公开(公告)号：US10364245B2

公开(公告)日：2019-07-30

申请号：US15987277

申请日：2018-05-23

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Carmelida Capaldi ,  Elisabetta Armani ,  Christopher Hurley ,  Barbara Giuseppina Avitabile-Woo ,  Roberta Lanaro ,  Neil Stuart Jennings

IPC: C07D471/04 ,  A61P11/00

Abstract: Compounds of formula (I) defined herein are p38 MAPK inhibitors and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

公开(公告)号：US10100050B2

公开(公告)日：2018-10-16

申请号：US15388350

申请日：2016-12-22

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Carmelida Capaldi ,  Elisabetta Armani ,  Andrew Steven Robert Jennings ,  Christopher Hurley

IPC: C07D471/04

Abstract: Compounds of formula (I) defined herein are p38 MAPK inhibitors and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

公开(公告)号：US09890169B2

公开(公告)日：2018-02-13

申请号：US15375281

申请日：2016-12-12

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Elisabetta Armani ,  Carmelida Capaldi

IPC: C07D487/04 ,  A61K31/519 ,  A61P11/06 ,  A61P11/08 ,  A61P17/06 ,  A61P37/08

CPC classification number: C07D487/04

Abstract: Triazolinone compounds of formula (I) defined herein exhibit human neutrophil elastase inhibitory properties and are useful for the therapy of diseases and conditions in which HNE is implicated.

公开(公告)号：US09868740B2

公开(公告)日：2018-01-16

申请号：US15317274

申请日：2014-06-12

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Lilian Alcaraz ,  Robert Andrew Heald ,  Jonathan Mark Sutton ,  Elisabetta Armani ,  Carmelida Capaldi

IPC: C07D487/04 ,  A61K31/519 ,  A61P11/06 ,  A61P11/08 ,  A61P11/12 ,  A61P11/00

CPC classification number: C07D487/04

Abstract: This invention relates to heterocyclic compounds, which are pyrimidinone derivatives having human neutrophil elastase inhibitory properties, and their use in therapy.

公开(公告)号：US20180009787A1

公开(公告)日：2018-01-11

申请号：US15712366

申请日：2017-09-22

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Jonathan Mark SUTTON ,  Robert Andrew Heald ,  Andrew Stephen Robert Jennings ,  Carmelida Capaldi ,  Elisabetta Armani

IPC: C07D403/04 ,  C07D417/14 ,  C07D413/14 ,  C07D403/14 ,  C07D401/14 ,  C07D471/04 ,  C07C309/29

CPC classification number: C07D403/04 ,  C07C309/29 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

Abstract: Compounds of formula (I) defined herein exhibit human neutrophil elastase inhibitory properties and are useful for the treatment of disease or conditions in which HNE is implicated

公开(公告)号：US09758521B2

公开(公告)日：2017-09-12

申请号：US15388178

申请日：2016-12-22

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Carmelida Capaldi ,  Elisabetta Armani ,  Andrew Steven Robert Jennings ,  Christopher Hurley

IPC: A61K31/44 ,  C07D471/04

CPC classification number: C07D471/04

Abstract: Compounds of formulae (I), (II), and (III), defined herein, are p38 MAPK inhibitors and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

公开(公告)号：US09365577B2

公开(公告)日：2016-06-14

申请号：US14108904

申请日：2013-12-17

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Lilian Alcaraz ,  Robert Andrew Heald ,  Jonathan Mark Sutton ,  Elisabetta Armani ,  Carmelida Capaldi

IPC: C07D487/04 ,  A61K31/519 ,  C07C309/20 ,  C07C309/29 ,  C07D453/02 ,  C07D487/08

CPC classification number: C07D487/04 ,  A61K9/0053 ,  A61K9/007 ,  C07C47/19 ,  C07C53/06 ,  C07C309/04 ,  C07C309/08 ,  C07C309/20 ,  C07C309/29 ,  C07D453/02 ,  C07D487/08 ,  C07D519/00

Abstract: Pyrimidinone compounds defined herein exhibit human neutrophil elastase inhibitory properties and are useful for treating diseases and conditions in which HINE is implicated.

Abstract translation: 本文定义的嘧啶酮化合物显示人嗜中性粒细胞弹性蛋白酶抑制性质，并且可用于治疗涉及HINE的疾病和病症。

公开(公告)号：US09023855B2

公开(公告)日：2015-05-05

申请号：US14177469

申请日：2014-02-11

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Toby Jonathan Blench ,  Christine Edwards ,  Robert Andrew Heald ,  Janusz Jozef Kulagowski ,  Jonathan Mark Sutton ,  Carmelida Capaldi

IPC: A61K31/519 ,  C07D487/00 ,  C07D487/04

CPC classification number: C07D487/04

Abstract: Compounds of formula (I): are useful as inhibitors of human neutrophil elastase.

Abstract translation: 式（I）化合物：可用作人中性粒细胞弹性蛋白酶的抑制剂。

公开(公告)号：US20140142074A1

公开(公告)日：2014-05-22

申请号：US14164527

申请日：2014-01-27

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Elisabetta ARMANI ,  Gabriele Amari ,  Carmelida Capaldi ,  Oriana Esposito ,  Ilaria Peretto

IPC: A61K31/5377 ,  A61K31/4439 ,  A61K31/44 ,  C07D417/12 ,  A61M16/14 ,  C07D401/12 ,  C07D213/56 ,  C07D213/55 ,  C07D213/89 ,  A61M15/00 ,  A61K31/496 ,  C07D413/12

CPC classification number: A61K31/5377 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/496 ,  A61M15/0045 ,  A61M15/009 ,  A61M16/14 ,  C07D213/55 ,  C07D213/56 ,  C07D213/69 ,  C07D213/89 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12

Abstract: The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1-phenyl-2-pyridinyl alkyl alcohols, methods of preparing such compounds, compositions containing them and therapeutic use thereof.

Abstract translation: 本发明涉及磷酸二酯酶4（PDE4）酶的抑制剂。 更具体地，本发明涉及作为1-苯基-2-吡啶基烷基醇的衍生物的化合物，制备这些化合物的方法，含有它们的组合物及其治疗用途。

公开(公告)号：US20140018345A1

公开(公告)日：2014-01-16

申请号：US13940555

申请日：2013-07-12

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Carmelida Capaldi ,  Robert Andrew Heald ,  Nicholas Charles Ray ,  Jonathan Mark Sutton

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: Compounds of formula (I): wherein R1, R2, R3, R5, R6, A1, A2, A3, A4 assume meanings as defined in formula (I) are inhibitors of neutrophil elastase.

Abstract translation: 式（I）化合物：其中R 1，R 2，R 3，R 5，R 6，A 1，A 2，A 3，A 4定义为式（I）中定义的含义是嗜中性粒细胞弹性蛋白酶抑制剂。