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公开(公告)号：US11759552B2
公开(公告)日：2023-09-19
申请号：US15899436
申请日：2018-02-20
Applicant: Cook Medical Technologies LLC
Inventor： John Neilan , David Murray , James Butler
IPC: A61L31/08 , A61L31/16 , A61L31/02 , A61L27/04 , A61L27/30 , A61L27/54 , B05D3/12 , A61F2/915 , A61F2/90
CPC classification number: A61L31/084 , A61L27/04 , A61L27/303 , A61L27/54 , A61L31/022 , A61L31/16 , B05D3/12 , A61F2/90 , A61F2/915 , A61L2300/416 , A61L2400/18 , A61L2420/02
Abstract: There is disclosed a method of improving the reliability of coating an implantable medical device, such as a stent, with bioactive material in the absence of a carrier material such as a matrix or polymer layer. The method involves cleaning volatile components from the exposed surfaces of the medical device, removing carbon deposits and then applying a uniform carbon layer in a controlled environment. The deliberately applied carbon layer masks impurities of the underlying native oxide layer and leads to more uniform bioactive material coating not only a over the surfaces of a single medical device but also from device to device within a batch and between batches of devices. This improves production as well as optimising the amount and release of drug on the medical device without the need for a carrier material.
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公开(公告)号：US20190161854A1
公开(公告)日：2019-05-30
申请号：US16200870
申请日：2018-11-27
Applicant: Cook Medical Technologies LLC
Inventor： John Neilan , David Murray , James Butler
Abstract: A method of modifying a surface of a medical device for implantation or disposition inside a patient is described. The medical device comprises a structure having at least one surface. The method includes the steps of: placing the medical device into a plasma chamber substantially free from contaminants and substantially sealing the plasma chamber from the atmosphere; removing at least an outermost layer of any oxide layer from the at least one surface of the structure by a plasma oxide-removal process, whilst maintaining the plasma chamber under seal from the atmosphere; and subsequently forming a new oxide layer at the least one surface of the structure by introducing at least one gas into the plasma chamber, whilst maintaining the plasma chamber under seal from the atmosphere. A medical device including a bulk material and an oxide layer disposed over at least one surface of the medical device. The oxide layer is substantially pure and free from contaminants.
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公开(公告)号：US10980923B2
公开(公告)日：2021-04-20
申请号：US15932323
申请日：2018-02-16
Applicant: Cook Medical Technologies LLC
Inventor： John Neilan , David Murray , James Butler
Abstract: There are disclosed implantable medical devices and apparatus for treating implantable medical devices during production, so as to cause the implantable medical devices to have abluminal surfaces and luminal surfaces with different functional characteristics and in particular surface energies. The luminal surfaces of the medical device are preferably coated with carbon, so as to have a low surface energy, which reduces the risk of thrombi forming when implanted into a patient's vessels. The abluminal surfaces are treated so as to have a high surface energy, such that a therapeutic, preferably bioactive, material, such as a drug, can adhere to the abluminal surfaces and preferably without any need for a containment layer such as polymer or other matrix material. Once the therapeutic material has been delivered into the tissue wall, the stent can remain within the patient's vessel without leaving any delivery artefacts, as occurs with some prior art drug eluting medical devices.
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公开(公告)号：US20200170814A1
公开(公告)日：2020-06-04
申请号：US16203892
申请日：2018-11-29
Applicant: Cook Medical Technologies LLC
Inventor： John Neilan , David Murray , James Butler
Abstract: A medical device such as a stent or medical balloon is functionalised prior to coating with a bioactive material, specifically by carboxylic acidification of the contact surface or surfaces of the medical device. The preferred process involves washing a stent or other medical device in a washing solution which may be sodium hydroxide, soaking in a carboxylic acid solution, rinsing in water to remove excess carboxylic acid, allowing to dry before applying a bioactive agent layer. It has been found that washing after functionalisation removes excess carboxylic acid and enhances the retention of bioactive agent on the contact surface or surfaces of the medical device leading to a more uniform and consistent layer of bioactive agent.
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公开(公告)号：US20200016299A1
公开(公告)日：2020-01-16
申请号：US16510352
申请日：2019-07-12
Applicant: Cook Medical Technologies LLC
Inventor： John Neilan , David Murray , James Butler
Abstract: A medical device such as a stent (10) or medical balloon (40) is at least partially coated with a saturated carboxylic acid layer in order to enhance biocompatibility, reduce thrombogenesis and increase endothelialisation. The coating is preferably of citric acid in non-crosslinked form and preferably non-porous so as to mask the underlying structure of the medical device. The acid coating forms an outer surface of at least a part of the medical device, that is has no other layer or material overlying it, save for in some embodiments a partial coating of a bioactive material.
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Patent Agency Ranking
公开(公告)号：US20200016298A1
公开(公告)日：2020-01-16
申请号：US16033765
申请日：2018-07-12
Applicant: Cook Medical Technologies LLC
Inventor： John Neilan , David Murray , James Butler
Abstract: A medical device such as a stent (10) or medical balloon (40) is at least partially coated with a carboxylic acid layer in order to enhance biocompatibility, reduce thrombogenesis and increase endothelialisation. The coating is preferably of citric acid in non-crosslinked form and preferably non-porous so as to mask the underlying structure of the medical device. The acid coating forms an outer surface of at least a part of the medical device, that is has no other layer or material overlying it, save for in some embodiments a partial coating of a bioactive material.
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公开(公告)号：US20170203011A1
公开(公告)日：2017-07-20
申请号：US15398184
申请日：2017-01-04
Applicant: COOK MEDICAL TECHNOLOGIES LLC
Inventor： John Neilan , David Murray , James Butler
Abstract: A medical device such as a stent (10) or medical balloon (40) is functionalised prior to coating with a bioactive material (54), specifically by acidification or basification of the contact surface or surfaces (50) of the medical device. Functionalisation with subsequent coating of bioactive agent directly onto the functionalised surface provides a significantly more consistent and reliable coating of bioactive agent on a medical device without requiring containment or time release devices.
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公开(公告)号：US20160361472A1
公开(公告)日：2016-12-15
申请号：US15177713
申请日：2016-06-09
Applicant: Cook Medical Technologies LLC
Inventor： John Neilan , David Murray
CPC classification number: A61L31/16 , A61L31/022 , A61L31/14 , A61L2300/214 , A61L2300/416 , A61L2300/606 , A61L2400/16 , A61L2400/18 , A61L2420/02
Abstract: An implantable medical device includes a bioactive material coated on a contact surface. The contact surface and bioactive material each has a defined surface energy density comprising a polar component and a non-polar component. The polar components of the surface energies are substantially matched and the non-polar components of the surface energies are substantially matched so as to allow optimised bonding and elution of the material when in situ within a patient. A method for manufacturing the device is also provided.
Abstract translation: 可植入医疗装置包括涂覆在接触表面上的生物活性材料。 接触表面和生物活性材料各自具有包含极性组分和非极性组分的限定的表面能量密度。 表面能的极性成分基本匹配，表面能的非极性成分基本匹配，从而允许材料在患者内原位时优化粘合和洗脱。 还提供了一种用于制造该装置的方法。
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公开(公告)号：US11752019B2
公开(公告)日：2023-09-12
申请号：US16203892
申请日：2018-11-29
Applicant: Cook Medical Technologies LLC
Inventor： John Neilan , David Murray , James Butler
CPC classification number: A61F2/90 , A61L29/16 , A61L31/022 , C22C19/03 , A61L2300/606
Abstract: A medical device such as a stent or medical balloon is functionalised prior to coating with a bioactive material, specifically by carboxylic acidification of the contact surface or surfaces of the medical device. The preferred process involves washing a stent or other medical device in a washing solution which may be sodium hydroxide, soaking in a carboxylic acid solution, rinsing in water to remove excess carboxylic acid, allowing to dry before applying a bioactive agent layer. It has been found that washing after functionalisation removes excess carboxylic acid and enhances the retention of bioactive agent on the contact surface or surfaces of the medical device leading to a more uniform and consistent layer of bioactive agent.
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公开(公告)号：US11193202B2
公开(公告)日：2021-12-07
申请号：US16200870
申请日：2018-11-27
Applicant: Cook Medical Technologies LLC
Inventor： John Neilan , David Murray , James Butler
IPC: A61L27/00 , C23C16/02 , A61L31/02 , A61L31/08 , A61L31/16 , A61L27/30 , A61L27/06 , A61L27/54 , A61F2/82 , C23C16/40 , C23C16/50 , H01J37/32
Abstract: A method of modifying a surface of a medical device for implantation or disposition inside a patient is described. The medical device comprises a structure having at least one surface. The method includes the steps of: placing the medical device into a plasma chamber substantially free from contaminants and substantially sealing the plasma chamber from the atmosphere; removing at least an outermost layer of any oxide layer from the at least one surface of the structure by a plasma oxide-removal process, whilst maintaining the plasma chamber under seal from the atmosphere; and subsequently forming a new oxide layer at the least one surface of the structure by introducing at least one gas into the plasma chamber, whilst maintaining the plasma chamber under seal from the atmosphere. A medical device including a bulk material and an oxide layer disposed over at least one surface of the medical device. The oxide layer is substantially pure and free from contaminants.
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