公开(公告)号：US10258618B2

公开(公告)日：2019-04-16

申请号：US15955542

申请日：2018-04-17

申请人： Buck Institute for Research on Aging ,  Unity Biotechnology, Inc. ,  Mayo Foundation for Medical Education and Research

发明人： Remi-Martin Laberge ,  Judith Campisi ,  Marco Demaria ,  Nathaniel David ,  Darren J. Baker ,  James L. Kirkland ,  Tamar Tchkonia ,  Yi Zhu ,  Jan M. A. van Deursen

IPC分类号： A61K9/00 ,  A61K31/496 ,  A61K31/5377 ,  A61P11/00 ,  A61K31/428 ,  A61K31/495 ,  A61K31/404 ,  A61K31/4375 ,  A61K45/06 ,  A61K31/4178 ,  A61K31/728 ,  C12N5/00 ,  A61K47/36

摘要： Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.

公开(公告)号：US09980962B2

公开(公告)日：2018-05-29

申请号：US15647688

申请日：2017-07-12

申请人： Buck Institute for Research on Aging ,  Unity Biotechnology, Inc. ,  Mayo Foundation for Medical Education and Research

发明人： Remi-Martin Laberge ,  Judith Campisi ,  Marco Demaria ,  Nathaniel David ,  Darren J. Baker ,  James L. Kirkland ,  Tamar Tchkonia ,  Jan M. A. van Deursen ,  Yi Zhu

IPC分类号： A61K31/537 ,  A61K31/496 ,  A61K31/495 ,  A61K31/5377 ,  A61K31/404 ,  A61K31/4375 ,  A61K31/428 ,  A61K45/06 ,  A61K9/00

CPC分类号： A61K31/496 ,  A61K9/0048 ,  A61K9/0073 ,  A61K31/404 ,  A61K31/4178 ,  A61K31/428 ,  A61K31/4375 ,  A61K31/495 ,  A61K31/5377 ,  A61K31/728 ,  A61K45/06 ,  A61K47/36 ,  C12N5/0081 ,  C12N2501/999 ,  C12N2503/02

摘要： Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.

公开(公告)号：US10517866B2

公开(公告)日：2019-12-31

申请号：US15981696

申请日：2018-05-16

申请人： Unity Biotechnology, Inc. ,  Buck Institute for Research on Aging ,  Mayo Foundation for Medical Education and Research

发明人： Remi-Martin Laberge ,  James L. Kirkland ,  Tamar Tchkonia ,  Yi Zhu ,  Nathaniel David ,  Alain Philippe Vasserot ,  Darren J. Baker ,  Bennett G. Childs ,  Jan M. A. van Deursen

IPC分类号： A61P9/10 ,  A61K31/496 ,  A61P11/00 ,  A61P27/02 ,  A61K31/428 ,  A61K31/495 ,  A61K31/5377 ,  A61K31/404 ,  A61K31/4375 ,  A61K45/06 ,  A61K31/4178 ,  A61K31/728 ,  C12N5/00 ,  A61K47/36 ,  A61K9/00 ,  C12Q1/48

摘要： Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.

公开(公告)号：US20190022090A1

公开(公告)日：2019-01-24

申请号：US16054667

申请日：2018-08-03

申请人： Unity Biotechnology, Inc. ,  Buck Institute for Research on Aging ,  Mayo Foundation for Medical Education and Research

发明人： Remi-Martin Laberge ,  Judith Campisi ,  Marco Demaria ,  Nathaniel David ,  Alain Philippe Vasserot ,  James L. Kirkland ,  Tamar Tchkonia ,  Yi Zhu ,  Darren J. Baker ,  Bennett G. Childs ,  Jan M.A. van Deursen

IPC分类号： A61K31/496 ,  A61K9/00 ,  A61K31/428 ,  A61K47/36 ,  C12N5/00 ,  A61K31/728 ,  A61K31/4178 ,  A61K45/06 ,  A61K31/4375 ,  A61K31/404 ,  A61K31/5377 ,  A61K31/495

CPC分类号： A61K31/496 ,  A61K9/0048 ,  A61K9/0073 ,  A61K31/404 ,  A61K31/4178 ,  A61K31/428 ,  A61K31/4375 ,  A61K31/495 ,  A61K31/5377 ,  A61K31/728 ,  A61K45/06 ,  A61K47/36 ,  A61P9/10 ,  A61P11/00 ,  A61P27/02 ,  C12N5/0081 ,  C12N2501/999 ,  C12N2503/02 ,  C12Q1/485

摘要： Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.

公开(公告)号：US20190000846A1

公开(公告)日：2019-01-03

申请号：US16025238

申请日：2018-07-02

申请人： Mayo Foundation for Medical Education and Research ,  Buck Institute for Research on Aging ,  Unity Biotechnology, Inc.

发明人： Jan M.A. van Deursen ,  Bennett G. Childs ,  Darren J. Baker ,  James L. Kirkland ,  Tamar Tchkonia ,  Yi Zhu ,  Nathaniel David ,  Remi-Martin Laberge ,  Judith Campisi ,  Marco Demaria

IPC分类号： A61K31/506 ,  A61P9/14 ,  A61K31/40 ,  A61K31/22

摘要： Foamy macrophages with senescence markers accumulate in the subendothelial space at the onset of atherosclerosis where they drive pathology by increasing expression of key atherogenic and inflammatory cytokines and chemokines. This invention provides senolytic agents that remove senescent cells that are present in or around atherosclerotic plaques. The agents inhibit or reverse thinning of the fibrous cap on atherosclerotic plaques. This has the effect of stabilizing the plaques, inhibiting rupture and preventing pathological sequelae that manifest as coronary artery disease. Senolytic agents used in this way complement the action of statins and other drugs that cause plaque regression. Thus, senolytic agents and lipid lowering drugs can be used in combination for enhanced therapeutic effect.

公开(公告)号：US20180303828A1

公开(公告)日：2018-10-25

申请号：US16007880

申请日：2018-06-13

申请人： Unity Biotechnology, Inc. ,  Buck Institute for Research on Aging ,  Mayo Foundation for Medical Education and Research

发明人： Remi-Martin Laberge ,  Judith Campisi ,  Marco Demaria ,  Nathaniel David ,  Darren J. Baker ,  James L. Kirkland ,  Tamar Tchkonia ,  Yi Zhu ,  Jan M.A. van Deursen

IPC分类号： A61K31/496 ,  A61K31/428 ,  A61K45/06 ,  A61K31/495 ,  A61K31/5377 ,  A61K9/00 ,  A61K31/404 ,  A61K31/4375

摘要： Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.

公开(公告)号：US20180235956A1

公开(公告)日：2018-08-23

申请号：US15955542

申请日：2018-04-17

申请人： Buck Institute for Research on Aging ,  Unity Biotechnology, Inc. ,  Mayo Foundation for Medical Education and Research

发明人： Remi-Martin Laberge ,  Judith Campisi ,  Marco Demaria ,  Nathaniel David ,  Darren J. Baker ,  James L. Kirkland ,  Tamar Tchkonia ,  Yi Zhu ,  Jan M.A. van Deursen

IPC分类号： A61K31/496 ,  A61K45/06 ,  A61K31/5377 ,  A61K31/495 ,  A61K9/00 ,  A61K31/428 ,  A61K31/404 ,  A61K31/4375

CPC分类号： A61K31/496 ,  A61K9/0048 ,  A61K9/0073 ,  A61K31/404 ,  A61K31/4178 ,  A61K31/428 ,  A61K31/4375 ,  A61K31/495 ,  A61K31/5377 ,  A61K31/728 ,  A61K45/06 ,  A61K47/36 ,  A61P11/00 ,  C12N5/0081 ,  C12N2501/999 ,  C12N2503/02

摘要： Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.

公开(公告)号：US20180193458A1

公开(公告)日：2018-07-12

申请号：US15742458

申请日：2016-07-08

申请人： Unity Biotechnology, Inc. ,  Buck Institute for Research on Aging ,  Mayo Foundation for Medical Education and Research

发明人： Jose Alberto Lopez-Dominguez ,  Remi-Martin Laberge ,  Judith Campisi ,  Albert Davalos ,  Marco Demaria ,  Nathaniel David ,  Alain Philippe Vasserot ,  Darren J. Baker ,  Bennett G. Childs ,  James L. Kirkland ,  Tamar Tchkonia ,  Jan M.A. van Deursen ,  Yi Zhu

IPC分类号： A61K45/06 ,  A61K31/407 ,  A61K31/428 ,  A61K31/4375 ,  A61K31/496 ,  C07K14/47 ,  A61P35/00 ,  A61P9/10

CPC分类号： A61K45/06 ,  A01K2227/105 ,  A01K2267/0375 ,  A61K31/40 ,  A61K31/4035 ,  A61K31/407 ,  A61K31/428 ,  A61K31/4375 ,  A61K31/496 ,  A61K31/635 ,  A61P9/10 ,  A61P35/00 ,  C07K14/4747 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/531 ,  A61K2300/00

摘要： Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders. Also included herein are methods for extending lifespan.

公开(公告)号：US20170196857A1

公开(公告)日：2017-07-13

申请号：US15455575

申请日：2017-03-10

申请人： Buck Institute for Research on Aging ,  Unity Biotechnology, Inc. ,  Mayo Foundation for Medical Education and Research ,  The John Hopkins University

发明人： Remi-Martin Laberge ,  Judith Campisi ,  Albert Davalos ,  Marco Demaria ,  Nathaniel David ,  Alain Philippe Vasserot ,  Darren J. Baker ,  Bennett G. Childs ,  James L. Kirkland ,  Tamar Tchkonia ,  Jan M.A. van Deursen ,  Jennifer Elisseeff ,  Chaekyu Kim ,  Okhee Jeon ,  Allyson K. Palmer

IPC分类号： A61K31/496 ,  A61K31/728

CPC分类号： A61K31/496 ,  A61K9/0048 ,  A61K9/0073 ,  A61K31/404 ,  A61K31/4178 ,  A61K31/428 ,  A61K31/4375 ,  A61K31/495 ,  A61K31/5377 ,  A61K31/728 ,  A61K45/06 ,  A61K47/36 ,  C12N5/0081 ,  C12N2501/999 ,  C12N2503/02

摘要： Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.

公开(公告)号：US20170027139A1

公开(公告)日：2017-02-02

申请号：US15067543

申请日：2016-03-11

申请人： Mayo Foundation for Medical Education and Research ,  Buck Institute for Research on Aging

发明人： Jan M.A. van Deursen ,  Darren J. Baker ,  James L. Kirkland ,  Tamar Tchkonia ,  Judith Campisi ,  Marco Demaria ,  Remi-Martin Laberge

IPC分类号： A01K67/027 ,  C12N15/85 ,  A61K49/00

CPC分类号： A01K67/0275 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/0393 ,  A61K49/0008 ,  C12N15/8509 ,  C12N2015/859 ,  C12N2830/008

摘要： This disclosure provides non-human animal models for age-related disorders and age-sensitive traits, particularly those caused by senescence-inducing stimuli, wherein the models comprise transgenes selectively expressed by senescent cells. The disclosure further provides methods for identifying therapeutic agents effective for treating or preventing age-related disorders and age-sensitive traits using the animal models, therapeutic agents identified using such methods, pharmaceutical compositions comprising the identified therapeutic agents, and methods of treating or preventing age-related disorders and age-sensitive traits.

摘要翻译： 本公开提供了用于年龄相关疾病和年龄敏感性状的非人类动物模型，特别是由衰老诱导刺激引起的性状，其中模型包含由衰老细胞选择性表达的转基因。 本公开进一步提供了用于鉴定使用动物模型治疗或预防年龄相关疾病和年龄敏感性状的治疗剂的方法，包括鉴定的治疗剂的药物组合物，以及治疗或预防年龄的方法 相关疾病和年龄敏感性状。