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    Inner catheter arrangement for a self-expanding medical device delivery system
    22.
    发明授权
    Inner catheter arrangement for a self-expanding medical device delivery system 有权
    用于自扩张医疗装置输送系统的内导管装置

    公开(公告)号：US09592142B2

    公开(公告)日：2017-03-14

    申请号：US14180064

    申请日：2014-02-13

    Applicant: Cook Medical Technologies LLC

    Inventor： Conor M. Dillon ,  John Neilan ,  Brent A. Mayle ,  James C. Merk ,  Dean R. Puckett ,  Tiffani L. Cannon ,  Darin Voorhies

    IPC: A61F2/966

    CPC classification number: A61F2/966 ,  Y10T29/49874

    Abstract: A delivery system for a self-expanding medical device is provided. The delivery system includes an outer sheath that radially restrains the medical device. First and second inner catheters are disposed within the outer sheath. The first inner catheter is a composite structure with a closed coil wire covered by a polymer outer layer. The second inner catheter is disposed within the closed coil wire but is not attached to the closed coil wire.

    Abstract translation: 提供了一种用于自扩张医疗装置的输送系统。 输送系统包括径向限制医疗装置的外护套。 第一和第二内导管设置在外护套内。 第一内导管是具有由聚合物外层覆盖的闭合线圈线的复合结构。 第二内导管设置在闭合线圈线内，但未附接到闭合线圈线。

    ENDOSCOPIC NEEDLE STYLET WITH ENHANCED-FLEXIBILITY LENGTHS
    23.
    发明申请
    ENDOSCOPIC NEEDLE STYLET WITH ENHANCED-FLEXIBILITY LENGTHS 审中-公开
    具增强灵活性长度的内窥镜针刺

    公开(公告)号：US20160331405A1

    公开(公告)日：2016-11-17

    申请号：US15146178

    申请日：2016-05-04

    Applicant: Cook Medical Technologies LLC

    Inventor： Fionán Keady ,  John Neilan ,  James Butler ,  Shay Joseph Lavelle

    IPC: A61B17/34 ,  A61B8/12

    CPC classification number: A61B17/3478 ,  A61B8/12 ,  A61B10/04 ,  A61B2010/045 ,  A61B2017/00867 ,  A61B2017/3413

    Abstract: A single-wire stylet may be constructed as an elongate single-wire, memory-metal alloy body with a generally cylindrical body profile, extending distally from a proximal end terminus, where embodiments include a polymeric distal tip member fixedly attached directly at a distal end of the single-wire body. At least one lengthwise portion of the single-wire body is at least partially in martensitic phase at operating temperatures at and below about 37° C. Where present, the polymeric distal tip member has a generally cylindrical body profile circumferentially bounded by an outer circumference substantially equal to or greater than that of the metal body. The polymeric distal tip member may be overmolded upon a distal-end tip length of an elongate single-wire, memory-metal alloy stylet body, where the distal end and/or discrete intermediate distal-portion length(s) that include martensitic-phase alloy and any polymeric member have greater flexibility than a proximal-most length of the alloy stylet body.

    Abstract translation: 单线探针可以被构造为具有大致圆柱形主体轮廓的细长单丝记忆金属合金体，其从近端终端向远侧延伸，其中实施例包括直接固定在远端 的单线体。 单丝主体的至少一个纵向部分在马氏体相中至少部分地处于等于或低于约37℃的操作温度。在存在的情况下，聚合物远侧末端构件具有大致圆柱形的主体轮廓，其外周基本上包围 等于或大于金属体的厚度。 聚合物远侧末端构件可以在细长单丝，记忆 - 金属合金探针体的远端尖端长度上包覆成型，其中远端和/或离散的中间远端部分长度包括马氏体相 合金和任何聚合物构件具有比最近的长度的合金探针体更大的柔性。

    Inner catheter arrangement for a self-expanding medical device delivery system
    24.
    发明授权
    Inner catheter arrangement for a self-expanding medical device delivery system 有权

    公开(公告)号：US09468546B2

    公开(公告)日：2016-10-18

    申请号：US14180064

    申请日：2014-02-13

    Applicant: Cook Medical Technologies LLC

    Inventor： Conor M. Dillon ,  John Neilan

    IPC: A61F2/966

    Abstract: A delivery system for a self-expanding medical device is provided. The delivery system includes an outer sheath that radially restrains the medical device. First and second inner catheters are disposed within the outer sheath. The first inner catheter is a composite structure with a closed coil wire covered by a polymer outer layer. The second inner catheter is disposed within the closed coil wire but is not attached to the closed coil wire.

    WIRE-EMBEDDED POLYMER-BODY NEEDLE
    25.
    发明申请
    WIRE-EMBEDDED POLYMER-BODY NEEDLE 有权
    电线嵌入式聚合物体针

    公开(公告)号：US20150099995A1

    公开(公告)日：2015-04-09

    申请号：US14492984

    申请日：2014-09-22

    Applicant: Cook Medical Technologies LLC

    Inventor： Michael S. Clancy ,  John Neilan ,  Darach McGrath

    IPC: A61M5/32 ,  A61B10/04 ,  A61M5/158 ,  A61B10/02

    CPC classification number: A61M5/3286 ,  A61B10/0233 ,  A61B10/04 ,  A61B17/3478 ,  A61B2010/045 ,  A61B2090/3925 ,  A61M5/158 ,  A61M2205/0266

    Abstract: A medical needle including an elongate tubular body having an outer wall defining at least one longitudinal lumen is provided. The at least one longitudinal lumen may be configured to provide access for at least one of a wire guide, a therapeutic tool, a diagnostic tool, a medicament, and/or contrast fluid. The body may be configured with sufficient length and flexibility to be extended out of and operated through a working channel of a surgical endoscope. The body further includes one or more wires embedded in, and secured substantially immovably relative to, the outer wall. A distal end of the body includes a needle tip configured with at least one sharpened surface configured to penetrate into body tissue.

    Abstract translation: 提供了包括具有限定至少一个纵向内腔的外壁的细长管状体的医疗针。 所述至少一个纵向内腔可以被配置为为线引导件，治疗工具，诊断工具，药物和/或对比流体中的至少一个提供通路。 身体可以构造成具有足够的长度和柔性，以延伸出并通过手术内窥镜的工作通道操作。 身体还包括一个或多个线，其相对于外壁嵌入并基本上不可移动地固定。 主体的远端包括配置有至少一个被锐化的表面的针头，构造成穿透身体组织。

    Anti-Aspiration Valve
    26.
    发明申请
    Anti-Aspiration Valve 有权
    防吸气阀

    公开(公告)号：US20130289711A1

    公开(公告)日：2013-10-31

    申请号：US13794010

    申请日：2013-03-11

    Applicant: COOK MEDICAL TECHNOLOGIES LLC

    Inventor： Alison Liddy ,  John Neilan ,  Michael Ryan ,  Gerard Treacy

    IPC: A61F2/06

    CPC classification number: A61F2/04 ,  A61F2/06 ,  A61F2/07 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2002/044 ,  A61F2230/0069 ,  A61F2250/0069

    Abstract: A prosthesis and a method for making a prosthesis for controlling flow through a bodily lumen are provided. The prosthesis includes a body having a proximal portion, a distal portion and a lumen extending therethrough and further includes a valve operably connected to the body. The valve has a distal end including a first portion of a surface of the valve lumen and a second portion of the surface that contact each other and form a seal in a closed configuration. The distal end of the valve is formed such that the first portion and the second portion of the surface of the valve lumen contact each other and the distal end is configured to open in response to a pressure that is greater than atmospheric pressure.

    Abstract translation: 提供了一种用于制造用于控制通过体腔流动的假体的假体和方法。 假体包括具有近端部分，远侧部分和延伸穿过其中的内腔的主体，并且还包括可操作地连接到身体的瓣膜。 阀具有远端，其包括阀腔表面的第一部分和表面的彼此接触并形成封闭构造的密封件的第二部分。 阀的远端形成为使得阀腔的表面的第一部分和第二部分彼此接触，并且远端构造成响应于大于大气压力的压力而打开。

    Implantable medical device with differentiated luminal and abluminal characteristics
    28.
    发明授权
    Implantable medical device with differentiated luminal and abluminal characteristics 有权

    公开(公告)号：US10980923B2

    公开(公告)日：2021-04-20

    申请号：US15932323

    申请日：2018-02-16

    Applicant: Cook Medical Technologies LLC

    Inventor： John Neilan ,  David Murray ,  James Butler

    IPC: A61L31/00 ,  A61L31/16 ,  A61L31/02 ,  A61L31/08 ,  A61L31/14 ,  A61L27/08 ,  A61L27/54

    Abstract: There are disclosed implantable medical devices and apparatus for treating implantable medical devices during production, so as to cause the implantable medical devices to have abluminal surfaces and luminal surfaces with different functional characteristics and in particular surface energies. The luminal surfaces of the medical device are preferably coated with carbon, so as to have a low surface energy, which reduces the risk of thrombi forming when implanted into a patient's vessels. The abluminal surfaces are treated so as to have a high surface energy, such that a therapeutic, preferably bioactive, material, such as a drug, can adhere to the abluminal surfaces and preferably without any need for a containment layer such as polymer or other matrix material. Once the therapeutic material has been delivered into the tissue wall, the stent can remain within the patient's vessel without leaving any delivery artefacts, as occurs with some prior art drug eluting medical devices.

    BIOACTIVE AGENT COATED MEDICAL DEVICE AND METHOD OF COATING SUCH A DEVICE
    29.
    发明申请
    BIOACTIVE AGENT COATED MEDICAL DEVICE AND METHOD OF COATING SUCH A DEVICE 审中-公开

    公开(公告)号：US20200170814A1

    公开(公告)日：2020-06-04

    申请号：US16203892

    申请日：2018-11-29

    Applicant: Cook Medical Technologies LLC

    Inventor： John Neilan ,  David Murray ,  James Butler

    IPC: A61F2/90 ,  A61L29/16 ,  A61L31/02 ,  C22C19/03

    Abstract: A medical device such as a stent or medical balloon is functionalised prior to coating with a bioactive material, specifically by carboxylic acidification of the contact surface or surfaces of the medical device. The preferred process involves washing a stent or other medical device in a washing solution which may be sodium hydroxide, soaking in a carboxylic acid solution, rinsing in water to remove excess carboxylic acid, allowing to dry before applying a bioactive agent layer. It has been found that washing after functionalisation removes excess carboxylic acid and enhances the retention of bioactive agent on the contact surface or surfaces of the medical device leading to a more uniform and consistent layer of bioactive agent.

    COATED MEDICAL DEVICE AND METHOD OF COATING SUCH A DEVICE
    30.
    发明申请
    COATED MEDICAL DEVICE AND METHOD OF COATING SUCH A DEVICE 审中-公开

    公开(公告)号：US20200016299A1

    公开(公告)日：2020-01-16

    申请号：US16510352

    申请日：2019-07-12

    Applicant: Cook Medical Technologies LLC

    Inventor： John Neilan ,  David Murray ,  James Butler

    IPC: A61L31/08 ,  A61L31/16 ,  A61L27/54 ,  A61F2/90

    Abstract: A medical device such as a stent (10) or medical balloon (40) is at least partially coated with a saturated carboxylic acid layer in order to enhance biocompatibility, reduce thrombogenesis and increase endothelialisation. The coating is preferably of citric acid in non-crosslinked form and preferably non-porous so as to mask the underlying structure of the medical device. The acid coating forms an outer surface of at least a part of the medical device, that is has no other layer or material overlying it, save for in some embodiments a partial coating of a bioactive material.

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