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公开(公告)号：US20160175252A1
公开(公告)日：2016-06-23
申请号：US15054479
申请日：2016-02-26
Applicant: Covidien LP
Inventor： Phillip Blaskovich , Valentino Tramontano , Joshua Kennedy , Rachit Ohri
IPC: A61K9/16 , A61K31/445 , A61K33/24 , A61K31/714
CPC classification number: A61K9/1682 , A61K9/1652 , A61K9/1694 , A61K31/445 , A61K31/714 , A61K33/24 , A61L15/28 , A61L27/20 , B01J13/12 , B01J13/125
Abstract: A process for forming microspheres is disclosed. The process includes contacting a solvent with a modified cellulose to form a solution; contacting the modified cellulose solution with at least one bioactive agent to form a discontinuous phase liquid; contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion; and contacting the emulsion with a third phase liquid to extract the solvent from the emulsion, thereby forming a plurality of modified cellulose microspheres.
Abstract translation: 公开了一种形成微球的方法。 该方法包括使溶剂与改性纤维素接触以形成溶液; 使改性纤维素溶液与至少一种生物活性剂接触以形成不连续相液体; 使不连续相液体与连续相液体接触以形成乳液; 并将乳液与第三相液体接触以从乳液中提取溶剂，从而形成多个改性的纤维素微球。
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22.发明申请Dissolution of Oxidized Cellulose and Particle Preparation by Cross-Linking With Multivalent Cations 有权氧化纤维素的溶解和通过与多价阳离子交联的颗粒制备公开(公告)号：US20140005378A1
公开(公告)日：2014-01-02
申请号：US13927316
申请日：2013-06-26
Applicant: Covidien LP , Confluent Surgical, Inc.
Inventor： Phillip Blaskovich , Valentino Tramontano , Rachit Ohri , Daniel S. Costa , Joshua Kennedy , Sajida Farooqi
CPC classification number: C08B1/003 , C08B15/00 , C08B15/005 , C08B15/02 , C08J3/075 , C08J3/096 , C08J3/14 , C08J2301/04 , C08L1/04
Abstract: A process for dissolving modified cellulose includes contacting modified cellulose solution with at least one multivalent cation to form a plurality of modified cellulose particles.
Abstract translation: 溶解改性纤维素的方法包括将改性纤维素溶液与至少一种多价阳离子接触以形成多个改性纤维素颗粒。
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公开(公告)号：US20140005375A1
公开(公告)日：2014-01-02
申请号：US13927311
申请日：2013-06-26
Applicant: Covidien LP , Confluent Surgical, Inc.
Inventor： Valentino Tramontano , Phillip Blaskovich , Rachit Ohri , Joshua Kennedy , Sajida Farooqi
IPC: C08B15/02
Abstract: A process for dissolving modified cellulose includes contacting modified cellulose with a solvent in a mixture to form swelled modified cellulose and then contacting the mixture with a salt to dissolve the swelled modified cellulose. The dissolved modified cellulose is used to form at least one of a predictably degrading coating, film, or a fiber.
Abstract translation: 溶解改性纤维素的方法包括将改性纤维素与溶剂在混合物中接触以形成溶胀的改性纤维素，然后使该混合物与盐接触以溶解溶胀的改性纤维素。 溶解的改性纤维素用于形成可预测降解的涂层，膜或纤维中的至少一种。
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