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公开(公告)号：US11759552B2
公开(公告)日：2023-09-19
申请号：US15899436
申请日：2018-02-20
Applicant: Cook Medical Technologies LLC
Inventor： John Neilan , David Murray , James Butler
IPC: A61L31/08 , A61L31/16 , A61L31/02 , A61L27/04 , A61L27/30 , A61L27/54 , B05D3/12 , A61F2/915 , A61F2/90
CPC classification number: A61L31/084 , A61L27/04 , A61L27/303 , A61L27/54 , A61L31/022 , A61L31/16 , B05D3/12 , A61F2/90 , A61F2/915 , A61L2300/416 , A61L2400/18 , A61L2420/02
Abstract: There is disclosed a method of improving the reliability of coating an implantable medical device, such as a stent, with bioactive material in the absence of a carrier material such as a matrix or polymer layer. The method involves cleaning volatile components from the exposed surfaces of the medical device, removing carbon deposits and then applying a uniform carbon layer in a controlled environment. The deliberately applied carbon layer masks impurities of the underlying native oxide layer and leads to more uniform bioactive material coating not only a over the surfaces of a single medical device but also from device to device within a batch and between batches of devices. This improves production as well as optimising the amount and release of drug on the medical device without the need for a carrier material.
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公开(公告)号：US11504253B2
公开(公告)日：2022-11-22
申请号：US16413132
申请日：2019-05-15
Applicant: Cook Medical Technologies LLC
Inventor： Olivia Ryan , James Butler , Joe Hayes , Sean Cummins
Abstract: A vascular intervention device delivery system includes a catheter with a proximal end attached to a handle, and a distal carrier segment for mounting a vascular intervention device thereon. A retractable sheath is movable from a first position covering the distal carrier segment to a second position retracted proximally uncovering the distal carrier segment. A pull is attached to the retractable sheath and extends proximally from the retractable sheath toward the handle. A majority of the length of the pull has a cross sectional shape with a concave side that faces the longitudinal axis and is opposite to a convex side that faces away from the longitudinal axis. The cross sectional shape has a width that is greater than a thickness.
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公开(公告)号：US20190161854A1
公开(公告)日：2019-05-30
申请号：US16200870
申请日：2018-11-27
Applicant: Cook Medical Technologies LLC
Inventor： John Neilan , David Murray , James Butler
Abstract: A method of modifying a surface of a medical device for implantation or disposition inside a patient is described. The medical device comprises a structure having at least one surface. The method includes the steps of: placing the medical device into a plasma chamber substantially free from contaminants and substantially sealing the plasma chamber from the atmosphere; removing at least an outermost layer of any oxide layer from the at least one surface of the structure by a plasma oxide-removal process, whilst maintaining the plasma chamber under seal from the atmosphere; and subsequently forming a new oxide layer at the least one surface of the structure by introducing at least one gas into the plasma chamber, whilst maintaining the plasma chamber under seal from the atmosphere. A medical device including a bulk material and an oxide layer disposed over at least one surface of the medical device. The oxide layer is substantially pure and free from contaminants.
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4.发明申请公开(公告)号：US20180161121A1
公开(公告)日：2018-06-14
申请号：US15837203
申请日：2017-12-11
Applicant: Cook Medical Technologies LLC
Inventor： James Butler , Melissa Lonn , Keith R. Milner , John Neilan
IPC: A61B90/00 , C22F1/16 , B32B15/01 , C22F1/10 , B21C1/02 , A61B17/22 , A61B17/221 , A61B17/34 , A61C7/20 , A61F2/01 , A61F2/07 , A61B17/00 , A61F2/86 , A61M25/00
CPC classification number: A61B90/39 , A61B17/0057 , A61B17/1214 , A61B17/22031 , A61B17/221 , A61B17/3415 , A61B2017/00358 , A61B2017/00526 , A61B2017/00831 , A61B2017/00867 , A61B2090/3966 , A61C7/20 , A61C2201/005 , A61C2201/007 , A61F2/013 , A61F2/07 , A61F2/82 , A61F2/86 , A61F2002/016 , A61F2240/001 , A61F2250/0098 , A61L29/123 , A61L29/18 , A61L31/124 , A61L31/18 , A61M25/0012 , A61M25/005 , A61M25/0108 , A61M2025/0063 , A61M2025/09108 , A61M2025/09133 , A61M2025/09141 , A61M2025/09166 , B21C1/02 , B21C23/22 , B32B15/01 , C22C19/03 , C22F1/10 , C22F1/16
Abstract: A radiopaque composite wire for medical applications has a core comprising a rare earth metal, an outer layer comprising a nickel-titanium alloy disposed over the core, and a controlled diffusion zone between the core and the outer layer. The controlled diffusion zone includes at least one compound phase comprising (a) the rare earth metal and (b) nickel and/or titanium.
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公开(公告)号：US20160331405A1
公开(公告)日：2016-11-17
申请号：US15146178
申请日：2016-05-04
Applicant: Cook Medical Technologies LLC
Inventor： Fionán Keady , John Neilan , James Butler , Shay Joseph Lavelle
CPC classification number: A61B17/3478 , A61B8/12 , A61B10/04 , A61B2010/045 , A61B2017/00867 , A61B2017/3413
Abstract: A single-wire stylet may be constructed as an elongate single-wire, memory-metal alloy body with a generally cylindrical body profile, extending distally from a proximal end terminus, where embodiments include a polymeric distal tip member fixedly attached directly at a distal end of the single-wire body. At least one lengthwise portion of the single-wire body is at least partially in martensitic phase at operating temperatures at and below about 37° C. Where present, the polymeric distal tip member has a generally cylindrical body profile circumferentially bounded by an outer circumference substantially equal to or greater than that of the metal body. The polymeric distal tip member may be overmolded upon a distal-end tip length of an elongate single-wire, memory-metal alloy stylet body, where the distal end and/or discrete intermediate distal-portion length(s) that include martensitic-phase alloy and any polymeric member have greater flexibility than a proximal-most length of the alloy stylet body.
Abstract translation: 单线探针可以被构造为具有大致圆柱形主体轮廓的细长单丝记忆金属合金体，其从近端终端向远侧延伸，其中实施例包括直接固定在远端 的单线体。 单丝主体的至少一个纵向部分在马氏体相中至少部分地处于等于或低于约37℃的操作温度。在存在的情况下，聚合物远侧末端构件具有大致圆柱形的主体轮廓，其外周基本上包围 等于或大于金属体的厚度。 聚合物远侧末端构件可以在细长单丝，记忆 - 金属合金探针体的远端尖端长度上包覆成型，其中远端和/或离散的中间远端部分长度包括马氏体相 合金和任何聚合物构件具有比最近的长度的合金探针体更大的柔性。
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Patent Agency Ranking
公开(公告)号：US20240074880A1
公开(公告)日：2024-03-07
申请号：US18364159
申请日：2023-08-02
Applicant: Cook Medical Technologies LLC
Inventor： John Neilan , David Murray , James Butler
CPC classification number: A61F2/90 , A61L29/16 , A61L31/022 , C22C19/03 , A61L2300/606
Abstract: A medical device such as a stent or medical balloon is functionalised prior to coating with a bioactive material, specifically by carboxylic acidification of the contact surface or surfaces of the medical device. The preferred process involves washing a stent or other medical device in a washing solution which may be sodium hydroxide, soaking in a carboxylic acid solution, rinsing in water to remove excess carboxylic acid, allowing to dry before applying a bioactive agent layer. It has been found that washing after functionalisation removes excess carboxylic acid and enhances the retention of bioactive agent on the contact surface or surfaces of the medical device leading to a more uniform and consistent layer of bioactive agent.
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公开(公告)号：US20240024543A1
公开(公告)日：2024-01-25
申请号：US18364055
申请日：2023-08-02
Applicant: Cook Medical Technologies LLC
Inventor： John Neilan , David Murray , James Butler
CPC classification number: A61L31/084 , A61L31/16 , A61L31/022 , A61L27/04 , A61L27/303 , A61L27/54 , B05D3/12 , A61F2/915
Abstract: There is disclosed a method of improving the reliability of coating an implantable medical device, such as a stent, with bioactive material in the absence of a carrier material such as a matrix or polymer layer. The method involves cleaning volatile components from the exposed surfaces of the medical device, removing carbon deposits and then applying a uniform carbon layer in a controlled environment. The deliberately applied carbon layer masks impurities of the underlying native oxide layer and leads to more uniform bioactive material coating not only a over the surfaces of a single medical device but also from device to device within a batch and between batches of devices. This improves production as well as optimising the amount and release of drug on the medical device without the need for a carrier material.
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公开(公告)号：US20220235454A1
公开(公告)日：2022-07-28
申请号：US17543054
申请日：2021-12-06
Applicant: Cook Medical Technologies LLC
Inventor： John Neilan , David Murray , James Butler
IPC: C23C16/02 , A61L31/02 , A61L31/08 , A61L31/16 , A61L27/30 , A61L27/06 , A61L27/54 , A61F2/82 , C23C16/40 , C23C16/50 , H01J37/32
Abstract: A method of modifying a surface of a medical device for implantation or disposition inside a patient is described. The medical device comprises a structure having at least one surface. The method includes the steps of: placing the medical device into a plasma chamber substantially free from contaminants and substantially sealing the plasma chamber from the atmosphere; removing at least an outermost layer of any oxide layer from the at least one surface of the structure by a plasma oxide-removal process, whilst maintaining the plasma chamber under seal from the atmosphere; and subsequently forming a new oxide layer at the least one surface of the structure by introducing at least one gas into the plasma chamber, whilst maintaining the plasma chamber under seal from the atmosphere. A medical device including a bulk material and an oxide layer disposed over at least one surface of the medical device. The oxide layer is substantially pure and free from contaminants.
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公开(公告)号：US10993742B2
公开(公告)日：2021-05-04
申请号：US16275926
申请日：2019-02-14
Applicant: Cook Medical Technologies LLC
Inventor： Fionán Keady , John Neilan , James Butler , Shay Joseph Lavelle
Abstract: A single-wire stylet may be constructed as an elongate single-wire, memory-metal alloy body with a generally cylindrical body profile, extending distally from a proximal end terminus, where embodiments include a polymeric distal tip member fixedly attached directly at a distal end of the single-wire body. At least one lengthwise portion of the single-wire body is at least partially in martensitic phase at operating temperatures at and below about 37° C. Where present, the polymeric distal tip member has a generally cylindrical body profile circumferentially bounded by an outer circumference substantially equal to or greater than that of the metal body. The polymeric distal tip member may be overmolded upon a distal-end tip length of an elongate single-wire, memory-metal alloy stylet body, where the distal end and/or discrete intermediate distal-portion length(s) that include martensitic-phase alloy and any polymeric member have greater flexibility than a proximal-most length of the alloy stylet body.
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公开(公告)号：US10772994B2
公开(公告)日：2020-09-15
申请号：US15398184
申请日：2017-01-04
Applicant: COOK MEDICAL TECHNOLOGIES LLC
Inventor： John Neilan , David Murray , James Butler
Abstract: A medical device such as a stent (10) or medical balloon (40) is functionalised prior to coating with a bioactive material (54), specifically by acidification or basification of the contact surface or surfaces (50) of the medical device. Functionalisation with subsequent coating of bioactive agent directly onto the functionalised surface provides a significantly more consistent and reliable coating of bioactive agent on a medical device without requiring containment or time release devices.
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