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21.发明授权In vitro method for identifying a compound using an eukaryotic mechanosensory transduction channel 有权使用真核机械感觉转导通道鉴定化合物的体外方法公开(公告)号：US07867721B2
公开(公告)日：2011-01-11
申请号：US11703343
申请日：2007-02-06
CPC分类号： C07K14/43581
摘要： The present invention provides, for the first time, nucleic acids encoding a eukaryotic mechanosensory transduction channel (MSC) protein. The proteins encoded by these nucleic acids form channels that can directly detect mechanical stimuli and convert them into electrical signals. These nucleic acids and the proteins they encode can be used as probes for sensory cells in animals, and can be used to diagnose and treat any of a number of human conditions involving inherited, casual, or environmentally-induced loss of mechanosensory transduction activity.
摘要翻译： 本发明首次提供了编码真核机械感应通道（MSC）蛋白质的核酸。 由这些核酸编码的蛋白质形成可以直接检测机械刺激并将其转换为电信号的通道。 这些核酸及其编码的蛋白质可用作动物感觉细胞的探针，可用于诊断和治疗许多涉及遗传，休闲或环境诱导的机械感觉转导活性丧失的人类病症。
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公开(公告)号：US07863433B2
公开(公告)日：2011-01-04
申请号：US11716362
申请日：2007-03-08
IPC分类号： C12N15/12 , C07K14/705
CPC分类号： G01N33/5041 , C07K14/705 , C07K14/723
摘要： The invention provides isolated nucleic acid and amino acid sequences of sensory cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sensory cell specific G-protein coupled receptors.
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23.发明授权Assays for sensory modulators using a sensory cell specific G-protein alpha subunit 失效使用感觉细胞特异性G蛋白α亚基的感觉调节剂的测定公开(公告)号：US07727729B2
公开(公告)日：2010-06-01
申请号：US11094036
申请日：2005-03-29
申请人： Charles S. Zuker
发明人： Charles S. Zuker
IPC分类号： G01N33/53 , G01N33/566 , C12P21/02 , C12Q1/00 , C07K14/47
CPC分类号： G01N33/6842 , G01N33/566 , G01N2333/705 , G01N2500/04
摘要： The invention identifies nucleic acid and amino acid sequences of a sensory cell specific G-protein alpha subunit that are specifically expressed in sensory cells, e.g., taste cells, antibodies to such G-protein alpha subunits, methods of detecting such nucleic acids and subunits, and methods of screening for modulators of a sensory cell specific G-protein alpha subunit.
摘要翻译： 本发明鉴定在感觉细胞中特异性表达的感觉细胞特异性G蛋白α亚基的核酸和氨基酸序列，例如味细胞，这种G蛋白α亚基的抗体，检测此类核酸和亚基的方法， 以及筛选感觉细胞特异性G蛋白α亚基的调节剂的方法。
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24.发明授权Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction 有权编码参与感觉转导的G蛋白偶联受体的核酸公开(公告)号：US07282557B2
公开(公告)日：2007-10-16
申请号：US10096144
申请日：2002-03-08
CPC分类号： G01N33/5041 , C07K14/705 , C07K14/723
摘要： The invention provides isolated nucleic acid and amino acid sequences of sensory cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sensory cell specific G-protein coupled receptors.
摘要翻译： 本发明提供了分离的感觉细胞特异性G蛋白偶联受体的核酸和氨基酸序列，这种受体的抗体，检测此类核酸和受体的方法，以及筛选感觉细胞特异性G蛋白偶联受体调节剂的方法。
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公开(公告)号：US06875574B1
公开(公告)日：2005-04-05
申请号：US09492028
申请日：2000-01-26
申请人： Charles S. Zuker
发明人： Charles S. Zuker
IPC分类号： C07K14/00 , C12P21/02 , C12Q1/00 , G01N33/53 , G01N33/566 , G01N33/567
CPC分类号： G01N33/6842 , G01N33/566 , G01N2333/705 , G01N2500/04
摘要： The invention identifies nucleic acid and amino acid sequences of a sensory cell specific G-protein alpha subunit that are specifically expressed in sensory cells, e.g., taste cells, antibodies to such G-protein alpha subunits, methods of detecting such nucleic acids and subunits, and methods of screening for modulators of a sensory cell specific G-protein alpha subunit.
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26.发明申请Mammalian Sweet and Amino Acid Heterodimeric Taste Receptors Comprising T1R3 and T1R1 有权包含T1R3和T1R1的哺乳动物甜氨基酸异二聚味道感受器公开(公告)号：US20110151483A1
公开(公告)日：2011-06-23
申请号：US12944515
申请日：2010-11-11
申请人： Charles S. Zuker , Jayaram Chandrashekar , Greg Nelson , Yifeng Zhang , Nicholas J. P. Ryba , Mark A. Hoon
发明人： Charles S. Zuker , Jayaram Chandrashekar , Greg Nelson , Yifeng Zhang , Nicholas J. P. Ryba , Mark A. Hoon
CPC分类号： G01N33/5076 , C07K14/705
摘要： The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising T1R3 and T1R1, two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
摘要翻译： 本发明提供了包含T1R3和T1R1的甜或氨基酸味受体的分离的核酸和氨基酸序列，来自感官G蛋白偶联受体的T1R家族的两种异源G蛋白偶联受体多肽，对这种受体的抗体， 检测这种核酸和受体，以及筛选甜味和氨基酸味觉受体调节剂的方法。
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公开(公告)号：US07507793B2
公开(公告)日：2009-03-24
申请号：US10645441
申请日：2003-08-20
申请人： Charles S. Zuker , Nicholas J. P. Ryba , Gregory A. Nelson , Mark A. Hoon , Jayaram Chandrashekar , Yifeng Zhang
发明人： Charles S. Zuker , Nicholas J. P. Ryba , Gregory A. Nelson , Mark A. Hoon , Jayaram Chandrashekar , Yifeng Zhang
IPC分类号： C07H21/04 , G01N33/53 , G01N33/567 , C12P21/06 , C07K14/00
CPC分类号： C07K14/705
摘要： The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.
摘要翻译： 本发明提供了包含来自感官G蛋白偶联受体的T1R家族的两种异源G蛋白偶联受体多肽，这种受体的抗体，检测这种核酸和受体的方法的甜味受体的分离的核酸和氨基酸序列， 以及筛选甜味受体调节剂的方法。
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公开(公告)号：US20090075294A1
公开(公告)日：2009-03-19
申请号：US11703343
申请日：2007-02-06
IPC分类号： G01N33/53
CPC分类号： C07K14/43581
摘要： The present invention provides, for the first time, nucleic acids encoding a eukaryotic mechanosensory transduction channel (MSC) protein. The proteins encoded by these nucleic acids form channels that can directly detect mechanical stimuli and convert them into electrical signals. These nucleic acids and the proteins they encode can be used as probes for sensory cells in animals, and can be used to diagnose and treat any of a number of human conditions involving inherited, casual, or environmentally-induced loss of mechanosensory transduction activity.
摘要翻译： 本发明首次提供了编码真核机械感应通道（MSC）蛋白质的核酸。 由这些核酸编码的蛋白质形成可以直接检测机械刺激并将其转换为电信号的通道。 这些核酸及其编码的蛋白质可用作动物感觉细胞的探针，可用于诊断和治疗许多涉及遗传，休闲或环境诱导的机械感觉转导活性丧失的人类病症。
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公开(公告)号：US20080318251A1
公开(公告)日：2008-12-25
申请号：US12121576
申请日：2008-05-15
申请人： Charles S. Zuker , Jayaram Chandrashekar , Greg Nelson , Yifeng Zhang , Nicholas J.P. Ryba , Mark A. Hoon
发明人： Charles S. Zuker , Jayaram Chandrashekar , Greg Nelson , Yifeng Zhang , Nicholas J.P. Ryba , Mark A. Hoon
IPC分类号： G01N33/566 , C07K14/47 , C12N5/06 , C12N5/08
CPC分类号： G01N33/5076 , C07K14/705
摘要： The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
摘要翻译： 本发明提供了包含来自感觉G蛋白偶联受体的T1R家族的两种异源G蛋白偶联受体多肽的分离的核酸和氨基酸味道受体的氨基酸序列，这些受体的抗体，检测此类核酸的方法 和受体以及筛选甜味和氨基酸味觉受体调节剂的方法。
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公开(公告)号：US07459277B2
公开(公告)日：2008-12-02
申请号：US11402202
申请日：2006-04-10
IPC分类号： G01N33/567 , C07K14/705
CPC分类号： C07K14/705 , G01N2333/726
摘要： The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors, the receptors comprising consisting of a monomer or homodimer of a T1R3 G-protein coupled receptor polypeptide, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
摘要翻译： 本发明提供了分离的甜味受体的核酸和氨基酸序列，所述受体包括由T1R3G-蛋白偶联受体多肽的单体或同二聚体组成，对这种受体的抗体，检测此类核酸和受体的方法，以及 筛选甜味和氨基酸味道受体调节剂的方法。
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