公开(公告)号：US08820928B2

公开(公告)日：2014-09-02

申请号：US13404033

申请日：2012-02-24

申请人： Arthur Back ,  David Robert Morsley ,  Richard Rogers ,  Sarah Almond ,  Charlie Chen ,  Yuwen Liu ,  Charles A. Francis ,  Ye Hong

发明人： Arthur Back ,  David Robert Morsley ,  Richard Rogers ,  Sarah Almond ,  Charlie Chen ,  Yuwen Liu ,  Charles A. Francis ,  Ye Hong

IPC分类号： G02C7/04 ,  C08L83/04 ,  G02B1/04 ,  C08G77/46 ,  C08G77/20

CPC分类号： C08L83/04 ,  C08G77/20 ,  C08G77/46 ,  G02B1/043 ,  C08L101/14 ,  C08L83/12

摘要： Silicone hydrogel contact lenses are produced without using volatile organic solvents to extract materials from the polymerized contact lens bodies, and instead are washed with aqueous liquids. The silicone hydrogel contact lenses so produced have ophthalmically wettable lens surfaces such that less than five percent of a batch of twenty or more such silicone hydrogel contact lenses have visually identifiable non-wetting spots when the contact lenses are located on eyes of subjects.

摘要翻译： 制造硅氧烷水凝胶隐形眼镜，而不使用挥发性有机溶剂从聚合的隐形眼镜体提取物质，而是用含水液体洗涤。 如此制造的硅酮水凝胶隐形眼镜具有眼睛可润湿的透镜表面，使得当隐形眼镜位于受试者的眼睛上时，少于一批二十或更多个这种硅氧水凝胶隐形眼镜的百分之五具有视觉上可识别的非润湿斑点。

公开(公告)号：US08646907B2

公开(公告)日：2014-02-11

申请号：US13395134

申请日：2010-09-21

申请人： Yun Zhang ,  Charlie Chen ,  Peter Zhu ,  Ying Ye ,  Hongjin Qiu

发明人： Yun Zhang ,  Charlie Chen ,  Peter Zhu ,  Ying Ye ,  Hongjin Qiu

IPC分类号： G02C7/04

CPC分类号： C08J7/16

摘要： A lens body comprising at least one form of boronic acid, boronic ester or boronic anhydride is provided. The lens body is contacted with a solution comprising at least one form of TRIS. A contact lens package including the contact lens, and methods of producing and using the contact lens, are also provided.

摘要翻译： 提供了包含至少一种形式的硼酸，硼酸酯或硼酸酐的透镜体。 透镜体与包含至少一种形式的TRIS的溶液接触。 还提供了包括隐形眼镜的隐形眼镜包，以及制造和使用隐形眼镜的方法。

公开(公告)号：US20140018465A1

公开(公告)日：2014-01-16

申请号：US13985109

申请日：2012-02-23

申请人： Yuwen Liu ,  Charlie Chen ,  Ye Hong ,  Charles A. Francis ,  Li Yao ,  Arthur Back

发明人： Yuwen Liu ,  Charlie Chen ,  Ye Hong ,  Charles A. Francis ,  Li Yao ,  Arthur Back

IPC分类号： G02B1/04

CPC分类号： G02B1/043 ,  C08F283/065 ,  C08L51/085 ,  C08L101/14

摘要： Silicone hydrogel contact lenses having a high water content are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1): wherein m of formula (1) represents one integer from 3 to 10, n of formula (1) represents one integer from 1 to 10, R1 of formula (1) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (1) is independently either a hydrogen atom or a methyl group; the lenses also include units derived from a second siloxane monomer having a number average molecular weight of at least 7,000 daltons, and at least one vinyl-containing cross-linking agent. The lenses have average equilibrium water contents from about 30% wt/wt to about 70% wt/wt when fully hydrated. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

摘要翻译： 描述了具有高水含量的硅氧烷水凝胶隐形眼镜。 透镜衍生自包含由式（1）表示的第一硅氧烷单体的可聚合组合物：其中式（1）的m表示3至10的一个整数，式（1）的n表示1至10的整数，R 1 式（1）的烷基是碳原子数为1〜4的烷基，式（1）的各R 2独立地为氢原子或甲基。 透镜还包括衍生自数均分子量为至少7,000道尔顿的第二硅氧烷单体的单元和至少一种含乙烯基交联剂。 当完全水合时，透镜具有约30重量％至约70重量％的平均水含量。 还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。

公开(公告)号：US08445614B2

公开(公告)日：2013-05-21

申请号：US13404034

申请日：2012-02-24

申请人： Charles A. Francis ,  Ying Zheng ,  Yuan Xu ,  Li Yao ,  Arthur Back ,  Ye Hong ,  Charlie Chen

发明人： Charles A. Francis ,  Ying Zheng ,  Yuan Xu ,  Li Yao ,  Arthur Back ,  Ye Hong ,  Charlie Chen

IPC分类号： C08F230/08 ,  C08F290/06 ,  G02B1/04

CPC分类号： C08F230/08 ,  C08F222/1006

摘要： Dimensionally stable silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1): wherein m of formula (1) represents one integer from 3 to 10, n of formula (1) represents one integer from 1 to 10, R1 of formula (1) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (1) is independently either a hydrogen atom or a methyl group; the lenses also include units derived from a second siloxane monomer represented by formula (2): wherein R1 of formula (2) is selected from either hydrogen atom or a methyl group; R2 of formula (2) is selected from either of hydrogen atom or a hydrocarbon group having 1 to 4 carbon atoms; m of formula (2) represents an integer of from 0 to 10; n of formula (2) represents an integer of from 4 to 100; a and b represent integers of 1 or more; a+b is equal to 20-500; b/(a+b) is equal to 0.01-0.22; the configuration of siloxane units includes a random configuration, the second siloxane monomer having a number average molecular weight of at least 3,000 daltons that is present in the polymerizable composition in an amount such that ratio of the first siloxane monomer to the second siloxane monomer is at least 2:1 based on unit parts by weight. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

摘要翻译： 描述了尺寸稳定的硅酮水凝胶隐形眼镜。 透镜衍生自包含由式（1）表示的第一硅氧烷单体的可聚合组合物：其中式（1）的m表示3至10的一个整数，式（1）的n表示1至10的整数，R 1 式（1）的烷基是碳原子数为1〜4的烷基，式（1）的各R 2独立地为氢原子或甲基。 透镜还包括衍生自由式（2）表示的第二硅氧烷单体的单元：其中式（2）的R 1选自氢原子或甲基; 式（2）的R2选自氢原子或碳原子数为1〜4的烃基; 式（2）的m表示0〜10的整数， 式（2）的n表示4〜100的整数， a和b表示1以上的整数; a + b等于20-500; b /（a + b）等于0.01-0.22; 硅氧烷单元的构型包括随机构型，第二硅氧烷单体的数均分子量为至少3,000道尔顿，其存在于可聚合组合物中，其量使得第一硅氧烷单体与第二硅氧烷单体的比率在 至少2：1，单位重量份。 还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。

公开(公告)号：US20120216489A1

公开(公告)日：2012-08-30

申请号：US13404041

申请日：2012-02-24

申请人： Paul Hungchaung Lee ,  Ronghua Liu ,  Xinfeng Shi ,  Yuwen Liu ,  Ye Hong ,  Charlie Chen ,  Li Yao ,  Arthur Back ,  Charles A. Francis

发明人： Paul Hungchaung Lee ,  Ronghua Liu ,  Xinfeng Shi ,  Yuwen Liu ,  Ye Hong ,  Charlie Chen ,  Li Yao ,  Arthur Back ,  Charles A. Francis

IPC分类号： B65B63/00 ,  C08L43/04

CPC分类号： B29D11/00038 ,  G02B1/043 ,  C08L101/14 ,  C08L83/04 ,  C08L33/10

摘要： Silicone hydrogel contact lenses that are derived from a polymerizable composition including at least one siloxane monomer and at least one hydrophilic monomer are described. These silicone hydrogel contact lenses have, when fully hydrated, has an equilibrium freezable water content of at least 25% wt/wt as determined by differential scanning calorimetry (DSC). Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

摘要翻译： 描述了衍生自包含至少一种硅氧烷单体和至少一种亲水单体的可聚合组合物的硅氧烷水凝胶隐形眼镜。 当通过差示扫描量热法（DSC）测定时，这些硅氧水凝胶隐形眼镜在完全水合时具有至少25％wt / wt的平衡可冷冻水含量。 还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。

公开(公告)号：US20120172486A1

公开(公告)日：2012-07-05

申请号：US13146414

申请日：2010-09-21

申请人： Peter Zhu ,  Ying Ye ,  Yun Zhang ,  Charlie Chen

发明人： Peter Zhu ,  Ying Ye ,  Yun Zhang ,  Charlie Chen

IPC分类号： C08L43/00 ,  B29D11/00

CPC分类号： C08J7/16

摘要： A contact lens is provided that has extended and rechargeable wettability. The contact lens includes a lens body that is a reaction product of a polymerizable composition. A first polyhydric alcohol having a 1,2 diol or 1,3 diol moiety is present on a lens surface of the lens body. A contact lens package including the contact lens, and methods of producing and using the contact lens, are also provided.

摘要翻译： 提供了一种具有延长和充分润湿性的隐形眼镜。 隐形眼镜包括作为可聚合组合物的反应产物的透镜体。 具有1,2-二醇或1,3-二醇部分的第一多元醇存在于透镜体的透镜表面上。 还提供了包括隐形眼镜的隐形眼镜包，以及制造和使用隐形眼镜的方法。

公开(公告)号：US07968018B2

公开(公告)日：2011-06-28

申请号：US11737059

申请日：2007-04-18

申请人： Jay Scott Daulton ,  Charlie Chen ,  Tim Warren

发明人： Jay Scott Daulton ,  Charlie Chen ,  Tim Warren

IPC分类号： B29D11/00 ,  B65D85/38 ,  B29C71/00

CPC分类号： B29D11/00067 ,  B29C33/60 ,  B29C37/0067 ,  B29D11/0025 ,  Y10S425/808

摘要： Methods of producing silicone hydrogel ophthalmic lenses include contacting one or more delensed silicone hydrogel ophthalmic lens with a liquid composition that contains alcohol, water, and a surfactant. The methods can be steps of an extraction/hydration procedure used in the production of silicone hydrogel contact lenses. In some examples, contacting silicone hydrogel ophthalmic lens products with a liquid composition that contains alcohol, water, and a surfactant can significantly reduce or prevent surface distortion of the ophthalmic lens resulting from the extraction procedure. Some methods include subsequently contacting the silicone hydrogel ophthalmic lens with a liquid composition consisting essentially of water and a surfactant.

摘要翻译： 生产硅酮水凝胶眼科镜片的方法包括将一种或多种疏水性硅氧水凝胶眼用透镜与含有醇，水和表面活性剂的液体组合物接触。 该方法可以是用于生产硅酮水凝胶隐形眼镜的提取/水合程序的步骤。 在一些实例中，将硅酮水凝胶眼用透镜产品与含有醇，水和表面活性剂的液体组合物接触可显着降低或防止由提取程序引起的眼科镜片的表面变形。 一些方法包括随后使硅氧水凝胶眼用透镜与基本上由水和表面活性剂组成的液体组合物接触。

公开(公告)号：US09164298B2

公开(公告)日：2015-10-20

申请号：US13983577

申请日：2012-02-23

申请人： Ye Hong ,  Li Yao ,  Yuwen Liu ,  Charlie Chen ,  Arthur Back

发明人： Ye Hong ,  Li Yao ,  Yuwen Liu ,  Charlie Chen ,  Arthur Back

IPC分类号： G02C7/04 ,  G02B1/04 ,  C08L83/12

CPC分类号： G02C7/049 ,  C08L83/12 ,  G02B1/043 ,  C08L101/14 ,  C08L83/04 ,  C08L51/085

摘要： Silicone hydrogel contact lenses are formed from the reaction product of a polymerizable composition comprising at least one acrylate-containing siloxane monomer, at least one hydrophilic vinyl-containing monomer, and at least one vinyl-containing cross-linking agent, wherein the polymerizable composition has a molar ratio of total amount of hydrophilic vinyl-containing monomer to total amount of acrylate-containing siloxane monomer of from 5:1 to 30:1, respectively. The silicone hydrogel contact lenses have good manufacturing processability, can be manufactured without the use of alcohol solvents, and have excellent surface wettability.

摘要翻译： 硅氧烷水凝胶隐形眼镜由包含至少一种含丙烯酸酯的硅氧烷单体，至少一种亲水性含乙烯基单体和至少一种含乙烯基交联剂的可聚合组合物的反应产物形成，其中可聚合组合物具有 亲水性含乙烯基单体的总量与含丙烯酸酯的硅氧烷单体的总量的摩尔比分别为5:1至30:1。 硅酮水凝胶隐形眼镜具有良好的制造加工性，可以在不使用醇溶剂的情况下制造，并且具有优异的表面润湿性。

公开(公告)号：US09057822B2

公开(公告)日：2015-06-16

申请号：US13983774

申请日：2012-02-23

申请人： Yuwen Liu ,  Ye Hong ,  Junhao Ge ,  Yuan Xu ,  Charlie Chen ,  Charles A. Francis ,  Li Yao ,  Arthur Back

发明人： Yuwen Liu ,  Ye Hong ,  Junhao Ge ,  Yuan Xu ,  Charlie Chen ,  Charles A. Francis ,  Li Yao ,  Arthur Back

IPC分类号： G02B1/04 ,  C08F283/12 ,  C08F236/20 ,  C08F226/00 ,  C08F283/06 ,  C08L51/08 ,  C08J11/02

CPC分类号： G02B1/043 ,  C08F226/00 ,  C08F236/20 ,  C08F283/065 ,  C08F283/126 ,  C08J11/02 ,  C08L51/085 ,  C08L83/04 ,  C08L101/14

摘要： Silicone hydrogel contact lenses that are derived from a polymerizable composition including a first siloxane monomer represented by formula (3): wherein m of formula (3) represents one integer from 3 to 10, n of formula (3) represents one integer from 1 to 10, R1 of formula (3) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (3) is independently either a hydrogen atom or a methyl group; and at least one vinyl ether-containing cross-linking agent are described. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described. In one example, the batches of silicone hydrogel contact lenses are dimensionally stable, and the method of making is a method of making dimensionally stable silicone hydrogel contact lenses.

摘要翻译： 衍生自包含由式（3）表示的第一硅氧烷单体的可聚合组合物的聚合性组合物的硅氧水凝胶隐形眼镜：式（3）的m表示3〜10的整数，式（3）的n表示1〜 10，式（3）的R 1为碳原子数1〜4的烷基，式（3）的各R 2独立地为氢原子或甲基。 和至少一种含乙烯基醚的交联剂。 还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。 在一个示例中，硅胶水凝胶隐形眼镜的批次是尺寸稳定的，并且制造方法是制备尺寸稳定的硅酮水凝胶隐形眼镜的方法。

公开(公告)号：US20140016086A1

公开(公告)日：2014-01-16

申请号：US13983774

申请日：2012-02-23

申请人： Yuwen Liu ,  Ye Hong ,  Junhao Ge ,  Yuan Xu ,  Charlie Chen ,  Charles A. Francis ,  Li Yao ,  Arthur Back

发明人： Yuwen Liu ,  Ye Hong ,  Junhao Ge ,  Yuan Xu ,  Charlie Chen ,  Charles A. Francis ,  Li Yao ,  Arthur Back

IPC分类号： G02C7/04

CPC分类号： G02B1/043 ,  C08F226/00 ,  C08F236/20 ,  C08F283/065 ,  C08F283/126 ,  C08J11/02 ,  C08L51/085 ,  C08L83/04 ,  C08L101/14

摘要： Silicone hydrogel contact lenses that are derived from a polymerizable composition including a first siloxane monomer represented by formula (3): wherein m of formula (3) represents one integer from 3 to 10, n of formula (3) represents one integer from 1 to 10, R1 of formula (3) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (3) is independently either a hydrogen atom or a methyl group; and at least one vinyl ether-containing cross-linking agent are described. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described. In one example, the batches of silicone hydrogel contact lenses are dimensionally stable, and the method of making is a method of making dimensionally stable silicone hydrogel contact lenses.

摘要翻译： 衍生自包含由式（3）表示的第一硅氧烷单体的可聚合组合物的聚合性组合物的硅氧水凝胶隐形眼镜：式（3）的m表示3〜10的整数，式（3）的n表示1〜 10，式（3）的R 1为碳原子数1〜4的烷基，式（3）的各R 2独立地为氢原子或甲基。 和至少一种含乙烯基醚的交联剂。 还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。 在一个示例中，硅胶水凝胶隐形眼镜的批次是尺寸稳定的，并且制造方法是制备尺寸稳定的硅酮水凝胶隐形眼镜的方法。