公开(公告)号：US5576546A

公开(公告)日：1996-11-19

申请号：US230145

申请日：1994-04-19

申请人： Daniel Gagnon

发明人： Daniel Gagnon

IPC分类号： G01T1/164

CPC分类号： G01T1/1642

摘要： In addition to the traditionally calculated photodetector sum signal or energy value, and X, Y position values, the second order moment of the photodetector signals is calculated from photodetector signals to obtain a value proportional to light spread out in the scintillation camera giving an indication of the depth of interaction "DOI". A position correction vector is selected according to the initially calculated position values and the second order moment value and is added to the initial position values to obtain more accurate scintillation event position values. The correction values can be calculated by interpolation using empirically determined or simulation determined values contained in a table. The method of correction using the second order value proportional to DOI can also be used to correct the first order moment value or energy value.

摘要翻译： 除了传统计算的光电检测器和信号或能量值和X，Y位置值之外，光电检测器信号的二阶矩由光电检测器信号计算，以获得与在闪烁照相机中展开的光成比例的值，给出 互动深度“DOI”。 根据初始计算的位置值和二阶矩值选择位置校正矢量，并将其添加到初始位置值以获得更精确的闪烁事件位置值。 可以通过使用包含在表中的经验确定或模拟确定的值进行插值来计算校正值。 使用与DOI成比例的二阶值的校正方法也可以用于校正一阶矩值或能量值。

公开(公告)号：US20170311919A1

公开(公告)日：2017-11-02

申请号：US15584726

申请日：2017-05-02

申请人： Daniel Gagnon

发明人： Daniel Gagnon

IPC分类号： A61B6/00 ,  G01N23/04 ,  A61B6/03 ,  G01T1/161 ,  A61B5/055

CPC分类号： A61B6/5235 ,  A61B5/0555 ,  A61B6/027 ,  A61B6/032 ,  A61B6/037 ,  A61B6/107 ,  A61B6/4241 ,  A61B6/4258 ,  A61B6/4417 ,  A61B6/482 ,  A61B6/50 ,  A61B6/5247 ,  G01N23/046 ,  G01T1/161

摘要： A PET/CT imaging system is provided. The imaging system includes a PET detection system having a plurality of detector rings and an axial gap between at least two adjacent detector rings within the plurality of detector rings. The imaging system includes a CT system having an x-ray generator and a CT detection system positioned within the axial gap between the at least two detector rings. The system is configured to collect PET data and CT data on the same volume of interest substantially simultaneously.

公开(公告)号：US20140095106A1

公开(公告)日：2014-04-03

申请号：US13630787

申请日：2012-09-28

申请人： Wenli WANG ,  Daniel Gagnon ,  Xiaofeng Niu

发明人： Wenli WANG ,  Daniel Gagnon ,  Xiaofeng Niu

IPC分类号： G06F19/00 ,  G01T1/164

CPC分类号： G01T1/2985 ,  A61B6/03 ,  A61B6/032 ,  A61B6/037 ,  A61B6/4258 ,  A61B6/4417 ,  A61B6/5205 ,  G06F19/00 ,  G06T11/005

摘要： A method and apparatus for determining a coincidence window for imaging a region of interest of an object using a Positron Emission Tomography (PET) scanner. The method includes determining a diameter of a transverse field of view (FOV) for imaging the region of interest of the object; and calculating the coincidence window based on the determined diameter, a ring diameter of the PET scanner, an axial length of the PET scanner, and a time-of-flight resolution of the PET scanner.

摘要翻译： 一种用于使用正电子发射断层摄影（PET）扫描仪确定用于对物体感兴趣区域成像的符合窗口的方法和装置。 该方法包括确定用于对物体的感兴趣区域成像的横视场（FOV）的直径; 以及基于确定的直径，PET扫描仪的环直径，PET扫描器的轴向长度和PET扫描仪的飞行时间分辨率来计算重合窗口。

公开(公告)号：US08511894B2

公开(公告)日：2013-08-20

申请号：US12907796

申请日：2010-10-19

申请人： Daniel Gagnon ,  Wenli Wang

发明人： Daniel Gagnon ,  Wenli Wang

IPC分类号： A61B6/04

CPC分类号： G06T11/005 ,  A61B6/037

摘要： A PET imaging system includes a measurement subsystem, a data acquisition subsystem, and a reconstruction subsystem. The measurement subsystem detects deflection in a patient pallet, and generates deflection information based on the detected deflection. The data acquisition subsystem receives the deflection information from the measurement subsystem and PET measurement data corresponding to a plurality of coincidence events from a PET scanner, and communicates the received deflection information and PET measurement data to the reconstruction subsystem. The reconstruction subsystem includes a processor that reconstructs a PET scan image using the deflection information and the PET measurement data communicated by the data acquisition subsystem.

摘要翻译： PET成像系统包括测量子系统，数据采集子系统和重建子系统。 测量子系统检测患者托盘中的偏转，并且基于检测到的偏转产生偏转信息。 数据采集​​子系统从PET扫描仪接收来自测量子系统的偏转信息和对应于多个符合事件的PET测量数据，并将接收到的偏转信息和PET测量数据传送到重构子系统。 重建子系统包括使用由数据采集子系统传送的偏转信息和PET测量数据重建PET扫描图像的处理器。

公开(公告)号：US08188439B2

公开(公告)日：2012-05-29

申请号：US12621691

申请日：2009-11-19

申请人： Daniel Gagnon ,  Kent Burr

发明人： Daniel Gagnon ,  Kent Burr

IPC分类号： G01T1/202

CPC分类号： G01T1/202

摘要： A gamma ray detector module that includes at least one crystal element arranged in a plane, a plurality of light sensors arranged to cover the at least one crystal element and to receive light emitted from the at least one crystal element, and a light guide arranged between the at least one crystal element and the light sensors, the light guide being optically connected to the at least one crystal element. Further, the light guide includes a narrow portion that positions at least one light sensor of the plurality of light sensors closer to the at least one crystal element than other light sensors of the plurality of light sensors. In addition, the light guide may include an angled recessed portion that positions another light sensor at an oblique tilt angle with respect to the plane of the at least one crystal element.

摘要翻译： 一种伽马射线检测器模块，包括布置在平面中的至少一个晶体元件，布置成覆盖所述至少一个晶体元件并且接收从所述至少一个晶体元件发射的光的多个光传感器，以及布置在 所述至少一个晶体元件和所述光传感器，所述光导件光学连接到所述至少一个晶体元件。 此外，光导包括将多个光传感器中的至少一个光传感器定位成比多个光传感器中的其它光传感器更靠近至少一个晶体元件的窄部。 此外，光导可以包括倾斜的凹部，其相对于至少一个晶体元件的平面以相对于倾斜倾斜角定位另一个光传感器。

公开(公告)号：US08080780B2

公开(公告)日：2011-12-20

申请号：US12649159

申请日：2009-12-29

申请人： Kent C. Burr ,  Daniel Gagnon

发明人： Kent C. Burr ,  Daniel Gagnon

IPC分类号： G01D18/00

CPC分类号： G01T1/208 ,  G01T1/1647

摘要： An apparatus and associated method for gamma ray detection that improves the timing resolution is provided. A crystal of interaction in a scintillation crystal array emits scintillation light in response to interaction with a gamma ray. The scintillation light is detected by one or more photomultiplier tubes. Each photomultiplier tube that detects the scintillation light detects the light at a different time. The apparatus determines the location of the gamma ray interaction and uses the location of the interaction to generate correction times for each waveform generated by the photomultiplier tubes. The waveforms are corrected with the correction timings and combined to extract a time of arrival estimate for the gamma ray. Noise thresholding is also used to select waveforms having low noise for combination to extract the time of arrival estimate.

摘要翻译： 提供了一种提高定时分辨率的用于伽马射线检测的装置和相关方法。 闪烁晶体阵列中的相互作用晶体响应于与γ射线的相互作用发射闪烁光。 闪烁光由一个或多个光电倍增管检测。 检测闪烁光的每个光电倍增管在不同的时间检测光。 该装置确定伽马射线相互作用的位置，并使用相互作用的位置来产生由光电倍增管产生的每个波形的校正时间。 波形用校正定时校正并组合以提取伽马射线的到达时间估计值。 噪声阈值也用于选择具有低噪声的波形用于组合以提取到达时间估计。

公开(公告)号：US08073109B2

公开(公告)日：2011-12-06

申请号：US12088090

申请日：2006-09-14

申请人： Daniel Gagnon ,  Wenli Wang ,  Zhiqiang Hu

发明人： Daniel Gagnon ,  Wenli Wang ,  Zhiqiang Hu

IPC分类号： G06K9/00

CPC分类号： G01T1/2985 ,  A61B6/037 ,  G01T1/1611 ,  G06T11/006

摘要： A method and system for use in positron emission tomography, wherein a first processor element (234) is configured to reconstruct a plurality of positron annihilation events detected during a positron emission tomography scan using a list-based reconstruction technique to generate first volumetric data. A second reconstructor (226) is configured to reconstruct the plurality of events using a second reconstruction technique to generate second volumetric data for determining an error correction (228), the error correction applied to the first volumetric data to generate corrected volumetric data for generating a human-readable image (234). In one embodiment a multiplicative error correction is performed on the plurality of events, the first processor element (234) reconstructing the corrected plurality of events; and the second volumetric data error correction comprises an additive error correction.

摘要翻译： 一种用于正电子发射断层摄影的方法和系统，其中第一处理器元件（234）被配置为使用基于列表的重建技术来重建在正电子发射断层摄影扫描期间检测到的多个正电子湮灭事件以产生第一体积数据。 第二重构​​器（226）被配置为使用第二重建技术来重建多个事件，以产生用于确定纠错（228）的第二体积数据，应用于第一体积数据的误差校正以产生校正的体积数据，以产生 人类可读的图像（234）。 在一个实施例中，对多个事件执行乘法误差校正，第一处理器元件（234）重建校正的多个事件; 并且第二体积数据误差校正包括加法误差校正。

公开(公告)号：US20110164801A1

公开(公告)日：2011-07-07

申请号：US13062222

申请日：2009-09-09

申请人： Daniel Gagnon ,  Zhiqiang Hu

发明人： Daniel Gagnon ,  Zhiqiang Hu

IPC分类号： G06K9/00

CPC分类号： G01R33/481 ,  G01R33/5608 ,  G06T7/11 ,  G06T2207/10088 ,  G06T2207/10104 ,  G06T2207/30004

摘要： When correcting attenuation in a nuclear image (e.g., PET or SPECT), an MR-based attenuation correction (AC) map (16) is generated using MR image data (14) of a subject (60). The subject (60) is then placed in a nuclear imaging device with a radioactive point or line source (18, 18′) from which transmission data is measured as the patient is imaged. In order to resolve ambiguity between air voxels and bone voxels in the MR-based AC map (16), estimated transmission data (24) is generated from the AC map and compared to the measured trans-mission data (22) from the point or line source. An error is iteratively calculated for the estimated and measured transmission data, and attenuation values of the AC map (16) are refined to minimize the error. The refined AC map (32) is used to correct attenuation in collected nuclear data (41) which is reconstructed into an attenuation corrected image (99) of the patient.

摘要翻译： 当校正核图像（例如PET或SPECT）中的衰减时，使用对象（60）的MR图像数据（14）来生成基于MR的衰减校正（AC）图（16）。 然后将受试者（60）放置在具有放射性点或线源（18,18'）的核成像装置中，当患者被成像时从该源成像传播数据。 为了解决基于MR的AC映像（16）中的空气体素和骨骼体素之间的模糊性，从AC映射生成估计的传输数据（24），并与测量的传输数据（22） 线源。 对于估计和测量的传输数据迭代地计算误差，并且AC映射（16）的衰减值被改进以使误差最小化。 精细AC图（32）用于校正收集的核数据（41）中的衰减，其被重建成患者的衰减校正图像（99）。

公开(公告)号：US20110105887A1

公开(公告)日：2011-05-05

申请号：US12995685

申请日：2009-05-29

申请人： Daniel Gagnon ,  Sameer Tipnis ,  Raymond Muzic

发明人： Daniel Gagnon ,  Sameer Tipnis ,  Raymond Muzic

IPC分类号： A61B5/055 ,  G06K9/00 ,  A61B5/05

CPC分类号： A61B6/507 ,  A61B6/037 ,  A61B6/486 ,  G06T11/006 ,  G06T2211/412

摘要： A diagnostic imaging device includes detector elements (16) for detecting y-rays indicative of nuclear decay events. Pairs of concurrently detected γ-rays define lines of response (LORs) which are collected, time stamped, and compiled in list-mode. In tissue perfusion studies, it is beneficial to use the data that concurrently maximizes contrast and signal-to-noise ratio in the reconstructed images. Using the list-mode data, events in an adjustable temporal window (33) are reconstructed and the reconstructed images are analyzed to determine a figure of merit based on contrast and signal-to-noise properties of the image. By iteratively adjusting the temporal window, extending its start point (36) backwards in time, and repeating the reconstructing, analyzing, and adjusting steps, an image with an optimal figure of merit is obtained.

摘要翻译： 诊断成像装置包括用于检测表示核衰变事件的y射线的检测器元件（16）。 对同时检测的γ射线定义了收集的行（LOR），并以列表模式进行时间戳和编译。 在组织灌注研究中，使用同时最大化重建图像中的对比度和信噪比的数据是有益的。 使用列表模式数据，重建可调节时间窗口（33）中的事件，并且分析重建图像以基于图像的对比度和信噪比特性确定品质因数。 通过迭代调整时间窗口，及时地将其起点（36）向后延伸，并重复重建，分析和调整步骤，获得具有最佳品质因数的图像。

公开(公告)号：US20110058722A1

公开(公告)日：2011-03-10

申请号：US12990285

申请日：2009-05-04

申请人： Zhiqiang Hu ,  Daniel Gagnon ,  Chi-Hua Tung

发明人： Zhiqiang Hu ,  Daniel Gagnon ,  Chi-Hua Tung

IPC分类号： G06K9/00

CPC分类号： G06T11/006 ,  G06T2211/424 ,  G06T2211/432

摘要： When compensating for truncated patient scan data acquired by a multi-modal PET/CT or PET/MR imaging system (14, 16), such as occurs when a patient is larger than a field of view for an anatomical imaging device, a segmented contour of a non-attenuation-corrected (NAC) PET image is used to identify a contour of the truncated region. An appropriate tissue type is used to fill in truncated regions of a truncated CT or MR image for the attenuation map. The corrected attenuation map is then used to generate an attenuation-corrected PET image of the patient or a region of interest. Alternatively, the system can be employed in PET/CT or PET/MR imaging scenarios where two modalities are performed sequentially (e.g., not simultaneously), and thus the contour derived from the PET scan can be compared to the CT or MR image to infer potential subject motion between the PET and CT or MR scans. Additionally, the system can be employed in PET imaging scenarios where the contour derived from the NAC PET image is used as emission boundary for scatter correction using single-scatter simulation, in which a tail-fitting procedure utilizes an emission boundary to define pure-scatter tails (e.g., in the absence of true coincidence events).

摘要翻译： 当补偿由多模式PET / CT或PET / MR成像系统（14,16）获取的截断的患者扫描数据时，例如当患者大于解剖成像装置的视野时发生，分割的轮廓 使用非衰减校正（NAC）PET图像来识别截断区域的轮廓。 使用适当的组织类型来填充用于衰减图的截断的CT或MR图像的截断区域。 然后校正的衰减图用于产生患者或感兴趣区域的衰减校正的PET图像。 或者，该系统可以用于PET / CT或PET / MR成像场合，其中顺序执行两种模式（例如，不同时执行），因此可以将从PET扫描导出的轮廓与CT或MR图像进行比较以推断 PET和CT或MR扫描之间的潜在主体运动。 此外，该系统可以用于PET成像场景，其中从NAC PET图像导出的轮廓用作使用单分散模拟的散射校正的发射边界，其中尾部拟合过程利用发射边界来定义纯散射 尾巴（例如，没有真正的巧合事件）。