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公开(公告)号：US12115288B2
公开(公告)日：2024-10-15
申请号：US16510352
申请日：2019-07-12
Applicant: Cook Medical Technologies LLC
Inventor： John Neilan , David Murray , James Butler
CPC classification number: A61L31/08 , A61F2/90 , A61L27/54 , A61L31/16 , A61F2250/0067 , A61L27/28 , A61L2300/416 , A61L2420/02
Abstract: A medical device such as a stent (10) or medical balloon (40) is at least partially coated with a saturated carboxylic acid layer in order to enhance biocompatibility, reduce thrombogenesis and increase endothelialisation. The coating is preferably of citric acid in non-crosslinked form and preferably non-porous so as to mask the underlying structure of the medical device. The acid coating forms an outer surface of at least a part of the medical device, that is has no other layer or material overlying it, save for in some embodiments a partial coating of a bioactive material.
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公开(公告)号：US11846016B2
公开(公告)日：2023-12-19
申请号：US17543054
申请日：2021-12-06
Applicant: Cook Medical Technologies LLC
Inventor： John Neilan , David Murray , James Butler
IPC: A61F2/82 , A61L31/02 , C23C16/02 , A61L31/08 , A61L31/16 , A61L27/30 , A61L27/06 , A61L27/54 , C23C16/40 , C23C16/50 , H01J37/32
CPC classification number: C23C16/0227 , A61F2/82 , A61L27/06 , A61L27/306 , A61L27/54 , A61L31/022 , A61L31/088 , A61L31/16 , C23C16/40 , C23C16/50 , H01J37/32449 , H01J37/32513 , A61F2210/0014 , A61F2210/0076 , A61F2240/001 , A61F2250/0067 , A61L2300/416 , A61L2400/18 , A61L2420/02 , H01J2237/335 , H01J2237/3321
Abstract: A method of modifying a surface of a medical device for implantation or disposition inside a patient is described. The medical device comprises a structure having at least one surface. The method includes the steps of: placing the medical device into a plasma chamber substantially free from contaminants and substantially sealing the plasma chamber from the atmosphere; removing at least an outermost layer of any oxide layer from the at least one surface of the structure by a plasma oxide-removal process, whilst maintaining the plasma chamber under seal from the atmosphere; and subsequently forming a new oxide layer at the least one surface of the structure by introducing at least one gas into the plasma chamber, whilst maintaining the plasma chamber under seal from the atmosphere. A medical device including a bulk material and an oxide layer disposed over at least one surface of the medical device. The oxide layer is substantially pure and free from contaminants.
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公开(公告)号：US10231819B2
公开(公告)日：2019-03-19
申请号：US15059041
申请日：2016-03-02
Applicant: Cook Medical Technologies LLC
Inventor： Alison Liddy , Michael Ryan , Gerard Treacy , Ger Houlihan , Shay Lavelle , John Neilan
Abstract: A prosthesis and a method of manufacturing the prosthesis for controlling flow through a bodily lumen are provided. The prosthesis includes a body having a proximal portion, a distal portion and a lumen extending therethrough. The prosthesis also includes a valve operably connected to the body. The valve has a proximal portion, a distal portion and a lumen extending through the valve, where the valve lumen is connected to the body lumen. The valve is configured to be closed in the absence of an antegrade pressure and a retrograde pressure, the retrograde pressure being greater than the antegrade pressure. The valve includes a material portion operably connected to the valve, the material portion providing increased stiffness to the valve relative to the valve alone, wherein the material portion is configured to facilitate self-reversion of the valve to the closed configuration.
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公开(公告)号：US20180236143A1
公开(公告)日：2018-08-23
申请号：US15899436
申请日：2018-02-20
Applicant: Cook Medical Technologies LLC
Inventor： John Neilan , David Murray , James Butler
CPC classification number: A61L31/084 , A61F2/90 , A61F2/915 , A61L27/04 , A61L27/303 , A61L27/54 , A61L31/022 , A61L31/16 , A61L2300/416 , A61L2400/18 , A61L2420/02 , B05D3/12
Abstract: There is disclosed a method of improving the reliability of coating an implantable medical device, such as a stent, with bioactive material in the absence of a carrier material such as a matrix or polymer layer. The method involves cleaning volatile components from the exposed surfaces of the medical device, removing carbon deposits and then applying a uniform carbon layer in a controlled environment. The deliberately applied carbon layer masks impurities of the underlying native oxide layer and leads to more uniform bioactive material coating not only a over the surfaces of a single medical device but also from device to device within a batch and between batches of devices. This improves production as well as optimising the amount and release of drug on the medical device without the need for a carrier material.
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公开(公告)号：US20170105854A1
公开(公告)日：2017-04-20
申请号：US14887950
申请日：2015-10-20
Applicant: COOK MEDICAL TECHNOLOGIES LLC
Inventor： Gerard Thomas Treacy , Don Frawley , John Neilan
CPC classification number: A61F2/88 , A61F2/90 , A61F2220/0075 , A61F2230/0054 , A61F2240/001 , A61F2250/0098
Abstract: A stent and method for treating an end of a pre-woven stent is provided. The method includes providing a pre-woven stent including a plurality of sharp ends. A pair of wire portions that extend in opposite helical directions around the stent are bent and woven into the stent to define a pair of overlapping crown portions. When the wires are woven into the stent a double weave portion of the stent is defined. The wires can be cut to define tail portions that are removed from the stent, leaving a single crown portion. The sharp ends can be alternatively treated by curving the ends to define rounded looped ends.
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Patent Agency Ranking
公开(公告)号：US20160361151A1
公开(公告)日：2016-12-15
申请号：US15244659
申请日：2016-08-23
Applicant: Cook Medical Technologies LLC
Inventor： Alison Liddy , John Neilan , Michael Ryan , Gerard Treacy
IPC: A61F2/04
CPC classification number: A61F2/04 , A61F2/06 , A61F2/07 , A61F2/2412 , A61F2/2415 , A61F2002/044 , A61F2230/0069 , A61F2250/0069
Abstract: A prosthesis and a method for making a prosthesis for controlling flow through a bodily lumen are provided. The prosthesis includes a body having a proximal portion, a distal portion and a lumen extending therethrough and further includes a valve operably connected to the body. The valve has a distal end including a first portion of a surface of the valve lumen and a second portion of the surface that contact each other and form a seal in a closed configuration. The distal end of the valve is formed such that the first portion and the second portion of the surface of the valve lumen contact each other and the distal end is configured to open in response to a pressure that is greater than atmospheric pressure.
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公开(公告)号：US20160082202A1
公开(公告)日：2016-03-24
申请号：US14956010
申请日：2015-12-01
Applicant: Cook Medical Technologies LLC
Inventor： Paul D. Devereux , Shay J. Lavelle , John Neilan
Abstract: Devices are illustrated which provide for accurately controlling the extension of a needle from a protective sheath to increase accuracy and improve the outcome of the treatment procedure.
Abstract translation: 示出了设备，其准确地控制针从保护护套延伸，以提高精度并改善治疗过程的结果。
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公开(公告)号：US20130289740A1
公开(公告)日：2013-10-31
申请号：US13790640
申请日：2013-03-08
Applicant: COOK MEDICAL TECHNOLOGIES LLC
Inventor： Alison Liddy , Michael Ryan , Gerard Treacy , Ger Houlihan , Shay Joseph Lavelle , John Neilan
IPC: A61F2/04
CPC classification number: A61F2/04 , A61F2/2412 , A61F2/2415 , A61F2002/044 , A61F2002/045 , A61F2230/0069 , A61F2240/001 , B05D1/18 , Y10T29/49426
Abstract: A prosthesis and a method of manufacturing the prosthesis for controlling flow through a bodily lumen are provided. The prosthesis includes a body having a proximal portion, a distal portion and a lumen extending therethrough. The prosthesis also includes a valve operably connected to the body. The valve has a proximal portion, a distal portion and a lumen extending through the valve, where the valve lumen is connected to the body lumen. The valve is configured to be closed in the absence of an antegrade pressure and a retrograde pressure, the retrograde pressure being greater than the antegrade pressure. The valve includes a material portion operably connected to the valve, the material portion providing increased stiffness to the valve relative to the valve alone, wherein the material portion is configured to facilitate self-reversion of the valve to the closed configuration.
Abstract translation: 提供了一种假体和制造用于控制通过体腔的流动的假体的方法。 假体包括具有近端部分，远侧部分和延伸通过其的内腔的主体。 假体还包括可操作地连接到身体的阀。 瓣膜具有近端部分，远端部分和延伸穿过瓣膜的内腔，其中阀腔连接到体腔。 阀被配置为在没有顺行压力和逆行压力的情况下关闭，逆行压力大于顺行压力。 所述阀包括可操作地连接到所述阀的材料部分，所述材料部分相对于所述阀单独地为所述阀提供增加的刚度，其中所述材料部分构造成促进所述阀自动回复到所述关闭构型。
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公开(公告)号：US11752019B2
公开(公告)日：2023-09-12
申请号：US16203892
申请日：2018-11-29
Applicant: Cook Medical Technologies LLC
Inventor： John Neilan , David Murray , James Butler
CPC classification number: A61F2/90 , A61L29/16 , A61L31/022 , C22C19/03 , A61L2300/606
Abstract: A medical device such as a stent or medical balloon is functionalised prior to coating with a bioactive material, specifically by carboxylic acidification of the contact surface or surfaces of the medical device. The preferred process involves washing a stent or other medical device in a washing solution which may be sodium hydroxide, soaking in a carboxylic acid solution, rinsing in water to remove excess carboxylic acid, allowing to dry before applying a bioactive agent layer. It has been found that washing after functionalisation removes excess carboxylic acid and enhances the retention of bioactive agent on the contact surface or surfaces of the medical device leading to a more uniform and consistent layer of bioactive agent.
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公开(公告)号：US11193202B2
公开(公告)日：2021-12-07
申请号：US16200870
申请日：2018-11-27
Applicant: Cook Medical Technologies LLC
Inventor： John Neilan , David Murray , James Butler
IPC: A61L27/00 , C23C16/02 , A61L31/02 , A61L31/08 , A61L31/16 , A61L27/30 , A61L27/06 , A61L27/54 , A61F2/82 , C23C16/40 , C23C16/50 , H01J37/32
Abstract: A method of modifying a surface of a medical device for implantation or disposition inside a patient is described. The medical device comprises a structure having at least one surface. The method includes the steps of: placing the medical device into a plasma chamber substantially free from contaminants and substantially sealing the plasma chamber from the atmosphere; removing at least an outermost layer of any oxide layer from the at least one surface of the structure by a plasma oxide-removal process, whilst maintaining the plasma chamber under seal from the atmosphere; and subsequently forming a new oxide layer at the least one surface of the structure by introducing at least one gas into the plasma chamber, whilst maintaining the plasma chamber under seal from the atmosphere. A medical device including a bulk material and an oxide layer disposed over at least one surface of the medical device. The oxide layer is substantially pure and free from contaminants.
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