公开(公告)号：US20090222076A1

公开(公告)日：2009-09-03

申请号：US12084421

申请日：2006-11-02

申请人： Hans-Reiner Figulla ,  Markus Ferrari

发明人： Hans-Reiner Figulla ,  Markus Ferrari

IPC分类号： A61F2/06

CPC分类号： A61F2/2418 ,  A61F2/2436 ,  A61F2002/9528 ,  A61F2230/0078 ,  A61F2230/008

摘要： The invention relates to a self-expandable medical instrument (100) for treating defects in a patient's heart, in particular for the transvascular implantation of a prosthetic heart valve (30), wherein the medical instrument (100) is introducible into the body of a patient in a minimally-invasive procedure using a catheter system (40) and comprises a stent (1) made of a flexible mesh (2) of thin wires or filaments (2′). In order to realize a positioning of medical instrument (100) in the patient's heart which is as precise as possible and to securely anchor same there, it is provided for the stent (1) composed of the flexible mesh (2) to exhibit in the expanded state of the medical instrument (100) a distal retention area (10) with a laterally-inverted beaded portion (12) which is engageable in at least one pocket (51) of the patient's defective heart valve (50), a proximal retention area (20), and a center area (15) positioned between the distal and the proximal retention area (10, 20).

摘要翻译： 本发明涉及一种用于治疗患者心脏中的缺陷的自扩张型医疗器械（100），特别是用于假体心脏瓣膜（30）的经血管植入，其中所述医疗器械（100）被引入到体内 患者在使用导管系统（40）的微创手术中，并且包括由细丝或细丝（2'）的柔性网（2）制成的支架（1）。 为了实现医疗器械（100）在患者心脏中尽可能精确地定位并且可靠地固定在那里，为由柔性网（2）组成的支架（1）提供在 医疗器械（100）的扩张状态具有横向倒置的串珠部分（12）的远侧保持区域（10），其可接合在患者的有缺陷心脏瓣膜（50）的至少一个口袋（51）中，近端保持 区域（20）和位于远端和近端保持区域（10,20）之间的中心区域（15）。

公开(公告)号：US20140275720A1

公开(公告)日：2014-09-18

申请号：US13261824

申请日：2012-09-04

申请人： Markus Ferrari

发明人： Markus Ferrari

IPC分类号： A61M1/12 ,  A61B5/0402

CPC分类号： A61M1/122 ,  A61B5/0402 ,  A61B5/06 ,  A61F2/01 ,  A61F2/82 ,  A61F2250/0096 ,  A61M1/1006 ,  A61M1/1008 ,  A61M1/101 ,  A61M1/1034 ,  A61M1/106 ,  A61M1/1072 ,  A61M1/12 ,  A61M1/125 ,  A61M2205/32

摘要： So as to be able to determine the position of a functional element as precisely as possible during the invasive use of a blood pump in a patient's body without the use of imaging methods, the blood pump is connected to a main sensor which records signals of the patient's heart, which are compared to other electrophysiological heart signals recorded by several sensors distributed on the body surface so as to allow the position of the blood pump to be determined by way of linking.

摘要翻译： 为了在不使用成像方法的情况下能够在患者体内侵入性地使用血液泵时尽可能精确地确定功能元件的位置，血泵连接到主传感器，该主传感器记录 将患者的心脏与通过分布在体表上的若干传感器记录的其他电生理心脏信号进行比较，以允许通过连接确定血液泵的位置。

公开(公告)号：US20070208292A1

公开(公告)日：2007-09-06

申请号：US10592287

申请日：2005-03-09

申请人： Markus Ferrari

发明人： Markus Ferrari

IPC分类号： A61M39/00

CPC分类号： A61M1/367 ,  A61M1/14 ,  A61M1/1698 ,  A61M2209/08 ,  Y10T137/4841 ,  Y10T137/4857

摘要： The invention relates to a device for exchanging and/or docking functional modules (1, 2), used for the extracorporeal circulation of bodily fluids, each functional module (1, 2) having at least one conduit (3; 4) comprising an inlet (5; 7) and an outlet (6; 8). The aim of the invention is to exchange the functional modules of an extracorporeal circuit as rapidly as possible, without detaching tubular connections and without having to establish a new connection. To achieve this, the invention is provided with elements (9, 10; 11, 12) for connecting the conduit (3) of a first functional module (1) to the inlet (5) and the outlet (6) of a second functional module (2), whereby the connection is established in such a way that the first functional module (1) is bypassed by means of the second functional module (2) to maintain the flow and the bodily fluid is diverted through the second functional module (2).

摘要翻译： 本发明涉及一种用于交换和/或对接用于体液的体外循环的功能模块（1,2）的装置，每个功能模块（1,2）具有至少一个导管（3; 4），其包括入口 （5; 7）和出口（6; 8）。 本发明的目的是尽可能快地更换体外电路的功能模块，而不需要拆卸管状连接，而不必建立新的连接。 为了实现这一点，本发明提供了用于将第一功能模块（1）的导管（3）连接到第二功能模块（1）的入口（5）和出口（6）的元件（9,10; 11,12） 模块（2），由此建立连接，使得第一功能模块（1）借助于第二功能模块（2）旁路以维持流动并且体液被转移通过第二功能模块（2） 2）。

公开(公告)号：US07691047B2

公开(公告)日：2010-04-06

申请号：US11569036

申请日：2005-05-10

申请人： Markus Ferrari

发明人： Markus Ferrari

IPC分类号： A61H31/00 ,  A61M1/10

CPC分类号： A61M1/1068 ,  A61M1/106 ,  A61M1/1086 ,  A61M1/12 ,  A61N1/0587

摘要： A device for epicardial support and/or the assuming of cardiac activity having a double membrane (1) consisting of an elastic inner membrane (2) and a non-expandable outer membrane (3) as well as a closed cavity (4) formed therebetween which can be inflated and deflated by means of a fluid. With the objective of further developing a device of the type as indicated at the outset which provides a simpler possibility of stimulating the heart in the critical post-operative phase, it is provided for at least one probe/electrode unit (7, 8) to be arranged on the inward facing side (6) of the inner membrane (2) to the heart (5) for epicardial ECG leads and/or signal transmission/conversion of an external pacemaker.

摘要翻译： 用于心外膜支持的装置和/或具有由弹性内膜（2）和不可扩张外膜（3）组成的双膜（1）以及形成在其间的封闭空腔（4）的心脏活动的装置 其可以通过流体膨胀和放气。 为了进一步开发如开始所示类型的装置，其提供了在关键的手术后阶段刺激心脏的更简单的可能性，为至少一个探针/电极单元（7,8）提供至少一个 布置在内膜（2）的内侧（6）到心脏（5）上用于心外膜心电信号引导和/或外部起搏器的信号传输/转换。

公开(公告)号：US07637880B2

公开(公告)日：2009-12-29

申请号：US11569038

申请日：2005-05-10

申请人： Markus Ferrari

发明人： Markus Ferrari

IPC分类号： A61M1/10

CPC分类号： A61M1/1068 ,  A61M1/106 ,  A61M1/12

摘要： A device for epicardial support and/or the assuming of cardiac activity having a double membrane (1) having an elastic inner membrane (2) and a non-expandable outer membrane (3) as well as a closed cavity (4) formed therebetween which can be inflated and deflated by means of a fluid. With the objective of further developing a device of the type, so that same can more simply and at substantially lesser risk administer medication to the pericardial sac, a second cavity (7) having a fluid-permeable wall limiting the second cavity (7) relative to the heart is provided at the inward facing side (6) of the inner membrane (2) relative to the heart (5) with this second cavity (7) being able to be filled with a fluid through a separate fluid line (9) from outside the patient's body or drained from within the body.

摘要翻译： 用于心外膜支持的装置和/或具有具有弹性内膜（2）和不可扩张外膜（3）的双膜（1）的心脏活动的装置以及在其间形成的闭合腔（4） 可以通过流体膨胀和放气。 为了进一步开发这种类型的装置，使得能够更简单地且以更低的风险向心包囊施用药物，具有限制第二腔（7）相对的流体可渗透壁的第二腔（7） 相对于心脏（5）在内膜（2）的向内侧（6）处设置有心脏，该第二空腔（7）能够通过单独的流体管线（9）填充流体， 从患者身体外部或从体内排出。

公开(公告)号：US20070225545A1

公开(公告)日：2007-09-27

申请号：US11569036

申请日：2005-05-10

申请人： Markus Ferrari

发明人： Markus Ferrari

IPC分类号： A61N1/362

CPC分类号： A61M1/1068 ,  A61M1/106 ,  A61M1/1086 ,  A61M1/12 ,  A61N1/0587

摘要： A device for epicardial support and/or the assuming of cardiac activity having a double membrane (1) consisting of an elastic inner membrane (2) and a non-expandable outer membrane (3) as well as a closed cavity (4) formed therebetween which can be inflated and deflated by means of a fluid. With the objective of further developing a device of the type as indicated at the outset which provides a simpler possibility of stimulating the heart in the critical post-operative phase, it is provided for at least one probe/electrode unit (7, 8) to be arranged on the inward facing side (6) of the inner membrane (2) to the heart (5) for epicardial ECG leads and/or signal transmission/conversion of an external pacemaker.

摘要翻译： 用于心外膜支持的装置和/或具有由弹性内膜（2）和不可扩张外膜（3）组成的双膜（1）以及形成在其间的封闭空腔（4）的心脏活动的装置 其可以通过流体膨胀和放气。 为了进一步开发如开始所示类型的装置，其提供了在关键的手术后阶段刺激心脏的更简单的可能性，为至少一个探针/电极单元（7,8）提供至少一个 布置在内膜（2）的内侧（6）到心脏（5）上用于心外膜心电信号引导和/或外部起搏器的信号传输/转换。

公开(公告)号：US10561773B2

公开(公告)日：2020-02-18

申请号：US13261824

申请日：2012-09-04

申请人： Markus Ferrari ,  Joerg Schumacher

发明人： Markus Ferrari ,  Joerg Schumacher

IPC分类号： A61M1/12 ,  A61B5/0402

摘要： So as to be able to determine the position of a functional element as precisely as possible during the invasive use of a blood pump in a patient's body without the use of imaging methods, the blood pump is connected to a main sensor which records signals of the patient's heart, which are compared to other electrophysiological heart signals recorded by several sensors distributed on the body surface so as to allow the position of the blood pump to be determined by way of linking.

公开(公告)号：US20100087773A1

公开(公告)日：2010-04-08

申请号：US12531129

申请日：2008-03-17

申请人： Markus Ferrari

发明人： Markus Ferrari

IPC分类号： A61M1/12

CPC分类号： A61M1/3666 ,  A61M1/1008 ,  A61M1/101 ,  A61M1/1037 ,  A61M1/106 ,  A61M1/1072 ,  A61M1/1086 ,  A61M1/1096 ,  A61M1/122 ,  A61M1/125 ,  A61M1/3667

摘要： The present invention relates to a device for circulating a body fluid in a body of a living organism, especially to support the heart and/or circulation of the living organism, comprising a catheter device which has at least one inlet portion to take up the body fluid at at least one first location within the body of the living organism, at least one outlet portion some distance from the at least one inlet portion to discharge the body fluid at at least one second location some distance from the at least one first location within the body of the living organism and a pump device for directed transport of the body fluid between the at least one inlet portion and the at least one outlet portion of the catheter device; and a valve arrangement coupled to the catheter device for controlled uptake of the body fluid as a function of operation of the pump device at the at least one inlet portion of the catheter device and controlled discharge of the body fluid at the at least one outlet portion of the catheter device.

摘要翻译： 本发明涉及一种用于使生物体的体内循环体液，特别是用于支撑活体的心脏和/或循环的装置，其包括导管装置，所述导管装置具有至少一个入口部分以吸收身体 在活体内的至少一个第一位置处的流体，至少一个出口部分，与至少一个入口部分有一定距离，以在距离至少一个第一位置至少一个第二位置处的体液排出， 活体的主体和用于在导管装置的至少一个入口部分和至少一个出口部分之间定向输送体液的泵装置; 以及耦合到所述导管装置的阀装置，用于根据在所述导管装置的所述至少一个入口部分处的所述泵装置的操作的功能来控制所述体液的吸收，并且在所述至少一个出口部分处控制排出所述体液 的导管装置。

公开(公告)号：US07507217B2

公开(公告)日：2009-03-24

申请号：US10592287

申请日：2005-03-09

申请人： Markus Ferrari

发明人： Markus Ferrari

IPC分类号： A61M37/00 ,  A61B19/00 ,  B01D29/00 ,  C02F9/00 ,  E03B11/00 ,  F17D1/00

CPC分类号： A61M1/367 ,  A61M1/14 ,  A61M1/1698 ,  A61M2209/08 ,  Y10T137/4841 ,  Y10T137/4857

摘要： A device for exchanging and/or docking functional modules (1, 2), and used for the extracorporeal circulation of bodily fluids, is provided. Each functional module (1, 2) includes at least one conduit (3; 4) comprising an inlet (5; 7) and an outlet (6; 8). The aim of the invention is to exchange the functional modules of an extracorporeal circuit as rapidly as possible, without detaching tubular connections and without having to establish a new connection. The invention is provided with elements (9, 10; 11, 12) for connecting the conduit (3) of a first functional module (1) to the inlet (5) and the outlet (6) of a second functional module (2). The connection is established in such a way that the first functional module (1) is bypassed by means of the second functional module (2) to maintain the flow and the bodily fluid is diverted through the second functional module (2).

摘要翻译： 提供了一种用于交换和/或对接功能模块（1,2）并用于体液的体外循环的装置。 每个功能模块（1,2）包括至少一个包括入口（5; 7）和出口（6; 8）的导管（3; 4）。 本发明的目的是尽可能快地更换体外电路的功能模块，而不需要拆卸管状连接，而不必建立新的连接。 本发明提供了用于将第一功能模块（1）的导管（3）连接到第二功能模块（2）的入口（5）和出口（6）的元件（9,10; 11,12） 。 建立连接，使得第一功能模块（1）通过第二功能模块（2）旁路以维持流动，并且体液通过第二功能模块（2）转移。

公开(公告)号：US20080021259A1

公开(公告)日：2008-01-24

申请号：US11569038

申请日：2005-05-10

申请人： Markus Ferrari

发明人： Markus Ferrari

IPC分类号： A61M1/10

CPC分类号： A61M1/1068 ,  A61M1/106 ,  A61M1/12

摘要： A device for epicardial support and/or the assuming of cardiac activity having a double membrane (1) having an elastic inner membrane (2) and a non-expandable outer membrane (3) as well as a closed cavity (4) formed therebetween which can be inflated and deflated by means of a fluid. With the objective of further developing a device of the type, so that same can more simply and at substantially lesser risk administer medication to the pericardial sac, a second cavity (7) having a fluid-permeable wall limiting the second cavity (7) relative to the heart is provided at the inward facing side (6) of the inner membrane (2) relative to the heart (5) with this second cavity (7) being able to be filled with a fluid through a separate fluid line (9) from outside the patient's body or drained from within the body.

摘要翻译： 用于心外膜支持的装置和/或具有具有弹性内膜（2）和不可扩张外膜（3）的双膜（1）的心脏活动的装置以及在其间形成的闭合腔（4） 可以通过流体膨胀和放气。 为了进一步开发这种类型的装置，使得能够更简单地且以更低的风险向心包囊施用药物，具有限制第二腔（7）相对的流体可渗透壁的第二腔（7） 相对于心脏（5）在内膜（2）的向内侧（6）处设置有心脏，该第二空腔（7）能够通过单独的流体管线（9）填充流体， 从患者身体外部或从体内排出。