公开(公告)号：US20250134395A1

公开(公告)日：2025-05-01

申请号：US18904912

申请日：2024-10-02

Applicant: Cardiac Pacemakers, Inc.

Inventor： Mojgan Goftari ,  Bin Mi ,  Viktoria A. Averina ,  Pramodsingh Hirasingh Thakur

IPC: A61B5/0205 ,  A61B5/00 ,  A61B5/11 ,  A61B7/04

Abstract: Systems and methods are disclosed to an ambulatory medical device. The ambulatory medical device comprising an activity sensor configured to produce an activity signal representative of activity level of a patient, a heart sound sensor configured to produce a heart sound signal, and a control circuit. The control circuit is configured to detect a change in activity level of the patient using the activity signal, enable monitoring of the heart sound signal in response to detecting the change in activity level, measure intensity of an S3 heart sound in the heart sound signal, and produce an indication of pulmonary hypertension (PH) when the measured intensity of the S3 heart sound exceeds a PH detection threshold intensity.

公开(公告)号：US20240423580A1

公开(公告)日：2024-12-26

申请号：US18752446

申请日：2024-06-24

Applicant: Cardiac Pacemakers, Inc.

Inventor： Mojgan Goftari ,  Viktoria A. Averina ,  Pramodsingh Hirasingh Thakur ,  Jonathan Bennett Shute

IPC: A61B7/04 ,  A61B5/00 ,  A61B5/0205 ,  A61B5/024 ,  A61B5/08 ,  A61B5/11 ,  A61B5/28 ,  G16H20/40 ,  G16H50/20 ,  G16H50/30

Abstract: Systems and methods for monitoring and managing aortic stenosis are disclosed. An exemplary medical-device system comprises a data receiver to receive heart sound information sensed by ambulatory heart sound sensors, and a stenosis detector to detect a change in aortic valve surface area from a baseline stenosis-free state using heart sound components such as S1 and S2 sounds. Based on the change in aortic valve surface area, the stenosis detector can generate an aortic stenosis indicator indicating a presence and severity of aortic stenosis. Such indicator can be provided to a user, trigger symptom monitoring and evaluation of functional deterioration in the patient, facilitate assessment of patient candidacy for aortic valve replacement, or triage heart failure management strategies.

公开(公告)号：US20240181263A1

公开(公告)日：2024-06-06

申请号：US18528985

申请日：2023-12-05

Applicant: Cardiac Pacemakers, Inc.

Inventor： Sean Thomas Horan ,  Pramodsingh Hirasingh Thakur

IPC: A61N1/368 ,  A61N1/365

CPC classification number: A61N1/3688 ,  A61N1/36521 ,  A61N1/36585 ,  A61N1/36842 ,  A61N1/36843

Abstract: Systems and methods are disclosed to control transition of a stimulation circuit configured to generate first and second stimulation signals in different respective first and second stimulation modes between the different respective first and second stimulation modes using a patient metric determined using received physiologic information of the patient including at least one of thoracic impedance information or respiration information from a first time period.

公开(公告)号：US11992306B2

公开(公告)日：2024-05-28

申请号：US17486521

申请日：2021-09-27

Applicant: Cardiac Pacemakers, Inc.

Inventor： Gezheng Wen ,  Pramodsingh Hirasingh Thakur ,  John D. Hatlestad ,  Qi An

IPC: A61B5/08 ,  A61B5/00 ,  A61B5/01 ,  A61B5/085 ,  A61B5/091

CPC classification number: A61B5/0826 ,  A61B5/01 ,  A61B5/085 ,  A61B5/091 ,  A61B5/4806 ,  A61B5/686 ,  A61B5/746 ,  A61B2562/0271

Abstract: Systems and methods to are disclosed to determine a sleep disordered breathing parameter of a patient, including receiving respiration information of the patient and temperature information of the patient and to determine the sleep disordered breathing parameter of the patient using the received respiration information and temperature information of the patient.

公开(公告)号：US11944430B2

公开(公告)日：2024-04-02

申请号：US16664315

申请日：2019-10-25

Applicant: Cardiac Pacemakers, Inc.

Inventor： Bin Mi ,  Pramodsingh Hirasingh Thakur ,  Keith R. Maile ,  Stephen B. Ruble ,  Jonathan Bennett Shute

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/0205 ,  A61B5/0215 ,  A61B5/053 ,  A61B5/11 ,  A61B5/366 ,  A61B7/04 ,  G16H50/30

CPC classification number: A61B5/14532 ,  A61B5/0006 ,  A61B5/0205 ,  A61B5/0215 ,  A61B5/1116 ,  A61B5/366 ,  A61B5/4839 ,  A61B5/686 ,  A61B7/045 ,  A61B5/053 ,  G16H50/30

Abstract: Systems, devices, and methods for monitoring and assessing blood glucose level in a patient are discussed. An exemplary system receives physiologic information from a patient using an ambulatory medical device. The physiologic information is correlated to, and different from, a direct glucose level measurement. The system determines a glucose index indicative of an abnormal blood glucose level using the received physiologic information by the two or more physiologic sensors. The system may use the glucose index to initiate or adjust a therapy, or to trigger a glucose sensor, separate from the two or more physiologic sensors, to directly measure blood glucose concentration.

公开(公告)号：US11883209B2

公开(公告)日：2024-01-30

申请号：US17994987

申请日：2022-11-28

Applicant: Cardiac Pacemakers, Inc.

Inventor： Pramodsingh Hirasingh Thakur ,  Yi Zhang ,  Qi An ,  Viktoria A. Averina

IPC: A61B5/00 ,  A61B5/091 ,  G16H40/63 ,  G16H50/30 ,  G16H50/20 ,  G16H40/67 ,  A61B5/0205 ,  A61N1/362 ,  A61N1/365 ,  A61B5/08 ,  A61B7/04

CPC classification number: A61B5/7275 ,  A61B5/0205 ,  A61B5/091 ,  A61B5/4836 ,  A61B5/686 ,  A61B5/7264 ,  A61B5/7282 ,  A61B5/746 ,  A61N1/3627 ,  A61N1/36585 ,  G16H40/63 ,  G16H40/67 ,  G16H50/20 ,  G16H50/30 ,  A61B5/0816 ,  A61B7/04

Abstract: Systems and methods for detecting worsening cardiac conditions such as worsening heart failure events are described. A system may include sensor circuits to sense physiological signals and signal processors to generate from the physiological signals first and second signal metrics. The system may include a risk stratifier circuit to produce a cardiac risk indication. The system may use at least the first signal metric to generate a primary detection indication, and use at least the second signal metric and the risk indication to generate a secondary detection indication. The risk indication may be used to modulate the second signal metric. A detector circuit may detect the worsening cardiac event using the primary and secondary detection indications.

公开(公告)号：US11850087B2

公开(公告)日：2023-12-26

申请号：US16386611

申请日：2019-04-17

Applicant: Cardiac Pacemakers, Inc.

Inventor： Jonathan Bennett Shute ,  Rezwan Ahmed ,  Bin Mi ,  Krzysztof Z. Siejko ,  Pramodsingh Hirasingh Thakur ,  Qi An

IPC: A61B7/02 ,  A61B5/00 ,  A61B7/04 ,  A61B5/349 ,  A61B5/0205 ,  A61N1/362 ,  A61B5/1455

CPC classification number: A61B7/026 ,  A61B5/0051 ,  A61B5/349 ,  A61B5/6803 ,  A61B5/6817 ,  A61B7/04 ,  A61B5/02055 ,  A61B5/1455 ,  A61B5/486 ,  A61B2562/0204 ,  A61N1/362

Abstract: Systems and methods for detecting heart sound information from a subject's head are described. A system embodiment includes a headgear to be worn on the subject's head, and first and second sensors to sense respectively first and second physiologic signals each representing vibration, motion, or displacement conducted through patient body tissue. The sensed physiologic signals contain heart sound information. At least one of the first or the second sensor is included in the headgear, and placed at a head location to sense a physiologic signal indicative of heart sounds. The system includes a processor to generate a composite signal using the sensed first and second physiologic signals. The system may generate a heart sound metric using the composite signal, and detect a cardiac event such as an arrhythmia or worsening heart failure.

公开(公告)号：US20230165536A1

公开(公告)日：2023-06-01

申请号：US17994987

申请日：2022-11-28

Applicant: Cardiac Pacemakers, Inc.

Inventor： Pramodsingh Hirasingh Thakur ,  Yi Zhang ,  Qi An ,  Viktoria A. Averina

IPC: A61B5/00 ,  A61B5/091 ,  G16H40/63 ,  G16H50/30 ,  G16H50/20 ,  G16H40/67 ,  A61B5/0205 ,  A61N1/362 ,  A61N1/365

CPC classification number: A61B5/7275 ,  A61B5/7282 ,  A61B5/091 ,  G16H40/63 ,  G16H50/30 ,  G16H50/20 ,  G16H40/67 ,  A61B5/0205 ,  A61B5/4836 ,  A61B5/686 ,  A61B5/7264 ,  A61B5/746 ,  A61N1/3627 ,  A61N1/36585 ,  A61B5/0816

Abstract: Systems and methods for detecting worsening cardiac conditions such as worsening heart failure events are described. A system may include sensor circuits to sense physiological signals and signal processors to generate from the physiological signals first and second signal metrics. The system may include a risk stratifier circuit to produce a cardiac risk indication. The system may use at least the first signal metric to generate a primary detection indication, and use at least the second signal metric and the risk indication to generate a secondary detection indication. The risk indication may be used to modulate the second signal metric. A detector circuit may detect the worsening cardiac event using the primary and secondary detection indications.

公开(公告)号：US11583196B2

公开(公告)日：2023-02-21

申请号：US16803672

申请日：2020-02-27

Applicant: Cardiac Pacemakers, Inc.

Inventor： Jonathan Bennett Shute ,  Sunipa Saha ,  Pramodsingh Hirasingh Thakur

IPC: A61B5/024 ,  A61B5/0205 ,  A61B5/08 ,  A61B5/00 ,  A61B5/11 ,  A61B5/363

Abstract: Systems and methods for detecting cardiac arrhythmia are discussed. An exemplary medical-device system includes an arrhythmia detector circuit that receives physiologic information, including respiration and heart beat information a patient, and determines whether a respiratory sinus arrhythmia (RSA) is present or absent using the respiration and the heart beat information. An indication of the presence or absence of RSA may be stored in a memory. The arrhythmia detector circuit can detect an AT episode using the indication of RSA.

公开(公告)号：US11480561B2

公开(公告)日：2022-10-25

申请号：US16518621

申请日：2019-07-22

Applicant: Cardiac Pacemakers, Inc.

Inventor： Gezheng Wen ,  Qi An ,  Pramodsingh Hirasingh Thakur ,  Deepa Mahajan

IPC: A61B5/0205 ,  G01N33/50

Abstract: Systems, devices, and methods for monitoring and assessing immunotherapy toxicity are discussed. An exemplary system receives physiologic information from a patient using an ambulatory medical device. In response to an immunotherapy such as CAR T-cell therapy, the system determines a toxicity indication using the received physiologic information. A therapy can be initiated or adjusted using the toxicity indication.