(公告)日：2020-08-13
申请号：US16864825
申请日：2020-05-01
发明人： James A. Johnson , John Lloyd , Heather Finlay , James Neels , Naveen Kumar Dhondi , Prashantha Gunaga , Abhisek Banerjee , Ashokkumar Adisechan
IPC分类号： C07D401/14 , C07D513/04 , C07D471/04 , C07D405/12 , C07D239/94 , A61K45/06 , A61K31/549 , A61K31/5377 , A61K31/517 , C07D417/14 , C07D417/12 , C07D413/14 , C07D407/12 , C07D403/12 , C07D403/04 , C07D401/12 , C07D239/95
摘要： A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
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公开(公告)号：US20190144426A1
公开(公告)日：2019-05-16
申请号：US16243400
申请日：2019-01-09
发明人： James A. Johnson , John Lloyd , Heather Finlay , James Neels , Naveen Kumar Dhondi , Prashantha Gunaga , Abhisek Banerjee , Ashokkumar Adisechan
IPC分类号： C07D401/14 , A61K31/5377 , C07D239/95 , C07D513/04 , A61K45/06 , C07D239/94 , C07D405/12 , C07D471/04 , A61K31/517 , C07D417/14 , C07D417/12 , C07D413/14 , C07D407/12 , C07D403/12 , C07D403/04 , C07D401/12 , A61K31/549
摘要： A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
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公开(公告)号：US10214511B2
公开(公告)日：2019-02-26
申请号：US15724566
申请日：2017-10-04
IPC分类号： C07D401/14 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D407/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/517 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D239/94 , C07D405/12 , C07D471/04 , C07D513/04
摘要： A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
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公开(公告)号：US20230322726A1
公开(公告)日：2023-10-12
申请号：US18125826
申请日：2023-03-24
发明人： James A. Johnson , John Lloyd , Heather Finlay , James Neels , Naveen Kumar Dhondi , Prashantha Gunaga , Abhisek Banerjee , Ashokkumar Adisechan
IPC分类号： C07D401/14 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D407/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/517 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D239/94 , C07D405/12 , C07D471/04 , C07D513/04
CPC分类号： C07D401/14 , A61K31/517 , A61K31/549 , A61K31/5377 , A61K45/06 , C07D239/94 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04
摘要： A compound of formula I
wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.-
公开(公告)号：US09822096B2
公开(公告)日：2017-11-21
申请号：US15249710
申请日：2016-08-29
IPC分类号： C07D401/14 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D407/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/517 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D239/94 , C07D405/12 , C07D471/04 , C07D513/04
CPC分类号： C07D401/14 , A61K31/517 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D239/94 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04
摘要： A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
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