公开(公告)号：US10549106B2

公开(公告)日：2020-02-04

申请号：US15675427

申请日：2017-08-11

Applicant: Cardiac Pacemakers, Inc.

Inventor： David J. Ternes ,  Pramodsingh Hirasingh Thakur ,  Stephen B. Ruble

IPC: A61N1/372 ,  A61N1/37 ,  A61N1/375 ,  A61N1/365

Abstract: Systems and methods for auditing an operation of an ambulatory medical device (AMD) are described. A system may include an auditor device and an analyzer circuit communicatively coupled to each other. The auditor device can sense from the patient, independently of and during the operation of the AMD, information about the operation of the AMD including sensed electrostimulation and a physiological signal in response to the electrostimulation. The analyzer unit may generate a device audit indicator indicating the functionality and performance of the AMD using the sensed physiological signal and the sensed AMD operation information. The system may output the device audit indicator to a user or a process, or to program device therapy for the AMD based on the device audit indicator.

公开(公告)号：US20200001092A1

公开(公告)日：2020-01-02

申请号：US16535890

申请日：2019-08-08

Applicant: CARDIAC PACEMAKERS, INC.

Inventor： Bin Mi ,  Pramodsingh Hirasingh Thakur ,  Jeffrey E. Stahmann ,  Keith R. Maile ,  Qi An ,  Brendan Early Koop ,  Yinghong Yu ,  Viktoria A. Averina ,  Michael J. Kane ,  Krzysztof Z. Siejko

IPC: A61N1/365 ,  A61B5/00 ,  A61B5/02 ,  A61B5/11 ,  A61N1/375 ,  G01C19/38 ,  G06F3/0346

Abstract: An implantable medical device (IMD) that includes a housing, a first electrode secured relative to the housing, a second electrode secured relative to the housing, and a gyroscope secured relative to the housing. The IMD may include circuitry in the housing in communication with the first electrode, the second electrode, and the gyroscope. The circuitry may be configured to determine and store a plurality of torsion data measurements, from which a representation of a twist profile may be determined.

公开(公告)号：US10478629B2

公开(公告)日：2019-11-19

申请号：US15630677

申请日：2017-06-22

Applicant: CARDIAC PACEMAKERS, INC.

Inventor： Qi An ,  Pramodsingh Hirasingh Thakur ,  Yinghong Yu ,  Jeffrey E. Stahmann ,  Michael J. Kane

IPC: A61N1/375 ,  A61N1/372 ,  A61N1/365 ,  A61N1/05 ,  A61N1/02 ,  A61N1/37 ,  A61B5/00 ,  A61B5/0215 ,  A61B5/029 ,  A61B5/053 ,  A61B7/00 ,  A61N1/378

Abstract: A leadless cardiac pacemaker (LCP) configured to sense cardiac activity and to pace a patient's heart. The LCP may include a housing, a first electrode secured relative to the housing, a second electrode secured relative to the housing, and a pressure sensor secured relative to the housing and coupled to the environment outside of the housing. The LCP may further include circuitry in the housing in communication with the first electrode, the second electrode, and the pressure sensor. The circuitry may be configured to determine and store a plurality of impedance-pressure data pairs, from which a representation of a pressure-volume loop may be determined.

公开(公告)号：US10350418B2

公开(公告)日：2019-07-16

申请号：US15334615

申请日：2016-10-26

Applicant: Cardiac Pacemakers, Inc.

Inventor： Qi An ,  Julie A. Thompson ,  Yinghong Yu ,  Yi Zhang ,  Pramodsingh Hirasingh Thakur

IPC: A61N1/365 ,  A61N1/368 ,  A61N1/372 ,  A61N1/362 ,  A61B7/04

Abstract: Devices and methods for improving device therapy such as cardiac resynchronization therapy by determining a value for a device parameter are described. An ambulatory medical device (AMD) can include a sensor circuit to sense a physiological signal and generate two or more signal metrics, and detect an event of worsening cardiac condition using the two or more signal metrics. In response to the detection of worsening cardiac condition, the AMD can determine, for a stimulator, a value of at least one stimulation parameter based on temporal responses of two or more signal metrics. The temporal responses include near-term and long-term responses to the stimulation. The AMD can program the stimulator with the determined parameter value, and generate stimulation according to the determined parameter value to stimulate target tissue.

公开(公告)号：US10271797B2

公开(公告)日：2019-04-30

申请号：US15472445

申请日：2017-03-29

Applicant: Cardiac Pacemakers, Inc.

Inventor： Yi Zhang ,  Pramodsingh Hirasingh Thakur ,  Viktoria A. Averina ,  Julie A. Thompson ,  Qi An ,  Jonathan Walter Krueger

IPC: A61B5/02 ,  A61B5/00 ,  A61B5/0402 ,  A61B5/11 ,  A61N1/365 ,  A61N1/39 ,  G06F19/00 ,  G16H40/63 ,  G16H50/20 ,  A61B5/0215 ,  A61B5/053

Abstract: Systems and methods for detecting a target cardiac condition such as events indicative of worsening heart failure are described. A system may include sensor circuits for sensing physiological signals and a signal processor for generating a predictor trend indicative of temporal change of the physiological signal. The predictor trend may be transformed into a sequence of transformed indices using a codebook that includes a plurality of threshold pairs each including onset and reset thresholds. The codebook may be constructed and updated using physiological data. The system may detect target cardiac condition using the transformed indices.

公开(公告)号：US20190117169A1

公开(公告)日：2019-04-25

申请号：US16223798

申请日：2018-12-18

Applicant: Cardiac Pacemakers, Inc.

Inventor： Pramodsingh Hirasingh Thakur ,  Qi An ,  Barun Maskara ,  Julie A. Thompson

IPC: A61B5/00 ,  A61B5/02 ,  A61N1/368 ,  A61B5/0205 ,  A61N1/365 ,  A61N1/36 ,  A61B7/04 ,  A61B5/091

Abstract: Systems and methods are described for subject rehospitalization management. In an example, multiple physiologic signals can be obtained from a subject using multiple sensors. In response to a hospitalization event, pre-hospitalization characteristics of the multiple physiologic signals can be identified. Post-hospitalization characteristics of the multiple physiologic signals can be identified, including characteristics that differ from their corresponding pre-hospitalization characteristics. Later subsequent physiologic signals can be further monitored after the hospitalization event, such as using the same multiple sensors, and subsequent physiologic signal characteristics can be identified. In an example, a heart failure diagnostic indication can be determined using information about the pre-hospitalization characteristics, the post-hospitalization characteristics, and the subsequent characteristics. Information about relative changes in signal characteristics from multiple sensors can be used to identify particular subject physiologic signals to monitor during subsequent periods.

公开(公告)号：US20190008467A1

公开(公告)日：2019-01-10

申请号：US16025201

申请日：2018-07-02

Applicant: Cardiac Pacemakers, Inc.

Inventor： Viktoria A. Averina ,  Pramodsingh Hirasingh Thakur ,  Ramesh Wariar ,  Qi An ,  Yi Zhang ,  Jeffrey E. Stahmann

IPC: A61B5/00 ,  G08B21/18 ,  G16H50/20

CPC classification number: A61B5/746 ,  A61B5/0031 ,  A61B5/4836 ,  A61B5/686 ,  A61B5/7275 ,  A61B5/7282 ,  A61N1/025 ,  A61N1/3627 ,  A61N1/365 ,  A61N1/3702 ,  G08B21/182 ,  G16H50/20 ,  G16H50/70 ,  G16H70/60

Abstract: Systems and methods for managing machine-generated alerts of a medical event such as worsening heart failure (WHF) are described. A patient management system includes a patient database of information about a correspondence between a plurality of alert thresholds (ATHs) and corresponding clinical outcome indicators (COIs) for a plurality of patients. A control circuit can query the patient database for a matching patient that meets specific query criteria compared to a target patient, retrieve an ATH-COI correspondence associated with the matching patient, and determine the alert threshold using a user input of a COI and the retrieved ATH-COI correspondence. A medical event detector detects the medical event using physiological signals sensed from the target patient and the determined alert threshold.

公开(公告)号：US20180344212A1

公开(公告)日：2018-12-06

申请号：US15992531

申请日：2018-05-30

Applicant: Cardiac Pacemakers, Inc.

Inventor： Qi An ,  Pramodsingh Hirasingh Thakur

IPC: A61B5/11 ,  A61N1/362 ,  A61B5/0205

CPC classification number: A61N1/3627 ,  A61B5/0022 ,  A61B5/02028 ,  A61B5/02438 ,  A61B5/029 ,  A61B5/0452 ,  A61B5/053 ,  A61B5/4836 ,  A61B7/04 ,  A61N1/36578 ,  A61N1/37282 ,  A61N1/3756

Abstract: Systems and methods for monitoring and treating patients with heart failure are described. A signal receiver may receive a heart sound (HS) signal and an impedance signal sensed from the patient. A heart sound detector circuit may use at least the received impedance signal to determine a HS detection window, and detect a HS component indicative of cardiac diastolic function from the received HS signal within the HS detection window. The system may include a heart failure detector circuit that may generate a cardiac diastolic function indicator (DFI) using the detected HS component and, in certain examples, may detect worsening heart failure using the generated DFI. The system may include a therapy circuit to deliver or adjust an electrostimulation therapy based on DFI.

公开(公告)号：US20180325466A1

公开(公告)日：2018-11-15

申请号：US15978963

申请日：2018-05-14

Applicant: Cardiac Pacemakers, Inc.

Inventor： Qi An ,  Pramodsingh Hirasingh Thakur ,  Amy Jean Brisben ,  Jeffrey E. Stahmann ,  David J. Ternes

IPC: A61B5/00 ,  A61B5/0205

CPC classification number: A61B5/7282 ,  A61B5/0031 ,  A61B5/0205 ,  A61B5/04012 ,  A61B5/0456 ,  A61B5/0472 ,  A61B5/14542 ,  A61B5/7264

Abstract: Systems and methods for monitoring patient for syncope are discussed. A syncope monitor system can detect a precipitating event associated with a syncope onset, and acquire hemodynamic data in response to the detection of the precipitating event. A syncope analyzer circuit may generate temporal profiles of one or more hemodynamic parameters using the hemodynamic data. The syncope analyzer may use the temporal profiles to detect a syncopal event and to classify the syncopal event into one of a plurality of syncope categories. The detection and classification information may be output to a user or a process.

公开(公告)号：US10058708B2

公开(公告)日：2018-08-28

申请号：US15176915

申请日：2016-06-08

Applicant: Cardiac Pacemakers, Inc.

Inventor： Yi Zhang ,  Viktoria A. Averina ,  Pramodsingh Hirasingh Thakur

IPC: A61B5/00 ,  A61N1/362 ,  A61N1/365 ,  A61N1/37 ,  A61B5/024

CPC classification number: A61N1/3627 ,  A61B5/02438 ,  A61B5/4836 ,  A61B5/7275 ,  A61B5/7282 ,  A61B7/04 ,  A61N1/36114 ,  A61N1/36507 ,  A61N1/36535 ,  A61N1/36542 ,  A61N1/36585 ,  A61N1/3702 ,  G16H50/20 ,  G16H50/30

Abstract: Systems, devices, or methods can be used to detect an event, or series of events, that can indicate worsening of congestive heart failure (CHF), or can be used to identify a subject at an elevated risk for developing CHF. A CHF event predictor can be provided using a characteristic minimum of subject cardiac intervals. In an example, the subject cardiac intervals can be obtained during a night-time period or during periods of reduced subject physical activity. A CHF event predictor can be determined using information about physiologic signals received from a subject, such as from a physiologic sensor associated with an ambulatory or implantable medical device.