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1.发明授权公开(公告)号：US11053323B2
公开(公告)日：2021-07-06
申请号：US15344633
申请日：2016-11-07
申请人： Covidien LP
发明人： Phillip Blaskovich , Valentino Tramontano , Rachit Ohri , Joshua Kennedy , Christopher M. Henry
摘要： A process for dissolving modified cellulose includes contacting modified cellulose solution with at least one multivalent cation to form a plurality of modified cellulose particles.
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公开(公告)号：US10040871B2
公开(公告)日：2018-08-07
申请号：US13927311
申请日：2013-06-26
摘要： A process for dissolving modified cellulose includes contacting modified cellulose with a solvent in a mixture to form swelled modified cellulose and then contacting the mixture with a salt to dissolve the swelled modified cellulose. The dissolved modified cellulose is used to form at least one of a predictably degrading coating, film, or a fiber.
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3.发明授权Dissolution of oxidized cellulose and particle preparation by cross-linking with multivalent cations 有权通过与多价阳离子交联，氧化纤维素和颗粒制剂的溶解公开(公告)号：US09499636B2
公开(公告)日：2016-11-22
申请号：US13927316
申请日：2013-06-26
发明人： Phillip Blaskovich , Valentino Tramontano , Rachit Ohri , Daniel S. Costa , Joshua Kennedy , Sajida Farooqi
CPC分类号： C08B1/003 , C08B15/00 , C08B15/005 , C08B15/02 , C08J3/075 , C08J3/096 , C08J3/14 , C08J2301/04 , C08L1/04
摘要： A process for dissolving modified cellulose includes contacting modified cellulose solution with at least one multivalent cation to form a plurality of modified cellulose particles.
摘要翻译： 溶解改性纤维素的方法包括将改性纤维素溶液与至少一种多价阳离子接触以形成多个改性纤维素颗粒。
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公开(公告)号：US20160089335A1
公开(公告)日：2016-03-31
申请号：US14848385
申请日：2015-09-09
申请人： Covidien LP
IPC分类号： A61K9/16 , A61K31/445
CPC分类号： A61K9/1647 , A61K9/0024 , A61K31/445
摘要： A microsphere is disclosed. The microsphere includes at least one biodegradable polymer and at least one local anesthetic, wherein about 75% of the at least one local anesthetic is released by about 72 hours and from about 80% to about 90% of the at least one local anesthetic is released by about 120 hours, thereby relieving chronic pain for at least 28 days.
摘要翻译： 公开了一种微球。 微球包括至少一种可生物降解的聚合物和至少一种局部麻醉剂，其中约75％的至少一种局部麻醉剂释放约72小时，并且至少一种局部麻醉剂的约80％至约90％释放 约120小时，从而缓解至少28天的慢性疼痛。
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公开(公告)号：US10584184B2
公开(公告)日：2020-03-10
申请号：US16022772
申请日：2018-06-29
申请人： Covidien LP
摘要： A process for dissolving modified cellulose includes contacting modified cellulose with a solvent in a mixture to form swelled modified cellulose and then contacting the mixture with a salt to dissolve the swelled modified cellulose. The dissolved modified cellulose is used to form at least one of a predictably degrading coating, film, or a fiber.
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公开(公告)号：US09687450B2
公开(公告)日：2017-06-27
申请号：US15054479
申请日：2016-02-26
申请人： Covidien LP
IPC分类号： A61K9/16 , A61K31/714 , A61K31/445 , A61K33/24 , B01J13/12 , A61L15/28 , A61L27/20
CPC分类号： A61K9/1682 , A61K9/1652 , A61K9/1694 , A61K31/445 , A61K31/714 , A61K33/24 , A61L15/28 , A61L27/20 , B01J13/12 , B01J13/125
摘要： A process for forming microspheres is disclosed. The process includes contacting a solvent with a modified cellulose to form a solution; contacting the modified cellulose solution with at least one bioactive agent to form a discontinuous phase liquid; contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion; and contacting the emulsion with a third phase liquid to extract the solvent from the emulsion, thereby forming a plurality of modified cellulose microspheres.
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7.发明申请Crosslinked Polymers with the Crosslinker as Therapeutic for Sustained Release 有权交联聚合物与交联剂作为持续释放的治疗剂公开(公告)号：US20130225857A1
公开(公告)日：2013-08-29
申请号：US13862500
申请日：2013-04-15
IPC分类号： C07C231/02 , C08G65/00
CPC分类号： C07C231/02 , A61K47/30 , A61K47/60 , A61K47/6903 , C07D207/46 , C08G65/00 , Y10T428/31551
摘要： Crosslinked polymers, methods for their preparation and use, are described in which the crosslinked polymers are formed from at least two polymer precursors, one of which is designed, upon degradation of the crosslinked polymer, to release the second polymer precursor in its original, unmodified chemical form.
摘要翻译： 描述了交联聚合物，其制备和使用方法，其中交联聚合物由至少两种聚合物前体形成，其中一种聚合物前体在交联聚合物降解时被设计为以其原始的未改性的方式释放第二聚合物前体 化学形式。
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公开(公告)号：US20190117575A1
公开(公告)日：2019-04-25
申请号：US16225169
申请日：2018-12-19
申请人： Covidien LP
发明人： Phillip Blaskovich , Rachit Ohri , Lan Pham
IPC分类号： A61K9/16 , A61L27/20 , A61L15/28 , B01J13/12 , A61K31/445 , A61K31/714 , A61K33/24
CPC分类号： A61K9/1682 , A61K9/1652 , A61K9/1694 , A61K31/445 , A61K31/714 , A61K33/24 , A61L15/28 , A61L27/20 , B01J13/12 , B01J13/125
摘要： A process for forming microspheres is disclosed. The process includes contacting a solvent with a modified cellulose to form a solution; contacting the modified cellulose solution with at least one bioactive agent to form a discontinuous phase liquid; contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion; and contacting the emulsion with a third phase liquid to extract the solvent from the emulsion, thereby forming a plurality of modified cellulose microspheres.
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公开(公告)号：US20180305468A1
公开(公告)日：2018-10-25
申请号：US16022772
申请日：2018-06-29
申请人： Covidien LP
摘要： A process for dissolving modified cellulose includes contacting modified cellulose with a solvent in a mixture to form swelled modified cellulose and then contacting the mixture with a salt to dissolve the swelled modified cellulose. The dissolved modified cellulose is used to form at least one of a predictably degrading coating, film, or a fiber.
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10.发明申请Dissolution of Oxidized Cellulose and Particle Preparation by Solvent and Non-Solvent Precipitation 审中-公开氧化纤维素的溶解和溶剂和非溶剂沉淀的颗粒制备公开(公告)号：US20160369013A1
公开(公告)日：2016-12-22
申请号：US15255263
申请日：2016-09-02
申请人： Covidien LP
发明人： Valentino Tramontano , Phillip Blaskovich , Rachit Ohri , Daniel S. Costa , Joshua Kennedy , Sajida Farooqi
CPC分类号： C08B1/003 , C08B15/00 , C08B15/005 , C08B15/02 , C08J3/096 , C08J3/14 , C08J2301/04
摘要： A process for dissolving modified cellulose includes contacting modified cellulose solution with at least one non-solvent to form a plurality of modified cellulose particles.
摘要翻译： 用于溶解改性纤维素的方法包括使改性纤维素溶液与至少一种非溶剂接触以形成多个改性的纤维素颗粒。
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